Changes in clinical and laboratory findings at the time of diagnosis of primary hyperparathyroidism in a University Hospital in São Paulo from 1985 to 2002

In contrast to most developed countries, most patients with primary hyperparathyroidism in Brazil are still symptomatic at diagnosis. However, we have been observing a change in this pattern, especially in the last few years. We evaluated 104 patients, 77 females and 27 males aged 11-79 years (mean: 54.4 years), diagnosed between 1985 and 2002 at a University Hospital. Diagnosis was made on the basis of clinical findings and of high total and/or ionized calcium levels, high or inappropriate levels of intact parathyroid hormone and of surgical findings in 80 patients. Patients were divided into three groups, i.e., patients diagnosed from 1985 to 1989, patients diagnosed from 1990 to 1994, and patients diagnosed from 1995 to 2002. The number of new cases diagnosed/year increased from 1.8/year in the first group to 6.0/year in the second group and 8.1/year in the third group. The first group comprised 9 patients (mean serum calcium ± SD, 13.6 ± 1.6 mg/dl), 8 of them (88.8%) defined as symptomatic. The second group comprised 30 patients (mean calcium ± SD, 12.2 ± 1.63 mg/dl), 22 of them defined as symptomatic (73.3%). The third group contained 65 patients (mean calcium 11.7 ± 1.1 mg/dl), 34 of them symptomatic (52.3%). Patients from the first group tended to be younger (mean ± SD, 43.0 ± 15 vs 55.1 ± 14.4 and 55.7 ± 17.3 years, respectively) and their mean serum calcium was significantly higher (P < 0.05). All of symptomatic patients independent of group had higher serum calcium levels (12.4 ± 1.53 mg/dl, N = 64) than asymptomatic patients (11.4 ± 1.0 mg/dl, N = 40). Our data showed an increase in the percentage of asymptomatic patients over the years in the number of primary hyperparathyroidism cases diagnosed. This finding may be due to an increased availability of diagnostic methods and/or to an increased awareness about the disease.

Mobiilipelien kehitys ja julkaisu monialustakehitystyökaluja hyödyntäen

Tässä kandidaatintyössä esitellään mobiilimarkkoiden pirstaloitumisongelma, ja se millaisia haasteita kehittäjät voivat kokea kehittäessään sovelluksia, jotka tukevat useampia mobiilialustoja. Lisäksi työssä esitellään erilaisia mobiilisovelluksissa käytettäviä monetisaatiomalleja. Työssä tarkastellaan myös monialustakehitystyökalujen ja HTML5-tekniikan soveltuvuutta mobiilialustojen kehityshaasteiden ratkaisemiseen. Työn lopuksi toteutetaan ja julkaistaan käytännön pelisovellus monialustatyökalulla eri alustoja tukien. Tämän demosovelluksen avulla perehdytään julkaisuprosesseihin käytännössä, tuoden esille eri alustojen asettamia vaatimuksia kehittäjälle.

Usability metric design for prenatal healthcare information system

This work goes through the concept of usability in general and healthcare, especially prenatal healthcare, context. Different frameworks and guidelines used to measure it are considered. A collection of metrics is suggested to be used at a prenatal unit of one Finnish healthcare district. The metrics consist of a set of 12 general measures and a supplementary System Usability Scale questionnaire including a Fun Toolkit Smileyometer. The metrics are tested in real life work situations by observing meetings with patients and presenting the questionnaire for the focus group personnel. A total of 6 focus group patient meetings were observed. This work suggests that in order to get more conclusive data from the metrics the focus groups need to be more involved and observation situations need to be more controlled. Revised metrics consist of the 12 general measures.

Sosioteknisen kuilun kaventaminen toiminnanohjausjärjestelmän ja käyttäjien välillä

Pro Gradu- tutkimuksen keskeisin tavoite on ollut selvittää, kuinka sosioteknistä kuilua kohdeyrityksen toiminnanohjausjärjestelmän ja käyttäjien välillä voitaisiin pienentää. Teo-reettisena viitekehyksenä on käytetty sosioteknistä systeemiteoriaa sekä teorioita liittyen tietoteknisen järjestelmän hyväksyntään. Toiminnanohjausjärjestelmät ovat tunnetusti välttämätön osa nykypäivää lähes kaikille yrityksille. Niiden käyttöönoton onnistumista ja käytön tehokkuutta voidaan parantaa huomioimalla sekä sosiaalinen että tekninen systeemi organisaatiossa. Sosiotekninen kuilu rakentuu kahden välttämättömän ja toisistaan riippuvaisen systeemin välille: sekä sosiaalinen systeemi eli henkilöstö ja heidän työtapansa että tekninen systeemi eli tekno-logia ja tieto on huomioitava ja aidosti sosioteknisessä muutoksessa molempia systeeme-jä muokattava. Organisaatio voi parantaa omilla toimillaan käyttäjien asennetta ja haluk-kuutta ja siten kaventaa kuilua sosiaalisen systeemin puolelta. Lisäksi teknistä systeemiä tulisi muokata paremmin vastaamaan käyttäjien toiveita, jotta kuilu kapenisi myös tekni-sen systeemin suunnasta. Tutkimus toteutettiin laadullisena ja aineistonkeräystapana käytettiin puolistrukturoituja haastatteluja kohdeyrityksessä.

Sotilasyksikön integraatio – koulutuskulttuurien kohtaaminen ja konfliktit

Tutkimuksen kohteena on yksi sotilasyksikkö, Reserviupseerikoulun Esikunta- ja viestikomppania. Kyseisessä yksikössä koulutetaan reservinupseereita sotilaspo-liisi-, huolto-, johtamisjärjestelmä- ja komentopaikkatehtäviin. Sotilaspoliisilinja ja huoltolinja ovat liittyneet yksikköön vuoden 2014 lopulla. Tämä integraatio on saanut aikaan tiedonintressin koulutuslinjojen kulttuureihin liittyen. Tarkoituksena on selvittää miten linjojen koulutuskulttuurit poikkeavat toisistaan ja mitä kulttuurien integraatiossa tapahtuu. Tutkimuksen tavoitteena on myös antaa suosituksia yksikölle mahdollisten kulttuuriristiriitojen ja konfliktien hallitsemiseksi. Tutkimus on luonteeltaan sosiaaliantropologista kauppatieteellistä kulttuurintutki-musta. Taustatieteinä ovat liiketaloustiede, antropologia, sosiologia ja osittain or-ganisaatiopsykologia. Tutkimusote on laadullinen ja aineiston hankinnan mene-telminä on käytetty yksikön kouluttajien haastatteluja ja osallistuvaa havainnointia. Tutkimusaineisto on analysoitu teoriaohjaavaa laadullista sisällönanalyysiä käyttäen. Analyysin tavoitteena oli tunnistaa erot integroituvissa koulutuskulttuureissa, ymmärtää eroista johtuvien konfliktien logiikkaa ja tarkastella kulttuurien vuotamisen logiikkaa. Esikunta- ja viestikomppanian koulutuskulttuurien erilaisuutta analysoitiin seuraavien teoriateemojen kautta: oppilaskäsitys, suhtautuminen upseerioppilaisiin, artefaktit (koulutusmenetelmät), arvot, asenteet ja kouluttamisen syväoletukset. Koulutuskulttuurien kohtaamista analysoitiin psykologisen omistajuuden, reviirikäyttäytymisen ja kulttuurin vuotamisen teorioiden kautta. Tutkimustulokset osoittavat, että kulttuurilla todella on merkitystä sotilasorganisaa-tion integraatiotilanteessa. Esikunta- ja viestikomppanian koulutuskulttuureissa on havaittavissa huomattavia eroja, mutta myös samankaltaisuuksia. Kulttuurien erot johtavat ristiriitaisuuksiin, konflikteihin, reviirikäyttäytymiseen ja saavat ihmiset osoittamaan mieltään eri tavoin. Toisaalta kulttuuripiirteillä on myös taipumusta vuotaa ympäristöön nopeuttaen uusien organisaation osien sopeutumista. Johtajan rooli kulttuurien hallinnassa on keskeinen. Johtajan oma kulttuuriorientaatio voi johtaa konflikteihin, mutta toisaalta myös ratkaista niitä. Tärkeimpänä johtopäätöksenä on, että suuressa sotilasyksikössä kannattaisi laatia strategia eli suunnitelma kulttuurin johtamista varten silloin, kun integraatio on tapahtumassa. Strategian avulla voidaan ottaa kantaa useisiin kulttuurillisiin ristiriitoihin, joita siis Esikunta- ja viestikomppaniankin tapauksessa ilmenee. Koko yksikön henkilöstä kannattaisi sitouttaa ja ottaa mukaan strategian laadintaan. Strategia selventäisi esimerkiksi yksikön arvoja, visiota, missiota, tehtäviä, erilaisten linjojen erityisasemaa ja poikkeuksia, haluttua ja toivottua toimintaa ja asennetta, palkitsemiskäytäntöjä, toisin sanoen kulttuurin eri tekijöitä. Strategia ei ole vain liiketaloudellinen tulosyksikön pitkän tähtäimen pakollinen työkalu, vaan myös sotilasorganisaation kulttuurin johtamisen väline.

Galantamine protects against lipopolysaccharide-induced acute lung injury in rats

Lipopolysaccharide (LPS)-induced endotoxemia triggers the secretion of proinflammatory cytokines and can cause acute lung injury (ALI). The high mobility group box 1 (HMGB1) protein plays an important role as a late mediator of sepsis and ALI. Galantamine (GAL) is a central acetylcholinesterase inhibitor that inhibits the expression of HMGB1. This study evaluated the effects of GAL by measuring levels of inflammatory mediators and observing histopathological features associated with LPS-induced ALI. Sixty 8-10 week old male Sprague-Dawley rats (200-240 g) were randomized into three groups as follows: control group, LPS group (7.5 mg/kg LPS), and LPS+GAL group (5 mg/kg GAL before LPS administration). Histopathological examination of lung specimens obtained 12 h after LPS administration was performed to analyze changes in wet-to-dry (W/D) weight ratio, myeloperoxidase (MPO) activity, and HMGB1 expression level. Additionally, plasma concentrations of tumor necrosis factor-α, interleukin-6, and HMGB1 were measured using an enzyme-linked immunosorbent assay at 0 (baseline), 3, 6, 9, and 12 h after LPS administration. Mortality in the three groups was recorded at 72 h. LPS-induced ALI was characterized by distortion of pulmonary architecture and elevation of MPO activity, W/D weight ratio, and levels of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin-6, and HMGB1. Pretreatment with GAL significantly reduced the LPS-induced lung pathological changes, W/D weight ratio, levels of pro-inflammatory cytokines and MPO activity (ANOVA). Moreover, GAL treatment significantly decreased the mortality rate (ANOVA). In conclusion, we demonstrated that GAL exerted a protective effect on LPS-induced ALI in rats.

Model-based testing of software systems : functionality and performance

Software is a key component in many of our devices and products that we use every day. Most customers demand not only that their devices should function as expected but also that the software should be of high quality, reliable, fault tolerant, efficient, etc. In short, it is not enough that a calculator gives the correct result of a calculation, we want the result instantly, in the right form, with minimal use of battery, etc. One of the key aspects for succeeding in today's industry is delivering high quality. In most software development projects, high-quality software is achieved by rigorous testing and good quality assurance practices. However, today, customers are asking for these high quality software products at an ever-increasing pace. This leaves the companies with less time for development. Software testing is an expensive activity, because it requires much manual work. Testing, debugging, and verification are estimated to consume 50 to 75 per cent of the total development cost of complex software projects. Further, the most expensive software defects are those which have to be fixed after the product is released. One of the main challenges in software development is reducing the associated cost and time of software testing without sacrificing the quality of the developed software. It is often not enough to only demonstrate that a piece of software is functioning correctly. Usually, many other aspects of the software, such as performance, security, scalability, usability, etc., need also to be verified. Testing these aspects of the software is traditionally referred to as nonfunctional testing. One of the major challenges with non-functional testing is that it is usually carried out at the end of the software development process when most of the functionality is implemented. This is due to the fact that non-functional aspects, such as performance or security, apply to the software as a whole. In this thesis, we study the use of model-based testing. We present approaches to automatically generate tests from behavioral models for solving some of these challenges. We show that model-based testing is not only applicable to functional testing but also to non-functional testing. In its simplest form, performance testing is performed by executing multiple test sequences at once while observing the software in terms of responsiveness and stability, rather than the output. The main contribution of the thesis is a coherent model-based testing approach for testing functional and performance related issues in software systems. We show how we go from system models, expressed in the Unified Modeling Language, to test cases and back to models again. The system requirements are traced throughout the entire testing process. Requirements traceability facilitates finding faults in the design and implementation of the software. In the research field of model-based testing, many new proposed approaches suffer from poor or the lack of tool support. Therefore, the second contribution of this thesis is proper tool support for the proposed approach that is integrated with leading industry tools. We o er independent tools, tools that are integrated with other industry leading tools, and complete tool-chains when necessary. Many model-based testing approaches proposed by the research community suffer from poor empirical validation in an industrial context. In order to demonstrate the applicability of our proposed approach, we apply our research to several systems, including industrial ones.

Organization of the marketing communication activities after fusion - the integration and the decision making processes

This master’s thesis was made in order to gain answers to the question of how the integration of the marketing communications and the decision making related to it in a geographically dispersed service organization could be improved in a situation where an organization has gone through a merger. The effects of the organizational design dimensions towards the integration of the marketing communications and the decision making related to it was the main focus. A case study as a research strategy offered a perfect frames for an exploratory study and the data collection was conducted by semi-structured interviews and observing. The main finding proved that from the chosen design dimensions, decentralization, coordination and power, could be found specific factors that in a geographically dispersed organization are affecting the integration of the marketing communications negatively. The effects can be seen mostly in the decision making processes, roles and in the division of responsibility, which are affecting the other dimensions and by this, the integration. In a post-merger situation, the coordination dimension and especially the information asymmetry and the information flow seem to have a largest affect towards the integration of the marketing communications. An asymmetric information distribution with the lack of business and marketing education resulted in low self-assurance and at the end in fragmented management and to the inability to set targets and make independent decisions. As conclusions it can be stated, that with the organizational design dimensions can the effects of a merger towards the integration process of the marketing communications to be evaluated.

Virtaustehokkuuden parantaminen tuotannossa visuaalisen ohjauksen avulla

Yrityksen kilpailukyvyn turvaaminen muuttuvassa toimintaympäristössä on välttämätöntä. Lean-ajattelun avulla tuotantoyritysten on mahdollista toimia tehokkaammin parantamalla virtausta. Tämän työn tarkoituksena on parantaa kotimaisen elintarviketeollisuusyrityksen tuotannon sisäisten materiaalivirtojen tehokkuutta. Tavoitteena tutkimuksella on löytää nykyisistä materiaalivirroista kehittämiskohteita sekä rakentaa niihin ratkaisuja. Tätä kautta kohdeyritystä autetaan saavuttamaan tehokkaampi ja turvallisempi työympäristö. Tutkimuksessa käytettiin kvalitatiivista tutkimusmenetelmää. Teoriaosiossa tehtiin kirjallisuuskatsaus lean-ajatteluun sekä visuaaliseen ohjaukseen. Teoriasta saatiin menetelmät materiaalivirtojen analysointiin sekä toiminnan kehittämiseen. Empiirisessä osiossa tietoa kerättiin tuotannon henkilöstön haastatteluilla sekä havainnoimalla työntekoa tuotannossa materiaalivirtojen kuvaamiseksi. Kuvausten perusteella paikallistettiin materiaalivirroista hukkia, joiden vähentämiseksi luotiin virtaustehokkuutta parantavia kehitysehdotuksia. Virtaustehokkuuden parantamisessa käytettiin hyödyksi materiaalitarpeesta ilmoittavaa andon-järjestelmää, joka kuuluu visuaalisen ohjauksen menetelmiin. Tämän lisäksi käytettiin kohdeyrityksellä jo käytössä olevaa 5S-menetelmää. Näiden menetelmien tehokas hyödyntäminen edellyttää kuitenkin lean-ajattelun periaatteiden mukaisia muutoksia työskentelytapoihin, materiaalien varastopaikkoihin sekä tuotannossa toimiviin osastoihin.

Interference of heating on the antimicrobial activity and chemical composition of Origanum vulgare L. (Lamiaceae) essential oil

Origanum vulgare L. (oregano), Lamiaceae, essential oil has a variety of biological properties and its antimicrobial activity has received a renewed interest for use in food conservation. The aim of this study was to evaluate the interference of heating on the antimicrobial activity and chemical composition of O. vulgare essential oil. The antimicrobial activity of the essential oil kept at room temperature and exposed to different heating temperatures (60, 80, 100 and 120 °C during 1 hour) was evaluated by observing antimicrobial effectiveness at absolute concentration and determining MIC values by the solid medium diffusion procedure. The essential oil chemical composition analysis was performed by GC-MS. O. vulgare essential oil showed interesting antimicrobial activity on all assayed microbial strains (Candida albicans, C.krusei, C. tropicalis, Bacillus cereus, Escherichia coli, Staphylococcus aureus, Yersinia enterocolitica, Salmonella enterica, Serratia marcencens), noted by large growth inhibition zones (30-42 mm). Heating treatment showed no significant interference (p < 0.05) on the essential oil antimicrobial activity, noted by the development of microbial growth inhibition zones with similar or close diameters when evaluating the essential oil kept at room temperature and after exposure to different thermal treatments. MIC values oscillated between 10and 40 µL.mL-1 (20µL.mL-1 for most strains). However, no significant difference (p < 0.05) was noted among the MIC values found for the essential oil aliquots exposed to different temperatures. Moreover, heating did not significantly (p < 0.05) affect the chemical composition of O. vulgare essential oil. Monoterpenes, terpenic compounds and sesquiterpenes were found in the essential oil, with carvacrol (68.06-70.27%) and p-cymene (12.85-15.81%) being the compounds found in the highest amounts. These results showed the thermal stability and intense antimicrobial properties of O. vulgare essential oil and support its possible concomitant use with heating temperatures in order to reach microbial safety in foods.

Detection of genetically modified maize events in Brazilian maize-derived food products

The Brazilian government has approved many transgenic maize lines for commercialization and has established a threshold of 1% for food labeling, which underscores need for monitoring programs. Thirty four samples including flours and different types of nacho chips were analyzed by conventional and real-time PCR in 2011 and 2012. The events MON810, Bt11, and TC1507 were detected in most of the samples, and NK603 was present only in the samples analyzed in 2012. The authorized lines GA21, T25, and the unauthorized Bt176 were not detected. All positive samples in the qualitative tests collected in 2011 showed a transgenic content higher than 1%, and none of them was correctly labeled. Regarding the samples collected in 2012, all positive samples were quantified higher than the threshold, and 47.0% were not correctly labeled. The overall results indicated that the major genetically modified organisms detected were MON810, TC1507, Bt11, and NK603 events. Some industries that had failed to label their products in 2011 started labeling them in 2012, demonstrating compliance with the current legislation observing the consumer rights. Although these results are encouraging, it has been clearly demonstrated the need for continuous monitoring programs to ensure consumers that food products are labeled properly.

Eletrical conductivity and deterioration of soybean seeds exposed to different storage conditions

Research with soybean seeds has revealed that the results of the electrical conductivity test may be influenced by storage temperature, particularly low temperature, such as 10ºC, suggesting that seed deterioration at low storage temperatures does not seem to be directly related to the loss of the cell membrane integrity. This study was conducted with seeds of two soybean cultivars with the objective of: a) studying the effect of different storage temperatures (10ºC; 20ºC; 25ºC; 20/10ºC and 25/10ºC) on the results of the electrical conductivity test; b) observing the behavior of fatty acids and carbohydrates during storage and studying its relation with the electrical conductivity results. Every three months, from a total of 18 months of storage, the physiological quality of seeds was evaluated using the germination, accelerated aging and electrical conductivity tests. Based on the obtained results, it can be concluded that the electrical conductivity test was not shown to be a good indicative of the deterioration process of seeds stored at low temperatures, and no direct relationship between changes in the fatty acids and carbohydrates and the behavior of the mentioned test for seeds stored at 10ºC was found.

Valmistusstrategian muodostaminen uudelle tuoteperheelle

Diplomityön tavoitteena on tutkia valmistusstrategian muodostamista rajaten tarkastelu yhteen tuoteperheeseen. Työn teoriaosuudessa suoritaan kirjallisuuskatsaus, jonka keskeisempänä tuloksena luodaan teoriaviitekehys valmistusstrategian muodostamisesta. Valmistusstrategian osa-alueiksi rajataan toimitusketjun rakenne, tuotantomuodon valinta, kapasiteetin suunnittelu sekä materiaalinohjaus. Työn soveltavassa osuudessa muodostetaan esitetyn teoriaviitekehyksen avulla valmistusstrategiaehdotelma Case – yrityksen uudelle tuoteperheelle. Valmistusstrategian tavoitteet sekä rajoitteet tunnistetaan tarkastelemalla yrityksen ylemmän tason strategioita, markkinavaatimuksia, valmistuksen resursseja sekä päivittäistä toimintaa. Kokonaisuudessaan diplomityö käsittelee valmistusstrategian muodostamista aikaisempaa kirjallisuutta yksityiskohtaisemmin ja käytännönläheisemmästä näkökulmasta. Case – yrityksen uudelle tuoteperheelle ehdotettu valmistusstrategia todetaan seuraavan yleisesti hyviä toimitusketjun johtamisen periaatteita.

Estado, bloco no poder e acumulação capitalista: uma abordagem teórica

State, power block and capitalist accumulation: a theoretical approach. This article aims to elaborate a theory, based on Poulantzas, about the role of the State in a capitalist economy through a relational perspective that perceives the State as a field and a strategic process for the disputes of class fractions within the power bloc. In order to do so, it exposes the relation between State and accumulation at an abstract-formal level, emphasising the limitations of studies that use only this dimension. Next, it analyzes the role of the power bloc in mediating between the abstract and concrete levels of the State, observing that public policies are elaborated as a result of the clashes within the power bloc. Finally, it promotes a discussion on the external constraints (international system) that are affected and affect the State and, consequently, the dynamics of the power bloc.

Information management in aircraft maintenance

Well managed information promotes competitive advantage and economic value for the company. The challenge is to use information effectively in complex networks. Decision making in network is complicated due to many independent sources of information. The aim of the present study was to identify and map the internal information flows and used information resourced by functions and roles, to make proposals to the case organization to improve the information management and to improve the situational awareness and process flows. In the present study, an inductive approach was applied, with the aim to find out gaps and bottlenecks of information flow of an aircraft maintenance organization and its network. The empirical part was conducted with observing the processes and with questionnaires. Theoretical part of this study consists on reviewing relevant literature on maintenance management in aviation and information management in aviation. Together with empirical evidence and the literature used in the study the gaps were found and suggestions for improvements were done. The outcome of this study contributes the organization in its bigger goal to improve the productivity. The information management of the network is one actor in the field and will pave the way to smoother operation and situational awareness. The lack of rules and requirements for information management and spreading is a challenge in information management. The excessive data overburden may cause problem in the actors’ situation-awareness due to non-availability of the right information.