1000 resultados para Portugal - Pol
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A ENAP Escola Nacional de Administra????o P??blica, com o apoio do Minist??rio do Planejamento, Or??amento e Gest??o, da Ag??ncia Brasileira de Coopera????o do Minist??rio das Rela????es Exteriores, do Centro Latino-americano de Administra????o para o Desenvolvimento (Clad) e da Caixa Econ??mica Federal, construiu uma s??rie de atividades de aprendizagem direcionadas a dirigentes e t??cnicos que atuam nas ??reas de planejamento estrat??gico e avalia????o de programas. Esses eventos de aprendizagem permitiram uma intensa troca de experi??ncias entre os 60 dirigentes e t??cnicos representantes de organismos governamentais de 16 pa??ses ibero-americanos ??? Argentina, Bol??via, Brasil, Chile, Col??mbia, Costa Rica, El Salvador, Guatemala, M??xico, Panam??, Paraguai, Peru, Portugal, Rep??blica Dominicana, Uruguai e Venezuela. A consolida????o desse per??odo de rica troca de experi??ncias est?? retratada nesta publica????o, que mostra o avan??o na constru????o de um conhecimento coletivo referente a desafios contempor??neos de nossos governos nas ??reas de planejamento e de avalia????o de programas sociais
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No contexto de reforma da administra????o p??blica, o objectivo do trabalho pretende dar conta das caracter??sticas dos modelos de direc????o p??blica, em particular dos dirigentes (Senior Executive Service: Top Public Service e Top Management Service), e do seu perfil em face dos novos desafios da administra????o p??blica. O objectivo principal deste trabalho foi caracterizar o sistema de designa????o/ nomea????o para os cargos de dirigente de livre escolha pol??tica, sistema conhecido na literatura como spoil system, com especial refer??ncia ao 1o e 2o n??veis, grupo I, dessas fun????es, no contexto da elite das direc????es-gerais em Portugal.
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Este informe expone de forma sumaria los diversos enfoques y aproximaciones que nueve pa??ses de la Uni??n Europea ??? seis antiguos miembros (Reino Unido, Alemania, Francia, Italia, Espa??a y Portugal) y tres miembros recientes (Letonia, Polonia y Hungr??a) ??? est??n usando para gestionar los conflictos de inter??s en el sector p??blico. En la primera parte, se presenta el marco conceptual y las definiciones con las que poder entender de qu?? hablamos cuando hablamos de corrupci??n y de conflictos de inter??s en el sector p??blico. Posteriormente, trata de las razones existentes tras las pol??ticas de regulaci??n y tratamiento de los conflictos de inter??s y la importancia de ellas para el funcionamiento adecuado de la democracia. A continuaci??n, se explican las caracter??sticas, peculiaridades y dilemas de esta pol??tica p??blica en el contexto de las teor??as y enfoques sobre pol??ticas p??blicas. El informe tambi??n examina los puntos comunes en las estructuras, m??todos y procesos utilizados para gestionar los conflictos de inter??s en los pa??ses estudiados, adem??s de explicitar las principales diferencias en los marcos legales, medios de implantaci??n, mecanismos de evaluaci??n y medios de ejecuci??n. Por ??ltimo, incluye una visi??n cr??tica de las ventajas y desventajas relacionadas con la utilidad de los instrumentos empleados y finaliza con recomendaciones relativas a c??mo formular e implantar pol??ticas de este tipo.
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The aims of this thesis were to better characterize HIV-1 diversity in Portugal, Angola, Mozambique and Cape Verde and to investigate the origin and epidemiological history of HIV-1 in these countries. The impact of these issues in diagnosis, disease progression and susceptibility to ARV therapy was also investigated. Finally, the nature, dynamics and prevalence of transmitted drug resistance (TDR) was determined in untreated HIV-1 infected patients. In Angola, practically all HIV-1 genetic forms were found, including almost all subtypes, untypable (U) strains, CRFs and URFs. Recombinants (first and second generation) were present in 47.1% of the patients. HIV/AIDS epidemic in Angola probably started in 1961, the major cause being the independence war, subsequently spreading to Portugal. In Maputo, 81% of the patients were infected with subtype C viruses. Subtype G, U and recombinants such as CRF37_cpx, were also present. The results suggest that HIV-1 epidemic in Mozambique is evolving rapidly in genetic complexity. In Cape Verde, where HIV-1 and HIV-2 co-circulate, subtype G is the prevailed subtype. Subtypes B, C, F1, U, CRF02_AG and other recombinant strains were also found. HIV-2 isolates belonged to group A, some being closely related to the original ROD isolate. In all three countries numerous new polymorphisms were identified in the RT and PR of HIV-1 viruses. Mutations conferring resistance to the NRTIs or NNRTIs were found in isolates from 2 (2%) patients from Angola, 4 (6%) from Mozambique and 3 (12%) from Cape Verde. None of the isolates containing TDR mutations would be fully sensitive to the standard first-line therapeutic regimens used in these countries. Close surveillance in treated and untreated populations will be crucial to prevent further transmission of drug resistant strains and maximize the efficacy of ARV therapy. In Portugal, investigation of a seronegative case infection with rapid progression to AIDS and death revealed that the patient was infected with a CRF14_BG-like R5-tropic strain selectively transmitted by his seropositive sexual partner. The results suggest a massive infection with a highly aggressive CRF14_BG like strain and/or the presence of an unidentified immunological problem that prevented the formation of HIV-1-specific antibodies. Near full-length genomic sequences obtained from three unrelated patients enabled the first molecular and phylogenomic characterization of CRF14_BG from Portugal; all sequences were strongly related with CRF14_BG Spanish isolates. The mean date of origin of CRF14_BG was estimated to be 1992. We propose that CRF14_BG emerged in Portugal in the early 1990s, spread to Spain in late 1990s as a consequence of IDUs migration and then to the rest of Europe. Most CRF14_BG strains were predicted to use CXCR4 and were associated with rapid CD4 depletion and disease progression. Finally, we provide evidence suggesting that the X4 tropism of CRF14_BG may have resulted from convergent evolution of the V3 loop possibly driven by an effective escape from neutralizing antibody response.
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Resumen basado en el de la publicaci??n
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Resumen tomado de la publicaci??n
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Resumen basado en el de la publicaci??n
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Resumen basado en el de la publicaci??n
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Resumen basado en el de la publicaci??n
Systematic review of Late Jurassic sauropods from the Museu Geológico collections (Lisboa, Portugal)
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The Museu Geológico collections house some of the first sauropod references of the Lusitanian Basin Upper Jurassic record, including the Lourinhasaurus alenquerensis and Lusotitan atalaiensis lectotypes, previously considered as new species of the Apatosaurus and Brachiosaurus genera, respectively. Several fragmentary specimens have been classical referred to those taxa, but the most part of these systematic attributions are not supported herein, excluding a caudal vertebra from Maceira (MG 8804) considered as cf. Lusotitan atalaiensis. From the material housed in the Museu Geológico were identified basal eusauropods (indeterminate eusauropods and turiasaurs) and neosauropods (indeterminate neosauropods, diplodods and camarasaurids and basal titanosauriforms). Middle caudal vertebrae with lateral fossae, ventral hollow border by pronounced ventrolateral crests and quadrangular cross-section suggest for the presence of diplodocine diplodocids in north area of the Lusitanian Basin Central Sector during the Late Jurassic. A humerus collected from Praia dos Frades (MG 4976) is attributed to cf. Duriatitan humerocristatus suggesting the presence of shared sauropod forms between the Portugal and United Kingdom during the Late Jurassic. Duriatitan is an indeterminate member of Eusauropoda and the discovery of new material in both territories is necessary to confirm this systematic approach. The studied material is in according with the previous recorded paleobiodiversity for the sauropod clade during the Portuguese Late Jurassic, which includes basal eusauropods (including turiasaurs), diplodocids and macronarians (including camarasaurids and basal titanosauriforms).
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Doutoramento em Economia.
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Mental health problems are common in primary health care, particularly anxiety and depression. This study aims to estimate the prevalence of common mental disorders and their associations with socio-demographic characteristics in primary care in Brazil (Family Health Strategy). It involved a multicenter cross-sectional study with patients from Rio de Janeiro, São Paulo, Fortaleza (Ceará State) and Porto Alegre (Rio Grande do Sul State), assessed using the General Health Questionnaire (GHQ-12) and the Hospital Anxiety and Depression Scale (HAD). The rate of mental disorders in patients from Rio de Janeiro, São Paulo, Fortaleza and Porto Alegre were found to be, respectively, 51.9%, 53.3%, 64.3% and 57.7% with significant differences between Porto Alegre and Fortaleza compared to Rio de Janeiro after adjusting for confounders. Prevalence proportions of mental problems were especially common for females, the unemployed, those with less education and those with lower incomes. In the context of the Brazilian government's moves towards developing primary health care and reorganizing mental health policies it is relevant to consider common mental disorders as a priority alongside other chronic health conditions.
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Universidade Estadual de Campinas . Faculdade de Educação Física
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The presence of mutations associated with integrase inhibitor (INI) resistance among INI-naive patients may play an important clinical role in the use of those drugs Samples from 76 HIV-1-infected subjects naive to INIs were submitted to direct sequencing. No differences were found between naive (25%) subjects and subjects on HAART (75%). No primary mutation associated with raltegravir or elvitegravir resistance was found. However, 78% of sequences showed at least one accessory mutation associated with resistance. The analysis of the 76 IN sequences showed a high polymorphic level on this region among Brazilian HIV-1-infected subjects, including a high prevalence of aa substitutions related to INI resistance. The impact of these findings remains unclear and further studies are necessary to address these questions.