Diseño y despliegue de una red inalámbrica segura y control de acceso de sensores IP

[ES]El proyecto está orientado a conseguir una comunicación inalámbrica y segura de una red de sensores IP. Por un lado, mediante el protocolo 6LoWPAN se consigue que los datos se transmitan mediante IPv6 y, por otro lado, gracias al protocolo LADON se establecen los servicios de seguridad de autenticación, integridad de datos, autorización y control de acceso.

A Multi Bearer Adaptable Communication Demonstrator for Train-to-Ground IP Communication to Increase Resilience

Preprint version

Integración de información topográfica diversa para la confección de un mapa del Monasterio de San Prudencio (La Rioja)

[ES] Los datos de este registro provienen de la una actividad académica que también aparece descrita en el repositorio y desde donde se puede acceder a otros trabajos relacionados con el Monasterio:

Telekomunikazio-sare eta zerbitzuak: ariketa ebaitziak

Helburuak: Ariketa-bilduma honen helburu nagusia bikoitza da, 'Telekomunikazio-sare eta zerbitzuak' (2001eko ikasketa-planetako Telekomunikazio Ingeniaritza Teknikoetako 2. mailan irakasten zena) eta 'Telekomunikazio-sare eta zerbitzuak I' (1995eko ikasketa-planetako Telekomunikazio Ingeniaritzako 2. mailan irakasten zena) irakasgaietako ikasleentzat (hortaz, ikasketarako) zein irakasleentzat (hots, irakaskuntzarako) lagungarri izatea. Horregatik, teorian ikasitako kontzeptuen aplikazio praktikoa islatzen duten ariketak dira bilduma honetakoak. Aipatutako irakasgaien konplexutasuna dela eta, liburu hau, 'Telekomunikazio-sare eta zerbitzuak: Teoria' testu-liburuaren lagungarri gisa argitaratu dugu. Norentzat izan daiteke baliagarria: 2001eko ikasketa-planetako Telekomunikazio Ingeniaritza Teknikoetako 2. mailan irakasten zen 'Telekomunikazio-sare eta zerbitzuak' eta 1995eko ikasketa-planetako Telekomunikazio Ingeniaritzako 2. mailan irakasten zen 'Telekomunikazio-sare eta zerbitzuak I' irakasgaietako ikasleentzat zein irakasleentzat.

Telekomunikazio-sare eta zerbitzuak: teoria

Helburuak: Testu-liburu honen helburua bikoitza da, 'Telekomunikazio-sare eta zerbitzuak' (2001eko ikasketa-planetako Telekomunikazio Ingeniaritza Teknikoetako 2. mailan irakasten zena) eta 'Telekomunikazio-sare eta zerbitzuak I' (1995eko ikasketa-planetako Telekomunikazio Ingeniaritzako 2. mailan irakasten zena) irakasgaietako ikasleentzat (hortaz, ikasketarako) zein irakasleentzat (hots, irakaskuntzarako) lagungarri izatea. Horregatik, ikasgelan azaldutako kontzeptuen kontsultarako testu-liburutzat har daiteke. Norentzat izan daiteke baliagarria: 2001eko ikasketa-planetako Telekomunikazio Ingeniaritza Teknikoetako 2. mailan irakasten zen 'Telekomunikazio-sare eta zerbitzuak' eta 1995eko ikasketa-planetako Telekomunikazio Ingeniaritzako 2. mailan irakasten zen 'Telekomunikazio-sare eta zerbitzuak I' irakasgaietako ikasleentzat zein irakasleentzat.

Enriching the content provided by cultural catalogues with data from institutional repositories

[EN] This paper is an outcome of the ERASMUS IP program called TOPCART, there are more information about this project that can be accessed from the following item:

Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes

Overactivation of ionotropic glutamate receptors in oligodendrocytes induces cytosolic Ca2+ overload and excitotoxic death, a process that contributes to demyelination and multiple sclerosis. Excitotoxic insults cause well-characterized mitochondrial alterations and endoplasmic reticulum (ER) dysfunction, which is not fully understood. In this study, we analyzed the contribution of ER-Ca2+ release through ryanodine receptors (RyRs) and inositol triphosphate receptors (IP(3)Rs) to excitotoxicity in oligodendrocytes in vitro. First, we observed that oligodendrocytes express all previously characterized RyRs and IP(3)Rs. Blockade of Ca2+-induced Ca2+ release by TMB-8 following alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptor-mediated insults attenuated both oligodendrocyte death and cytosolic Ca2+ overload. In turn, RyR inhibition by ryanodine reduced as well the Ca2+ overload whereas IP3R inhibition was ineffective. Furthermore, AMPA-triggered mitochondrial membrane depolarization, oxidative stress and activation of caspase-3, which in all instances was diminished by RyR inhibition. In addition, we observed that AMPA induced an ER stress response as revealed by alpha subunit of the eukaryotic initiation factor 2 alpha phosphorylation, overexpression of GRP chaperones and RyR-dependent cleavage of caspase-12. Finally, attenuating ER stress with salubrinal protected oligodendrocytes from AMPA excitotoxicity. Together, these results show that Ca2+ release through RyRs contributes to cytosolic Ca2+ overload, mitochondrial dysfunction, ER stress and cell death following AMPA receptor-mediated excitotoxicity in oligodendrocytes. Cell Death and Disease (2010) 1, e54; doi:10.1038/cddis.2010.31; published online 15 July 2010

Control de almacén automatizado con dos ejes lineales.

[ES]El objetivo principal de este Trabajo Fin de Grado es automatizar un almacén con dos ejes lineales con la meta final de programar un panel de operador para que, ya sea un usuario u operario pueda introducir si desea depositar o recoger un palé, indicando la posición mediante un sistema de coordenadas las cuales dividen a las estanterías del almacén en filas y columnas. Para ello se cambiará parte del hardware de control, el cual incluye el antiguo módulo de posicionamiento (IP 246) que hasta ahora, controlaba el almacén. Esta tarjeta está limitada a un software ya desfasado, sin posibilidad de implementar un panel de operador con los requisitos demandados en la industria de hoy en día. También se ha utilizado una CPU S7-300, a diferencia de la SIMATIC S5 que se utilizaba con la antigua tarjeta.

Modelling and Simulation of ERTMS for Current and Future Mobile Technologies

Nowadays, train control in-lab simulation tools play a crucial role in reducing extensive and expensive on-site railway testing activities. In this paper, we present our contribution in this arena by detailing the internals of our European Railway Train Management System in-lab demonstrator. This demonstrator is built over a general-purpose simulation framework, Riverbed Modeler, previously Opnet Modeler. Our framework models both ERTMS subsystems, the Automatic Train Protection application layer based on movement authority message exchange and the telecommunication subsystem based on GSM-R communication technology. We provide detailed information on our modelling strategy. We also validate our simulation framework with real trace data. To conclude, under current industry migration scenario from GSM-R legacy obsolescence to IP-based heterogeneous technologies, our simulation framework represents a singular tool to railway operators. As an example, we present the assessment of related performance indicators for a specific railway network using a candidate replacement technology, LTE, versus current legacy technology. To the best of our knowledge, there is no similar initiative able to measure the impact of the telecommunication subsystem in the railway network availability.

FTY720 attenuates excitotoxicity and neuroinflammation

Background: FTY720 (fingolimod, Gilenya(TM)), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy has been related to induced lymphopenia and consequent immunosuppression via modulation of S1P(1) receptors (S1P(1)R). However, due to its lipophilic nature, FTY720 crosses the blood brain barrier (BBB) and could act directly on neural cells. In this study, we investigated the effectiveness of FTY720 as a neuroprotective agent using in vitro and in vivo models of excitotoxic neuronal death and examined if FTY720 exerts a direct action on neurons, or/and an indirect modulation of inflammation-mediated neurodegeneration as a possible mechanism of neuroprotection. Methods: Primary neuronal and organotypic cortical cultures were treated with N-methyl-D-aspartic acid (NMDA) to induce excitotoxic cell death (measured by lactate dehydrogenase (LDH) assay or propidium iodide uptake, respectively). The effects of FTY720 treatment (10, 100 and 1,000 nM) on neuronal survival were examined. As an in vivo model of neuronal death and inflammation, we used intracerebroventricular (icv) administration of kainic acid (KA; 0.5 mu g/2 mu l) in Sprague-Dawley rats. FTY720 was applied icv (1 mu g/2 mu l), together with KA, plus intraperitoneally (ip; 1 mg/kg) 24 h before, and daily, until sacrifice 3 days after icv. Rats were evaluated for neurological score, neuronal loss in CA3 hippocampal region and activation of microglia at the lesion site. In addition, we tested FTY720 as a modulator of microglia responses using microglial cell cultures activated with lipopolysaccharide (LPS) and its effects in stress signalling pathways using western blotting for p38 and JNK1/2 mitogen-activated protein kinases (MAPKs). Results: FTY720 was able to reduce excitotoxic neuronal death in vitro. Moreover, in vivo repeated FTY720 administration attenuated KA-induced neurodegeneration and microgliosis at the CA3 lesion site. Furthermore, FTY720 negatively modulates p38 MAPK in LPS-activated microglia, whereas it had no effect on JNK1/2 activation. Conclusions: These data support a role for FTY720 as a neuroprotective agent against excitotoxin-induced neuronal death and as a negative modulator of neuroinflammation by targeting the p38 MAPK stress signalling pathway in microglia.

Impuesto sobre el patrimonio: divergencias normativas en la Comunidad Autónoma Vasca

El presente trabajo analiza las principales divergencias que se dan a nivel autonómico en cuanto a la normativa que sanciona el patrimonio neto. Tratando de este modo de esclarecer de un modo técnico cuales son y qué efectos producen dichas diferencias, y si realmente es tanta la diferencia existente, en cuanto a tributación, entre las tres Haciendas Forales. A pesar de que son muchas las diferencias existentes, he considerado que las que mayor diferencia suponen para el contribuyente son las derivadas de la tarifa del impuesto, del mínimo exento, del tratamiento y valoración de las participaciones y del límite conjunto renta patrimonio. De ahí, que una vez realizada una introducción en lo referente a los aspectos más genéricos del impuesto se analizan los aspectos del impuesto que mayor debate generan en el ámbito tributario, y que son los que mayor parte del trabajo soportan. Con los resultados obtenidos del análisis el lector podrá evaluar, de manera objetiva y apoyándose en un trabajo técnico, los diferentes aspectos analizados.