A spectroscopically normal type Ic supernova from a very massive progenitor

We present observations of the Type Ic supernova (SN Ic) 2011bm spanning a period of about one year. The data establish that SN 2011bm is a spectroscopically normal SN Ic with moderately low ejecta velocities and with a very slow spectroscopic and photometric evolution (more than twice as slow as SN 1998bw). The Pan-STARRS1 retrospective detection shows that the rise time from explosion to peak was 40 days in the R band. Through an analysis of the light curve and the spectral sequence, we estimate a kinetic energy of 7-17 foe and a total ejected mass of 7-17 Mo, 5-10 Mo of which is oxygen and 0.6-0.7 Mo is 56Ni. The physical parameters obtained for SN 2011bm suggest that its progenitor was a massive star of initial mass 30-50 Mo. The profile of the forbidden oxygen lines in the nebular spectra show no evidence of a bi-polar geometry in the ejected material.

Defining the role of common variation in the genomic and biological architecture of adult human height

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated 1/42,000, 1/43,700 and 1/49,500 SNPs explained 1/421%, 1/424% and 1/429% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/I 2-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.

Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

SN 2009ip at late times - an interacting transient at+2 years

We present photometric and spectroscopic observations of the interacting transient SN 2009ip taken during the 2013 and 2014 observing seasons. We characterize the photometric evolution as a steady and smooth decline in all bands, with a decline rate that is slower than expected for a solely Co-56-powered supernova at late phases. No further outbursts or eruptions were seen over a two year period from 2012 December until 2014 December. SN 2009ip remains brighter than its historic minimum from pre-discovery images. Spectroscopically, SN 2009ip continues to be dominated by strong, narrow (less than or similar to 2000 km s(-1)) emission lines of H, He, Ca, and Fe. While we make tenuous detections of [Fe II] lambda 7155 and [O I] lambda lambda 6300, 6364 lines at the end of 2013 June and the start of 2013 October, respectively, we see no strong broad nebular emission lines that could point to a core-collapse origin. In general, the lines appear relatively symmetric, with the exception of our final spectrum in 2014 May, when we observe the appearance of a redshifted shoulder of emission at +550 km s(-1). The lines are not blueshifted, and we see no significant near-or mid-infrared excess. From the spectroscopic and photometric evolution of SN 2009ip until 820 d after the start of the 2012a event, we still see no conclusive evidence for core-collapse, although whether any such signs could be masked by ongoing interaction is unclear.

Arrêt du Grand-conseil... (qui casse un arrêt rendu par le Parlement de Nancy, le 23 février dernier, lequel déclarait nuls les publications et enregistrements faits par le bailliage, siège présidial de Nancy, le 13 dudit mois.)

[Acte. 1776-03-13. Paris]

(Arrêt du grand conseil qui déclare nul l'arrêt du parlement de Nancy, du 27 mars 1776, touchant l'enregistrement dans les bailliages des édits, déclarations et arrêts.)

[Acte. 1776-04-25. Paris]

Arrêt du Grand Conseil... (qui annule l'arrêt du Parlement de Nancy du 31 mai dernier, ordonne que, sans s'y arrêter, les arrêts du Conseil du 13 mars précédent et du 25 avril dernier seront exécutés, etc.)

[Acte. 1776-06-21. Paris]

Arrêt du grand conseil qui déclare nul un arrêt du parlement de Nancy, du 5 juillet 1776 (rendu contre les officiers du présidial de Dieuze.)

[Acte. 1776-08-07. Paris]

[2 phot. de la maison des parents de Jeanne d'Arc à Domrémy, par A. Odinot, phot. à Nancy, don F. Romanet du Caillaud en 1887]

Donateur : Romanet Du Caillaud, Frédéric (18..-19..?)

[3 albums, 264 phot., Edités par la Compagnie des Chemins de fer de l'Est: Huit jours dans les Vosges: Gérardmer et environs. Clichés A. Thiriat. Photosollographie J. Royer. Nancy, Bergeret, s.d. Les villes d'eau de l'Est... De Paris en Italie par le chemin de fer de l'Est et le Saint-Gothard, publiés chez le même éditeur. Don de la compagnie des Chemins de fer de l'Est en 1898]

Donateur : Compagnie des chemins de fer de l'Est