Operational Reliability Analysis of a Three-Tiered Thin-Client ERP-system in an International Corporate Environment

Internationalization and the following rapid growth have created the need to concentrate the IT systems of many small-to-medium-sized production companies. Enterprise Resource Planning systems are a common solution for such companies. Deployment of these ERP systems consists of many steps, one of which is the implementation of the same shared system at all international subsidiaries. This is also one of the most important steps in the internationalization strategy of the company from the IT point of view. The mechanical process of creating the required connections for the off-shore sites is the easiest and most well-documented step along the way, but the actual value of the system, once operational, is perceived in its operational reliability. The operational reliability of an ERP system is a combination of many factors. These factors vary from hardware- and connectivity-related issues to administrative tasks and communication between decentralized administrative units and sites. To accurately analyze the operational reliability of such system, one must take into consideration the full functionality of the system. This includes not only the mechanical and systematic processes but also the users and their administration. All operational reliability in an international environment relies heavily on hardware and telecommunication adequacy so it is imperative to have resources dimensioned with regard to planned usage. Still with poorly maintained communication/administration schemes no amount of bandwidth or memory will be enough to maintain a productive level of reliability. This thesis work analyzes the implementation of a shared ERP system to an international subsidiary of a Finnish production company. The system is Microsoft Dynamics Ax, currently being introduced to a Slovakian facility, a subsidiary of Peikko Finland Oy. The primary task is to create a feasible base of analysis against which the operational reliability of the system can be evaluated precisely. With a solid analysis the aim is to give recommendations on how future implementations are to be managed.

Hallituksen ja toimitusjohtajan välisen suhteen kehittäminen listaamattomissa suomalaisissa osakeyhtiöissä

Työn tavoitteen oli selvittää mitä erityspiirteitä suomalaisissa listaamattomissa osakeyhtiöissä on ja niiden pohjalta ymmärtää minkälainen hallituksen ja toimitusjohtajan välinen suhde on. Tutkimusmetodologia oli empiirinen eksploratiivinen tutkimus ja tutkimusmenetelmä oli kvalitatiivinen perustuen seitsemään teemahaastatteluun. Tutkimuksen tuloksena oli, että osakeyhtiöt ovat erilaisia perustuen yhtiön omistajamäärään, omistuksen hajaantumiseen ja omistajien aktiivisuuteen. Pääsääntöisesti omistajat ovat lähellä yhtiön toimin- taa. Omistajat rakentavat yrityskulttuuria palkkaamalla hallituksen jäseniksi kulloiseenkin tilanteeseen sopivimmat henkilöt. Suomalaisia toimitusjohtajia pidetään ihmiskäsitykseltään pääsääntöisesti stewardeina ja ihmiskäsitykseen vaikuttaa olennaisesti kulttuurimme. Luottamus on hallituksen ja toimitusjohtajan välisen suh- teen kulmakiviä.

Wonderalp. Une science émerveillée. Les Alpes et la culture de la curiosité

WonderAlp est un cabinet de curiosités réalisé à partir d'une documentation provenant d'anciens ouvrages de voyages dans les Alpes. L'app présente des images de dragons, de fossiles, de cristaux, de plantes, d'animaux, de phénomènes naturels. Elle donne des clés pour retrouver et comprendre l'émerveillement devant la nature qui animait la science à l'époque de la curiosité (XVIe-XVIIIe siècles). WonderAlp is a cabinet of curiosities that transforms your iPad or Android into an Early Modern Wunderkammer. It displays objects discovered in the Alps during the early period of exploration. These are grouped under three titles : "Dragons of the Alps", "Fossils and Crystals", "Plants to Landscapes". It helps apprehend a natural world that is both rational and wonderful, scholarly and popular, unlike the compartmentalized thinking of modern life.

Yritysten sosiaalisen vastuun tarkastelua vuosina 2000 ja 2006/Corporate Social Responsibility year 2000 and 2006

Tutkimuksen tarkoitus on selvittää, miten yritysten ajattelutapa sosiaalisesta vastuusta on muuttunut vuodesta 2000 vuoteen 2006. Lisäksi vastataan kysymyksiin, mistä osa-alueista sosiaalinen vastuu muodostuu, miten kirjoittelu sosiaalisesta vastuusta on muuttunut määrällisesti ja sisällöllisesti. Tutkimus on luonteeltaan laadullinen ja analyysimenetelmänä on käytetty diskurssianalyysiä. Tutkimusaineisto koostuu johtavien talousalan lehtien Talouselämä ja Kauppalehden artikkeleista vuosilta 2000 ja 2006. Artikkeleista saatua tietoa peilataan teoriatietoon ja näin pyritään hahmottamaan tutkimuksen tulokset. Tutkimuksen tulokset osoittavat, että vuonna 2000 lehdet ovat kirjoittaneet jonkin verran enemmän sosiaalisesta vastuusta kuin vuonna 2006. Molempina vuosina sijoittavat arvostavat vastuullista toimintaa. Yrityksen arvot ovat usein määritelty ”ylhäältä-alas”. Työntekijöiden pahoinvointi on lisääntynyt entisestään vuodesta 2000 vuoteen 2006. Syynä tähän kirjoitusten mukaan ovat esimerkiksi huono johtaminen ja työtehtävien organisointi. Sosiaalisen vastuun mittaaminen on hankalaa ja ikääntyviä työntekijöitä yritetään pitää yrityksissä mahdollisimman pitkään. Tulospalkkausjärjestelmät ovat käytössä muutamassa yrityksessä. Työn, perheen ja vapaa-ajan sovittaminen yhteen on vuodesta 2000 muuttunut entistäkin tärkeämmäksi vuonna 2006. Lopputulos on, että sosiaalisen vastuun kanto on huonontunut vuodesta 2000 vuoteen 2006.

Corporate governancen raportointi, case Osuuskauppa Hämeenmaa

Tämän tutkielman tarkoitus oli tutkia corporate governancen raportointia suomalaisen normiston mukaan. Suositus listayhtiöiden hallinnointi- ja ohjausjärjestelmästä (corporate governance) tuli voimaan vuonna 2004, ja se on tarkoitettu Helsingin Pörssissä listattujen yhtiöiden noudatettavaksi. Listaamattomien yhtiöiden hallinnoinnin kehittämisestä (corporate governance) Keskuskauppakamari julkaisi vuonna 2006 asialuettelon. Laajasti omistetut osuuskunnat Keskuskauppakamari huomioi vuonna 2006 erillisessä kannanotossa, jonka mukaan laajasti omistettujen osuuskuntien tulisi noudattaa nykyistä listayhtiöille annettua suositusta siltä osin, kuin se on mahdollista. Tutkielman teoreettinen viitekehys käsittelee corporate governancen ja sen raportoinnin taustateorioita sekä corporate governancen suomalaista normistoa. Corporate governanen ja sen raportoinnin taustateorioita ovat tässä tutkimuksessa agenttiteoria, stewardship - teoria, stakeholder -teoria, legitimacy -teoria ja transaktiokustannusteoria. Corporate governancen raportointia käytännössä on tutkittu benchmarking-tutkimuksen avulla. Tutkielman empiirisen osan case-tutkimus on tehty Osuuskauppa Hämeenmaassa. Case-tutkimuksen tavoitteena oli löytää kohdeyrityksen corporate governancen raportoinnista kehityskohteita. Tutkimuksen tuloksissa näkyy corporate governancen raportoinnin vapaaehtoisuus sekä osuuskuntamuotoisen yrityksen erityispiirteet.

Corporate Social and Regional Responsibility - The View of Small and Medium-sized Enterprises

The objective of this research was to understand and describe what corpo-rate social and regional responsibility is in SMEs and define the meaning of these concepts to the community and region. Corporate social respon-sibility (CSR) creates a basis for regional responsibility. Regional respon-sibility is a new concept and this research examines it from SMEs’ view-point. This is a theoretical research and the aim is to create a theoretical framework of SMEs’ corporate social and regional responsibility. This framework supports the future research on the subject. The research results show that CSR of SMEs is practical, informal and dependent on the scarce resources of SMEs. CSR is a complex and deep concept and SMEs have their own way of interpreting it. It can be stated that CSR-practises in SMEs are closely connected to employment, envi-ronment, community and supply chain. The challenge is to find motivation to socially and regionally responsible behaviour in SMEs. Benefiting from responsible behaviour and the attitude of SME’s owner-manager are the key reasons for SMEs to involve in CSR and regional responsibility. The benefits of this involvement are for example improved image, reputation and market position. CSR can also be used in SMEs as risk management tool and in cost reduction. This study indicates also that creation of strate-gic partnerships, local government participation, a proper legal system and financial support are the basic issues which support CSR of SMEs. This research showed that regional responsibility of SMEs includes active participation in regional strategy processes, L&RED initiatives and regional philanthropy. For SMEs regional responsibility means good relationships with the community and other related stakeholders, involvement in L&RED initiatives and acting responsibly towards the operating environment. In SMEs’ case this means that they need to understand the benefits of this kind of involvement in order to take action and participate. As regional responsibility includes the relationships between firm and the community, it can be stated that regional responsibility extends CSR’s view of stakeholders and emphasises both, the regional stakeholders and public-private partnerships. Community engagement and responsible be-haviour towards community can be seen as a part of SMEs’ social and regional responsibility. This study indicates that social and regional re-sponsibility of SMEs have a significant influence on the community and region where they are located. Better local and regional relationships with regional and community actors are the positive impacts of social and re-gional responsibility of SMEs. Socially and regionally responsible behav-iour creates a more positive environment and deepens the involvement of SMEs to community and L&RED initiatives.

Prevention of vascular dysfunction and arterial hypertension in mice generated by assisted reproductive technologies by addition of melatonin to culture media.

Assisted reproductive technologies (ART) induce vascular dysfunction in humans and mice. In mice, ART-induced vascular dysfunction is related to epigenetic alteration of the endothelial nitric oxide synthase (eNOS) gene, resulting in decreased vascular eNOS expression and nitrite/nitrate synthesis. Melatonin is involved in epigenetic regulation, and its administration to sterile women improves the success rate of ART. We hypothesized that addition of melatonin to culture media may prevent ART-induced epigenetic and cardiovascular alterations in mice. We, therefore, assessed mesenteric-artery responses to acetylcholine and arterial blood pressure, together with DNA methylation of the eNOS gene promoter in vascular tissue and nitric oxide plasma concentration in 12-wk-old ART mice generated with and without addition of melatonin to culture media and in control mice. As expected, acetylcholine-induced mesenteric-artery dilation was impaired (P = 0.008 vs. control) and mean arterial blood pressure increased (109.5 ± 3.8 vs. 104.0 ± 4.7 mmHg, P = 0.002, ART vs. control) in ART compared with control mice. These alterations were associated with altered DNA methylation of the eNOS gene promoter (P < 0.001 vs. control) and decreased plasma nitric oxide concentration (10.1 ± 11.1 vs. 29.5 ± 8.0 μM) (P < 0.001 ART vs. control). Addition of melatonin (10(-6) M) to culture media prevented eNOS dysmethylation (P = 0.005, vs. ART + vehicle), normalized nitric oxide plasma concentration (23.1 ± 14.6 μM, P = 0.002 vs. ART + vehicle) and mesentery-artery responsiveness to acetylcholine (P < 0.008 vs. ART + vehicle), and prevented arterial hypertension (104.6 ± 3.4 mmHg, P < 0.003 vs. ART + vehicle). These findings provide proof of principle that modification of culture media prevents ART-induced vascular dysfunction. We speculate that this approach will also allow preventing ART-induced premature atherosclerosis in humans.

Optimized exosome isolation protocol for cell culture supernatant and human plasma.

Extracellular vesicles represent a rich source of novel biomarkers in the diagnosis and prognosis of disease. However, there is currently limited information elucidating the most efficient methods for obtaining high yields of pure exosomes, a subset of extracellular vesicles, from cell culture supernatant and complex biological fluids such as plasma. To this end, we comprehensively characterize a variety of exosome isolation protocols for their efficiency, yield and purity of isolated exosomes. Repeated ultracentrifugation steps can reduce the quality of exosome preparations leading to lower exosome yield. We show that concentration of cell culture conditioned media using ultrafiltration devices results in increased vesicle isolation when compared to traditional ultracentrifugation protocols. However, our data on using conditioned media isolated from the Non-Small-Cell Lung Cancer (NSCLC) SK-MES-1 cell line demonstrates that the choice of concentrating device can greatly impact the yield of isolated exosomes. We find that centrifuge-based concentrating methods are more appropriate than pressure-driven concentrating devices and allow the rapid isolation of exosomes from both NSCLC cell culture conditioned media and complex biological fluids. In fact to date, no protocol detailing exosome isolation utilizing current commercial methods from both cells and patient samples has been described. Utilizing tunable resistive pulse sensing and protein analysis, we provide a comparative analysis of 4 exosome isolation techniques, indicating their efficacy and preparation purity. Our results demonstrate that current precipitation protocols for the isolation of exosomes from cell culture conditioned media and plasma provide the least pure preparations of exosomes, whereas size exclusion isolation is comparable to density gradient purification of exosomes. We have identified current shortcomings in common extracellular vesicle isolation methods and provide a potential standardized method that is effective, reproducible and can be utilized for various starting materials. We believe this method will have extensive application in the growing field of extracellular vesicle research.

An Advocacy for the Use of 3D Stem Cell Culture Systems for the Development of Regenerative Medicine: An Emphasis on Photoreceptor Generation

The availability of stem cells is of great promise to study early developmental stages and to generate adequate cells for cell transfer therapies. Although many researchers using stem cells were successful in dissecting intrinsic and extrinsic mechanisms and in generating specific cell phenotypes, few of the stem cells or the differentiated cells show the capacity to repair a tissue. Advances in cell and stem cell cultivation during the last years made tremendous progress in the generation of bona fide differentiated cells able to integrate into a tissue after transplantation, opening new perspectives for developmental biology studies and for regenerative medicine. In this review, we focus on the main works attempting to create in vitro conditions mimicking the natural environment of CNS structures such as the neural tube and its development in different brain region areas including the optic cup. The use of protocols growing cells in 3D organoids is a key strategy to produce cells resembling endogenous ones. An emphasis on the generation of retina tissue and photoreceptor cells is provided to highlight the promising developments in this field. Other examples are presented and discussed, such as the formation of cortical tissue, the epithelial gut or the kidney organoids. The generation of differentiated tissues and well-defined cell phenotypes from embryonic stem (ES) cells or induced pluripotent cells (iPSCs) opens several new strategies in the field of biology and regenerative medicine. A 3D organ/tissue development in vitro derived from human cells brings a unique tool to study human cell biology and pathophysiology of an organ or a specific cell population. The perspective of tissue repair is discussed as well as the necessity of cell banking to accelerate the progress of this promising field.

Quand la culture entre dans les recherches en psychologie du développement

Dans la psychologie dévelopementale proposée par Jérôme Bruner, la question de la " culture " se traduit par l'attention particulière donnée aux processus par lesquels une personne rend signifiante la situation dans laquelle elle est engagée. De fait, dans la psychologie du développement de ces cinquante dernières années, la place de la " culture " varie parallèlement à celle des questions du sens (privé) et de la signification (partagée) des connaissances, des actions et des objets de culture. Dans cet article, nous identifions quatre traditions de travaux qui abordent la " culture " dans le développement. Cela met en évidence certains problèmes théoriques et méthodologiques, et nous permet de souligner certains enjeux actuels de la psychologie sociale et culturelle du développement.