Desenvolvimento de nanopartículas de quitosana para adminstração nasal de zidovudina

Zidovudine (AZT) is the drug most commonly used in AIDS treatment, isolated or in combination with other antiretroviral agents, but it has certain limitations due to its therapeutic dose-dependent haematological toxicity. In addition, it has low oral bioavailability, since it undergoes pre-systemic metabolism. The nasal route has been used as an alternative route for drug administration, because it can promote its direct absorption to blood circulation, avoiding hepatic metabolism. However, this route presents as a factor limiting the mucociliary clearance mechanisms that remove quickly the formulation of the nasal cavity. To prolong the residence time of formulations, in this direction, has been proposed the development of mucoadhesive systems. Among the various existing systems, the use of chitosan (QS), as mucoadhesive polymer, has been widely exploited in the preparation of nanoparticles (NPs). The objective of this study was to develop and characterize QS’s NPs for intranasal administration of AZT. For both NPs have been developed by ionic crosslinking of QS with sodium tripolyphosphate (TPP). These NPs were characterized by studies of particle size distribution, zeta potential, morphology, mucoadhesion tests, assessing the ability of encapsulation of the drug and permeation profile of AZT. The evaluation of AZT in the NPs was determined by UV-Vis spectroscopy. Mucoadhesion measures were made using a texture analyzer, using a mucin disk and porcine mucous membrane , and permeation assay were conducted using porcine nasal mucous membrane adapted to the Franz cell. These results suggest that the systems in hand have great potential for nasal AZT administration

Acupuntura no tratamento de discopatias intervertebrais em cães

The intervertebral disc disease is considered a major neurological disorder involving the spinal cord, being a disease commonly seen in dogs in clinical practice of small animals. The pathophysiology of most discopathies have not been fully elucidated, but it is known that the symptoms observed will depend on the severity of spinal cord compression and location of spinal injury, ranging from localized pain to complete paralysis. Through a detailed clinical examination and laboratory tests, we choose the most appropriate treatment for each patient, which can be conservative, through the use of anti-inflammatories, analgesics and acupuncture or surgical, through decompression techniques. Acupuncture, therapeutic method of ancient Chinese medicine, uses the stimulation of specific points on the body in order to balance the body's physiological. The action mechanism of acupuncture in discopathies has not been fully elucidated, but its analgesic effects, anti-inflammatory and restoration of sensory and motor function are known, showing results as good as surgical therapy

Artemidia independente: Vidas Imperfeitas, o quadrinho em um diálogo entre linguagem e suporte

The term “independent media art” expresses an artistic-scientific process performed in the Art- Science Communication interface presented as Final Paper in Visual Arts baccalaureate modality. The first part consists in gather, in artisticscientific research, an overview of the production of independent comics, mainly in Brazil, as well as some of the manifestations that were derived from it. The identification is made from bibliographical and iconographical survey, both printed and virtual materials. The second part discusses the production of a comic of my own - Imperfect Lives - published independently. This work is inserted in the line of research “Artistic Processes and Procedures” of the Department of Fine Arts of the Art Institute of UNESP and describes: Creative process, production, dissemination and influences. The third and final section brings together the work done by me during the four-year course, whose theme has some relation with comics. Experiments are in various media, using one or another characteristic intrinsic to them. The monography includes as an appendix a copy of each issue of the fanzine Imperfect Lives. The methodology used was Freinetiana Educational Cybernetics, developed in the research group “Art media and Videoclip”, whose leading advisor is the one from this Final Paper. The result and discussion of the artistic research and scientific monography were reported in the following versions: PDF File repository for dissemination in the virtual library of the Institute of Arts. Hardcover version for physical collection in the Library of the Institute of Arts. Paper version for the committee. Template version appropriate for submission to International Scientific Congress in the area of Arts

Water mass reconstruction by Nd isotopic analysis from Mid Atlantic oceanic sediments

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Utilização da acupuntura no tratamento de cães com discopatia intervertebral

The intervertebral disc diseases have a high casuistic in clinical routines veterinary among dogs. These conditions can cause pain, paresis or paralysis of limbs depending on the degree of injury. Clinical signs are not limited to the intervertebral disc, other anatomical parts are included. In conventional medicine, treatment may be surgical or clinical, by the use of corticosteroids with muscle relaxants. Acupuncture was an alternative to treating these diseases due to its anti-inflammatory and analgesic effects. Although there are few studies for the treatment of discopathies, acupuncture triggers the release of substances such as dynorphins, beta-endorphins and serotonin, among others; that act inhibiting somatic and visceral pain. Electroacupuncture is used to potentiate the effects of acupuncture. It can be performed with different frequencies according to the clinical evolution. However there are different opinions related to the greater efficacy in relation to acupuncture. The restraint and monitoring of the treated animal are important factors for its recovery. The association between acupuncture and conventional treatment (surgical or clinical) achieved better results than acupuncture alone. This proves that acupuncture can be considered an option in order to minimize the complications of surgery or assist in patient recovery

Artemídia escrevente: a caligrafia entre a arte e o design

The term “writing media art” expresses an artisticscientific process performed in the Art-Science Communication interface presented as Final Paper in Visual Arts baccalaureate modality. The first part gathers, in artistic-scientific research, a historical overview of the relation between image and writing, which its main focus is calligraphy and its different expressions in art and design, including their interrelations. The identification is made from bibliographical and iconographical survey, both printed and virtual materials. This approach involves the selection of authors’ statements and comments in order to offer a deeper historical basis, since it comes to facts and events. The second part relates to the set of works produced during the four-year period of the Visual Arts course, including a reflection about the creation process and all that surrounds it – influences, memories, visions etc. – to finally establish a connection between all these elements in order to make clear this incredible web of creation. This work is inserted in the line of research “Artistic Processes and Procedures” of the Department of Fine Arts of the Art Institute of UNESP and describes: creative process, production and influences. The methodology used was Freinetiana Educational Cybernetics, developed in the research group “Art media and Videoclip”, whose leading advisor is the one from this Final Paper. The result and discussion of the artistic-scientific research were reported in monography in the following versions: PDF File repository for dissemination in the virtual library of the Institute of Arts; hardcover version for physical collection in the Library of the Institute of Arts; paper version for the committee; template version appropriate for submission to International Scientific Congress in the area of Arts

Avaliação de métodos de triagem e de detecção fenotípica de ß-lactamase de espectro ampliado (ESBL)

The catalytic function of extended-spectrum β-lactamases can result in high degrees of bacterial resistance to β-lactamic antimicrobials and in the emergence of ESBL among the members of Enterobacteriaceae family, especially Klebsiella pneumoniae and Escherichia coli. This occurs due to the dissemination and emergence of new variants of these enzymes caused by the high utilization of antibiotics like broad-spectrum cephalosporins. The ESBL are β-lactamases capable of conferring bacterial resistance to the penicillins, 1st, 2nd and 3rd generation cephalosporins, and aztreonam (but not cephamycins and carbapenems) through the hydrolysis of these antibiotics. In view of this phenomenon, the exact screening and detection of the producers of ESBL are essential for the appropriate selection of the antimicrobial therapy. The purposes of this study were to evaluate the best antimicrobial for the selection of ESBL producers and to determine the best method for the detection of such microorganisms. We evaluated 200 sequential bacterial samples including the species Klebsiella pneumoniae (56.5%), Escherichia coli (34%), Proteus mirabilis (8.5%) and Klebsiella oxytoca (1%), previously characterized as ESBL producers between February and September 2008 in the Laboratory of Microbiology, Botucatu Medical School - UNESP, Botucatu, São Paulo State, Brazil. To select the ESBL-producer bacteria, we used the disks recommended by CLSI 2008, aztreonam (ATM), cefpodoxime (CPD), ceftriaxone (CRO), cefotaxime (CTX) and ceftazidime (CAZ), besides cefepime (FEP). ESBL production was confirmed by three methods: double disk screening, ESBL Etest®, and Vitek® automated system. The disks employed in the double disk screening were: penicillin associated with β-lactamase inhibitor, amoxicillin-clavulanic acid, and two β-lactamic antibiotics, ceftazidime and cefotaxime...(Complete abstract click electronic access below)

Comparação das técnicas semi-quantitativa e quantitativa nas infecções relacionadas a cateter em neonatos e determinação da resistência à oxacilina nos Staphylococcus spp

Study the semi-quantitative and quantitative technique in the diagnosis of catheter-related infections in newborns and to determine oxacillin resistance in Staphylococcus isolated. It was analyzed 353 catheter tips from 273 newborns in the Neonatal Unit of Hospital FMB. To confirm the diagnosis of infection, were analyzed the clinical data of newborns, the presence of at least one positive blood culture and growth of ≥ 1000 CFU/mL on quantitative culture and/or ³15 UFC on semiquantitative culture, with the same microorganism isolation (species and drug sensitivity) in blood culture and no other focus of infection except the catheter. The disk diffusion technique was used to check similarity of strains and resistance to oxacillin. Of the 353 tips analyzed, 39 were included in this study as the inclusion criteria. The semiquantitative culture was positive in 26 (66.7%) catheters and quantitative culture was positive in 24 (61.5%). Of 273 patients, 19 (6.9%) had a diagnosis of catheter-related bloodstream Infection (CR-BSI). Of the 19 episodes of CR-BSI, S. epidermidis was the predominant etiological agent (84.2%). The resistance to the antibiotic methicillin was found in 14 (73.7%) strains of Staphylococcus. The semiquantitative method was more sensitive (79%) compared with the quantitative method (63%). The use of antibiotics may have influenced the sensitivity of the quantitative method as the microorganisms present in the lumen are exposed to higher concentrations of antibiotics administered via the catheter

Análise da influência da concentração de feixeis de fibras de bambu em ensaios de piso

Bamboo has one of the highest growth rates among plants, however, its lignifications (which confers resistance) takes around a few years and, therefore, certain physical characteristics and mechanical, that depend on this process will only be acquired between the three to six years old. In addition, bamboo also has significant density variations in different parts of the stem, both in the radial direction as the axial. In particular the radial direction, where the density found in the inner and outer (near the bark) of a single stem can range on average from 0.5 to 0.9 g/cm3. Thus, the application of bamboo as a floor, there to examine whether both sides of the bamboo (internal and external), provide resistance properties required for that purpose. In this study sought to characterize and quantify the influence of the concentration of fiber bundles in the inner and outer sides of rules or bamboo strips of bamboo flooring through testing service. Analyses performed were based on ASTM D 2394- 83 for wooden floors and derivatives. This was necessary because of the absence of a specific prohibition of the use and testing of floors made of bamboo and its products. The data were analyzed by ball indentation test shooting, test for resistance to abrasion, indentation test for stress / load treadmill test and by indentation loads applied to small areas - test the jump. The results of the tests were extremely friendly bamboo, even this presents considerable differences between the resistances obtained from assay of the cover of the inner and outer face, being comparable with those of many commonly used to manufacture wood flooring. This comparison was made possible by information from technical trials of several floors made with wood

Estudo da deformação heterogênea no ensaio do anel de atrito

The plastic deformation is widely used in the metallurgical market due to its positive factors such as low prices and high speed production. Forming process products are obtained in high quality, both surface quality and mechanical properties. Friction is an importante factor in metal forming. Friction study in metal forming can be accomplished indirectly, such as the ring test of friction. Two samples of different materials being mild steel and copper alloy were used. The results showed the influence of friction in the flow behavior of the deformation of the second phase, as evidenced by standard metallography. It is observed that in the outer regions of the ring, plastic deformation occured in the radial direction. In the central region of the disc deformation occured in the direction of compression and the inner region of the ring flux lines showed a significant deformation in the radial direction towards the center of the ring

Estudo fenotípico e genotípico da produção de biofilme por Staphylococcus aureus isolados de leite bubalino e ambiente de ordenha

Pós-graduação em Microbiologia Agropecuária - FCAV

Fatores e mecanismos que influenciam a resistência em soja a Anticarsia gemmatalis Hübner e Spodoptera frugiperda (J. E. Smith)

Pós-graduação em Agronomia (Entomologia Agrícola) - FCAV

Estudo eletroquímico do sistema microestruturado montmorilonita-8- hidroxiquinolina na presença de íons metálicos

Pós-graduação em Química - IBILCE

Os ídolos nas revistas teen: uma análise de Atrevida, Capricho e Todateen

This study aims to conduct a comparative analysis of the cover stories of magazines Atrevida, published by Escala, Capricho, published by Abril, and Todateen, published by AltoAstral, published between 2008 and 2012, which give prominence to the phenomena with more recurring presence on the covers. The objective of the research is to analyze the criteria for newsworthiness adopted by publications targeting a teenage audience, relating them to cover highlights involving idols of that audience. As object, we study the press coverage given to four magazines phenomena of cultural industry: the actors in the Twilight saga, the actors of the Disney Channel series, singer Justin Bieber and actors of Brazilian soap opera Rebelde. The work begins with a history of magazine journalism, from its origin to the journalism geared toward teenage readers, through the history of women's magazines and variety. Then, we present the theoretical concepts from the Theory News (Traquina) in confrontation with the notions of consumption (Canclini) and behavior (Featherstone). Finally, analysis of the corpus, which was defined by a cutout thematic within this period, divided into two major groups of news reports: those in which the idol is the news, and those in which he serves as a guide for the reader

Analise de desgaste em materiais aplicados em discos de freio

Baja SAE competitions challenge engineering students to design and build offroad vehicles, preparing them for the competitive job market. This monograph aims to study a part of the braking of a Baja SAE vehicle system, the brake disc. Giving attention to the wear suffered by discs of two different materials, steel 1045 and stainless steel 304, helping the team Piratas do Vale Bardahl in the best selection between them. Braking tests were performed on a test bench. Both discs have suffered the same braking conditions. Brake pads material, brake line pressure, braking time, number of braking, were parameters which were repeated in the testing of different types of disk, in order to ensure a high power comparison between the obtained data. Before and after the disk tests were weighed and measured, to make a comparison. After the brake tests, the disks were subjected to hardness and surface roughness testing. With the data collected and observations made in the worn parts, the comparison between these two materials was made, obtaining a selection of the best material for the team. The tests showed that steel 1045 has more advantages, compared to stainless steel 304, when applied to brake discs, on the tested conditions