El aprendizaje a través del juego como herramienta en el diseño de actividades de valor añadido en un currículum integrador de Ciencias Biomédicas

Esta actividad, diseñada desde el Departamento de Ciencias Biomédicas Básicas, se apoya en: 1. la integración de materias básicas (para contextualizar la experiencia clínica desde la perspectiva de sus fundamentos); 2. la formación interprofesional al trabajar con alumnos de diferentes Grados de nuestra Facultad y 3. el aprendizaje a través del juego, para facilitar un abordaje motivante y divertido a los destinatarios de la acción. Esta nueva experiencia consiste en una gymkhana por equipos en base a un caso clínico, en la que por primera vez se trabajan el aprendizaje y la docencia en diversas disciplinas básicas integradas, a través del juego y la competición entre grupos de alumnos (TBL).

Refugiados: un ejercicio de reflexión global y acción local

En una sociedad donde la ausencia de valores ha originado una crisis social y financiera, debemos educar a nuestros estudiantes para que sean profesionales responsables, capaces y honestos. El objetivo de este proyecto es despertar en los alumnos el interés por la faceta más social de la profesión. La Arquitectura tiene herramientas y estrategias para diseñar entornos que mejoren la vida de las personas. Pensar de manera global y dar solución local a los problemas de la humanidad es una asignatura más para los arquitectos. Refugiados, una crisis humanitaria, es el tema elegido para este proyecto. Concretamente, por ser de actualidad, lo hemos centrado en la crisis de los refugiados sirios.

Identificación de redes nacionales y mundiales de distribución de petróleo y gas natural y su relación con la conformación de comunidades

El presente proyecto investiga la relación entre las organizaciones con el medio y marketing, para lo cual se debe mencionar el conflicto de intereses de la comunidad y de la organización, y como se intenta percibir a la organización como un buen vecino dentro de la comunidad. A su vez éste estudio cuenta con objetivos basados en la identificación de redes de distribución de petróleo y gas natural, tanto nacionales como internacionales, para así abarcar un sector estratégico más preciso, y mostrar las relación entre las organizaciones y la conformación de comunidades. Se tienen en cuenta factores elementales en el estudio de este sector energético, como son sus principales componentes, así como un marco teórico específico que permita desarrollar el concepto de conformación de comunidades para lograr una exitosa aplicación del mismo. Del mismo modo se incluirán temas relacionados con marketing, pero desde un punto de vista más cercano a la comunidad, tomando los medios y el marketing como un concepto más importante en el impacto de las organizaciones en la comunidad, es decir tomando el concepto de marketing como aquellas comunidades que rodean las organizaciones, como éstas dos interactúan, y que impactos tienen una sobre la otra. De la misma manera se tienen resultados en cuanto a planteamientos más profundos sobre conceptos de marketing que no son desarrollados muy a menudo, los cuales conservan su esencia fundamental y siguen impactando en silencio a las organizaciones, pero que si lo estudiamos y aprovechamos de algún modo lograremos beneficios para nuestra organización y para los intereses colectivos.

Melodías para el tigre. Pablo de Rebullida y los indios de la Talamanca, 1694 - 1709

ResumenAnaliza la labor misionera a cabo de Fray Pablo de Rebullida en Talamanca, Costa Rica, donde la Orden de los Franciscanos se encargó de la evangelización de los indios. El artículo se refiere a los métodos de evangelización y a la resistencia tenaz de los indígenas, que culmina con el levantamiento generalizado de 1709.AbstractAn analysis of the missionary work of Fray Pablo de Rebullida in Talamanca, Costa Rica, where entrusted with evangelization of the Indian. Includes a discussion of the methods of evangelization and the firm resistance of the Indian population, which climaxed in the general uprising of 1709.

Los escritos de Fray Pablo de Rebullioda. Recopilación y transcripción de Mario Humbero Ruz

IntroducciónJesús, María y JoséLa gran majestad del altísimo Dios quiera que al recibido de ésta halle a vuestra paternidad con entera salud para amarle y servirle. Yo, al presente, la tengo buena para lo que me quisiere mandar.Estando prosiguiendo la convesión de los chánguenes trajéronme los térrabas un papel blanco sin habler escrito en él, diciéndome que los borucas se lo habían dado. Yo he juzgado que querían saber la verdad si los indios me han mierto o qué mi persona después me quedé solo.Proseguí los dictámenes de la obediencia y a donde pensaba hallar 300 indios encontré con 1800 infieles...

La concepción de “ser humano” en Pablo Freire

This article analizes how Pablo Freire, one of the main education theoreticians with broad trajectory and world influence and with a big contibution to what it is known as alternative pedagogy, conceives the human been and his participation in and with the world. He has built his conception on this matter through several publications, merged from his teaching practice.

THE BORDER CHARACTER OF URBANITE SUBJECT IN PABLO NERUDA

ABSTRACT: The imagetic process in Pablo Neruda's work is built through the creation of images resulting from life experiences kept in memories. It is also an existential questioning of the poet based upon the critical look on the historical and personal moment. In this creative process, Neruda's imagetic world strongly references Temuco's natural aspects, the everyday setting of his childhood and adolescence, part of the scenery that remained in his memory and crystalized in his works. The ascertainment that Neruda, in the transition from province to metropolis, does not reach his emotional final destination, remaining in a long transitory state (threshold), allowing us to highlight the emergence of a "border subject", situated between the provincial universe and the urban universe. In Neruda, the concept of border does not only references a territorial boundary between two regions that are politically and culturally different, but also temporal boundaries, since in his stay in the city the poet turns into a body that experiences the location and establishes a critical relationship towards it: he describes it poetically and develops a temporal mobility from the city to the province. This border state shows an intermediary position in individuals that by moving within his/her own country feel in the margins of his/her own culture. In neruda, the notion of border is a recurring issue in the subject of cities, in which the border is related to the geographical space (country, city and harbor) with the time space (present and past), and with cultural space in which concerns the regional identity differences of a certain country. Thus, it is important to approach the analysis of border overcoming regarding the geographical and cultural issues, but above all to the subjective formulations as a result of interpersonal processes. KEYWORDS: Border; Identity; Pablo Neruda.

The user-led disruption : self-(re)broadcasting at Justin.tv and elsewhere

The rise of videosharing and self-(re)broadcasting Web services is posing new threats to a television industry already struggling with the impact of filesharing networks. This paper outlines these threats, focussing especially on the DIY re-broadcasting of live sports using Websites such as Justin.tv and a range of streaming media networks built on peer-to-peer filesharing technology.

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

To identify multiple sclerosis (MS) susceptibility loci, we conducted a genome-wide association study (GWAS) in 1,618 cases and used shared data for 3,413 controls. We performed replication in an independent set of 2,256 cases and 2,310 controls, for a total of 3,874 cases and 5,723 controls. We identified risk-associated SNPs on chromosome 12q13-14 (rs703842, P = 5.4 x 10(-11); rs10876994, P = 2.7 x 10(-10); rs12368653, P = 1.0 x 10(-7)) and upstream of CD40 on chromosome 20q13 (rs6074022, P = 1.3 x 10(-7); rs1569723, P = 2.9 x 10(-7)). Both loci are also associated with other autoimmune diseases. We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001).

A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis

Background Several lines of evidence suggests that transcription factors are involved in the pathogenesis of Multiple Sclerosis (MS) but a complete mapping the whole network has been elusive. One of the reasons is that there are several clinical subtypes of MS and transcription factors which may be involved in one subtype may not be in others. We investigated the possibility that this network could be mapped using microarray technologies and modern bioinformatics methods on a dataset from whole blood in 99 untreated MS patients (36 Relapse Remitting MS, 43 Primary Progressive MS, and 20 Secondary Progressive MS) and 45 age-matched healthy controls, Methodology/Principal Findings We have used two different analytical methodologies: a differential expression analysis and a differential co-expression analysis, which have converged on a significant number of regulatory motifs that seem to be statistically overrepresented in genes which are either differentially expressed (or differentially co-expressed) in cases and controls (e.g. V$KROX_Q6, p-value < 3.31E-6; V$CREBP1_Q2, p-value < 9.93E-6, V$YY1_02, p-value < 1.65E-5). Conclusions/significance: Our analysis uncovered a network of transcription factors that potentially dysregulate several genes in MS or one or more of its disease subtypes. Analysing the published literature we have found that these transcription factors are involved in the early T-lymphocyte specification and commitment as well as in oligodendrocytes dedifferentiation and development. The most significant transcription factors motifs were for the Early Growth response EGR/KROX family, ATF2, YY1 (Yin and Yang 1), E2F-1/DP-1 and E2F-4/DP-2 heterodimers, SOX5, and CREB and ATF families.

High temperature reduces apple fruit colour via modulation of the anthocyanin regulatory complex

The biosynthesis of anthocyanin in many plants is affected by environmental conditions. In apple (Malus×domestica Borkh.), concentrations of fruit anthocyanins are lower under hot climatic conditions. We examined the anthocyanin accumulation in the peel of maturing 'Mondial Gala' and 'Royal Gala' apples, grown in both temperate and hot climates, and using artificial heating of on-tree fruit. Heat caused a dramatic reduction of both peel anthocyanin concentration and transcripts of the genes of the anthocyanin biosynthetic pathway. Heating fruit rapidly reduced expression of the R2R3 MYB transcription factor (MYB10) responsible for coordinative regulation for red skin colour, as well as expression of other genes in the transcriptional activation complex. A single night of low temperatures is sufficient to elicit a large increase in transcription of MYB10 and consequently the biosynthetic pathway. Candidate genes that can repress anthocyanin biosynthesis did not appear to be responsible for reductions in anthocyanin content. We propose that temperature-induced regulation of anthocyanin biosynthesis is primarily caused by altered transcript levels of the activating anthocyanin regulatory complex.

Book review : "Artificial Hells: participatory art and the politics of spectatorship by Claire Bishop"

In the years since Nicolas Bourriaud’s Relational Aesthetics (1998) was published, a plethora of books (Shannon Jackson’s Social Works: Performing Art, Supporting Publics [2011], Nato Thompson’s Living as Form: Socially Engaged Art from 1991–2011 [2011], Grant Kester’s Conversation Pieces: Community and Communication in Modern Art [2004], Pablo Helguera’s Education for Socially Engaged Art: A Material and Techniques Handbook [2011]), conferences and articles have surfaced creating a rich and textured discourse that has responded to, critiqued and reconfigured the proposed social utopias of Bourriaud’s aesthetics. As a touchstone for this emerging discourse, Relational Aesthetics outlines in a contemporary context the plethora of social and process-based art forms that took as their medium the ‘social’. It is, however, Clare Bishop’s book Artificial Hells: Participatory Art and the Politics of Spectatorship (Verso), that offers a deeper art historical and theoretically considered rendering of this growing and complicated form of art, and forms a central body of work in this broad constellation of writings about participatory art, or social practice art/socially engaged art (SEA), as it is now commonly known...