998 resultados para I-123
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Se estudia la relación entre educación y desarrollo económico. Se señala que en nuestros días ha sido superado el concepto de la educación considerada como un derecho humano universal. De hecho la educación se considera hoy, a la vez que un elemento de formación integral, un instrumento indispensable del desarrollo económico-social. Se pone de manifiesto la importancia de las dimensiones de la educación, dentro de las cuales está el hombre, la cultura y la sociedad. En el mundo actual ya no es posible considerar la educación como algo aislado. Así la educación se proyecta en tres dimensiones: una, la física o el hombre; otra, de carácter espiritual o la cultura, y la tercera, de relación, la sociedad, concebida en un sentido cada vez más extenso o universalista. De este modo la extensión y valoración de la educación se presentan como exigencias de nuestro tiempo. Cuestiones como la superrepoblación del mundo, su desigual distribución sobre la tierra, los problemas sociales, el arrollador avance de la técnica y otras muchas circunstancias han evidenciado la necesidad de los planes de desarrollo económico, sin que se hayan puesto en práctica con anterioridad los planes adecuados de educación. Por último se señala que pese a todo, no es momento de volver la mirada al pasado, sino al futuro, porque las sucesivas etapas del plan de desarrollo económico nos obligan a mirar hacia el porvenir. Se recomienda que no todo el peso económico de la educación nacional pueda recaer sobre el Estado. Hace falta que los municipios, las entidades más diversas y la sociedad entera colaboren de un modo más positivo y eficaz en el impulso decisivo que ahora más que nunca requieren todos los grados de la enseñanza, además de las bibliotecas, los centros de documentación y de investigación científica.
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En el presente trabajo se proponen unos módulos de actividades encaminadas al conocimiento de las nociones básicas previas al aprendizaje matemático. Asimismo se propone el empleo de una metodología adecuada en la que han de tener en cuenta las fases : -vivencial -manipulativa -verbal -gráfica -simbólica.
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1.Este artículo es parte de la transferencia de conocimientos del proyecto de investigación. Vivir entre islas: paisajes insulares, conectividad y cultura material en las comunidades de las Islas Baleares durante la prehistoria reciente (2500-123 BC) (HAR2012-32620) financiado por el Ministerio de Economia y Competitividad. 2. ArqueoUIB (Departament de Ciències Històriques i Teoria de les Arts, UIB).
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Resumen tomado de la publicación
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Resumen basado en el de la publicaci??n
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Resumen basado en el de la publicaci??n
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Syftet med föreliggande undersökning var att studera sambandet mel¬lan hundars ålder och deras inlärnings- respektive problemlösnings¬förmåga. Undersökningen genomför¬des på 17 hundar med ett ålders¬spann på 12 -123 månader. Hun¬darna genomförde en inlärningsövning och en problemlösnings¬övning. Det visade sig finnas en svag icke sig¬nifikans tendens att de yngre hundarna hade ett lägre antal träningstill¬fällen. En slutsats som kan dras från detta är att det krävs ett stort stickprov för att få fram reliabla resultat gällande yngre och äldre hun¬dars inlärningsförmåga.
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This study aims to bring back the debate on the use of the purchasing power of the State as instrument to boost other public policies established by federal entities. Besides putting it in a context of innovation in the public sector, the study of this issue must consider all its variables and questions, whwther of legal, economic, social or political order, starting with the one I consider the most important: the possibility of the State to assert its power of puchasing in order to design and promote markets, searching to achieve other objectives rather than those traditionally accepted. Thus, in the analysis of a direct application of a new practice, this study evaluates the implementation of the Additional Law number 123/06, which gives a differentiating treatment to micro and small enterprises in public contracting. By means of interviews, information was collected with the relevant actors in in this phase. The conclusion was that aspects such as the heterogeneity of the segment of the MPE`s and their low capacity of articulation, along with the endogenous obstacles of the instituion of the bidding, contribute decively to the low stage of the implementation that occurs at this moment.
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Partial neutralization of the myotoxic effect of Bothrops jararacussu venom (BV) and two of its myotoxins [bothropstoxin-I (BthTX-I), catalytically inactive, and II (BthTX-II), showing low PLA(2) activity], by the lyophilized aqueous extract of Tabernaemontana catharinensis (AE), was studied in rat isolated soleus muscle preparations (in vitro) and through i.m. injection in the gastrocnemius muscle (in vivo) by determination of creatine kinase (CK) activity and histopathological analysis. Incubation of soleus muscle for 1 h with BV or toxins (20 mug/ml) plus AE (400 mug/ml) added immediately after BV, BthTX-I or BthTX-II reduced CK levels by 53%, 37% and 56%, respectively. The myonecrotic effects of BV (20 mug/ml) upon soleus muscle was reduced 24%, 35% and 36% when AE (400 mug/ml) was added 1 h after BV and CK was evaluated 30 min, 1 and 2 h later, respectively. For BthTX-I these values were 46%, 48% and 47%, while for BthTX-II no inhibitory effect was detected. Histological analysis of soleus muscle after incubation with AE (400 mug/ml, I h) did not reveal any change in muscle fibers, but severe necrosis induced by -BV or toxins (20 mug/ml) was clearly in evidence, and decreased significantly when soleus muscle was protected by AE. This protection was also observed when AE was administered 1 h after BV or BthTX-I, but not after BthTX-II. AE did not inhibit the catalytic PLA(2), activity of BthTX-II or BV and did not change the PAGE pattern of BV, BthTX-I or BthTX-II. In vivo assays were performed in 100-g rats and maximal CK release was attained at a dose of 100 mug of BV, 3 h after injection. AE was not effective when injected 20 s after BV or toxins. However, injecting BV or toxins (100 mug), which were pre-incubated with AE (2 mg) caused an inhibition of 57%, 59% and 51%, respectively, with zero time pre-incubation, but was less effective with I h pre-incubation. This plant represents a potential source of promising myotoxin inhibitors. (C) 2004 Elsevier GmbH. All rights reserved.
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This work describes the synthesis, IR and (13)C CPMAS NMR spectroscopic as well the thermal characterization of the new dicarboxylate complexes [Pd(2)(ox)(2)(4,4'-bipy)]n (1), [Pd(2)(ox)(2)(bpe)](n) (2) and [Pd(2)(ox)(2)(pz)](n) (3) {ox = oxalate, bipy = 4,4'-bipyridine, bpe = 1,2-bis(4-pyridyl)ethane, pz = pyrazine}. TG experiments reveal that compounds 1-3 undergo thermal decomposition in three steps. Metal palladium was the final product of the thermal decompositions, which was identified by X-ray powder diffraction.
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Bothropstoxin-I (BthTX-1), a Lys49 phospholipase A(2) homolog with no apparent catalytic activity, was first isolated from Bothrops jararacussu snake venom and completely sequenced in this laboratory. It is a 121-amino-acid single polypeptide chain, highly myonecrotic, despite its inability to catalyze hydrolysis of egg yolk phospholipids, and has 14 half-cystine residues identified at positions 27, 29, 44, 45, 50, 51, 61, 84, 91, 96, 98, 105, 123, and 131 (numbering according to the conventional alignment including gaps, so that the last residue is Cys 131). In order to access its seven disulfide bridges, two strategies were followed: (1) Sequencing of isolated peptides from (tryptic + SV8) and chymotryptic digests by Edman-dansyl degradation; (2) crystallization of the protein and determination of the crystal structure so that at least two additional disulfide bridges could be identified in the final electron density map. Identification of the disulfide-containing peptides from the enzymatic digests was achieved following the disappearance of the original peptides from the HPLC profile after reduction and carboxymethylation of the digest. Following this procedure, four bridges were initially identified from the tryptic and SV8 digests: Cys50-Cys131, Cys51-Cys98, Cys61-Cys91, and Cys84-Cys96. From the chymotryptic digest other peptides were isolated either containing some of the above bridges, therefore confirming the results from the tryptic digest, or presenting a new bond between Cys27 and Cys123. The two remaining bridges were identified as Cys29-Cys45 and Cys44-Cys105 by determination of the crystal structure, showing that BthTX-1 disulfide bonds follow the normal pattern of group II PLA(2)s.
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Bothropstoxin-I (BthTX-I), a Lys49 phospholipase A2 homolog with no apparent catalytic activity, was first isolated from Bothrops jararacussu snake venom and completely sequenced in this laboratory. It is a 121-amino-acid single polypeptide chain, highly myonecrotic, despite its inability to catalyze hydrolysis of egg yolk phospholipids, and has 14 half-cystine residues identified at positions 27, 29, 44, 45, 50, 51, 61, 84, 91, 96, 98, 105, 123, and 131 (numbering according to the conventional alignment including gaps, so that the last residue is Cys 131). In order to access its seven disulfide bridges, two strategies were followed: (1) Sequencing of isolated peptides from (tryptic + SV8) and chymotryptic digests by Edman-dansyl degradation; (2) crystallization of the protein and determination of the crystal structure so that at least two additional disulfide bridges could be identified in the final electron density map. Identification of the disulfide-containing peptides from the enzymatic digests was achieved following the disappearance of the original peptides from the HPLC profile after reduction and carboxymethylation of the digest. Following this procedure, four bridges were initially identified from the tryptic and SV8 digests: Cys50-Cysl31, Cys51-Cys98, Cys61-Cys91, and Cys84-Cys96. From the chymotryptic digest other peptides were isolated either containing some of the above bridges, therefore confirming the results from the tryptic digest, or presenting a new bond between Cys27 and Cys 123. The two remaining bridges were identified as Cys29-Cys45 and Cys44-Cysl05 by determination of the crystal structure, showing that BthTX-I disulfide bonds follow the normal pattern of group II PLA2s. © 2001 Plenum Publishing Corporation.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)