884 resultados para city centre development, overcrowding, project management, site management, space


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Dissertação de mestrado em Construção e Reabilitação Sustentáveis

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Dissertação de mestrado em Sistemas de Informação

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Dissertação de mestrado integrado em Engenharia Civil

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Dissertação de mestrado integrado em Engenharia Civil

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Dissertação de mestrado em Estudos de Gestão

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Dissertação de mestrado integrado em Arquitectura (área de especialização de Cultura Arquitectónica)

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Dissertação de Mestrado em MPA – Administração Pública

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OBJECTIVE: The purpose of this article is to present the specific public health indicators recently developed by EUROCAT that aim to summarize important aspects of the public health impact of congenital anomalies in a few quantitative measures. METHODS: The six indicators are: (1) congenital anomaly perinatal mortality, (2) congenital anomaly prenatal diagnosis prevalence, (3) congenital anomaly termination of pregnancy, (4) Down syndrome livebirth prevalence, (5) congenital anomaly pediatric surgery, and (6) neural tube defects (NTD) total prevalence. Data presented for this report pertained to all cases (livebirths, fetal deaths, or stillbirths after 20 weeks of gestation and terminations of pregnancy for fetal anomaly [TOPFA]) of congenital anomaly from 27 full member registries of EUROCAT that could provide data for at least 3 years during the period 2004 to 2008. Prevalence of anomalies, prenatal diagnosis, TOPFA, pediatric surgery, and perinatal mortality were calculated per 1000 births. RESULTS: The overall perinatal mortality was approximately 1.0 per 1000 births for EUROCAT registries with almost half due to fetal and the other half due to first week deaths. There were wide variations in perinatal mortality across the registries with the highest rates observed in Dublin and Malta, registries in countries where TOPFA are illegal, and in Ukraine. The overall perinatal mortality across EUROCAT registries slightly decreased between 2004 and 2008 due to a decrease in first week deaths. The prevalence of TOPFA was fairly stable at about 4 per 1000 births. There were variations in livebirth prevalence of cases typically requiring surgery across the registries; however, for most registries this prevalence was between 3 and 5 per 1000 births. Prevalence of NTD decreased by about 10% from 1.05 in 2004 to 0.94 per 1000 in 2008. CONCLUSION: It is hoped that by publishing the data on EUROCAT indicators, the public health importance of congenital anomalies can be clearly summarized to policy makers, the need for accurate data from registries emphasized, the need for primary prevention and treatment services highlighted, and the impact of current services measured.

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Several types of drugs currently used in clinical practice were screened in vitro for their potentiation of the antifungal effect of the fungistatic agent fluconazole (FLC) on Candida albicans. These drugs included inhibitors of multidrug efflux transporters, antimicrobial agents, antifungal agents, and membrane-active compounds with no antimicrobial activity, such as antiarrhythmic agents, proton pump inhibitors, and platelet aggregation inhibitors. Among the drugs tested in an agar disk diffusion assay, cyclosporine (Cy), which had no intrinsic antifungal activity, showed a potent antifungal effect in combination with FLC. In a checkerboard microtiter plate format, however, it was observed that the MIC of FLC, as classically defined by the NCCLS recommendations, was unchanged when FLC and Cy were combined. Nevertheless, if a different reading endpoint corresponding to the minimal fungicidal concentration needed to decrease viable counts by at least 3 logs in comparison to the growth control was chosen, the combination was synergistic (fractional inhibitory concentration index of <1). This endpoint fitted to the definition of MIC-0 (optically clear wells) and reflected the absence of the trailing effect, which is the result of a residual growth at FLC concentrations greater than the MIC. The MIC-0 values of FLC and Cy tested alone in C. albicans were >32 and >10 microg/ml, respectively, and decreased to 0.5 and 0.625 microg/ml when the two drugs were combined. The combination of 0.625 microg of Cy per ml with supra-MICs of FLC resulted in a potent antifungal effect in time-kill curve experiments. This effect was fungicidal or fungistatic, depending on the C. albicans strain used. Since the Cy concentration effective in vitro is achievable in vivo, the combination of this agent with FLC represents an attractive perspective for the development of new management strategies for candidiasis.

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En els últims anys hi ha hagut un interès creixent per la disciplina de Gestió de Projectes. Durant un temps els projectes eren gestionats per gerents que tenien coneixements tècnics previs sobre un problema a resoldre. Però l’elevat índex de fracàs en aquest tipus de gestió porta canvis en la manera de dirigir els projectes. Es comença a reconèixer la gestió de projectes com una habilitat especifica i sorgeix el concepte de Oficina de Gestió de Projectes, com a òrgan responsable dels processos de gestió de projectes. L’objectiu fonamental d’aquest document és donar les pautes per implementar una Oficina de Gestió de Projectes i establir una metodologia de projecte basada en el manual de bones pràctiques PMBOK per una organització TIC, per tal de normalitzar els projectes TIC i facilitar-ne el seguiment, control i visió global.

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This is the Centre's second project with BCPP. The first project integrated the pharmacy into their support network and addressed issues important to street drinkers in a safe environment. This project will build on the previous project. It will encourage and facilitate self worth, self esteem and further encourage a sense of responsibility and confidence to access other health and support services. The pharmacist will provide information sessions, 1-1 support and training to staff and volunteers. This project will also see them linking up with the SOLACE project in Irvinestown which BCPP has also supported.

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El projecte "Estratègies de gestió de projectes informàtics" descriu les estratègies que cal seguir per gestionar els diversos projectes d'un entorn informàtic. Es tracta de definir la millor manera de dirigir un projecte informàtic, estimar l'esforç que requerirà, la divisió per fases, la temporització de cada tasca i l'execució del projecte.

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Revisión de las diferentes estrategias y procedimientos para la gestión de proyectos informáticos.

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L¿abast del projecte és el servei del sistema de gestió d¿enllumenat d¿un edifici d¿oficines.