God Calls

sermon text; MS Word document

A Map of the Dead Sea, Low plains and Gulf of Eloth, [1812 May 4]

A pen-and-ink map of the Dead Sea from Jericho to the Gulf of Eloth on a grid. The map accompanied a letter by Winthrop (HUG 1203.5 Box 1, Folder 13).

12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids.

Protein kinase C (PKC) isoenzymes are essential components of cell signaling. In this study, we investigated the regulation of PKC-alpha in murine B16 amelanotic melanoma (B16a) cells by the monohydroxy fatty acids 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE] and 13(S)-hydroxyoctadecadienoic acid [13(S)-HODE]. 12(S)-HETE induced a translocation of PKC-alpha to the plasma membrane and focal adhesion plaques, leading to enhanced adhesion of B16a cells to the matrix protein fibronectin. However, 13(S)-HODE inhibited these 12(S)-HETE effects on PKC-alpha. A receptor-mediated mechanism of action for 12(S)-HETE and 13(S)-HODE is supported by the following findings. First, 12(S)-HETE triggered a rapid increase in cellular levels of diacylglycerol and inositol trisphosphate in B16a cells. 13(S)-HODE blocked the 12(S)-HETE-induced bursts of both second messengers. Second, the 12(S)-HETE-increased adhesion of B16a cells to fibronectin was sensitive to inhibition by a phospholipase C inhibitor and pertussis toxin. Finally, a high-affinity binding site (Kd = 1 nM) for 12(S)-HETE was detected in B16a cells, and binding of 12(S)-HETE to B16a cells was effectively inhibited by 13(S)-HODE (IC50 = 4 nM). In summary, our data provide evidence that regulation of PKC-alpha by 12(S)-HETE and 13(S)-HODE may be through a guanine nucleotide-binding protein-linked receptor-mediated hydrolysis of inositol phospholipids.

TRANSFORMAÇÃO SOCIAL SERVIDA À MESA Interpretação cultural e sociorreligiosa do lava-pés em Jo 13,1-17

O lava-pés em Jo 13,1-17 é objeto dessa tese que tem por objetivo apresentar sua significação cultural e sociorreligiosa. Em meio à complexidade do caráter polissêmico do relato joanino o foco da análise volta-se para o contexto das características do costume cultural implicados no lava-pés em ambiente de refeição no mundo mediterrâneo do primeiro século da EC. Com base na análise da história da redação o relato joanino é apresentado como fruto de um processo de recuperação da memória tradicional para ressignificar o valor e dignidade do lava-pés e dos sujeitos aos quais essa tarefa era atribuída: mulheres, escravos e crianças. No contexto da comunidade joanina o lava-pés transforma-se em proposta não apenas de renúncia ou inversão de status, mas de reciprocidade de papéis assumida por todos como gesto concreto e, ao mesmo tempo, simbólico, de abolição de qualquer discriminação ou desigualdade que possa existir entre as pessoas. O lava-pés, nos dois estratos que descrevem as primeiras interpretações predominantes na comunidade (Jo 13, 12-17 e Jo 13,6-10), não é, pois, ritual religioso de purificação de pecado, nem apenas o testemunho de um serviço humilde de quem renuncia provisoriamente ao seu status, mas sim a expressão da identidade de um discipulado que pretende viver um igualitarismo radical no cotidiano do exercício de poder e da divisão de suas tarefas.

The competent prescriber: 12 core competencies for safe prescribing

Prescribing errors remain a significant cause of patient harm. Safe prescribing is not just about writing a prescription, but involves many cognitive and decision-making steps. A set of national prescribing competencies for all prescribers (including non-medical) is needed to guide education and training curricula, assessment and credentialing of individual practitioners. We have identified 12 core competencies for safe prescribing which embody the four stages of the prescribing process – information gathering, clinical decision making, communication, and monitoring and review. These core competencies, along with their learning objectives and assessment methods, provide a useful starting point for teaching safe and effective prescribing.

New Structural Topologies in a Series of 3d Metal Complexes with Isomeric Phenylenediacetates and 1,3,5-Tris(1-imidazolyl)benzene Ligand: Syntheses, Structures, and Magnetic and Luminescence Properties

In this article we present the syntheses, characterizations, magnetic and luminescence properties of five 3d-metal complexes, Co(tib)(1,2-phda)](n)center dot(H2O)(n) (1), Co-3(tib)(2)(1,3-phda)(3)(H2O)](n)center dot(H2O)(2n) (2), Co-5(tib)(3)(1,4-phda)(5)(H2O)(3)](n)center dot(H2O)(7n) (3), Zn-3(tib)(2)(1,3-phda)(3)](n)center dot(H2O)(4n) (4), and Mn(tib)(2)(H2O)(2)](n)center dot(1,4-phdaH)(2n)center dot(H2O)(4n) (5), obtained from the use of isomeric phenylenediacetates (phda) and the neutral 1,3,5-tris(1-imidazolyl)benzene (tib) ligand. Single crystal X-ray structures showed that 1 constitutes 3,5-connected 2-nodal nets with a double-layered two-dimensional (2D) structure, while 2 forms an interpenetrated 2D network (3,4-connected 3-nodal net). Complex 3 has a complicated three-dimensional structure with 10-nodal 3,4,5-connected nets. Complex 4, although it resembles 2 in stoichiometry and basic building structures, forms a very different overall 2D assembly. In complex 5 the dicarboxylic acid, upon losing only one of the acidic protons, does not take part in coordination; instead it forms a complicated hydrogen bonding network with water molecules. Magnetic susceptibility measurements over a wide range of temperatures revealed that the metal ions exchange very poorly through the tib ligand, but for the Co(II) complexes the effects of nonquenched orbital contributions are prominent. The 3d(10) metal complex 4 showed strong luminescence with lambda(max) = 415 nm (lambda(ex) = 360 nm).

截止波长12μm的InAs0.04Sb0.96/GaAs的熔体外延生长及特性研究

用熔体外延(ME)法在半绝缘(100)GaAs衬底上成功生长出了截止波长为12 μm的InAs0.04Sb0.96外延层.傅立叶变换红外(FTIR)透射光谱揭示,InAsSb合金的禁带宽度被强烈变窄.通过分析InAs0.04Sb0.96外延层载流子浓度的温度依存性表明,其室温禁带宽度为0.105 5 eV,与透射光谱测得的数值很好地一致.通过测量12～300 K的吸收光谱,研究了InAs0.04Sb0.96/GaAs的禁带宽度的温度依存性.霍尔测量得出300 K下样品的电子迁移率为4.47×104 cm2/Vs,载流子浓度为8.77×1015 cm-3;77 K下电子迁移率为2.15×104 cm2/Vs,载流子浓度为1.57×1015 cm-3;245 K下的峰值迁移率为4.80×104 cm2/Vs.

Si（5,5,12）-一个大元胞的稳定表面

于2010-11-23批量导入

3～5.3μmIn_xGa_(1-x)As/Al_yGa_(1-y)As/Al_zGa_(1-z)As非对称台阶量子阱红外探测器

于2010-11-23批量导入

1.3μm InGaAsP/InP应变多量子阱部分增益耦合DFB激光器

在国内首次报道了采用直接刻蚀有源区技术在应变多量子阱有源区结构基础上制作了1.3μm InGaAsP/InP部分增益耦合DFB激光器，器件采用全MOVPE生长，阈值电流10mA,边模抑制比(SMSR)大于35dB,在端面未镀膜情况下器件单纵模成品率较高。

优质应变Si_(1-x)Ge_x/Si超晶格的气源分子束处延

于2010-11-23批量导入

优化生长的In_xGa_(1-x)As缓冲层上双势垒In_yGa_(1-y)As/Al_zGa_(1-z)As/GaAs/Al_zGa_(1-z)As多量子阱应变状态测量

一种多步生长方法应用于GaAs衬底上的In_xGa_(1-x)As缓冲层的MOCVD生长.在这种In_xGa_(1-x)As缓冲层上生长的In_yGa_(1-y)As/Al_zGa_(1-z)As/GaAs/Al_zGa_(1-x)As双垫垒量子阱材料表现出了很好的晶格特性和光学性质.超晶格的室温光伏谱中出现很强的22H高阶机制吸收峰,表明超晶格界面质量很好.主要应用X射线双晶衍射方法,给出了样品中各层的应变状态.据此,合理地解释了样品的光学测试结果.

LP-MOVPE生长的1.3μmInGaAsP/InP张压应变交替MQW特性

于2010-11-23批量导入

应变Si（1-x）Ge_x/Si异质结材料的GSMBE生长及X射线双晶衍射研究

于2010-11-23批量导入