869 resultados para establishing an enterprise
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Universidade Estadual de Campinas. Faculdade de Educação Física
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Universidade Estadual de Campinas . Faculdade de Educação Física
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There are, at least, two major questions concerning the molecular development of the olfactory nerve pathway. First, what are the molecular cues responsible for guiding axons from the nasal cavity to the olfactory bulb? Second, what is the molecular basis of axon targeting to specific glomeruli once axons reach the olfactory bulb? Studies in the primary olfactory pathway have focused on the role of the extracellular matrix and ensheathing cells in establishing an initial substrate for growth of pioneer axons between the periphery and brain. The primary axons also express a multitude of cell adhesion molecules that regulate fasciculation of axons and hence may play a role in fascicle formation in the olfactory nerve. Although the olfactory neuroepithelium principally consists of a morphologically homogeneous class of primary olfactory neurons, there are numerous subpopulations of olfactory neurons expressing chemically distinct phenotypes. In particular, numerous subpopulations have been characterized by expression of unique carbohydrate residues and olfactory receptor proteins. Some of these molecules have recently been implicated in axon guidance and targeting to specific glomeruli.
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In the early postoperative period of Cushing`s disease patients, desmopressin may stimulate ACTH secretion in the remnant corticotrophic tumour, but not in nontumour suppressed cells. Objective The aim of this study is to evaluate the serum cortisol responses to desmopressin after pituitary surgery, establishing an optimal cut-off for absolute increment (Delta) of serum cortisol (F) suitable to predict recurrence risk. Design Retrospective case record study. Patients Fifty-seven Cushing`s disease patients submitted to pituitary surgery and desmopressin stimulation in the early postoperative with a long-term follow-up (20-161 months) were studied. Methods and measurements Serum cortisol levels after desmopressin test (10 mu g IV) 15-30 days after adenomectomy were used to determine Delta F (absolute increment of F: F peak - F baseline). Sensitivity and specificity of Delta F were calculated and a ROC curve was performed to establish an optimal cut-off for Delta F to predict recurrence risk. Results Fifteen patients had immediate postoperative failure (basal F > 165 nmol/l; 6 mu g/dl) and one patient was lost during the follow-up. Forty-one patients achieved initial remission and were followed-up. Five of 11 patients who recurred had Delta F > 193 nmol/l (7 mu g/dl), but none of 30 patients who remained in prolonged remission showed Delta F > 193 nmol/l after postoperative desmopressin stimulation. Conclusions Persistence of cortisol response (Delta F > 193 nmol/l) to desmopressin in the early postoperative period can help to identify Cushing`s disease patients with initial remission who present risk for later recurrence.
Wildlife damage, insurance/compensation for farmers and conservation: Sri Lankan elephants as a case
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The interference with agriculture has been recognised as the main cause for the current conflict between farmers and wild elephants in Sri Lanka, as elsewhere in the Asian elephant range. Thus compensating farmers for the damages caused by elephants is essential, if this endangered species is to survive in the long run. This paper explores the practicality of establishing an improved publicly funded insurance/compensation scheme to recompense farmers for the elephant damages. It does so by analysing results from two contingent valuation surveys undertaken in Sri Lanka. We find that possible public support of farmers plus urban dwellers significantly exceeds the financial requirement of the insurance scheme proposed in this study for perpetuity. The article also shows that it is often inappropriate from an economic viewpoint to analyse crop insurance as if it only involves the insurance of a private good because important positive externalities can arise from ‘crop’ damages by wildlife, e.g. elephants. The use of agricultural land by some species is essential for their long-term survival and this is often positively valued by the community as a whole.
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The selection of an Enterprise Resource Planning (ERP) system is one of the most sensitive and highest impact processes in the area of information systems and technologies, because it supports and integrates the whole business of an organization. Hence the importance of deciding the best solution in order to contribute to the organization's competitiveness in a global and increasingly demanding market. Therefore, it is essential to provide tools to support decision making, turning complex and often intangible decisions into simple and quantifiable scenarios. This study addressed the adoption of the Analytical Hierarchy Process (AHP) multicriteria decision method to support the selection of an ERP system. The literature review was the source used to obtain the set of the most relevant criteria to be considered in this decision, which were subsequently validated through systematic application of various surveys of experts and people related to the field of ERP systems. To support the application of AHP, according to the model obtained in the study, it was developed a web application that will be available to the general public. The responsible for the acquisition of ERP systems can use it to easily apply the AHP method based on validated decision model. On the other hand, the web application can be used as a validation tool, allowing collecting data for future developments of the decision model.
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Dissertação para a obtenção do Grau de Mestre em Auditoria Orientador: Mestre Carlos Manuel Antunes Mendes
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In this paper we present VERITAS, a tool that focus time maintenance, that is one of the most important processes in the engineering of the time during the development of KBS. The verification and validation (V&V) process is part of a wider process denominated knowledge maintenance, in which an enterprise systematically gathers, organizes, shares, and analyzes knowledge to accomplish its goals and mission. The V&V process states if the software requirements specifications have been correctly and completely fulfilled. The methodologies proposed in software engineering have showed to be inadequate for Knowledge Based Systems (KBS) validation and verification, since KBS present some particular characteristics. VERITAS is an automatic tool developed for KBS verification which is able to detect a large number of knowledge anomalies. It addresses many relevant aspects considered in real applications, like the usage of rule triggering selection mechanisms and temporal reasoning.
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Devido ao facto de hoje em dia a informação que é processada numa rede informática empresarial, ser cada vez mais de ordem confidencial, torna-se necessário que essa informação esteja o mais protegida possível. Ao mesmo tempo, é necessário que esta a informação esteja disponível com a devida rapidez, para os parceiros certos, num mundo cada vez mais globalizado. Com este trabalho pretende-se efectuar o estudo e implementação da segurança, numa pequena e genérica rede de testes, que facilmente seja extrapolada, para uma rede da dimensão, de uma grande empresa com potenciais ramificações por diversos locais. Pretende-se implementar/monitorização segurança quer externamente, (Internet service provider ISP) quer internamente (activos de rede, postos de trabalho/utilizadores). Esta análise é baseada na localização (local, wireless ou remota), e, sempre que seja detectada qualquer anomalia, seja identificada a sua localização, sendo tomadas automaticamente acções de protecção. Estas anomalias poderão ser geridas recorrendo a ferramentas open source ou comerciais, que façam a recolha de toda a informação necessária, e tomem acções de correcção ou alerta mediante o tipo de anomalia.
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Dissertação apresentada ao Instituto Superior de Contabilidade e Administração do Porto para a obtenção do grau de Mestre em Empreendedorismo e Internacionalização. Orientada pela Professora Doutora Maria Clara Dias Pinto Ribeiro
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Trabalho Final de Mestrado para obtenção do grau de Mestre em Engenharia Mecânica
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Composition is a practice of key importance in software engineering. When real-time applications are composed it is necessary that their timing properties (such as meeting the deadlines) are guaranteed. The composition is performed by establishing an interface between the application and the physical platform. Such an interface does typically contain information about the amount of computing capacity needed by the application. In multiprocessor platforms, the interface should also present information about the degree of parallelism. Recently there have been quite a few interface proposals. However, they are either too complex to be handled or too pessimistic.In this paper we propose the Generalized Multiprocessor Periodic Resource model (GMPR) that is strictly superior to the MPR model without requiring a too detailed description. We describe a method to generate the interface from the application specification. All these methods have been implemented in Matlab routines that are publicly available.
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Dissertação para obtenção do grau de Mestre em Engenharia Civil na Área de Especialização de Edificações
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Trabalho Final de Mestrado para obtenção do grau de Mestre em Engenharia Mecânica
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Relatório da Prática Profissional Supervisionada Mestrado Em Educação Pré-Escolar