Oleic acid modulates mRNA expression of liver X receptor (LXR) and its target genes ABCA1 and SREBP1c in human neutrophils

Purpose: Regulation of liver X receptors (LXRs) is essential for cholesterol homeostasis and inflammation. The present study was conducted to determine whether oleic acid (OA) could regulate mRNA expression of LXRα and LXRα-regulated genes and to assess the potential promotion of oxidative stress by OA in neutrophils. Methods: Human neutrophils were treated with OA at different doses and LXR target gene expression, oxidative stress production, lipid efflux and inflammation state were analyzed. Results: We describe that mRNA synthesis of both LXRα and ABCA1 (a reverse cholesterol transporter) was induced by OA in human neutrophils. This fatty acid enhanced the effects of LXR ligands on ABCA1 and LXR expression, but it decreased the mRNA levels of sterol regulatory element-binding protein 1c (a transcription factor that regulates the synthesis of triglycerides). Although OA elicited a slight oxidative stress in the short term (15–30 min) in neutrophils, it is unlikely that this is relevant for the modulation of transcription in our experimental conditions, which involve longer incubation time (i.e., 6 h). Of physiological importance is our finding that OA depresses intracellular lipid levels and that markers of inflammation, such as ERK1/2 and p38 mitogen-activated protein kinase phosphorylation, were decreased by OA treatment. In addition, 200 μM OA reduced the migration of human neutrophils, another marker of the inflammatory state. However, OA did not affect lipid peroxidation induced by pro-oxidant agents. Conclusions: This work presents for the first time evidence that human neutrophils are highly sensitive to OA and provides novel data in support of a protective role of this monounsaturated acid against the activation of neutrophils during inflammation.

El edificio urbano como gesto cívico. A propósito de la obra de Francisco Candel

La relación dialéctica entre la casa y la ciudad es el tema de este breve discurso, partiendo del modelo clásico, que Alberti formula y describe, y pasando a través de los sucesivos modelos, romántico burgués, moderno y posmoderno, para llegar a definir el sentido, en el entorno actual, de la casa entre medianeras que la limitan jurídica y físicamente. La posibilidad de observar el canon moderno, sin renunciar a una convincente inserción del modelo en la ciudad de ascendencia burguesa, se argumenta por medio de dos ejemplos tomados del mismo arquitecto, Francisco Candel Jiménez, en el ensanche de una ciudad de provincias, Albacete, tratando de demostrar que se puede ser rigurosamente moderno en el lenguaje y, a la vez, obediente a los límites urbanos establecidos. En el primer caso, un edificio de tres plantas para vivienda y estudio de arquitectura en entreplanta, la modestia del entorno no impide que el edificio inscrito en él sea a la vez altamente singular sin sustraerse a las reglas del planeamiento oficial. En el segundo, edificio de viviendas en cinco alturas más ático, y “atendiendo a su carácter urbano y a la actualidad de soluciones técnicas y constructivas”, despliega una amplia ceremonia de cortesía, que, por medio de los recursos propios de una avanzada high-tech, juega con los ritmos de su doble límite, doméstico y urbano, y hace que su modernidad radical eleve la dignidad del vecindario urbano que lo acompaña, sin alzar la voz, pero transmitiendo una lección de arquitectura que hace ciudad.

Repertorio de geografia : deducido de los principios de geografía astronómica, física y política de D. Francisco Verdejo Paez /

Mode of access: Internet.

Obras completas de D. Francisco Martinez de la Rosa.

t. 1. Poesías. Poðetica española. Apéndices sobre la poesía didactica, la tragedia y la comedia española. --t. 2. Obras dramaticas. --t. 3. Hernan Perez del Pulgar: bosquejo histórico con Las hazañas del Gran Capitan. Doña Isabel de Solis, reina de Granada: novela histórica. --t. 4-5. Espíritu del siglo.

El nuevo sol de la Francia : relación de las solemnes fiestas que celebró el Colegio Imperial de la Compañía de Jesús en la canonización de S. Juan Francisco Regis ... /

Contiene: Poema español, que en varios metros, canta las glorias de S. Juan Francisco Regis ... / le recitò D. Antonio Maria Pimienta y Torrezar ..., p. 1-33 de segunda secuencia de pag., con port. propia. - Poema Español, que en varios metros canta las glorias de S. Juan Francisco Regis ... / le recitò D. Enrique Ruiz Sabelli ..., p. 35-68 de segunda secuencia. - Poema español, que en varios metros canta las glorias de S. Juan Francisco Regis ... / le recitaron D. Antonio Maria de Cisneros ... y Don Antonio Lorea ..., p. 69-94 de segunda secuencia. - Poema español, que en varios metros canta las glorias de S. Juan Francisco Regis ... / le havian de recitar el Excmo Señor Don Pedro de Alcantara de Guzmàn, Conde de Niebla ... y el Señor D. Joachin Ossorio ..., p. 95-132 de segunda secuencia. - Sermón panegírico a la canonización de San Juan Francisco Regis ... / predicóle ... Fr. Pedro Infante de Amaya..., p. 1-87 de tercera secuencia de pag.. - Sermon predicado en el Colegio Imperial, en la Fiesta de la Canonizacion de San Juan Francisco Regis / por ... Fr. Gregorio del Barrio ... del Orden de la SS. Trinidad de Redemptores Calzados, p. 87-119. - Sermón en las fiestas de la canonización de S. Juan Francisco Regis... / predicado por ... Fr. Jacinto de Mendoza... , p. 120-152. - Sermón a la canonización de S. Juan Francisco Regis ... / predicolo ... Manuel de Castro y Coloma, p. 153-203. - Sermón que predicó... Manuel López Aguirre ... en la fiesta de la canonización de San Juan Francisco Regis ..., p. 204-232.

(Figure 2) Mean discharge per day (total and baseflow part) of the San Francisco River and daily precipitation at station ECPL (Planta), in 2007

We investigated controls on the water chemistry of a South Ecuadorian cloud forest catchment which is partly pristine, and partly converted to extensive pasture. From April 2007 to May 2008 water samples were taken weekly to biweekly at nine different subcatchments, and were screened for differences in electric conductivity, pH, anion, as well as element composition. A principal component analysis was conducted to reduce dimensionality of the data set and define major factors explaining variation in the data. Three main factors were isolated by a subset of 10 elements (Ca2+, Ce, Gd, K+, Mg2+, Na+, Nd, Rb, Sr, Y), explaining around 90% of the data variation. Land-use was the major factor controlling and changing water chemistry of the subcatchments. A second factor was associated with the concentration of rare earth elements in water, presumably highlighting other anthropogenic influences such as gravel excavation or road construction. Around 12% of the variation was explained by the third component, which was defined by the occurrence of Rb and K and represents the influence of vegetation dynamics on element accumulation and wash-out. Comparison of base- and fast flow concentrations led to the assumption that a significant portion of soil water from around 30 cm depth contributes to storm flow, as revealed by increased rare earth element concentrations in fast flow samples. Our findings demonstrate the utility of multi-tracer principal component analysis to study tropical headwater streams, and emphasize the need for effective land management in cloud forest catchments.

(Tables 1-3) Water chemistry of cloud forest streams at baseflow conditions, Rio San Francisco, Ecuador

We investigated controls on the water chemistry of a South Ecuadorian cloud forest catchment which is partly pristine, and partly converted to extensive pasture. From April 2007 to May 2008 water samples were taken weekly to biweekly at nine different subcatchments, and were screened for differences in electric conductivity, pH, anion, as well as element composition. A principal component analysis was conducted to reduce dimensionality of the data set and define major factors explaining variation in the data. Three main factors were isolated by a subset of 10 elements (Ca2+, Ce, Gd, K+, Mg2+, Na+, Nd, Rb, Sr, Y), explaining around 90% of the data variation. Land-use was the major factor controlling and changing water chemistry of the subcatchments. A second factor was associated with the concentration of rare earth elements in water, presumably highlighting other anthropogenic influences such as gravel excavation or road construction. Around 12% of the variation was explained by the third component, which was defined by the occurrence of Rb and K and represents the influence of vegetation dynamics on element accumulation and wash-out. Comparison of base- and fast flow concentrations led to the assumption that a significant portion of soil water from around 30 cm depth contributes to storm flow, as revealed by increased rare earth element concentrations in fast flow samples. Our findings demonstrate the utility of multi-tracer principal component analysis to study tropical headwater streams, and emphasize the need for effective land management in cloud forest catchments.

"Lancea", Lusitanian Word, and the "Lancienses" Ethnogenesis

Analysis of the word lancea, of Hispanic origin after Varro, and of place names, people´s names and personal names derived from it. It confirms that the spear was the most important weapon in the Bronze Age, belonging to the iuventus and used as heroic and divine symbol. This analysis confirms also the personality of the Lusitanians, a people related to the Celts but with more archaic archaeological, linguistic and cultural characteristics originated in the tradition of the Atlantic Bronze in the II millennium BC. It is also relevant to better know the organisation of Broze and Iron Age societies and the origin of Indo-Europeans peoples in Western Europe and of pre-Roman peoples of Iberia.

Imágenes como recurso pedagógico para la enseñanza de vocabulario en inglés en estudiantes de primaria del Colegio Francisco de Paula Santander IED

Tesis (Licenciado en Lenguas Castellana, Inglés y Francés).--Universidad de La Salle. Facultad de Ciencias de La Educación. Licenciatura en Lengua Castellana, Inglés y Francés, 2015

Prevalencia y factores asociados al síndrome de agotamiento profesional en residentes de diferentes especialidades médicas : una revisión de la literatura de los últimos 15 años

El Síndrome de Agotamiento Profesional (SAP), es común en los trabajadores de la salud, particularmente en los expuestos a altos niveles de estrés en el trabajo e incluye el agotamiento emocional, despersonalización y baja realización personal. Se considera que los médicos residentes presentan una mayor prevalencia del síndrome que los médicos debido a que se encuentran en entrenamiento, período en el cual están sometidos a alta carga laboral debido a las largas horas de trabajo, horarios irregulares, privación de sueño, intensas demandas emocionales, así como la presión de dominar un gran conocimiento clínico. Objetivo. Determinar la prevalencia del Síndrome de Agotamiento Profesional o Burnout en la población de médicos residentes. Metodología. Se realizó una búsqueda de artículos en la base de datos electrónica Pubmed, seleccionando aquellos publicados entre los años 2001 al 2016, tanto en idioma inglés como en español, a texto completo y enfocados en estudios en médicos residentes. Resultados. Los hallazgos sugieren que el Síndrome de Agotamiento Profesional o Burnout es altamente prevalente, que varía de acuerdo a la residencia que se esté realizando, encontrando un promedio del 50% con un rango de 27% a 75% entre las diferentes especialidades de la población estudiada y, en consecuencia, puede constituir un problema de salud que amerita atención en cada Institución, esto a pesar de que la prevalencia pueda variar de un lugar a otro y en las diferentes especialidades. Conclusiones. El SAP o Burnout constituye un problema de salud entre la población de médicos residentes, lo que sugiere la conveniencia de diseñar medidas para su prevención como informar en la inducción al programa de residencia sobre el riesgo de la aparición del síndrome y sus síntomas, consultar tempranamente ante signos de alarma, adecuar el sistema de vigilancia epidemiológica para que incluya esta condición específica y ajustar o disminuir la carga laboral entre otras.

FRANCISCO J. C. DANTAS AND THE DRAMATIC CONDITION OF THE NORTHEASTERN PEOPLE

Francisco J. C. Dantas, a novelist from Sergipe in Brazil, is seen as the responsible for resurrecting the regionalism in the Brazilian literary scenery. His novels glimpse narrators who see the world always by the bias of bitterness and hopelessness. It is evident in the characters the pessimism and disenchantment. This work aims to present the dramatic condition of the northeastern people alive in Francisco J. C. Dantas. Therefore, it will be analyzed the narrators of both author's first novels: Coivara da Memória and Os Desvalidos.

The representation of the northeastern migrant: interstices and culture in the figure of Francisco da Silva in "Liberdade", by Ruth Laus

It serves as the object of analysis of this article the representation of the northeastern migrant in the figure of the male character Francisco da Silva, protagonist of the short story "Liberdade", by Ruth Laus, as a fictional character who lives "in an interrogatory, interstitial space between the act of representation [...] and the presence of community itself" (Bhabha, 1998, p. 22) where he comes to enter and to settle. Chico, as he is known, embarks on a crowded truck, and his fate, like that of many other migrants, is the Southeast region of Brazil, where, between São Paulo and Rio de Janeiro, he chooses the sea. To the same extent, beyond the concept(s) of culture(s), and the need to (re)think the concept of [cultural] human community - here adding the cultural term to the proposal of Bhabha (1998), as a way of thinking about the role of the individual - are taken and analyzed, also, the cultural identity concepts based on the difference itself. It is thought in what way, then, and through what imposing character, the wealth and the values ​​of the Northeast, although managed to be spread on national home soil, yet not are conspicuous by their guarantee of permanence of its inhabitants in their homeland.  

Benefit cost analysis applied to behavioral and engineering safety countermeasures in San Francisco, California

The state of the practice in safety has advanced rapidly in recent years with the emergence of new tools and processes for improving selection of the most cost-effective safety countermeasures. However, many challenges prevent fair and objective comparisons of countermeasures applied across safety disciplines (e.g. engineering, emergency services, and behavioral measures). These countermeasures operate at different spatial scales, are funded often by different financial sources and agencies, and have associated costs and benefits that are difficult to estimate. This research proposes a methodology by which both behavioral and engineering safety investments are considered and compared in a specific local context. The methodology involves a multi-stage process that enables the analyst to select countermeasures that yield high benefits to costs, are targeted for a particular project, and that may involve costs and benefits that accrue over varying spatial and temporal scales. The methodology is illustrated using a case study from the Geary Boulevard Corridor in San Francisco, California. The case study illustrates that: 1) The methodology enables the identification and assessment of a wide range of safety investment types at the project level; 2) The nature of crash histories lend themselves to the selection of both behavioral and engineering investments, requiring cooperation across agencies; and 3) The results of the cost-benefit analysis are highly sensitive to cost and benefit assumptions, and thus listing and justification of all assumptions is required. It is recommended that a sensitivity analyses be conducted when there is large uncertainty surrounding cost and benefit assumptions.