Thermoelectric Outer Planets Spacecraft (TOPS) Advanced Systems Technology Project; final report.

At head of title: National Aeronautics and Space Administration.

Advances in prodrug design

The background of prodrug design is presented herein as the basis for introducing new and advanced latent systems, taking into account mainly the versatility of polymers and other macromolecules as carriers. PDEPT (Polymer-Directed Enzyme Prodrug Therapy); PELT (Polymer-Enzyme Liposome Therapy); CDS (Chemical Delivery System); ADEPT(Antibody-Directed Enzyme Prodrug Therapy); GDEPT/VDEPT (Gene-Directed Enzyme Prodrug Therapy/Virus-Directed Enzyme Prodrug Therapy); ODDS (Osteotropic Drug Delivery System) and LEAPT (Lectin-directed enzyme-activated prodrug therapy) are briefly described and some examples are given. © 2005 Bentham Science Publishers Ltd.

Social cars : sensing, gathering, sharing and conveying social cues to road users

Intelligent Transport Systems (ITS) resembles the infrastructure for ubiquitous computing in the car. It encompasses a) all kinds of sensing technologies within vehicles as well as road infrastructure, b) wireless communication protocols for the sensed information to be exchanged between vehicles (V2V) and between vehicles and infrastructure (V2I), and c) appropriate intelligent algorithms and computational technologies that process these real-time streams of information. As such, ITS can be considered a game changer. It provides the fundamental basis of new, innovative concepts and applications, similar to the Internet itself. The information sensed or gathered within or around the vehicle has led to a variety of context-aware in-vehicular technologies within the car. A simple example is the Anti-lock Breaking System (ABS), which releases the breaks when sensors detect that the wheels are locked. We refer to this type of context awareness as vehicle/technology awareness. V2V and V2I communication, often summarized as V2X, enables the exchange and sharing of sensed information amongst cars. As a result, the vehicle/technology awareness horizon of each individual car is expanded beyond its observable surrounding, paving the way to technologically enhance such already advanced systems. In this chapter, we draw attention to those application areas of sensing and V2X technologies, where the human (driver), the human’s behavior and hence the psychological perspective plays a more pivotal role. The focal points of our project are illustrated in Figure 1: In all areas, the vehicle first (1) gathers or senses information about the driver. Rather than to limit the use of such information towards vehicle/technology awareness, we see great potential for applications in which this sensed information is then (2) fed back to the driver for an increased self-awareness. In addition, by using V2V technologies, it can also be (3) passed to surrounding drivers for an increased social awareness, or (4), pushed even further, into the cloud, where it is collected and visualized for an increased, collective urban awareness within the urban community at large, which includes all city dwellers.

Applying quality control in building energy modelling: Comparative simulation of a high performance building

Quality control is considered from the simulator's perspective through comparative simulation of an ultra energy-efficient building with EE4-DOE2.1E and EnergyPlus. The University of Calgary's Leadership in Energy and Environmental Design Platinum Child Development Centre, with a 66% certified energy cost reduction rating, was the case study building. A Natural Resources Canada incentive program required use of EE4 interface with DOE2.1E simulation engine for energy modelling. As DOE2.1E lacks specific features to simulate advanced systems such as radiant cooling in the CDC, an EnergyPlus model was developed to further evaluate these features. The EE4-DOE2.1E model was used for quality control during development of the base EnergyPlus model and simulation results were compared. Advanced energy systems then added to the EnergyPlus model generated small difference in estimated total annual energy use. The comparative simulation process helped identify the main input errors in the draft EnergyPlus model. The comparative use of less complex simulation programs is recommended for quality control when producing more complex models. © 2009 International Building Performance Simulation Association (IBPSA).

From bit level systolic arrays to HDTV processor chips

The paper starts presents the work initially carried out by Queen's University and RSRE (now Qinetiq) in the development of advanced architectures and microchips based on systolic array architectures. The paper outlines how this has led to the development of highly complex designs for high definition TV and highlights work both on advanced signal processing architectures and tool flows for advanced systems. © 2006 IEEE.

Improving reporting management with relational database management system

Data management consists of collecting, storing, and processing the data into the format which provides value-adding information for decision-making process. The development of data management has enabled of designing increasingly effective database management systems to support business needs. Therefore as well as advanced systems are designed for reporting purposes, also operational systems allow reporting and data analyzing. The used research method in the theory part is qualitative research and the research type in the empirical part is case study. Objective of this paper is to examine database management system requirements from reporting managements and data managements perspectives. In the theory part these requirements are identified and the appropriateness of the relational data model is evaluated. In addition key performance indicators applied to the operational monitoring of production are studied. The study has revealed that the appropriate operational key performance indicators of production takes into account time, quality, flexibility and cost aspects. Especially manufacturing efficiency has been highlighted. In this paper, reporting management is defined as a continuous monitoring of given performance measures. According to the literature review, the data management tool should cover performance, usability, reliability, scalability, and data privacy aspects in order to fulfill reporting managements demands. A framework is created for the system development phase based on requirements, and is used in the empirical part of the thesis where such a system is designed and created for reporting management purposes for a company which operates in the manufacturing industry. Relational data modeling and database architectures are utilized when the system is built for relational database platform.

Wireless Sensor Networks for Paddy Field Crop Monitoring Application in Kuttanad

The evolution of wireless sensor network technology has enabled us to develop advanced systems for real time monitoring. In the present scenario wireless sensor networks are increasingly being used for precision agriculture. The advantages of using wireless sensor networks in agriculture are distributed data collection and monitoring, monitor and control of climate, irrigation and nutrient supply. Hence decreasing the cost of production and increasing the efficiency of production.This paper describes the application of wireless sensor network for crop monitoring in the paddy fields of kuttand, a region of Kerala, the southern state of India.

Development and Deployment of Wireless Sensor Network in Paddy Fields of Kuttanad

The evolution of wireless sensor network technology has enabled us to develop advanced systems for real time monitoring. In the present scenario wireless sensor networks are increasingly being used for precision agriculture. The advantages of using wireless sensor networks in agriculture are distributed data collection and monitoring, monitor and control of climate, irrigation and nutrient supply. Hence decreasing the cost of production and increasing the efficiency of production. This paper describes the development and deployment of wireless sensor network for crop monitoring in the paddy fields of Kuttanad, a region of Kerala, the southern state of India.

Energy Optimized Secure Routing Protocol for Wireless Sensor Networks

The evolution of wireless sensor network technology has enabled us to develop advanced systems for real time monitoring. In the present scenario wireless sensor networks are increasingly being used for precision agriculture. The advantages of using wireless sensor networks in agriculture are distributed data collection and monitoring, monitor and control of climate, irrigation and nutrient supply. Hence decreasing the cost of production and increasing the efficiency of production. This paper describes the security issues related to wireless sensor networks and suggests some techniques for achieving system security. This paper also discusses a protocol that can be adopted for increasing the security of the transmitted data

A Novel Planar Fractal Antenna with CPW-Feed for Multiband Applications

In this paper, a multiband antenna using a novel fractal design is presented. The antenna structure is formed by inscribing a hexagonal slot within a circle. This base structure is then scaled and arranged within the hexagon along its sides without touching the outer structure. The proposed CPW fed, low profile antenna offers good performance in the 1.65 – 2.59 GHz, 4.16 – 4.52 GHz and 5.54 – 6.42 GHz bands and is suitable for GSM 1800/1900, Bluetooth, IMT advanced systems and upper WLAN applications. The antenna has been fabricated on a substrate of height 1.6 mm and εr = 4.4 and simulation and experimental results are found to be in good agreement

Georgia y Rusia: la identidad como factor delimitador de los intereses y políticas de ambos estados con sus efectos en la Guerra de Osetia del Sur en 2008

Esta monografía se centra en evaluar mediante un enfoque constructivista, y a partir de una serie de hechos históricos, cómo la identidad construida por Rusia y Georgia fue el detonante de la Guerra de Osetia del Sur en 2008. Para tal objetivo, se partirá del supuesto que este conflicto fue el resultado de las diferencias entre ambos actores que desarrollaron una serie de políticas antagónicas, enmarcadas en una cultura de anarquía hobbesiana la cual se configuró tras la Revolución de las Rosas y la posterior llegada de Mijaíl Saakashvili al poder, puesto que Georgia se convertiría en el principal aliado de occidente en el Cáucaso, basado en un rol anti ruso y disidente de la influencia del Kremlin en la zona, divergiendo con el liderazgo de Rusia el cual se fundamenta en una identidad construida a raíz de su pasado imperial y hegemónico.

Integració 3D de detectors de píxels híbrids

La miniaturització de la industria microelectrònica és un fet del tot inqüestionables i la tecnologia CMOS no n'és una excepció. En conseqüència la comunitat científica s'ha plantejat dos grans reptes: En primer lloc portar la tecnologia CMOS el més lluny possible ('Beyond CMOS') tot desenvolupant sistemes d'altes prestacions com microprocessadors, micro - nanosistemes o bé sistemes de píxels. I en segon lloc encetar una nova generació electrònica basada en tecnologies totalment diferents dins l'àmbit de les Nanotecnologies. Tots aquests avanços exigeixen una recerca i innovació constant en la resta d'àrees complementaries com són les d'encapsulat. L'encapsulat ha de satisfer bàsicament tres funcions: Interfície elèctrica del sistema amb l'exterior, Proporcionar un suport mecànic al sistema i Proporcionar un camí de dissipació de calor. Per tant, si tenim en compte que la majoria d'aquests dispositius d'altes prestacions demanden un alt nombre d'entrades i sortides, els mòduls multixip (MCMs) i la tecnologia flip chip es presenten com una solució molt interessant per aquests tipus de dispositiu. L'objectiu d'aquesta tesi és la de desenvolupar una tecnologia de mòduls multixip basada en interconnexions flip chip per a la integració de detectors de píxels híbrids, que inclou: 1) El desenvolupament d'una tecnologia de bumping basada en bumps de soldadura Sn/Ag eutèctics dipositats per electrodeposició amb un pitch de 50µm, i 2) El desenvolupament d'una tecnologia de vies d'or en silici que permet interconnectar i apilar xips verticalment (3D packaging) amb un pitch de 100µm. Finalment aquesta alta capacitat d'interconnexió dels encapsulats flip chip ha permès que sistemes de píxels tradicionalment monolítics puguin evolucionar cap a sistemes híbrids més compactes i complexes, i que en aquesta tesi s'ha vist reflectit transferint la tecnologia desenvolupada al camp de la física d'altes energies, en concret implantant el sistema de bump bonding d'un mamògraf digital. Addicionalment s'ha implantat també un dispositiu detector híbrid modular per a la reconstrucció d'imatges 3D en temps real, que ha donat lloc a una patent.

Inter-comparison of stratospheric mean-meridional circulation and eddy mixing among six reanalysis data sets

The stratospheric mean-meridional circulation (MMC) and eddy mixing are compared among six meteorological reanalysis data sets: NCEP-NCAR, NCEP-CFSR, ERA-40, ERA-Interim, JRA-25, and JRA-55 for the period 1979–2012. The reanalysis data sets produced using advanced systems (i.e., NCEP-CFSR, ERA-Interim, and JRA-55) generally reveal a weaker MMC in the Northern Hemisphere (NH) compared with those produced using older systems (i.e., NCEP/NCAR, ERA-40, and JRA-25). The mean mixing strength differs largely among the data products. In the NH lower stratosphere, the contribution of planetary-scale mixing is larger in the new data sets than in the old data sets, whereas that of small-scale mixing is weaker in the new data sets. Conventional data assimilation techniques introduce analysis increments without maintaining physical balance, which may have caused an overly strong MMC and spurious small-scale eddies in the old data sets. At the NH mid-latitudes, only ERA-Interim reveals a weakening MMC trend in the deep branch of the Brewer–Dobson circulation (BDC). The relative importance of the eddy mixing compared with the mean-meridional transport in the subtropical lower stratosphere shows increasing trends in ERA-Interim and JRA-55; this together with the weakened MMC in the deep branch may imply an increasing age-of-air (AoA) in the NH middle stratosphere in ERA-Interim. Overall, discrepancies between the different variables and trends therein as derived from the different reanalyses are still relatively large, suggesting that more investments in these products are needed in order to obtain a consolidated picture of observed changes in the BDC and the mechanisms that drive them.