960 resultados para Exchange of publications


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Com as atuais exigências do mercado, as empresas têm de dar respostas cada vez mais rigorosas aos clientes, como entregas mais regulares e quantidades mais reduzidas, preços mais baixos e tempos de resposta e entregas menores. Processos e produtos mais flexíveis e inovadores são a chave para a sobrevivência e sucesso de muitas empresas: cumprindo os prazos, aumentando a produtividade dos processos, respondendo rapidamente às necessidades do mercado, reduzindo o stock em toda a cadeia, reduzindo tempo e custos operacionais e integrando todas as estruturas de forma a facilitar a troca de informação, refere Russel e Taylor III, (2003). Nos últimos anos temos assistido a uma constante mudança cultural nas empresas, onde a motivação e o desempenho dos seus colaboradores são tidos como essenciais. No grupo SONAE, as práticas existentes continuam a orientar para uma cultura verdadeiramente inovadora. A implementação da metodologia Kaizen foi uma autêntica revolução em que foram desenvolvidas inúmeras ideias, assentando numa forte mudança cultural. O presente estudo pretende clarificar todo o processo de melhoria contínua através da implementação de ferramentas que lhe estão associadas, bem como as auditorias a esses mesmos procedimentos. Cada vez mais, são identificadas estratégias de melhoria contínua baseadas na filosofia Kaizen como forma de fazer face aos novos desafios. Com a implementação do Kaizen, este projeto terá como principal objetivo averiguar se os funcionários estão a obter resultados positivos nas suas funções diárias, bem como nas tarefas em conjunto com os colegas da sua equipa ou de outras equipas. Assim surge o interesse de um estudo de caso realizado na Direção de Serviços Administrativos da SONAE.

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O empreendedorismo tem-se assumido cada vez mais como uma área impulsionadora do desenvolvimento económico dos vários países. O empreendedor tem-se mostrado como um indivíduo capaz de forçar este desenvolvimento através da implementação das suas ideias e projetos criativos e/ou através da sustentabilidade em áreas menos desenvolvidas. De notar que o empreendedorismo atua nas mais diversas áreas, desde a tecnologia, passando pelo turismo, agricultura, atividades industriais ou até mesmo ao nível da responsabilidade e atuação social. Não é portanto, um veículo de desenvolvimento de países ricos ou pobres, desenvolvidos ou em vias de desenvolvimento, é sim, um meio de alcançar mais e melhores resultados, funcionando como força motriz igualmente importante, em grandes metrópoles ou em meios locais rurais. Para que os projetos de empreendedorismo avancem (ou não), é essencial saber reter do plano de negócio a sua real utilidade. Esta ferramenta ao serviço do empreendedor visa ajudar na tomada de decisão, tornando todos os elementos direta ou indiretamente ligados ao projeto, efetivamente visíveis, para que seja viável analisar o seu impacto. Deste modo, pretende-se com esta dissertação dar resposta a questões relacionadas com a viabilidade económico-financeira do projeto em estudo, procurando impulsionar a economia local e nacional através da recuperação e valorização de biscoitos nacionais. É também intuito incluir a perspetiva da Responsabilidade Social neste projeto, para que haja um real intercâmbio de saberes com a comunidade.

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Dissertation submitted in partial fulfillment of the requirements for the Degree of Master of Science in Geospatial Technologies.

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Dissertação para obtenção do Grau de Mestre em Tecnologia e Segurança Alimentar

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This paper presents some of the results already achieved in the European project titled "Simulation for Entrepreneurship - ENTRE4FUTURE". Seven organizations from six different countries participate in this project. Organizations are from two different groups. We have a group of five educational organizations from Romania (project leader), Portugal, Spain, Austria and Denmark. The second group is constituted by two affiliates of chambers of commerce of Romania and Cyprus. The purpose of ENTRE4FUTURE is the exchange of professional experience in matters relating to teaching methodologies, with the curricula of the business simulation and the methodology used in the business simulation courses as an effective method in entrepreneurship for education among young people, the use of the innovative technologies in the business simulation courses between two levels of education - high school and university. The project had its start in 2014 and the end will be in 2016. By this time some results have already been achieved, which passed through the creation of the project website, the reports of the three meetings already held, the presentation of a new curricula for the business simulation courses and a first draft of the Good Practice Guide "Simulation for entrepreneurship".

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Publications are often used as a measure of research work success. Human T-lymphotropic virus (HTLV) type 1 and 2 are human retroviruses, which were discovered in the early 1980s, and it is estimated that 15-20 million people are infected worldwide. This article describes a bibliometric review and a coauthorship network analysis of literature on HTLV indexed in PubMed in a 24-year period. A total of 7,564 documents were retrieved, showing a decrease in the number of documents from 1996 to 2007. HTLV manuscripts were published in 1,074 journals. Japan and USA were the countries with the highest contribution in this field (61%) followed by France (8%). Production ranking changed when the number of publications was normalized by population (Dominican Republic and Japan), by gross domestic product (Guinea-Bissau and Gambia), and by gross national income per capita (Brazil and Japan). The present study has shed light on some of the defining features of scientific collaboration performed by HTLV research community, such as the existence of core researchers responsible for articulating the development of research in the area, facilitating wider collaborative relationships and the integration of new authors in the research groups.

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Dissertação para obtenção do Grau de Mestre em Engenharia e Gestão Industrial

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Dissertação para obtenção do Grau de Mestre em Engenharia Civil – Perfil de Estruturas

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Na globalização dos mercados económicos, as empresas têm uma enorme necessidade de reduzir os custos produtivos e aumentar a sua produtividade face à forte concorrência dos países emergentes. É neste contexto político e económico que as empresas têm de adotar estratégias para assegurar a sua sustentabilidade e competividade. O paradigma Lean Production distingue-se no meio industrial, e tem como principal objetivo reduzir os custos e eliminar os desperdícios associados ao sector. Este paradigma é apoiado em distintas ferramentas, nomeadamente, SMED. A metodologia SMED foi criada e aplicada pela primeira vez nos finais da década de cinquenta e, desde então, tem sido largamente utilizada nos setores industriais, pois permite obter vantagens ao nível da eficiência produtiva, através da redução dos custos de produção especificamente, no tempo total de mudança de ferramenta e no tamanho dos lotes, eliminando assim os custos associados a stock. A presente dissertação tem como objetivo a implementação do método proposto Single Minute Exchange of Die- Upgrade (SMED-Up). Esta metodologia é uma alteração ao método tradicional SMED, com o intuito de dar resposta à redução dos tempos de Setup, com tecnologia e métodos associados à realidade atual. Para aprovar este método, implementou-se na prensa hidráulica existente nas instalações da empresa Britefil, S.A. Fábrica Nacional de Bombas, S.A. Com base nos resultados obtidos nas quatro fases do método SMED-Up, foram desenvolvidas soluções e avaliados os respetivos impactos, a partir dos índices de desempenho do processo. Foi possível reduzir 53,0% do tempo total de mudança de molde face à situação inicial existente na empresa.

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Double Degree. A Work Project, presented as part of the requirements for the Award of a Master’s Degree in Management from NOVA – School of Business and Economics and a Masters Degree in International Business, Strategy and Innovation from Maastricht University

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The technological evolution of the past fifty years has provided Humanity the contact with the last frontier of knowledge: space. An unknown world, explored by a small group of nations, which has become crucial to understanding who we are and where we come from. Space assets in recent years have opened the way to a digital society, shaped by the rapid exchange of information, whose means are mostly in space. A place of fascination and curiosity, restricted to a few people in these decades, which may soon be changing. This essay addresses some legal issues concerning the private exploration of space. Liability on space tourism is the core of this investigation, focusing on the comprehension of the international legal framework and its connection with the states national law. In particular, the study of the main international treaties, the U.S. legal system of space law and the developments in Europe are the fundamental tools of the current analysis, not forgetting the point of view of a possible international harmonization. Besides the needed theoretical context on the evolution of space law and a brief approach of the technical matters of the current aerospace engineering, the goal is to examine the characteristics of international space law and its relation with the new private actors, responsible for providing suborbital flights, operating in a near future. Within these circumstances, given the economic potential of the growing private space industry, it is essential to discuss the legal aspects of a spatial regulation. Being liability, undoubtedly, the emerging issue in the legal debate on this topic, it is important to safeguard the interests of the operators, States and, above all, future space tourists.

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Exosomes are small membrane vesicles secreted by most cell types, either normal or malignant and are found in most body fluids such as saliva, plasma and breast milk. In the past decade, the interest in these vesicles has been growing more and more since it was found that besides their beneficial functions such as the removal of cellular debris and unnecessary proteins during cell maturation process, they can also interact with other cells and transfer information between them, thus helping diseases like cancer to progress. The present work intended to use gold nanoparticles as vehicles for gene silencing in an attempt to reduce the tumor-derived exosome secretion, regulated by Rab27a protein, and also aimed to compare the exosome secretion between two breast cell lines, MCF7 and MDA. Changes in RAB27A gene expression were measured by Real-time Quantitative PCR and it was revealed a decreased in RAB27A gene expression, as expected. Exosomes were isolated and purified by two different methods, ultracentrifugation and the commercial kit ExoQuick™ Solution, and further characterized using Western Blot analysis. ExoQuick™ Solution was proven to be the most efficient method for exosome isolation and it was revealed that MDA cells secrete more exosomes. Furthermore, the isolated MCF7-derived exosomes were placed together with a normal bronchial/tracheal epithelial cell line (BTEC) for an additional assay, which aimed to observe the uptake of exosomes by other cells and the exosomes’ capability of promoting cell-cell communication. This observation was made based on alterations in the expression levels of c-Myc and miR-21 genes and the fact that they both have an increased expression in BTEC cells incubated with tumor-derived exosomes when compared to control cells (without incubation with the exosomes) lead us to the conclusion that the exosome uptake and exchange of information between the exosomes and the normal cells did occurred.

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Cooperation between police forces is a topic that is increasingly relevant. The emergence of new threats, as well as looking for new ways to fight crime, require from the, careful monitoring and strict sharing of all relevant information. This Work is entitled “The GNR and cooperation between Criminal Police Bodies in the Risk Society. Case Study: District of Lisbon” and aims to study the cooperation and coordination between police forces in Lisbon district, and verify if there is an parallel between the rule of law and the police procedures. The work is organized in four chapters. The first consists in a theoretical framework to perceive the context and objectives of this work. The second addresses the role of the, the different types of cooperation and instruments that promote cooperation between them. The third presents and analyzes the results. Finally, the fourth and last chapter the conclusions are woven answered the questions derived and starting question, tested hypotheses, and those limitations and future recommendations. In conclusion, the District of Lisbon, there is cooperation, materialized in a constant exchange of information, based on personal and informal relationship between the elements of the various Police Forces.

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Tax evasion and fraud threaten the economic and social objectives of modern tax systems, precluding the state funding for the satisfaction of collective needs and the fair distribution of wealth, being a violation of basic principles and values of our society. In tax law, to give tax administration the necessary powers to supervise and control the information provided by taxpayers and combat tax evasion and fraud, over the last years the grounds for a derogation of bank secrecy without judicial authorization have been extended, which raises some constitutional compatibility issues. Similarly, this tendency of making this legal regime more flexible and increasing automatic exchange of information has been followed by the European Union and the international community. Banking secrecy, as a professional secrecy, is an instrument to protect the right to privacy but also appears as an anti-abuse and repressive mechanism of evasive and fraudulent behaviors. Because of the conflict of interests will always be necessary to make a practical agreement between them, ensuring the legality and the due guarantees of the taxpayers but also an effective way to combat tax evasion and fraud. Bank secrecy cannot be one method to, behind the right to privacy, taxpayers practice illegal activities. But the practice of these irregular conducts also does not justify a total annihilation of the right to banking secrecy, uncovering all documents and bank information’s. Although considering the legislative changes, the administrative derogation of bank secrecy will always be what the tax administration does of it.

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Dissertação de mestrado integrado em Engenharia e Gestão Industrial