From defined polymer architectures to structure-property relationships in vivo

Makromolekulare Wirkstoffträgersysteme sind von starkem Interesse bezüglich der klinischen Anwendung chemotherapeutischer Agenzien. Um ihr klinisches Potential zu untersuchen ist es von besonderer Bedeutung das pharmakokinetische Profil in vivo zu bestimmen. Jede Veränderung der Polymerstruktur beeinflusst die Körperverteilung des entsprechenden Makromoleküls. Aufgrund dessen benötigt man detailliertes Wissen über Struktur-Eigenschaftsbeziehungen im lebenden Organismus, um das Nanocarrier System für zukünftige Anwendungen einzustellen. In dieser Beziehung stellt das präklinische Screening mittels radioaktiver Markierung und Positronen-Emissions-Tomographie eine nützliche Methode für schnelle sowie quantitative Beobachtung von Wirkstoffträgerkandidaten dar. Insbesondere poly(HPMA) und PEG sind im Arbeitsgebiet Polymer-basierter Therapeutika stark verbreitet und von ihnen abgeleitete Strukturen könnten neue Generationen in diesem Forschungsbereich bieten.rnDie vorliegende Arbeit beschreibt die erfolgreiche Synthese verschiedener HPMA und PEG basierter Polymer-Architekturen – Homopolymere, Statistische und Block copolymere – die mittels RAFT und Reaktivesterchemie durchgeführt wurde. Des Weiteren wurden die genannten Polymere mit Fluor-18 und Iod-131 radioaktiv markiert und mit Hilfe von microPET und ex vivo Biodistributionsstudien in tumortragenden Ratten biologisch evaluiert. Die Variation in Polymer-Architektur und darauffolgende Analyse in vivo resultierte in wichtige Schlussfolgerungen. Das hydrophile / lipophile Gleichgewicht hatte einen bedeutenden Einfluss auf das pharmakokinetische Profil, mit besten in vivo Eigenschaften (geringe Aufnahme in Leber und Milz sowie verlängerte Blutzirkulationszeit) für statistische HPMA-LMA copolymere mit steigendem hydrophoben Anteil. Außerdem zeigten Langzeitstudien mit Iod-131 eine verstärkte Retention von hochmolekularen, HPMA basierten statistischen Copolymeren im Tumorgewebe. Diese Beobachtung bestätigte den bekannten EPR-Effekt. Hinzukommend stellen Überstrukturbildung und damit Polymergröße Schlüsselfaktoren für effizientes Tumor-Targeting dar, da Polymerstrukturen über 200 nm in Durchmesser schnell vom MPS erkannt und vom Blutkreislauf eliminiert werden. Aufgrund dessen wurden die hier synthetisierten HPMA Block copolymere mit PEG Seitengruppen chemisch modifiziert, um eine Verminderung in Größe sowie eine Reduktion in Blutausscheidung zu induzieren. Dieser Ansatz führte zu einer erhöhten Tumoranreicherung im Walker 256 Karzinom Modell. Generell wird die Körperverteilung von HPMA und PEG basierten Polymeren stark durch die Polymer-Architektur sowie das Molekulargewicht beeinflusst. Außerdem hängt ihre Effizienz hinsichtlich Tumorbehandlung deutlich von den individuellen Charakteristika des einzelnen Tumors ab. Aufgrund dieser Beobachtungen betont die hier vorgestellte Dissertation die Notwendigkeit einer detaillierten Polymer-Charakterisierung, kombiniert mit präklinischem Screening, um polymere Wirkstoffträgersysteme für individualisierte Patienten-Therapie in der Zukunft maßzuschneidern.rn

THE APPLICATION OF PATH ANALYSIS TO ASSESSMENT OF IRON NUTRITIONAL STATUS IN MAN

Path analysis has been applied to components of the iron metabolic system with the intent of suggesting an integrated procedure for better evaluating iron nutritional status at the community level. The primary variables of interest in this study were (1) iron stores, (2) total iron-binding capacity, (3) serum ferritin, (4) serum iron, (5) transferrin saturation, and (6) hemoglobin concentration. Correlation coefficients for relationships among these variables were obtained from published literature and postulated in a series of models using measures of those variables that are feasible to include in a community nutritional survey. Models were built upon known information about the metabolism of iron and were limited by what had been reported in the literature in terms of correlation coefficients or quantitative relationships. Data were pooled from various studies and correlations of the same bivariate relationships were averaged after z- transformations. Correlation matrices were then constructed by transforming the average values back into correlation coefficients. The results of path analysis in this study indicate that hemoglobin is not a good indicator of early iron deficiency. It does not account for variance in iron stores. On the other hand, 91% of the variance in iron stores is explained by serum ferritin and total iron-binding capacity. In addition, the magnitude of the path coefficient (.78) of the serum ferritin-iron stores relationship signifies that serum ferritin is the most important predictor of iron stores in the proposed model. Finally, drawing upon known relations among variables and the amount of variance explained in path models, it is suggested that the following blood measures should be made in assessing community iron deficiency: (1) serum ferritin, (2) total iron-binding capacity, (3) serum iron, (4) transferrin saturation, and (5) hemoglobin concentration. These measures (with acceptable ranges and cut-off points) could make possible the complete evaluation of all three stages of iron deficiency in those persons surveyed at the community level. ^

ARREDA HOMEM QUE AÍ VEM MULHER... Representações de Gênero nas Manifestações da Pombagira

Arreda homem que aí vem mulher... , trata das representações de gênero nas manifestações da Pombagira, entidade espiritual da religiosidade afro-brasileira. O trabalho faz uma leitura diferenciada sobre a figura da Pombagira trazendo-a para o campo social, mostrando sua construção e suas funções, desmistificando sua associação com o mal que supomos esteja relacionado com a sua função de intermediadora das relações amorosas, vinculadas ao poder via sexualidade, além da sua manifestação como contestadora do papel feminino construído. A pesquisa foi realizada por meio da observação dos rituais e entrevistas semi-estruturadas com sacerdotes, sacerdotisas e adeptos da religiosidade afro-brasileira em terreiros de Candomblé e Umbanda na cidade de Porto Velho - Rondônia. Apresentamos no primeiro capítulo algumas observações sobre as suas imagens, funções e representações. No segundo capítulo trazemos as construções da sua figura pelos cientistas sociais, religiosos, entrevistados e entrevistadas. O terceiro capítulo foi dedicado às observações sobre as representações da Pombagira, objetivo central do trabalho.AU)

ARREDA HOMEM QUE AÍ VEM MULHER... Representações de Gênero nas Manifestações da Pombagira

Arreda homem que aí vem mulher... , trata das representações de gênero nas manifestações da Pombagira, entidade espiritual da religiosidade afro-brasileira. O trabalho faz uma leitura diferenciada sobre a figura da Pombagira trazendo-a para o campo social, mostrando sua construção e suas funções, desmistificando sua associação com o mal que supomos esteja relacionado com a sua função de intermediadora das relações amorosas, vinculadas ao poder via sexualidade, além da sua manifestação como contestadora do papel feminino construído. A pesquisa foi realizada por meio da observação dos rituais e entrevistas semi-estruturadas com sacerdotes, sacerdotisas e adeptos da religiosidade afro-brasileira em terreiros de Candomblé e Umbanda na cidade de Porto Velho - Rondônia. Apresentamos no primeiro capítulo algumas observações sobre as suas imagens, funções e representações. No segundo capítulo trazemos as construções da sua figura pelos cientistas sociais, religiosos, entrevistados e entrevistadas. O terceiro capítulo foi dedicado às observações sobre as representações da Pombagira, objetivo central do trabalho.AU)

Lady Cheveley; or, The woman of honour.

A satire in verse, written in answer to Lady Bulwer-Lytton's attack on her husband in "Cheveley, the man of honour."

Evenings of a working man : being the occupation of his scanty leisure /

Stories, verses, and essays.

Lectures on the sphere and duties of woman : and other subjects /

Introduction -- Sphere and duties of woman -- Education of woman -- Moral uses of poetry -- The moral nature of man -- Progress and prospects of society.

“A Man After God’s Own Heart”: Biblical, Hegemonic and Toxic Masculinities in As Meat Loves Salt

Maria McCann paints a dark picture of masculinity and its effects in her novel As Meat Loves Salt (2001). The violent Jacob Cullen struggles with his masculinity as he faces the intricacies of religion, sexuality and politics in the midst of the English Civil War where he falls in love with fellow soldier Christopher Ferris. By using R.W. Connell and James Messerschmidt’s framework for the hierarchy of masculinities, I explore masculinities on local, regional and global levels and emphasized femininity in a close reading of McCann’s novel. My aim is not only to analyse the masculinities of the novel but also to use the framework to redefine toxic masculinity in order to make it a useable concept when analysing masculinities in literature. I redefine toxic masculinity because it lacks a clear definition anchored in an established framework used to study masculinity that does not see masculinity as inherently toxic. I believe that anchoring it to Connell and Messerschmidt’s framework will make it a useable concept. Due to the novel’s relationship to the Bible, I will use masculinity studies done on David and Jesus from the Bible to compare and reveal similarities with the masculinities in the novel, how they appear on the local, regional and global levels in the novel and its effects. I draw parallels between the love story in As Meat Loves Salt to the love story of David and Jonathan in the Bible by using queer readings of David and Jonathan in order to explore how masculinity affects the relationships and how the novel uses these two love stories as a study of toxic masculinity and how it relates it to hegemonic masculinity.

ARREDA HOMEM QUE AÍ VEM MULHER... Representações de Gênero nas Manifestações da Pombagira

Arreda homem que aí vem mulher... , trata das representações de gênero nas manifestações da Pombagira, entidade espiritual da religiosidade afro-brasileira. O trabalho faz uma leitura diferenciada sobre a figura da Pombagira trazendo-a para o campo social, mostrando sua construção e suas funções, desmistificando sua associação com o mal que supomos esteja relacionado com a sua função de intermediadora das relações amorosas, vinculadas ao poder via sexualidade, além da sua manifestação como contestadora do papel feminino construído. A pesquisa foi realizada por meio da observação dos rituais e entrevistas semi-estruturadas com sacerdotes, sacerdotisas e adeptos da religiosidade afro-brasileira em terreiros de Candomblé e Umbanda na cidade de Porto Velho - Rondônia. Apresentamos no primeiro capítulo algumas observações sobre as suas imagens, funções e representações. No segundo capítulo trazemos as construções da sua figura pelos cientistas sociais, religiosos, entrevistados e entrevistadas. O terceiro capítulo foi dedicado às observações sobre as representações da Pombagira, objetivo central do trabalho.AU)

A girl from Ohio

A GIRL FROM OHIO is a dark and comic novel about the plight of an older woman who wants to connect with a special man in post-9/11 New York City. Fortyeight year old Kathy has had boyfriends-but the wrong ones. She wants to find a good man for genuine love and commitment while at the same time doubting such a man exists. As she engages in her search via writing an ad for an Internet dating site, she recollects growing up in Ohio, past transgressions and an array of ill-fated relationships. When her interest with a special man, Jim, develops, Kathy struggles to trust herselfand Jim. After realizing that Jim is the real deal, Kathy softens her hardened exterior and opens herself to the possibility of having true love. In the end, Kathy learns that she has to allow herself to change. She must let love in.

Reference list of 265 sources used for the discovery of relationships between data clusters and metadata properties

Visual cluster analysis provides valuable tools that help analysts to understand large data sets in terms of representative clusters and relationships thereof. Often, the found clusters are to be understood in context of belonging categorical, numerical or textual metadata which are given for the data elements. While often not part of the clustering process, such metadata play an important role and need to be considered during the interactive cluster exploration process. Traditionally, linked-views allow to relate (or loosely speaking: correlate) clusters with metadata or other properties of the underlying cluster data. Manually inspecting the distribution of metadata for each cluster in a linked-view approach is tedious, specially for large data sets, where a large search problem arises. Fully interactive search for potentially useful or interesting cluster to metadata relationships may constitute a cumbersome and long process. To remedy this problem, we propose a novel approach for guiding users in discovering interesting relationships between clusters and associated metadata. Its goal is to guide the analyst through the potentially huge search space. We focus in our work on metadata of categorical type, which can be summarized for a cluster in form of a histogram. We start from a given visual cluster representation, and compute certain measures of interestingness defined on the distribution of metadata categories for the clusters. These measures are used to automatically score and rank the clusters for potential interestingness regarding the distribution of categorical metadata. Identified interesting relationships are highlighted in the visual cluster representation for easy inspection by the user. We present a system implementing an encompassing, yet extensible, set of interestingness scores for categorical metadata, which can also be extended to numerical metadata. Appropriate visual representations are provided for showing the visual correlations, as well as the calculated ranking scores. Focusing on clusters of time series data, we test our approach on a large real-world data set of time-oriented scientific research data, demonstrating how specific interesting views are automatically identified, supporting the analyst discovering interesting and visually understandable relationships.

Daughter of Eve, "Femme Fatale", and Persecuted Artist: The Mythic Transgressive Woman in Oscar Wilde's and Richard Strauss's "Salome"

Historically, Salome was an unexceptional figure who never catalyzed John the Baptist's death. However, in Christian Scripture, she becomes the dancing seductress as fallen daughter of Eve.  Her stepfather Herod promises Salome his kingdom if she dances for him, but she follows her mother’s wish to have John beheaded. In Strauss’s opera, after Wilde's Symbolist-Decadent play, Salome becomes independent of Herodias’ will, and the mythic avatar of the femme fatale and persecuted artist who Herod has killed after she kisses John's severed head.  Her signature key of C# major, resolving to the C major sung by Herod and Jokanaan at her death, represent her tragic fate musically.

These things are alive: relationships between material culture, communities, and archaeological legislation

This paper deals with the relationship between different sets of archaeological legislation, material culture and communities. First it presents a historical sketch of the heritage legislation in the West and its contemporary uses. Secondly, it shows how alternative archaeological agencies, such as community archaeology, deal with these problems. The discussion is especially relevant in Brazil, where contract archaeology is presently overwhelming, and the issue is raised in the last part of the paper.

Staff training in autism: The one-eyed wo/man….

Having well-trained staff is key to ensuring good quality autism services, especially since people affected with autism generally tend to have higher support needs than other populations in terms of daily living as well as their mental and physical health. Poorly-trained staff can have detrimental effects on service provision and staff morale and can lead to staff burn-out as well as increased service user anxiety and stress. This paper reports on a survey with health, social care, and education staff who work within the statutory autism services sector in the UK that explored their knowledge and training with regards to autism. Interview data obtained from staff and service users offer qualitative illustrations of survey findings. Overall, the findings expose an acute lack of autism specific training that has detrimental impacts. At best this training was based on brief and very basic awareness raising rather than on in-depth understanding of issues related to autism or skills for evidence-based practice. Service users were concerned with the effects that lack of staff training had on the services they received. The paper concludes with a discussion of policy routes to achieving quality staff training based on international best practice. The focus is on improving the quality of life and mental health for services users and staff as well as making potentially significant cost-savings for governments.