Genetic studies of body mass index yield new insights for obesity biology
| Data(s) |
12/02/2015
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| Resumo |
<p>Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.</p> |
| Identificador | |
| Idioma(s) |
eng |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Locke , A E , Kahali , B , Berndt , S I , Justice , A E , Pers , T H , Day , F R , Powell , C , Vedantam , S , Buchkovich , M L , Yang , J , Croteau-Chonka , D C , Esko , T , Fall , T , Ferreira , T , Gustafsson , S , Kutalik , Z , Luan , J , Mägi , R , Randall , J C , Winkler , T W , Wood , A R , Workalemahu , T , Faul , J D , Smith , J A , Hua Zhao , J , Zhao , W , Chen , J , Fehrmann , R , Hedman , Å K , Karjalainen , J , Schmidt , E M , Absher , D , Amin , N , Anderson , D , Beekman , M , Bolton , J L , Bragg-Gresham , J L , Buyske , S , Demirkan , A , Deng , G , Ehret , G B , Feenstra , B , Feitosa , M F , Fischer , K , Goel , A , Gong , J , Jackson , A U , Kanoni , S , Kleber , M E , Kristiansson , K , Lim , U , Lotay , V , Mangino , M , Mateo Leach , I , Medina-Gomez , C , Medland , S E , Nalls , M A , Palmer , C D , Pasko , D , Pechlivanis , S , Peters , M J , Prokopenko , I , Shungin , D , Stančáková , A , Strawbridge , R J , Ju Sung , Y , Tanaka , T , Teumer , A , Trompet , S 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DOI: 10.1038/nature14177 |
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article |
