985 resultados para Matrices genéricas
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Resumen basado en el de la publicación
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Resumen basado en el de la publicación
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Resumen basado en el de la publicación.
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En esta comunicación se explicará cómo a través de la elaboración de un proyecto, propuesto como actividad importante de post-laboratorio, en dos asignaturas de experimentación, de Ingeniería Química, se facilitan estrategias y recursos para que el alumnado sea capaz de auto-gestionarse además de integrar el trabajo en equipo durante el proceso. La planificación de las tareas, así como el seguimiento permiten reorientar el proceso, posibilitando mejores resultados finales. Mientras que en la primera asignatura se guía el trabajo en equipo, en la segunda se da más libertad para gestionar los datos obtenidos en el laboratorio
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This paper presents a study reformatting and reanalyzing data collected in a 1955 study of the perception of sixteen different consonants in consonant-vowel combinations, by human listeners.
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We consider the application of the conjugate gradient method to the solution of large, symmetric indefinite linear systems. Special emphasis is put on the use of constraint preconditioners and a new factorization that can reduce the number of flops required by the preconditioning step. Results concerning the eigenvalues of the preconditioned matrix and its minimum polynomial are given. Numerical experiments validate these conclusions.
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Matrix-assisted laser desorption/ionization (MALDI) is a key ionization technique in mass spectrometry (MS) for the analysis of labile macromolecules. An important area of study and improvements in relation to MALDI and its application in high-sensitivity MS is that of matrix design and sample preparation. Recently, 4-chloro-alpha-cyanocinnamic acid (ClCCA) has been introduced as a new rationally designed matrix and reported to provide an improved analytical performance as demonstrated by an increase in sequence coverage of protein digests obtained by peptide mass mapping (PMM) (Jaskolla, T. W.; et al. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 12200-12205). This new matrix shows the potential to be a superior alternative to the commonly used and highly successful alpha-cyano-4-hydroxycinnamic acid (CHCA). We have taken this design one step further by developing and optimizing an ionic liquid matrix (ILM) and liquid support matrix (LSM) using ClCCA as the principle chromophore and MALDI matrix compound. These new liquid matrices possess greater sample homogeneity and a simpler morphology. The data obtained from our studies show improved sequence coverage for BSA digests compared to the traditional CHCA crystalline matrix and for the ClCCA-containing ILM a similar performance to the ClCCA crystalline matrix down to 1 fmol of BSA digest prepared in a single MALDI sample droplet with current sensitivity levels in the attomole range. The LSMs show a high tolerance to contamination such as ammonium bicarbonate, a commonly used buffering agent.