Cognitive processes associated with the professional development of Mathematics teacher. 'Procesos cognitivos asociados al desarrollo profesional del profesor de Matem??ticas'

Resumen basado en el de la publicaci??n

Conceptualizing professional development in mathematics : elements of a model. 'Conceptualización del desarrollo profesional en matemáticas : elementos de un modelo'.

Resumen basado en el de la publicación

Doctoral Education and Skills Development : an International and Historical Perspective. 'Educación doctoral y desarrollo de competencias : una perspectiva internacional e histórica'.

Monográfico con el título: 'Competencias docentes en la Educación Superior'. Resumen basado en el de la publicación

Human development in a globalized world : education towards peace, cultural diversity and sustainable development

Monogr??fico con el t??tulo: "La educaci??n como quehacer de convicciones : homenaje acad??mico a Jos?? Antonio Ib????ez-Mart??n"

Usefulness of the Bayley scales of infant and toddler development, third edition, in the early diagnosis of language disorder

Resumen tomado de la publicaci??n

The creation of a Terena Mermaid on an Environmental lesson: a case of Teacher Professional Development

Monogr??fico con el t??tulo: " Formaci??n de profesores. Perspectivas de Brasil, Colombia, Espa??a y Portugal"

A human ribonuclease induces apoptosis associated with p21WAF1/CIP1 induction and JNK inactivation

Ribonucleases are promising agents for use in anticancer therapy. Among the different ribonucleases described to be cytotoxic, a paradigmatic example is onconase which manifests cytotoxic and cytostatic effects, presents synergism with several kinds of anticancer drugs and is currently in phase II/III of its clinical trial as an anticancer drug against different types of cancer. The mechanism of cytotoxicity of PE5, a variant of human pancreatic ribonuclease carrying a nuclear localization signal, has been investigated and compared to that of onconase. Methods: Cytotoxicity was measured by the MTT method and by the tripan blue exclusion assay. Apoptosis was assessed by flow cytometry, caspase enzymatic detection and confocal microscopy. Cell cycle phase analysis was performed by flow cytometry. The expression of different proteins was analyzed by western blot.n Results: We show that the cytotoxicity of PE5 is produced through apoptosis, that it does not require the proapoptotic activity of p53 and is not prevented by the multiple drug resistance phenotype. We also show that PE5 and onconase induce cell death at the same extent although the latter is also able to arrest the cell growth. We have compared the cytotoxic effects of both ribonucleases in the NCI/ADR-RES cell line by measuring their effects on the cell cycle, on the activation of different caspases and on the expression of different apoptosis- and cell cycle-related proteins. PE5 increases the number of cells in S and G2/M cell cycle phases, which is accompanied by the increased expression of cyclin E and p21WAF1/CIP1 together with the underphosphorylation of p46 forms of JNK. Citotoxicity of onconase in this cell line does not alter the cell cycle phase distribution and it is accompanied by a decreased expression of XIAP. Conclusions: We conclude that PE5 kills the cells through apoptosis associated with the p21WAF1/CIP1 induction and the inactivation of JNK. This mechanism is significantly different from that found for onconase

museology and community development in the XXI Century

Each time more, museology professionals are confronted with terms such as community, social inequality, social inclusion and development in their quotidian. Be it in conferences, publications or museum programmes, these are increasingly recurrent terms which, in great part, translate the dynamics of a relationship between museology and community development that has been constructed since the late 60’s. Although it is not new, such relationship has gone through a major bloom in the early 90’s and arrives today as an emerging priority within the world of museology. A first glance on the subject reveals that very different approaches and forms of action share the efforts in endowing museology with a role in community development today. In addition, despite of its growing popularity, it seems to be some misunderstandings on what the work with community development requires and truly signifies, as can be pointed out in a number of assertions originated from the field of museology. Accompanying such a plural environment, discussions and disagreements about to what extend museology is able to claim a role in social change also mark its affairs with community development. People are faced, indeed, with a rather polemic and intricate scenario. To a great extend, language barriers hinder the exchange of information on current initiatives and previous experiences, as well as on the development of concepts, approaches and proposals. Lack of better interactions among the groups of museology professionals and social actors who carry out different works with community development also contributes to making the potential of museology as a resource for development more difficult to be visualised.

Conducive hearing loss: its effect on speech perception and language development

This paper discusses the effects of conducive hearing loss on language development.