Alumnado con trastorno del espectro autista.

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Carme Aymerich : mestra pionera de l'expressió i la comunicació en educació. 'Carme Aymerich : profesora pionera de la expresión y la comunicación en la educación'.

Se detallan aspectos relativos a la vida y obra de Carme Aymerich. Se analizan sus trabajos en materia pedagógica, como son el fomento de la comunicación e intercambio cultural. Fue pionera en materia de educación a distancia, impulsó acuerdos y convenios de colaboración entre instituciones.

Enerxías alternativas e acuicultura mariña. 'Energías alternativas y acuicultura marina'.

Se analiza el estado actual de las distintas tecnologías energéticas. Se parte de la idea de que las energías son renovables y que la Unión Europea está aumentando su dependencia de energías extranjeras, lo cual podría causar problemas geopolíticos en el futuro. Las energías analizadas son: energía geotérmica, energía solar térmica, energía fotovoltaica, energía eólica, la biomasa y la energía de corrientes marinas. Se realiza una análisis de la dependencia energética derivados de las actividades de la acuicultura y se presentan diversas alternativas que permitan el mejor aprovechamiento energético. Finalmente, se detalla un experimento de utilización de energías alternativas para actividades de acuicultura.

La metacognición en los estilos de aprendizaje de estudiantes de postgrado durante la elaboración del trabajo de grado : caso : la Universidad Rafael Maria Baralt (UNERMB).

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La webquest como herramienta de enseñanza-aprendizaje en educación superior.

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Incorporaci??n de peque??as secuencias de cine comercial en la ense??anza de las drogodependencias : ensayo piloto en la asignatura de Toxicolog??a

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La reflexi?? socioling????stica a les aules de prim??ria i secund??ria : diversitat, usos i actituds

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Una aula amb un nen amb trastorn de l'espectre autista : un gran repte

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Mirem, llegim i parlem de llibres

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A l'escola, fem teatre

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Distinct Unfolding and Refolding Pathways of Ribonuclease A Revealed by Heating and Cooling Temperature Jumps

Heating and cooling temperature jumps (T-jumps) were performed using a newly developed technique to trigger unfolding and refolding of wild-type ribonuclease A and a tryptophan-containing variant (Y115W). From the linear Arrhenius plots of the microscopic folding and unfolding rate constants, activation enthalpy (ΔH#), and activation entropy (ΔS#) were determined to characterize the kinetic transition states (TS) for the unfolding and refolding reactions. The single TS of the wild-type protein was split into three for the Y115W variant. Two of these transition states, TS1 and TS2, characterize a slow kinetic phase, and one, TS3, a fast phase. Heating T-jumps induced protein unfolding via TS2 and TS3; cooling T-jumps induced refolding via TS1 and TS3. The observed speed of the fast phase increased at lower temperature, due to a strongly negative ΔH# of the folding-rate constant. The results are consistent with a path-dependent protein folding/unfolding mechanism. TS1 and TS2 are likely to reflect X-Pro114 isomerization in the folded and unfolded protein, respectively, and TS3 the local conformational change of the β-hairpin comprising Trp115. A very fast protein folding/unfolding phase appears to precede both processes. The path dependence of the observed kinetics is suggestive of a rugged energy protein folding funne

Pressure-jump-induced kinetics reveals a hydration dependent folding/unfolding mechanism of ribonuclease A

Pressure-jump (p-jump)-induced relaxation kinetics was used to explore the energy landscape of protein folding/unfolding of Y115W, a fluorescent variant of ribonuclease A. Pressure-jumps of 40MPa amplitude (5ms dead-time) were conducted both to higher (unfolding) and to lower (folding) pressure, in the range from 100 to 500MPa, between 30 and 50°C. Significant deviations from the expected symmetrical protein relaxation kinetics were observed. Whereas downward p-jumps resulted always in single exponential kinetics, the kinetics induced by upward p-jumps were biphasic in the low pressure range and monophasic at higher pressures. The relative amplitude of the slow phase decreased as a function of both pressure and temperature. At 50°C, only the fast phase remained. These results can be interpreted within the framework of a two-dimensional energy surface containing a pressure- and temperature-dependent barrier between two unfolded states differing in the isomeric state of the Asn-113–Pro-114 bond. Analysis of the activation volume of the fast kinetic phase revealed a temperature-dependent shift of the unfolding transition state to a larger volume. The observed compensation of this effect by glycerol offers an explanation for its protein stabilizing effect

Hints for a fast precessing relativistic radio jet in LS I + 61° 303

Here we discuss two consecutive MERLIN observations of the X-ray binary LS I +61° 303 . The first observation shows a double-sided jet extending up to about 200 AU on both sides of a central source. The jet shows a bent S-shaped structure similar to the one displayed by the well-known precessing jet of SS 433 . The precession suggested in the first MERLIN image becomes evident in the second one, showing a one-sided bent jet significantly rotated with respect to the jet of the day before. We conclude that the derived precession of the relativistic (beta=0.6) jet explains puzzling previous VLBI results. Moreover, the fact that the precession is fast could be the explanation of the never understood short term (days) variability of the associated gamma-ray source 2CG 135+01 / 3EG J0241+6103

La Webquest com a eina d'aprenentatge per a la planificació

La finalitat de l’experiència és oferir un recurs multimèdia, una webquest, per a l’alumnat dels estudis de Grau de Mestre en Educació Primària, per tal que aprenguin una forma més de realitzar planificacions didàctiques d’acord amb el marc teòric que sustenta l’Educació Inclusiva, l’accés universal a un currículum per a tothom i la normativa en matèria d’educació. L’experiència promou la innovació educativa mitjançant l'adequació dels ensenyaments a l'EEES, possibilitant el desenvolupament de determinades competències dels plans d'estudis implicats. Alhora, promou l'experimentació i avaluació de noves metodologies docents i l'elaboració i avaluació de materials d'aprenentatge autònom.

A human ribonuclease induces apoptosis associated with p21WAF1/CIP1 induction and JNK inactivation

Ribonucleases are promising agents for use in anticancer therapy. Among the different ribonucleases described to be cytotoxic, a paradigmatic example is onconase which manifests cytotoxic and cytostatic effects, presents synergism with several kinds of anticancer drugs and is currently in phase II/III of its clinical trial as an anticancer drug against different types of cancer. The mechanism of cytotoxicity of PE5, a variant of human pancreatic ribonuclease carrying a nuclear localization signal, has been investigated and compared to that of onconase. Methods: Cytotoxicity was measured by the MTT method and by the tripan blue exclusion assay. Apoptosis was assessed by flow cytometry, caspase enzymatic detection and confocal microscopy. Cell cycle phase analysis was performed by flow cytometry. The expression of different proteins was analyzed by western blot.n Results: We show that the cytotoxicity of PE5 is produced through apoptosis, that it does not require the proapoptotic activity of p53 and is not prevented by the multiple drug resistance phenotype. We also show that PE5 and onconase induce cell death at the same extent although the latter is also able to arrest the cell growth. We have compared the cytotoxic effects of both ribonucleases in the NCI/ADR-RES cell line by measuring their effects on the cell cycle, on the activation of different caspases and on the expression of different apoptosis- and cell cycle-related proteins. PE5 increases the number of cells in S and G2/M cell cycle phases, which is accompanied by the increased expression of cyclin E and p21WAF1/CIP1 together with the underphosphorylation of p46 forms of JNK. Citotoxicity of onconase in this cell line does not alter the cell cycle phase distribution and it is accompanied by a decreased expression of XIAP. Conclusions: We conclude that PE5 kills the cells through apoptosis associated with the p21WAF1/CIP1 induction and the inactivation of JNK. This mechanism is significantly different from that found for onconase