Advances in prodrug design

Autoria(s): Távora de Albuquerque Silva, Antonio; Chin, Chung Man; Castro, Lúcia Fioravanti; Carvalho Güido, Rafael Victorio; Ferreira, Elizabeth Igne
Contribuinte(s)

Universidade Estadual Paulista (UNESP)
Data(s)

27/05/2014

27/05/2014

01/10/2005
Resumo

The background of prodrug design is presented herein as the basis for introducing new and advanced latent systems, taking into account mainly the versatility of polymers and other macromolecules as carriers. PDEPT (Polymer-Directed Enzyme Prodrug Therapy); PELT (Polymer-Enzyme Liposome Therapy); CDS (Chemical Delivery System); ADEPT(Antibody-Directed Enzyme Prodrug Therapy); GDEPT/VDEPT (Gene-Directed Enzyme Prodrug Therapy/Virus-Directed Enzyme Prodrug Therapy); ODDS (Osteotropic Drug Delivery System) and LEAPT (Lectin-directed enzyme-activated prodrug therapy) are briefly described and some examples are given. © 2005 Bentham Science Publishers Ltd.
Formato

893-914
Identificador

http://dx.doi.org/10.2174/138955705774329528

Mini-Reviews in Medicinal Chemistry, v. 5, n. 10, p. 893-914, 2005.

1389-5575

http://hdl.handle.net/11449/68433

10.2174/138955705774329528

WOS:000231837000003

2-s2.0-24944549193
Idioma(s)

eng
Relação

Mini-Reviews in Medicinal Chemistry
Direitos

closedAccess
Palavras-Chave #Latent advanced systems #Macromolecules carriers #Prodrug design #Selective delivery systems #aminosalicylic acid #ampicillin #antiinflammatory agent #antileishmanial agent #antimalarial agent #antineoplastic agent #bisphosphonic acid derivative #cytochrome P450 #diclofenac #doxorubicin #flucytosine #ibuprofen #irinotecan #isoniazid #ketoprofen #mevinolin #mitomycin #nitrofural #paclitaxel derivative #photosensitizing agent #prodrug #salazosulfapyridine #tacrolimus #testosterone derivative #tiaprofenic acid #tolmetin #trigonelline #tryptamine derivative #unindexed drug #antibody directed enzyme prodrug therapy #bactericidal activity #binding affinity #blood brain barrier #Chagas disease #diarrhea #drug absorption #drug activation #drug design #drug distribution #drug identification #drug receptor binding #drug screening #drug selectivity #drug stability #drug structure #drug synthesis #drug targeting #drug transformation #gastrointestinal toxicity #gene expression #human #hypercholesterolemia #in vivo study #macromolecule #malaria #minimum inhibitory concentration #nephrotoxicity #organoleptic property #osteoporosis #review #rheumatoid arthritis #structure activity relation #structure analysis #tuberculosis #ulcerative colitis #Animals #Antibodies #Drug Carriers #Drug Delivery Systems #Drug Design #Gene Therapy #Humans #Lectins #Macromolecular Substances #Osteoporosis #Prodrugs #Viruses
Tipo

info:eu-repo/semantics/review
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