Orientaciones y estrategias dirigidas al profesorado para trabajar con alumnado con trastorno por d??ficit de atenci??n e hiperactividad

Esta gu??a pretende contribuir a la mejora de la atenci??n educativa del alumnado con necesidad espec??fica de apoyo educativo por presentar dificultades de aprendizaje en general, y en particular para el alumnado que presenta TDAH (trastorno por d??ficit de atenci??n con o sin hiperactividad). Dirigida al profesorado en general, en ella se facilitan orientaciones y estrategias que permiten ajustar la atenci??n a las necesidades educativas que presenta este alumnado, tanto en el ??mbito escolar como en el familiar

Educaci?? permanent, comprom??s i experi??ncies de la praxi

Resumen basado en el de la publicaci??n

El huerto escolar : muchas ventajas y algunos inconvenientes

Se despejan las dudas sobre las ventajas que presenta el huerto escolar y cu??les son sus principales inconvenientes. A trav??s del huerto se fomenta la creatividad, toma de decisiones, actitud cr??tica y responsable, en temas como el consumismo, etc. Cualquiera de los ejercicios que vienen en el libro de texto se puede modificar y adaptar a contenidos del huerto.

Aprendemos haciendo

Se presenta un proyecto en el que participa el claustro del CEIP Rodr??guez Galv??n basado en la importancia del aprendizaje competencial del alumnado. A trav??s de este proyecto se puede participar y trabajar en contextos reales cuyos aprendizajes permiten el desarrollo de las competencias b??sicas. Se toma como eje tem??tico el voluntariado y se dise??a al amparo de la convocatoria Comenius, en colaboraci??n con centros de Ruman??a, Turqu??a, Italia, Portugal, Bulgaria y Polonia. Conjuntamente con los aprendizajes competenciales, se prioriza el trabajo de la educaci??n en valores, en concreto con la preparaci??n y desarrollo mensual de una acci??n de voluntariado orientada a la adquisici??n de pr??cticas solidarias.

Satisfacci??n y motivaci??n del profesorado en el primer curso en grados de ciencias sociales

Resusmen basado en el de la publicaci??n

Rutas naturales por Espa??a y Chile

T??tulo tomado de la cubierta

Mejora del espacio exterior escolar desde la participaci??n comunitaria

Resumen basado en el de la publicaci??n

Ecolog??as de saberes dentro de la Universidad : propuestas de intervenci??n para liberar dispositivos docentes

Resumen basado en el de la publicaci??n

El huerto escolar : recurso educativo del geocentro

El trabajo obtuvo un premio de la Modalidad A de los Premios Tom??s Garc??a Verdejo a las buenas practicas educativas en la Comunidad Aut??noma de Extremadura para el curso 2011-2012

V Semana de las lenguas

El trabajo obtuvo un premio de la Modalidad A de los Premios Tom??s Garc??a Verdejo a las buenas pr??cticas educativas en la Comunidad Aut??noma de Extremadura para el curso 2011

Combination treatment in the rehabilitation of visuo-spatial neglect

Resumen tomado de la publicaci??n

Role of lipids in human nutrition

Fat is a major contributor to energy intake in most Western diets, supplying 35–40% of food energy. It is described as being ‘energy-dense’, because a gram of fat (9 kcal/g) yields more than twice as much metabolisable energy as a gram of either carbohydrate or protein (4 kcal/g). Most of the fat we consume in our diet is in the form of triacylglycerol (90-95%), with cholesterol and phospholipids making up the bulk of the remainder. Dietary advice invariably stresses the importance of fat reduction, yet fats have diverse roles in human nutrition. They are important as a source of energy, both for immediate utilisation by the body and in laying down a storage depot (adipose tissue) for later utilisation when food intake is reduced, they act as a vehicle for the ingestion and absorption of fat-soluble vitamins, and they have diverse structural and functional roles in the body. Cholesterol is also an essential component of cell membranes and is the precursor for synthesis of hormones. This chapter describes the structure, digestion, transport and functional properties of dietary fat in the body and explains the basis of associations between fat consumption and chronic disease.

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology.

Calixarene and Resorcarene Based Receptors: From Structural and Thermodynamic Studies to the Synthesis of a New Mercury(II) Selective Material

Materials used in current technological approaches for the removal of mercury lack selectivity. Given that this is one of the main features of supramolecular chemistry, receptors based on calix[4]arene and calix[4]resorcarene containing functional groups able to interact selectively with polluting ions while discriminating against biologically essential ones were designed. Thus two receptors, a partially functionalized calix[4]arene derivative, namely, 5,11,17,23-tetra-tert-butyl [25-27-bis(diethyl thiophosphate amino)dihydroxy] calix[4]arene (1) and a fully functionalized calix[4]resorcarene, 4,6,10,12,16,18,22,24-diethyl thiophosphate calix[4]resorcarene (2) are introduced. Mercury(II) was the identified target due to the environmental and health problems associated with its presence in water Thus following the synthesis and characterization of 1 and 2 in solution ((1)HNMR) and in the solid state (X-ray crystallography) the sequence of experimental events leading to cation complexation studies in acetonitrile and methanol ((1)H NMR, conductance, potentiometric, and calorimetric measurements) with the aim of assessing their behavior as mercury selective receptors are described. The cation selectivity pattern observed in acetonitrile follows the sequence Hg(II) > Cu(II) > Ag(I). In methanol 1 is also selective for Hg(II) relative to Ag(I) but no interaction takes place between this receptor and Cu(II) in this solvent. Based on previous results and experimental facts shown in this paper, it is concluded that the complexation observed with Cu(II) in acetonitrile occurs through the acetonitrile-receptor adduct rather than through the free ligand. Receptor 2 has an enhanced capacity for uptaking Hg(II) but forms metalate complexes with Cu(II). These studies in solution guided the inmobilization of receptor 1 into a silica support to produce a new and recyclable material for the removal of Hg(II) from water. An assessment on its capacity to extract this cation from water relative to Cu(II) and Ag (I) shows that the cation selectivity pattern of the inmobilized receptor is the same as that observed for the free receptor in methanol. These findings demonstrate that fundamental studies play a critical role in the selection of the receptor to be attached to silicates as well as in the reaction medium used for the synthesis of the new decontaminating agent.

Gaining ligand selectivity in thyroid hormone receptors via entropy

Nuclear receptors are important targets for pharmaceuticals, but similarities between family members cause difficulties in obtaining highly selective compounds. Synthetic ligands that are selective for thyroid hormone (TH) receptor beta (TR beta) vs. TR alpha reduce cholesterol and fat without effects on heart rate; thus, it is important to understand TR beta-selective binding. Binding of 3 selective ligands (GC-1, KB141, and GC-24) is characterized at the atomic level; preferential binding depends on a nonconserved residue (Asn-331 beta) in the TR beta ligand-binding cavity (LBC), and GC-24 gains extra selectivity from insertion of a bulky side group into an extension of the LBC that only opens up with this ligand. Here we report that the natural TH 3,5,3`-triodothyroacetic acid (Triac) exhibits a previously unrecognized mechanism of TR beta selectivity. TR x-ray structures reveal better fit of ligand with the TR alpha LBC. The TR beta LBC, however, expands relative to TR alpha in the presence of Triac (549 angstrom(3) vs. 461 angstrom(3)), and molecular dynamics simulations reveal that water occupies the extra space. Increased solvation compensates for weaker interactions of ligand with TR beta and permits greater flexibility of the Triac carboxylate group in TR beta than in TR alpha. We propose that this effect results in lower entropic restraint and decreases free energy of interactions between Triac and TR beta, explaining subtype-selective binding. Similar effects could potentially be exploited in nuclear receptor drug design.