Cancer mortality inequalities in urban areas: a Bayesian small area analysis in Spanish cities

Background: Intra-urban inequalities in mortality have been infrequently analysed in European contexts. The aim of the present study was to analyse patterns of cancer mortality and their relationship with socioeconomic deprivation in small areas in 11 Spanish cities. Methods: It is a cross-sectional ecological design using mortality data (years 1996-2003). Units of analysis were the census tracts. A deprivation index was calculated for each census tract. In order to control the variability in estimating the risk of dying we used Bayesian models. We present the RR of the census tract with the highest deprivation vs. the census tract with the lowest deprivation. Results: In the case of men, socioeconomic inequalities are observed in total cancer mortality in all cities, except in Castellon, Cordoba and Vigo, while Barcelona (RR = 1.53 95%CI 1.42-1.67), Madrid (RR = 1.57 95%CI 1.49-1.65) and Seville (RR = 1.53 95%CI 1.36-1.74) present the greatest inequalities. In general Barcelona and Madrid, present inequalities for most types of cancer. Among women for total cancer mortality, inequalities have only been found in Barcelona and Zaragoza. The excess number of cancer deaths due to socioeconomic deprivation was 16,413 for men and 1,142 for women. Conclusion: This study has analysed inequalities in cancer mortality in small areas of cities in Spain, not only relating this mortality with socioeconomic deprivation, but also calculating the excess mortality which may be attributed to such deprivation. This knowledge is particularly useful to determine which geographical areas in each city need intersectorial policies in order to promote a healthy environment.

Do socioeconomic inequalities in mortality vary between different Spanish cities? a pooled cross-sectional analysis

Background: The relationship between deprivation and mortality in urban settings is well established. This relationship has been found for several causes of death in Spanish cities in independent analyses (the MEDEA project). However, no joint analysis which pools the strength of this relationship across several cities has ever been undertaken. Such an analysis would determine, if appropriate, a joint relationship by linking the associations found. Methods: A pooled cross-sectional analysis of the data from the MEDEA project has been carried out for each of the causes of death studied. Specifically, a meta-analysis has been carried out to pool the relative risks in eleven Spanish cities. Different deprivation-mortality relationships across the cities are considered in the analysis (fixed and random effects models). The size of the cities is also considered as a possible factor explaining differences between cities. Results: Twenty studies have been carried out for different combinations of sex and causes of death. For nine of them (men: prostate cancer, diabetes, mental illnesses, Alzheimer’s disease, cerebrovascular disease; women: diabetes, mental illnesses, respiratory diseases, cirrhosis) no differences were found between cities in the effect of deprivation on mortality; in four cases (men: respiratory diseases, all causes of mortality; women: breast cancer, Alzheimer’s disease) differences not associated with the size of the city have been determined; in two cases (men: cirrhosis; women: lung cancer) differences strictly linked to the size of the city have been determined, and in five cases (men: lung cancer, ischaemic heart disease; women: ischaemic heart disease, cerebrovascular diseases, all causes of mortality) both kinds of differences have been found. Except for lung cancer in women, every significant relationship between deprivation and mortality goes in the same direction: deprivation increases mortality. Variability in the relative risks across cities was found for general mortality for both sexes. Conclusions: This study provides a general overview of the relationship between deprivation and mortality for a sample of large Spanish cities combined. This joint study allows the exploration of and, if appropriate, the quantification of the variability in that relationship for the set of cities considered.

Lipschitz compact operators

We introduce the notion of Lipschitz compact (weakly compact, finite-rank, approximable) operators from a pointed metric space X into a Banach space E. We prove that every strongly Lipschitz p-nuclear operator is Lipschitz compact and every strongly Lipschitz p-integral operator is Lipschitz weakly compact. A theory of Lipschitz compact (weakly compact, finite-rank) operators which closely parallels the theory for linear operators is developed. In terms of the Lipschitz transpose map of a Lipschitz operator, we state Lipschitz versions of Schauder type theorems on the (weak) compactness of the adjoint of a (weakly) compact linear operator.

Changes in the Photoreceptor Mosaic of P23H-1 Rats During Retinal Degeneration: Implications for Rod-Cone Dependent Survival

Purpose. To investigate the spatiotemporal relationship between rod and cone degeneration in the P23H-1 rat. Methods. Control Sprague-Dawley (SD) and P23H-1 rats of ages ranging from P30 to P365 were used. Retinas were processed for whole mounts or cross sections and rods and cones were immunodetected. We used newly developed image analysis techniques to quantify the total population of L/M cones (the most abundant cones in the rat) and analyzed the rings of rod-cone degeneration. Results. In P23H-1 rats, rod degeneration occurs rapidly: first the rod outer segment shortens, at P30 there is extensive rod loss, and by P180 rod loss is almost complete except for the most peripheral retina. The numbers of L/M cones are, at all postnatal ages, lower in P23H-1 rats than in control SD rats, and decrease significantly with age (by P180). Rod and cone degeneration is spatiotemporally related and occurs in rings that appear already at P90 and spread throughout the entire retina. At P180, the rings of rod-cone degeneration are more abundant in the equatorial retina and are larger in the dorsal retina. Conclusions. This work describes for the first time that in the P23H-1 rat, rod and cone degeneration is spatiotemporally related and occurs in rings. Cone loss follows rod loss and starts very soon, even before P30, the first age analyzed here. The characteristics of the rings suggest that secondary cone degeneration is influenced by retinal position and/or other intrinsic or extrinsic factors.

La Acción Tutorial en la Facultad de Económicas: perspectivas presentes y futuras

El Programa de Acción Tutorial de Económicas, conocido coloquialmente como PATEC, cumple su novena edición en el presente curso académico 2013-2014. Desde sus inicios el PATEC se ha adaptado a las distintas titulaciones adscritas al Centro gracias a su gran flexibilidad, aspecto fundamental si tenemos en cuenta el tamaño y la heterogeneidad de nuestro Centro y las diferentes características de nuestros estudiantes. El objetivo de esta comunicación es dar a conocer el PATEC, sus objetivos, características y datos más relevantes, así como analizar su evolución lo que nos permitirá obtener una radiografía completa del Programa. Teniendo en cuenta las dificultades encontradas en la implementación del Programa en sus distintas ediciones trataremos de abordar planteamientos alternativos entre los que se encuentra la creación de una Red de Tutores que persigue optimizar la labor tutorial y facilitar el trabajo de futuros tutores. Asimismo, se expondrán diferentes experiencias innovadoras llevadas a cabo con el objetivo de incrementar la participación del alumnado.

Trends in socioeconomic inequalities in preventable mortality in urban areas of 33 Spanish cities, 1996–2007 (MEDEA project)

Background: Preventable mortality is a good indicator of possible problems to be investigated in the primary prevention chain, making it also a useful tool with which to evaluate health policies particularly public health policies. This study describes inequalities in preventable avoidable mortality in relation to socioeconomic status in small urban areas of thirty three Spanish cities, and analyses their evolution over the course of the periods 1996–2001 and 2002–2007. Methods: We analysed census tracts and all deaths occurring in the population residing in these cities from 1996 to 2007 were taken into account. The causes included in the study were lung cancer, cirrhosis, AIDS/HIV, motor vehicle traffic accidents injuries, suicide and homicide. The census tracts were classified into three groups, according their socioeconomic level. To analyse inequalities in mortality risks between the highest and lowest socioeconomic levels and over different periods, for each city and separating by sex, Poisson regression were used. Results: Preventable avoidable mortality made a significant contribution to general mortality (around 7.5%, higher among men), having decreased over time in men (12.7 in 1996–2001 and 10.9 in 2002–2007), though not so clearly among women (3.3% in 1996–2001 and 2.9% in 2002–2007). It has been observed in men that the risks of death are higher in areas of greater deprivation, and that these excesses have not modified over time. The result in women is different and differences in mortality risks by socioeconomic level could not be established in many cities. Conclusions: Preventable mortality decreased between the 1996–2001 and 2002–2007 periods, more markedly in men than in women. There were socioeconomic inequalities in mortality in most cities analysed, associating a higher risk of death with higher levels of deprivation. Inequalities have remained over the two periods analysed. This study makes it possible to identify those areas where excess preventable mortality was associated with more deprived zones. It is in these deprived zones where actions to reduce and monitor health inequalities should be put into place. Primary healthcare may play an important role in this process.

Cómo mejorar el PATEC: comparativa de experiencias en universidades públicas españolas

En este curso 2014-2015 se cumplen 10 años del inicio del Programa de Acción Tutorial de la Facultad de Económicas (PATEC). En estos años este programa se ha ido consolidando e incrementando su relevancia en la Facultad y, en especial, a través de su web. Además, este programa se ofrece a todos los alumnos del centro con independencia del curso o la titulación en la que estén matriculados y se diseñan actividades complementarias que contribuyen a la formación integral del alumnado. En este sentido, la experiencia acumulada permite tener una amplia perspectiva para reflexionar sobre cómo debe ser el PATEC en los próximos años. No sólo teniendo en cuenta esta experiencia sino también considerando la organización y funcionamiento de otros programas de acción tutorial que existen en otras universidades españolas. Así, el objetivo de este trabajo es analizar el funcionamiento de programas de acción tutorial implantados en otros centros para identificar las mejores prácticas con el fin de estudiar la posibilidad de introducirlas en el funcionamiento del PATEC. De esta manera podemos reflexionar sobre nuestras prácticas y mejorar la eficiencia del PATEC para ofrecer a todo su alumnado un servicio de calidad adaptado a sus necesidades académicas, profesionales y personales.

Memoria de la Red de tutores del Programa de Acción Tutorial de la Facultad de Económicas (PATEC)

En el presente curso 2013-2014 el Programa de Acción Tutorial en la Facultad de Ciencias Económicas y Empresariales cumple su novena edición. En el curso 2007-2008, con el objetivo de que el Programa de Acción Tutorial fuera considerado una herramienta dirigida a los alumnos del Centro con identidad propia, pasó a llamarse Programa de Acción Tutorial de Económicas (PATEC) pues coloquialmente al Centro se le identifica con la Facultad de Económicas. Desde entonces, el Programa se ha ido consolidando año a año en la Facultad y son muchas las fortalezas que lo han convertido en un programa con un gran potencial. No obstante, existen ciertas debilidades que se repiten cada año a las que se ha tratado de dar respuesta en las distintas ediciones. El objetivo de la presente comunicación es dar a conocer la evolución del PATEC desde el curso 2007-2008 hasta la actualidad así como las acciones que se han llevado a cabo para subsanar las dificultades encontradas.

Red de investigación en docencia universitaria de la UA: “Universidad, Docencia, Género e Igualdad” (II)

La Red de investigación en docencia universitaria “Universidad, docencia, genero e igualdad” persigue avanzar en la calidad e innovación de las enseñanzas universitarias a partir de la inclusión de la perspectiva de género. Se busca dar cumplimiento a las directrices generales de los nuevos planes de estudio respecto del principio de igualdad de oportunidades entre hombres y mujeres en la formación universitaria (Real Decreto 1393/2007. BOE nº 260, 30 de octubre de 2007). En la tercera edición de la Red, y dada su composición multidisciplinar, se desarrollaron dos líneas de investigación: por un lado, se continuó trabajando en el mantenimiento del “Portal web con recursos docentes con perspectiva de género”, proyecto financiado por el Instituto de la Mujer (PACUI, 2012) e iniciado en el curso 2012-2013, incrementándose en un 36% la colección de recursos; y, por otro, se inició una nueva línea de investigación con la que se busca desarrollar una herramienta informática de ayuda para la redacción de textos con lenguaje inclusivo.

Enzyme mediated synthesis of polypyrrole in the presence of chondroitin sulfate and redox mediators of natural origin

Polypyrrole (PPy) was synthesized by enzyme mediated oxidation of pyrrole using naturally occurring compounds as redox mediators. The catalytic mechanism is an enzymatic cascade reaction in which hydrogen peroxide is the oxidizer and soybean peroxidase, in the presence of acetosyringone, syringaldehyde or vanillin, acts as a natural catalysts. The effect of the initial reaction composition on the polymerization yield and electrical conductivity of PPy was analyzed. Morphology of the PPy particles was studied by scanning electron microscopy and transmission electron microscopy whereas the chemical structure was studied by X-ray photoelectron and Fourier transformed infrared spectroscopic techniques. The redox mediators increased the polymerization yield without a significant modification of the electronic structure of PPy. The highest conductivity of PPy was reached when chondroitin sulfate was used simultaneously as dopant and template during pyrrole polymerization. Electroactive properties of PPy obtained from natural precursors were successfully used in the amperometric quantification of uric acid concentrations. PPy increases the amperometric sensitivity of carbon nanotube screen-printed electrodes toward uric acid detection.

Difusión de contenido obsceno dentro del Horario de Protección al Menor en el Perú: Análisis del reality show Esto es Guerra

En el presente artículo se analiza el contenido que difunde Esto es Guerra, el reality show peruano con alto índice de preferencia en la audiencia infantil durante el 2014, acusado de transmitir escenas con contenido sexual. El objetivo de esta investigación es determinar si existen rastros de material obsceno en este bloque televisivo y si este transgrede el Horario de Protección al Menor, reconocido en el marco legal peruano. Su justificación se enmarca en la escasez de estudios que se han realizado sobre realities en el Perú, los constantes pedidos de la sociedad para que este programa deje de transmitirse y las sanciones que ha recibido de parte de organismos estatales. La metodología empleada se basa en un análisis de contenido de la séptima temporada de Esto es Guerra, en el que se tendrán en cuenta los mensajes que transmiten los conductores y participantes a través de su comportamiento. La investigación determinó que el reality show de competencia presenta segmentos que podrían ser considerados como obscenos, aunque su duración es muy limitada y no representativa en relación a todo el programa.

Universidad, discapacidad e integración

En la actualidad, la proliferación de investigaciones dedicadas a la integración de las personas con discapacidad se ha incrementado notablemente. Uno de los campos más implicados en esta temática es el ámbito educativo, en el que las actitudes que los estudiantes muestran hacia la discapacidad son fundamentales para la integración del alumnado con discapacidad. El propósito del estudio consiste en evaluar las actitudes de los estudiantes universitarios hacia los alumnos con discapacidad en función del curso y la titulación de los estudiantes. Participaron 349 alumnos de la Universidad de Alicante con edades comprendidas entre 18 y 32 años (M= 21,60, DT= 2,32). Diseñamos un cuestionario tipo Likert (1=nada de acuerdo, 5= totalmente de acuerdo), donde se estiman las actitudes de los estudiantes. Los resultados de los análisis de varianza indicaron diferencias estadísticamente significativas en las actitudes de los estudiantes en función del curso y de la titulación. Nuestro estudio muestra que, en general, los alumnos presentan actitudes favorables hacia los alumnos con discapacidad, no obstante, encontramos que desde ciertas titulaciones, y en los cursos superiores, los estudiantes indican mayor nivel de sensibilización hacia la discapacidad.

Inherited Photoreceptor Degeneration Causes the Death of Melanopsin-Positive Retinal Ganglion Cells and Increases Their Coexpression of Brn3a

Purpose: To study the population of intrinsically photosensitive retinal ganglion cells (melanopsin-expressing RGCs, m+RGCs) in P23H-1 rats, a rat model of inherited photoreceptor degeneration. Methods: At postnatal (P) times P30, P365, and P540, retinas from P23H dystrophic rats (line 1, rapid degeneration; and line 3, slow degeneration) and Sprague Dawley (SD) rats (control) were dissected as whole-mounts and immunodetected for melanopsin and/or Brn3a. The dendritic arborization of m+RGCs and the numbers of Brn3a+RGCs and m+RGCs were quantified and their retinal distribution and coexpression analyzed. Results: In SD rats, aging did not affect the population of Brn3a+RGCs or m+RGCs or the percentage that showed coexpression (0.27%). Young P23H-1 rats had a significantly lower number of Brn3a+RGCs and showed a further decline with age. The population of m+RGCs in young P23H-1 rats was similar to that found in SD rats and decreased by 22.6% and 28.2% at P365 and P540, respectively, similarly to the decrease of the Brn3a+RGCs. At these ages the m+RGCs showed a decrease of their dendritic arborization parameters, which was similar in both the P23H-1 and P23H-3 lines. The percentage of coexpression of Brn3a was, however, already significantly higher at P30 (3.31%) and increased significantly with age (10.65% at P540). Conclusions: Inherited photoreceptor degeneration was followed by secondary loss of Brn3a+RGCs and m+RGCs. Surviving m+RGCs showed decreased dendritic arborization parameters and increased coexpression of Brn3a and melanopsin, phenotypic and molecular changes that may represent an effort to resist degeneration and/or preferential survival of m+RGCs capable of synthesizing Brn3a.