Bento Box Discovery

Poster presentation at the University of Maryland Libraries Research & Innovative Practice Forum on June 8, 2016. The poster proposes that the UMD Libraries should evaluate adoption of Bento Box Discovery for improved user search experience.

AN EXAMINATION OF HYDROXYL RADICAL: OUR CURRENT UNDERSTANDING OF THE OXIDATIVE CAPACITY OF THE TROPOSPHERE THROUGH EMPIRICAL, BOX, AND GLOBAL MODELING APPROACHES

Hydroxyl radical (OH) is the primary oxidant in the troposphere, initiating the removal of numerous atmospheric species including greenhouse gases, pollutants that are detrimental to human health, and ozone-depleting substances. Because of the complexity of OH chemistry, models vary widely in their OH chemistry schemes and resulting methane (CH4) lifetimes. The current state of knowledge concerning global OH abundances is often contradictory. This body of work encompasses three projects that investigate tropospheric OH from a modeling perspective, with the goal of improving the tropospheric community’s knowledge of the atmospheric lifetime of CH4. First, measurements taken during the airborne CONvective TRansport of Active Species in the Tropics (CONTRAST) field campaign are used to evaluate OH in global models. A box model constrained to measured variables is utilized to infer concentrations of OH along the flight track. Results are used to evaluate global model performance, suggest against the existence of a proposed “OH Hole” in the tropical Western Pacific, and investigate implications of high O3/low H2O filaments on chemical transport to the stratosphere. While methyl chloroform-based estimates of global mean OH suggest that models are overestimating OH, we report evidence that these models are actually underestimating OH in the tropical Western Pacific. The second project examines OH within global models to diagnose differences in CH4 lifetime. I developed an approach to quantify the roles of OH precursor field differences (O3, H2O, CO, NOx, etc.) using a neural network method. This technique enables us to approximate the change in CH4 lifetime resulting from variations in individual precursor fields. The dominant factors driving CH4 lifetime differences between models are O3, CO, and J(O3-O1D). My third project evaluates the effect of climate change on global fields of OH using an empirical model. Observations of H2O and O3 from satellite instruments are combined with a simulation of tropical expansion to derive changes in global mean OH over the past 25 years. We find that increasing H2O and increasing width of the tropics tend to increase global mean OH, countering the increasing CH4 sink and resulting in well-buffered global tropospheric OH concentrations.

The Role of PME-1 in Cancer: Therapeutic Implication

Protein phosphatase 2A (PP2A) plays a major role in maintaining cellular signaling homeostasis in human cells by reversibly affecting the phosphorylation of a variety of proteins. Protein phosphatase methylesterase-1 (PME-1) negatively regulates PP2A activity by reversible demethylation and active site binding. Thus far, it is known that overexpression of PME-1 in human gliomas contributes to ERK pathway signaling, cell proliferation, and malignant progression. Whether PME-1-mediated PP2A inhibition promotes therapy resistance in gliomas is unknown. Specific PP2A targets regulated by PME-1 in cancers also remain elusive. Additionally, whether oncogenic function of PME-1 can be generalized to various human cancers needs to be investigated. This study demonstrated that PME-1 expression promotes kinase inhibitor resistance in glioblastoma (GBM). PME-1 silencing sensitized GBM cells to a group of clinically used indolocarbazole multikinase inhibitors (MKIs). To facilitate the quantitative evaluation of MKIs by cancer-cell specific colony formation assay, Image-J software-plugin ‘ColonyArea’ was developed. PME-1-silencing was found to reactivate specific PP2A complexes and affect PP2A-target histone deacetylase HDAC4 activity. The HDAC4 inhibition induced synthetic lethality with MKIs similar to PME-1 depletion. However, synthetic lethality by both approaches required co-expression of a pro-apoptotic protein BAD. In gliomas, PME-1 and HDAC4 expression was associated with malignant progression. Using tumor PME-1, HDAC4 and BAD expression based stratification signatures this study defined patient subgroups that are likely to respond to MKI alone or in combination with HDAC4 inhibitor therapies. In contrast to the oncogenic role of PME-1 in certain cancer types, this study established that colorectal cancer (CRC) patients with high tumor PME-1 expression display favorable prognosis. Interestingly, PME-1 regulated survival signaling did not operate in CRC cells. Summarily, this study potentiates the candidacy of PME-1 as a therapy target in gliomas, but argues against generalization of these findings to other cancers, especially CRC.

Closing Pandora's box: a defence of Alvin Plantinga's epistemology of religious belief

I argue (1) that Alvin Plantinga’s theory of warrant is plausible and (2) that, contrary to the Pandora’s Box objection, there are certain serious world religions that cannot successfully use Plantinga’s epistemology to demonstrate that their beliefs could be warranted in the same way that Christian belief can be warranted. In arguing for (1), I deploy Ernest Sosa’s Swampman case to show that Plantinga’s proper function condition is a necessary condition for warrant. I then engage three objections to Plantinga’s theory of warrant, each of which attempts to demonstrate that his conditions for warrant are neither necessary nor sufficient. Having defended the plausibility of Plantinga’s theory of warrant, I present and expand his key arguments to the effect that naturalism cannot make use of it. These arguments provide the conceptual tools that are needed to argue for (2): that there are certain world religions that cannot legitimately use Plantinga’s theory of warrant to demonstrate that their beliefs could be warranted in the same way that Christian belief can be warranted.

Population structure and sexual maturity of the calico box crab Hepatus epheliticus Linnaeus (Brachyura, Hepatidae) from Yucatan Peninsula, Mexico

The calico box crab Hepatus epheliticus is an abundant species from shallow and continental shelf waters of the Atlantic coast of USA and Mexico. Information about population structure and sexual maturity is absent, even though this crab is caught to be used as bait for the octopus fishery in the Campeche Bank, Mexico. In order to achieve such information, a total of 768 individuals were collected from January to March 2010 through baited traps installed in the Yucatan Peninsula, Mexico. Our results showed that sex ratio is biased towards more males than females (1:0.55), contradicting to that reported in other brachyuran crabs. The absence of ovigerous females suggests that they did not enter into the traps during embryogenesis. Males reached a larger maximum size than females (64.0 +/- 6.15 and 58.4 +/- 5.60 mm carapace width, respectively). The general scheme of growth being positive allometric throughout ontogeny of both sexes. Males presented a transition phase from juveniles to adult corresponding to the puberty moult. The estimation of the onset of functional sexual maturity revealed a steady situation for the population, with 21.5 and 13.8% of males and females, respectively, morphologically immature at the time of catch. This study constitutes the first report on population structure and sexual maturity in a population of the calico box crab H. epheliticus.

Desenvolvimento de sistema de análise e descrição de funções para uma PME

Mestrado em Gestão de Recursos Humanos

Determinantes financeiros da estrutura de capital das PME industriais portuguesas ao longo dos ciclos económicos

Dissertação de Mestrado em Gestão Empresarial. Faculdade de Economia, Univ. do Algarve, 2004

O perfil da excelência nas PME's turísticas do Algarve

Dissertação de mest. em Gestão Empresarial, Faculdade de Economia, Univ. do Algarve, 2004

Fatores relevantes no relacionamento Banca-PME : orientações para gestores de PME

Mestrado em Ciências Empresariais

Gestão de Tesouraria: O Impacto da Actual Crise Económica e Financeira nas PME Portuguesas

A crise económica e financeira despoletada nos EUA em 2007 teve um impacto devasto na economia dos países, empresas e famílias, e que ainda hoje se fazem sentir. Portugal foi um dos países fortemente afetados, culminando com o resgate financeiro em 2011, pelo que todos os seus efeitos limitaram e dificultaram o crescimento económico do país e consequentemente o crescimento das empresas. O estudo tem como principal objetivo analisar o desempenho económico e financeiro da média das PME portuguesas não financeiras e identificar quais as determinantes da tesouraria líquida, em períodos de estabilidade ou de crise económica. Os dados utilizados, indicadores económicos e financeiros, foram obtidos na plataforma do Banco de Portugal, e após o tratamento destes dados, foi efetuada a regressão linear múltipla com dados em painel. Embora o estudo contribua com evidência empírica para a temática da gestão de tesouraria, a utilização de outro tipo de dados além de dados financeiros complementaria o estudo. A análise descritiva mostra que a média das PME em estudo apresentam uma tesouraria líquida negativa, apresentando uma melhoria a partir do ano de 2009. Os resultados da regressão revelam que as variáveis independentes (dimensão, endividamento, maturidade do passivo, oportunidades de crescimento e o ciclo de conversão de caixa) são determinantes da tesouraria líquida. Os resultados revelam ainda que a crise não possui capacidade explicativa quanto à tesouraria líquida, resultado divergente de estudos efetuados anteriormente. Este estudo contribui para uma melhor compreensão das decisões quanto à gestão de tesouraria das empresas portuguesas, auxiliando como instrumento de gestão para as empresas e os seus gestores.

Development and optimization of fluoxetine orally disintegrating tablets using Box-Behnken design

Purpose: To develop and optimise some variables that influence fluoxetine orally disintegrating tablets (ODTs) formulation. Methods: Fluoxetine ODTs tablets were prepared using direct compression method. Three-factor, 3- level Box-Behnken design was used to optimize and develop fluoxetine ODT formulation. The design suggested 15 formulations of different lubricant concentration (X1), lubricant mixing time (X2), and compression force (X3) and then their effect was monitored on tablet weight (Y1), thickness (Y2), hardness (Y3), % friability (Y4), and disintegration time (Y5). Results: All powder blends showed acceptable flow properties, ranging from good to excellent. The disintegration time (Y5) was affected directly by lubricant concentration (X1). Lubricant mixing time (X2) had a direct effect on tablet thickness (Y2) and hardness (Y3), while compression force (X3) had a direct impact on tablet hardness (Y3), % friability (Y4) and disintegration time (Y5). Accordingly, Box-Behnken design suggested an optimized formula of 0.86 mg (X1), 15.3 min (X2), and 10.6 KN (X3). Finally, the prediction error percentage responses of Y1, Y2, Y3, Y4, and Y5 were 0.31, 0.52, 2.13, 3.92 and 3.75 %, respectively. Formula 4 and 8 achieved 90 % of drug release within the first 5 min of dissolution test. Conclusion: Fluoxetine ODT formulation has been developed and optimized successfully using Box- Behnken design and has also been manufactured efficiently using direct compression technique.

A importancia do coaching na gestao de uma PME

No decorrer desta dissertação será possível verificar a importância do coaching no planeamento e gestão de uma PME. Através de um modelo previamente definido, o modelo TGROW, e da sua aplicação a um caso especifico procura-se os resultados obtidos através desta metodologia e a sua implicação dos processos e no desempenho do trabalho. Com este estudo pretende-se assim demonstrar que é possível melhorar os níveis de produtividade e eficiência dentro de uma organização através do coaching, nomeadamente pela relevância atribuída ás pessoas dentro da organização. Desta forma, apostando na formação dos colaboradores da empresa e de algum modo possibilitando o acesso a um programa de coaching terá como consequência uma valorização dos recurdos humanos da empresa e uma melhoria dos seus resultados globais. Com a aplicação do modelo TGROW a uma PME foi possível registar mudanças significativas no modus operandi do colaborador constatando-se que estas mudanças contribuíram para uma melhoria no desempenho e na eficácia das tarefas realizadas.