The Kepler-454 system: a small, not-rocky inner planet, a Jovian world, and a distant companion

Kepler-454 (KOI-273) is a relatively bright (V = 11.69 mag), Sun-like star that hosts a transiting planet candidate in a 10.6 day orbit. From spectroscopy, we estimate the stellar temperature to be 5687 ± 50 K, its metallicity to be [m/H] = 0.32 ± 0.08, and the projected rotational velocity to be v sin i <2.4 km s^-1. We combine these values with a study of the asteroseismic frequencies from short cadence Kepler data to estimate the stellar mass to be , the radius to be 1.066 ± 0.012 R_o, and the age to be Gyr. We estimate the radius of the 10.6 day planet as 2.37 ± 0.13 R_⊕. Using 63 radial velocity observations obtained with the HARPS-N spectrograph on the Telescopio Nazionale Galileo and 36 observations made with the HIRES spectrograph at the Keck Observatory, we measure the mass of this planet to be 6.8 ± 1.4 M_⊕. We also detect two additional non-transiting companions, a planet with a minimum mass of 4.46 ± 0.12 M_J in a nearly circular 524 day orbit and a massive companion with a period >10 years and mass >12.1 M_J. The 12 exoplanets with radii ⊕ and precise mass measurements appear to fall into two populations, with those ⊕ following an Earth-like composition curve and larger planets requiring a significant fraction of volatiles. With a density of 2.76 ± 0.73 g cm^-3, Kepler-454b lies near the mass transition between these two populations and requires the presence of volatiles and/or H/He gas.

Marketing Societal: uma contribuição para o crescimento sustentável das organizações

Hoje é indiscutível a necessidade de as organizações incorporarem o desenvolvimento sustentável ou, pelo menos, minimizarem os impactos causados no desenvolvimento de seu processo produtivo. É vital, para as organizações, a realização de ações que evidenciem a sua parcela de contribuição para com o meio social. Diante disso, as estratégias de marketing nas organizações vêm procurando desenvolver ações voltadas à satisfação de seus clientes, despertando novos desejos nas necessidades já existentes e atendendo-os com o maior nível de qualidade possível em todos os processos. Entretanto, isto não tem sido o suficiente, pois os consumidores têm exigido mais: querem organizações comprometidas com o bem-estar social da sociedade. Com a acirrada concorrência no mercado, as organizações buscam diferenciais essenciais que garantam a sua vantagem competitiva sobre as demais organizações. Tendo em vista tal cenário, a administração conta com uma ferramenta que traz benefícios a todos os envolvidos no processo, que é o Marketing Societal, em que a organização investe no social, provisionando um retorno de resultados para a organização.

Infestación por "Dirofilaria immitis" en las Islas Canarias

Programa de doctorado: Microbiología. La fecha de publicación es la fecha de lectura

Caso de estudio. Megatex, compitiendo creativamente en un mundo cambiante

El caso hace la presentación sencilla de un problema común entre las pequeñas empresas en Colombia, en la época de principios de los años 2000, la falta de financiación para su capital de trabajo, establecida sobre una empresa importadora. Se conduce, entonces, a una solución integral, que se soporta tanto en la creatividad como en la estrategia, en las exigencias del mercado como en el análisis de rentabilidad. El análisis cuantitativo se hace sobre las consecuencias de las decisiones sobre los plazos y descuentos comerciales.

The Warwick-Edinburgh Mental Well-Being Scale

Background There is increasing international interest in the concept of mental well-being and its contribution to all aspects of human life. Demand for instruments to monitor mental well-being at a population level and evaluate mental health promotion initiatives is growing. This article describes the development and validation of a new scale, comprised only of positively worded items relating to different aspects of positive mental health: the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS). Methods WEMWBS was developed by an expert panel drawing on current academic literature, qualitative research with focus groups, and psychometric testing of an existing scale. It was validated on a student and representative population sample. Content validity was assessed by reviewing the frequency of complete responses and the distribution of responses to each item. Confirmatory factor analysis was used to test the hypothesis that the scale measured a single construct. Internal consistency was assessed using Cronbach’s alpha. Criterion validity was explored in terms of correlations between WEMWBS and other scales and by testing whether the scale discriminated between population groups in line with pre-specified hypotheses. Test-retest reliability was assessed at one week using intra-class correlation coefficients. Susceptibility to bias was measured using the Balanced Inventory of Desired Responding. Results WEMWBS showed good content validity. Confirmatory factor analysis supported the single factor hypothesis. A Cronbach’s alpha score of 0.89 (student sample) and 0.91 (population sample) suggests some item redundancy in the scale. WEMWBS showed high correlations with other mental health and well-being scales and lower correlations with scales measuring overall health. Its distribution was near normal and the scale did not show ceiling effects in a population sample. It discriminated between population groups in a way that is largely consistent with the results of other population surveys. Test–retest reliability at one week was high (0.83). Social desirability bias was lower or similar to that of other comparable scales. Conclusions WEMWBS is a measure of mental well-being focusing entirely on positive aspects of mental health. As a short and psychometrically robust scale, with no ceiling effects in a population sample, it offers promise as a tool for monitoring mental well-being at a population level. Whilst WEMWBS should appeal to those evaluating mental health promotion initiatives, it is important that the scale’s sensitivity to change is established before it is recommended in this context.

Malnutrition in pre-dialysis chronic kidney disease patients in a teaching hospital in Southern Nigeria.

Background: Malnutrition is a complication in chronic kidney disease (CKD) known to affect quality of life and prognosis although not often diagnosed. It is associated with rapid progression to end stage renal disease (ESRD) and mortality. Early identification and treatment will slow down progression to ESRD and mortality. Objective: To determine the prevalence and pattern of malnutrition in pre-dialysis CKD patients in Southern Nigeria. Methods: One hundred and twenty consecutive pre-dialysis CKD and 40 control subjects without CKD were studied. Data obtained from participants were demographics, body mass index (BMI), and aetiology of CKD. Indices used to assess presence of malnutrition were low BMI, hypocholesterolaemia and hypoalbuminaemia. Statistical significance was taken at 0.05 level. Results: The mean age of the CKD subjects was 48.8±16.6years with a male: female ratio of 1.7:1. Prevalence of malnutrition in the CKD subjects was 46.7%, higher than 27.5% observed in the controls (p=0.033). Prevalence of malnutrition increased significantly across CKD stages 2 to 5 (p=0.020). It was significantly commoner in elderly patients (p=0.047) but not significantly different between males and females(p=0.188). Conclusion: Malnutrition is common in pre-dialysis CKD patients even in early CKD stages. Prevalence of malnutrition increases with worsening kidney function and increasing age.

El bibliotecario profesional y para-profesional

Los programas que se brindan en el programa OEA/ UNA/ MEP/ no podrían realizarse sin la colaboración de distinguidos colegas y amigos que debemos mencionar a continuación, junto con el nombre de los cursos que están impartiendo.

Efeito de dois programas de reabilitação psicomotora (atividade contínua versus atividade intervalada) na capacidade neuromotora de idosos institucionalizados

Objetivo: Investigar o efeito de dois programas de reabilitação psicomotora (atividade contínua versus atividade intervalada) na capacidade neuromotora de idosos institucionalizados. Metodologia: A amostra integrou 17 participantes (85,81±6,26 anos) que, numa fase inicial, mantiveram as atividades durante 6 semanas (período de controlo) e, posteriormente, 9 integraram um programa com intervenção intervalada (GI) e 8 um programa com intervenção contínua (GC). Ambos os programas tiveram a duração de 12 semanas, com uma periodicidade de 2 sessões por semana e duração de 60 minutos. Foram avaliadas as variáveis atenção (Trail Making Test), capacidade de planeamento (Torre de Londres), o desempenho em situação de dupla tarefa (Timed Up and Go modificado) e equilíbrio (Timed Up and Go e Índice de Tinetti). Resultados: O GI evidenciou melhorias significativas nas variáveis da atenção, da capacidade de planeamento, dupla tarefa e equilíbrio (p<0,05), enquanto que o GC apenas o evidenciou na variável capacidade de planeamento (p<0,05). Conclusão: Os resultados sugerem que o programa de reabilitação psicomotora com atividade intervalada será mais benéfico para os idosos institucionalizados que programa com atividade contínua, particularmente na atenção, no desempenho em situação de dupla tarefa e no equilíbrio; ABSTRACT: Objective: To research the effect of two psychomotor rehabilitation programs (continuous activity against intervealed activity) in the neuromotor ability of institutionalized elderly people. Metodology: The sample had 17 participants (85.81 ± 6.26 years), that in an initial phase retained activity for 6 weeks (control period) and then, 9 integrated a program with intervealed intervention (GI) and 8 a program with continuous intervention (GC). ). Both of the programs had 12 weeks, 2 sessions per week and 60 minutes per session. Was evaluated the variables attention (Trail Making Test); planning capacity (London Tower); dual task capacity (modified Timed Up and Go) and balance (Timed Up and Go and Tinetti Index). Results: The GI showed significant improvements in the variables attention, performance in dual task ability and balance (p<0,05), while GC revealed significant improvements in planning capacity (p<0,05). Conclusion: The results suggest that the psychomotor rehabilitation program with intervealed activity will be more beneficial for the institutionalized elderly than the program with continuous activity, particularly in the attention, planning capacity, performance in dual task ability and balance.

Proyecto de estructuración de la disciplina matemática para el nivel medio superior de la Universidad Autónoma de Nuevo León, México

En las preparatorias de la U.A.N.L., a diferencia de las preparatorias del resto de las universidades mexicanas, desde el año 1993 se modificaron los cursos de matemática utilizándose un sistema modular en el cual la disciplina Matemática se imparte en cuatro módulos de 9 semanas cada uno separados por 9 semanas en las cuales no se enseña Matemática. La enseñanza fragmentada de esta disciplina provoca discontinuidad y falta de sistematicidad y vinculación entre los temas y poca asimilación de los contenidos que se traduce en olvido de muchos aspectos importantes por parte de los estudiantes. Es nuestro propósito diseñar un programa para la disciplina Matemática, con el que se logre una enseñanza didáctica y metodológica adecuada, basado en los fundamentos del enfoque histórico cultural y la teoría de la actividad.

Social desirability bias in the reporting of alcohol consumption: a randomized trial

OBJECTIVE: To investigate reporting of alcohol consumption, we manipulated the contexts of questions in ways designed to induce social desirability bias. METHOD: We undertook a two-arm, parallel-group, individually randomized trial at an Australian public university. Students were recruited by email to a web-based "Research Project on Student Health Behavior." Respondents answered nine questions about their physical activity, diet, and smoking. They were unknowingly randomized to a group presented with either (A) three questions about their alcohol consumption or (B) seven questions about their alcohol dependence and problems (under a prominent header labeled "Alcohol Use Disorders Identification Test"), followed by the same three alcohol consumption questions from (A). RESULTS: A total of 3,594 students (mean age = 27, SD = 10) responded and were randomized: 1,778 to Group A and 1,816 to Group B. Outcome measures were the number of days they drank alcohol, the typical number of drinks they consumed per drinking day, and the number of days they consumed six or more drinks. The primary analysis included participants with any alcohol consumption in the preceding 4 weeks (1,304 in Group A; 1,340 in Group B) using between-group, two-tailed t tests. RESULTS: In Groups A and B, respectively, means (and SDs) of the number of days drinking were 5.89 (5.92) versus 6.06 (6.12), p = .49; typical number of drinks per drinking day: 4.02 (3.87) versus 3.82 (3.76), p = .17; and number of days consuming six or more drinks: 1.69 (2.94) versus 1.67 (3.25), p = .56. CONCLUSIONS: We could not reject the null hypothesis because earlier questions about alcohol dependence and problems showed no sign of biasing the respondents' subsequent reports of alcohol consumption. These data support the validity of university students' reporting of alcohol consumption in web-based studies.

Clinical events reported by surgeons assessing their peers

BACKGROUND: All surgical deaths in Queensland, Australia are reviewed by external surgeon peers, and clinical events are recorded. The study objective was to classify clinical events in surgical patients who died.

METHODS: Deaths notified to the Queensland Audit of Surgical Mortality between 2007 and 2013 were assessed by surgeons' peers who decided whether a clinical event occurred. The most serious clinical event per patient was analyzed.

RESULTS: Peer surgeons reviewed 4,816 deaths. Most patients (70.7%) had no clinical event. Events were preventable in 58% of patients and less than 1 in 10 events was severe. The most frequent events were classified as patient assessment (34.5%), suboptimal therapy (15.3%), and delays (15.1%).

CONCLUSIONS: Peer review of all surgical deaths identifies preventable clinical events and provides opportunities to improve decision making, better therapy and reduce delay in implementing appropriate surgical care. Review feedback to surgeons and other stakeholders should improve patient safety and quality.

A THEORETICAL STUDY OF INTERACTION OF NANOPARTICLES WITH BIOMOLECULE

Many types of materials at nanoscale are currently being used in everyday life. The production and use of such products based on engineered nanomaterials have raised concerns of the possible risks and hazards associated with these nanomaterials. In order to evaluate and gain a better understanding of their effects on living organisms, we have performed first-principles quantum mechanical calculations and molecular dynamics simulations. Specifically, we will investigate the interaction of nanomaterials including semiconducting quantum dots and metallic nanoparticles with various biological molecules, such as dopamine, DNA nucleobases and lipid membranes. Firstly, interactions of semiconducting CdSe/CdS quantum dots (QDs) with the dopamine and the DNA nucleobase molecules are investigated using similar quantum mechanical approach to the one used for the metallic nanoparticles. A variety of interaction sites are explored. Our results show that small-sized Cd4Se4 and Cd4S4 QDs interact strongly with the DNA nucleobase if a DNA nucleobase has the amide or hydroxyl chemical group. These results indicate that these QDs are suitable for detecting subcellular structures, as also reported by experiments. The next two chapters describe a preparation required for the simulation of nanoparticles interacting with membranes leading to accurate structure models for the membranes. We develop a method for the molecular crystalline structure prediction of 1,2-Dimyristoyl-sn-glycero-3-phosphorylcholine (DMPC), 1,2-Dimyristoyl-sn-glycero-3-phosphorylethanolamine (DMPE) and cyclic di-amino acid peptide using first-principles methods. Since an accurate determination of the structure of an organic crystal is usually an extremely difficult task due to availability of the large number of its conformers, we propose a new computational scheme by applying knowledge of symmetry, structural chemistry and chemical bonding to reduce the sampling size of the conformation space. The interaction of metal nanoparticles with cell membranes is finally carried out by molecular dynamics simulations, and the results are reported in the last chapter. A new force field is developed which accurately describes the interaction forces between the clusters representing small-sized metal nanoparticles and the lipid bilayer molecules. The permeation of nanoparticles into the cell membrane is analyzed together with the RMSD values of the membrane modeled by a lipid bilayer. The simulation results suggest that the AgNPs could cause the same amount of deformation as the AuNPs for the dysfunction of the membrane.

Covalent Protein Adduction by Drugs of Abuse

Recreational abuse of the drugs cocaine, methamphetamine, and morphine continues to be prevalent in the United States of America and around the world. While numerous methods of detection exist for each drug, they are generally limited by the lifetime of the parent drug and its metabolites in the body. However, the covalent modification of endogenous proteins by these drugs of abuse may act as biomarkers of exposure and allow for extension of detection windows for these drugs beyond the lifetime of parent molecules or metabolites in the free fraction. Additionally, existence of covalently bound molecules arising from drug ingestion can offer insight into downstream toxicities associated with each of these drugs. This research investigated the metabolism of cocaine, methamphetamine, and morphine in common in vitro assay systems, specifically focusing on the generation of reactive intermediates and metabolites that have the potential to form covalent protein adducts. Results demonstrated the formation of covalent adduction products between biological cysteine thiols and reactive moieties on cocaine and morphine metabolites. Rigorous mass spectrometric analysis in conjunction with in vitro metabolic activation, pharmacogenetic reaction phenotyping, and computational modeling were utilized to characterize structures and mechanisms of formation for each resultant thiol adduction product. For cocaine, data collected demonstrated the formation of adduction products from a reactive arene epoxide intermediate, designating a novel metabolic pathway for cocaine. In the case of morphine, data expanded on known adduct-forming pathways using sensitive and selective analysis techniques, following the known reactive metabolite, morphinone, and a proposed novel metabolite, morphine quinone methide. Data collected in this study describe novel metabolic events for multiple important drugs of abuse, culminating in detection methods and mechanistic descriptors useful to both medical and forensic investigators when examining the toxicology associated with cocaine, methamphetamine, and morphine.