939 resultados para LIM,Nativi digitali,Immigrati digitali,mappa cognitiva
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Un profesor de Lengua extranjera actúa como mediador cuando es capaz de motivar y fomentar la autoestima positiva de los alumnos, ofreciéndoles datos de su progreso o resolviendo los errores que puedan presentarse, a fin de realizar las tareas comunicativas con éxito. Ello implica, necesariamente, la adecuación a las diferencias individuales y a los estilos cognitivos de cada sujeto2, potenciándose, de este modo, las respuestas creativas y divergentes
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RESUMO: Neste trabalho pretende-se mostrar o trabalho desenvolvido num ambiente inclusivo numa turma onde se encontra um aluno com défice cognitivo ligeiro. Dele faz parte a pesquisa bibliográfica sobre a inclusão, deficiência mental e perturbações emocionais. Para identificar as diversas problemáticas da turma utilizámos a sociometria, observação naturalista entre outros. Após a recolha da informação definimos objectivos e estratégias sempre com base na inclusão. De seguida procedemos à intervenção junto do grupo nas áreas da socialização, comunicação e académica. No final realizámos a avaliação das diversas actividades de forma a percebermos se os objectivos foram alcançados. ABSTRACT: In this paper we want to show all the work we had trying to include on a regular class a student with mental retardation. To do so, we search for definitions of inclusion, mental retardation and emotional disorders to help us understand the student problem. We used the several techniques that help us find out how the students react with each other. After this we decided which objectives we wanted to achieve which this work and selected different strategies to work based on inclusion and stared working with the group. Finally we evaluated the work to see if it had helped the students or not.
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Esta investigación expone un marco interpretativo para estudiar los territorios imaginados del Caribe Colombiano, reconstruidos en un proceso geohistórico a través de los textos escolares en ciencias sociales y el aprendizaje de los estudiantes en Bogotá, partiendo desde la última constitución colombiana en 1991 hasta el 2005. En el primer capitulo, “la configuración de la nación: Una lectura de las representaciones territoriales en torno a la herencia de un modelo hispánico centralista”, se considera un proceso de re-construcción de territorios imaginados en el contexto de la nación como categoría de análisis. En el segundo, “la articulación de la memoria y la representación textual” se indaga desde la identidad regional para cuestionar lo que se podría entender como el costeño y la relación existente desde un marco cognitivo de los estudiantes: la memoria, examinando las diversas formas de estereotipización por medio de los textos escolares en ciencias sociales y la relación con su aprendizaje. Para el tercero, “la construcción del otro marginal en relación al otro hegemónico” se contextualiza los planteamientos de la educación en Colombia, apoyada en gran parte en los textos escolares y su empleo, cuestionando la existencia de un visión analítica de la diversidad cultural en el centro del país, haciendo referencia a la identificación de los habitantes del Caribe. Finalmente, se concluye que los territorios del Caribe son estereotipizados desde los imaginarios céntricos, por medio de representaciones textuales y el proceso derivado de su aprendizaje, evidenciándose una la lucha por el significado, desatándose un primer paso a el cuestionamiento de su reconocimiento, en contra de su inmersión en la lógica de la colonialidad del poder.
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CSRP3 or muscle LIM protein (MLP) is a nucleocytoplasmic shuttling protein and a mechanosensor in cardiac myocytes. MLP regulation and function was studied in cultured neonatal rat myocytes treated with pharmacological or mechanical stimuli. Either verapamil or BDM decreased nuclear MLP while phenylephrine and cyclic strain increased it. These results suggest that myocyte contractility regulates MLP subcellular localization. When RNA polymerase II was inhibited with alpha-amanitin, nuclear MLP was reduced by 30%. However, when both RNA polymerase I and II were inhibited with actinomycin D, there was a 90% decrease in nuclear MLP suggesting that its nuclear translocation is regulated by both nuclear and nucleolar transcriptional activity. Using cell permeable synthetic peptides containing the putative nuclear localization signal (NLS) of MLP, nuclear import of the protein in cultured rat neonatal myocytes was inhibited. The NLS of MLP also localizes to the nucleolus. Inhibition of nuclear translocation prevented the increased protein accumulation in response to phenylephrine. Furthermore, cyclic strain of myocytes after prior NLS treatment to remove nuclear MLP resulted in disarrayed sarcomeres. Increased protein synthesis and brain natriuretic peptide expression were also prevented suggesting that MLP is required for remodeling of the myo filaments and gene expression. These findings suggest that nucleocytoplasmic shuttling MLP plays an important role in the regulation of the myocyte remodeling and hypertrophy and is required for adaptation to hypertrophic stimuli. (C) 2009 Elsevier Inc. All rights reserved.
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Impaired mechanosensing leads to heart failure and we have previously shown that a decreased ratio of cytoplasmic to nuclear CSRP3/Muscle LIM protein (MLP ratio) is associated with a loss of mechanosensitivity. Here we tested whether passive or active stress/strain was important in modulating the MLP ratio and determined whether this correlated with heart function during the transition to failure. We exposed cultured neonatal rat myocytes to 10% cyclic mechanical stretch at 1 Hz, or electrically paced myocytes at 6.8 V (1 Hz) for 48 h. The MLP ratio decreased 50% (P < 0.05, n = 4) only in response to electrical pacing, suggesting impaired mechanosensitivity. Inhibition of contractility with 10 μM blebbistatin resulted in a ∼3 fold increase in the MLP ratio (n = 8, P < 0.05), indicating that myocyte contractility regulates nuclear MLP. Inhibition of histone deacetylase (HDAC) signaling with trichostatin A increased nuclear MLP following passive stretch, suggesting that HDACs block MLP nuclear accumulation. Inhibition of heme-oxygenase1 (HO-1) activity with PPZII blocked MLP nuclear accumulation. To examine how mechanosensitivity changes during the transition to heart failure, we studied a guinea pig model of angiotensin II infusion (400 ng/kg/min) over 12 weeks. Using subcellular fractionation we showed that the MLP ratio increased 88% (n = 4, P < 0.01) during compensated hypertrophy, but decreased significantly during heart failure (P < 0.001, n = 4). The MLP ratio correlated significantly with the E/A ratio (r = 0.71, P < 0.01 n = 12), a clinical measure of diastolic function. These data indicate for the first time that myocyte mechanosensitivity as indicated by the MLP ratio is regulated primarily by myocyte contractility via HO-1 and HDAC signaling.
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Dissertação apresentada ao Programa de Pós-graduação em Comunicação da Universidade Municipal de São Caetano do Sul.