Biomechanical modeling of parotid glands morphing in head & neck radiation therapy treatments

Durante i trattamenti radioterapici dei pazienti oncologici testa-collo, le ghiandole parotidee (PGs) possono essere indebitamente irradiate a seguito di modificazioni volumetriche-spaziali inter/intra-frazione causate da fattori quali il dimagrimento, l’esposizione a radiazioni ionizzanti ed il morphing anatomico degli organi coinvolti nelle aree d’irraggiamento. Il presente lavoro svolto presso la struttura di Fisica Medica e di Radioterapia Oncologica dell’A.O.U di Modena, quale parte del progetto di ricerca del Ministero della Salute (MoH2010, GR-2010-2318757) “ Dose warping methods for IGRT and Adaptive RT: dose accumulation based on organ motion and anatomical variations of the patients during radiation therapy treatments ”, sviluppa un modello biomeccanico in grado di rappresentare il processo di deformazione delle PGs, considerandone la geometria, le proprietà elastiche e l'evoluzione durante il ciclo terapeutico. Il modello di deformazione d’organo è stato realizzato attraverso l’utilizzo di un software agli elementi finiti (FEM). Molteplici superfici mesh, rappresentanti la geometria e l’evoluzione delle parotidi durante le sedute di trattamento, sono state create a partire dai contorni dell’organo definiti dal medico radioterapista sull’immagine tomografica di pianificazione e generati automaticamente sulle immagini di setup e re-positioning giornaliere mediante algoritmi di registrazione rigida/deformabile. I constraints anatomici e il campo di forze del modello sono stati definiti sulla base di ipotesi semplificative considerando l’alterazione strutturale (perdita di cellule acinari) e le barriere anatomiche dovute a strutture circostanti. L’analisi delle mesh ha consentito di studiare la dinamica della deformazione e di individuare le regioni maggiormente soggette a cambiamento. Le previsioni di morphing prodotte dal modello proposto potrebbero essere integrate in un treatment planning system per metodiche di Adaptive Radiation Therapy.

(Table T3) Distribution of radiolarian taxa in sediments of ODP Leg 180 sites

Cores from the 11 sites drilled during Leg 180 showed radiolarian assemblages that appear only in the Quaternary sediments. The most diverse and well-preserved assemblages were found in hemipelagic sediments from Holes 1108A, 1110A, and 1115B.

Metaphysics of love in the religious philosophy of Pável Florensky

This article focuses on the analysis of the concept of love in the religious philosophy of Pavel Florensky, who shares the ontological approach to the consideration of love with other representatives of Russian religious philosophy (N. berdyaev and S. bulgakov). We pay more careful attention to the understanding of love-άγαπαν by Florensky. We have drawn the conclusion that, in the philosophy of P. Florensky, Love, closely connected with truth and beauty, is considered an ontological basis existence of personality. We develop the ideas of Pavel Florensky, and accordingly assume that it is possible to synthesise love-agape and love-eros around the idea of sacrificial love. Agapelogical and erotical ‘bezels’ of one jewel of love is aspects of united love, which is given by God. this gift of God, the gift of united love, is kept by humans through prayer and deeds of love.

Between "uxor", "mater" and "concubina". Profile and identity of the Emperor Constantine in Late Roman legislation

We aspire to shape the Constantine’s personality in particular by analyzing his loving relationship, first with Minervina and then with Fausta, and not forgetting the bond with his mother Helena, hence the reference to uxor, mater and concubina in our title. We will analyze if these women exercised any influence on the composition of his production rules and, if so, to what extent they were able to determine the historical development of the following decades. From this point of view we must consider in general the emperor had to combine their political claims and government with these relationships, showing great skill in handling times and ways, always putting the first to the second.

Bilingual Lexical Access in Reading : Analyzing the Effect of Semantic Context on Non-Selective Access in Bilingual Memory

Recent empirical studies about the neurological executive nature of reading in bilinguals differ in their evaluations of the degree of selective manifestation in lexical access as implicated by data from early and late reading measures in the eye-tracking paradigm. Currently two scenarios are plausible: (1) Lexical access in reading is fundamentally language non-selective and top-down effects from semantic context can influence the degree of selectivity in lexical access; (2) Cross-lingual lexical activation is actuated via bottom-up processes without being affected by top-down effects from sentence context. In an attempt to test these hypotheses empirically, this study analyzed reader-text events arising when cognate facilitation and semantic constraint interact in a 22 factorially designed experiment tracking the eye movements of 26 Swedish-English bilinguals reading in their L2. Stimulus conditions consisted of high- and low-constraint sentences embedded with either a cognate or a non-cognate control word. The results showed clear signs of cognate facilitation in both early and late reading measures and in either sentence conditions. This evidence in favour of the non-selective hypothesis indicates that the manifestation of non-selective lexical access in reading is not constrained by top-down effects from semantic context.

Teknikundervisning i grundskolan : En systematisk litteraturstudie om hur undervisningen kan utformas så att eleverna utvecklar förmågor i ämnet teknik

Syftet med denna studie var att se vad tidigare forskning säger om på vilka sätt elever kan utveckla förmågorna att analysera och reflektera kring tekniska lösningar samt se behov och lösa problem med hjälp av teknik, som anges i kursplanen för ämnet teknik i grundskolan. För att besvara dessa frågeställningar har en systematisk litteraturstudie gjorts där tidigare forskning har använts för att sammanställa ett resultat. Sökningar har gjorts i databaserna Summon, Eric (via Ebsco) och NorDiNa och relevanta artiklar har valts ut, sammanställts och diskuterats. I studien framkommer ett antal faktorer som är viktiga för elevernas utveckling av förmågorna. En faktor som framkommit i denna studie är behovet av diskussioner där eleverna får möjlighet att delge sina reflektioner kopplat till tekniska lösningar och ta till sig andras reflektioner, vilket har visat sig vara viktig för elevernas analysförmåga. En annan faktor är att eleverna behöver tid att testa och konstruera om för att utveckla sina idéer samt ges möjlighet att koppla tekniken till sin vardag. Det har också visat sig vara viktigt att problemlösningsuppgifterna inte är styrda att leda till ett specifikt resultat utan istället handlar om att träna elevernas förmåga att upptäcka olika lösningsförslag.

Modellistica e controllo di attuatori idraulici

La tesi tratta della modellistica e del controllo di un attuatore idraulico con valvola a quattro vie. Inizialmente si definiscono le grandezze e le formule fondamentali per descrivere un sistema idraulico e costruirne il modello matematico. Successivamente si ricava il modello non lineare del sistema nello spazio degli stati, quindi lo si linearizza per poterlo descrivere e studiare anche tramite funzioni di trasferimento. Si ricava quindi, utilizzando anche Matlab e Simulink, il controllo da applicare al modello linearizzato e si testa il comportamento del sistema in risposta a diversi segnali di ingresso. Infine si applica lo stesso controllore al sistema non lineare e si confrontano i due diversi comportamenti.

O negro na construção da identidade nacional: auto e heteroimagens no romance abolicionista cubano e brasileiro

Die vorliegende Arbeit nahm sich vor, das Bild des Afroamerikaners in jeweils zwei kubanischen und brasilianischen Romanen des 19. Jahrhunderts zu analysieren: El negro Francisco, Cecilia Valdés, A escrava Isaura und O mulato. Das Hauptziel war es, zu untersuchen, wie das Bild des Afroabstammenden von den Autoren angeeignet und instrumentalisiert wurde, um Veränderungen in ihren Gesellschaften zu erzielen. Darüber hinaus, versuchte man darzustellen, wie der Afroamerikaner und seine Kultur aus dem kubanischen und brasilianischen nationalen Projekt ausgeschlossen wurden. Zunächst wurden die Haupttheorien über die Konstruktion von Auto- und Heterostereotypen vorgestellt und auf die Relevanz der Stereotypenbildung im kolonialen Kontext hingewiesen. Daraufhin wurde der historische Kontext der Sklaverei und der Abolition in Kuba und in Brasilien dargelegt. Auf diese Basis wurden die Werke analysiert. Im letzten Kapitel wurde auf die Resultate der Fragestellungen eingegangen, die die vorliegende Arbeit geleitet haben. Solche wie: Welche Bilder der Weißen und der Schwarzen wurden in den Werken kreiert? Wie positioniert sich der Autor bezüglich der Abolition und der Vermischung der Ethnien? Welche Bedeutung hatten die ethnischen Diskurse im kubanischen und brasilianischen kollektiven Gedächtnis des 19. Jahrhunderts? Es konnte gezeigt werden, dass das Bild des Afroamerikaners in den Romanen verwendet wurde, um die Zukunft der eigenen Nation zu projizieren, von der der Schwarze nur ein Teil werden könnte, wenn er die weiße Kultur und Hautfarbe annehmen würde, das heißt, wenn er sich dem Prozess eines physischen und kulturellen „branqueamento“ unterziehen würde. Die abolitionistische Narrative, auch wenn sie nach außen hin dem Schwarzen zu verteidigen scheint, trug in Wahrheit zur Fixierung und Perpetuierung der ethnischen Stereotype bei, die die Schwarzen in den marginalen Sphären der Gesellschaft verewigten und die Macht in den Händen der Weißen konsolidierten.

Decision-making process in Portuguese Erasmus student mobility: case study

With the evolution of nowadays knowledge-based economies, the labour class becomes more competitive. As a way of getting skills that bring benefits to their careers, university students take advantage of the many opportunities available and go abroad to study. This study develops and empirically tests a structural model that examines the antecedents that influence the decision-making process of an Erasmus student under mobility for studies (EMS) in Aveiro, Coimbra and Porto (2014-2015). Reliability analysis, exploratory factor analysis and linear regressions were used to evaluate the model. Based on a survey with a sample of 872 valid responses, this study has demonstrated that EMS students are also influenced by touristic factors, which gives support to what has recently been approached by other authors. Conclusions and suggestions can be applied by other organizations, mainly Higher Education Institutions in order to attract more EMS students.

Energía y valor de germinación en las especies arbóreas genízaro (Phitecellobium saman (Jacq.) Benth.) y guanacaste negro (Enterolobium cyclocarpum (Jacq.) Griseb.)

Este ensayo se realizó en el vivero de la Facultad de Recursos Naturales y del Ambiente de la Universidad Nacional Agraria en Managua, Nicaragua. Semillas de genízaro (Phitecellobium saman(Jacq.) Benth.) y guanacaste negro (Enterolobium cyclocarpum(Jacq.) Griseb.,) se tilizaron para cuantifi car el porcentaje, energía y valor de la germinación al aplicar tratamientos pre – germinati- vos de sumersión en agua a punto de ebullición, seguido en ambos casos por 24 horas de reposo en agua a temperatura ambiente, previo a la siembra. También se evaluó el corte en el extremo de la testa de la semilla donde se encuentra el micrópilo. Para estudiar la germinación se seleccionaron 400 semillas por especie divididas en cuatro bloques de 100, sembradas en bandejas almacigueras de polietileno de 100 cavidades cada una. La duración del ensayo fue de 20 días con aplicaciones diarias de riego en las primeras horas de la mañana. El tratamiento pre germinativo que dio mejores resultados fue el rompimiento de la testa en el extremo donde se encuentra el micrópilo, con porcentaje de germinación superior a 90% y mayor valor y energías de germinación.

2C-Cas9: a versatile tool for clonal analysis of gene function.

CRISPR/Cas9-mediated targeted mutagenesis allows efficient generation of loss-of-function alleles in zebrafish. To date, this technology has been primarily used to generate genetic knockout animals. Nevertheless, the study of the function of certain loci might require tight spatiotemporal control of gene inactivation. Here, we show that tissue-specific gene disruption can be achieved by driving Cas9 expression with the Gal4/UAS system. Furthermore, by combining the Gal4/UAS and Cre/loxP systems, we establish a versatile tool to genetically label mutant cell clones, enabling their phenotypic analysis. Our technique has the potential to be applied to diverse model organisms, enabling tissue-specific loss-of-function and phenotypic characterization of live and fixed tissues.

Nutrient content in aboveground biomass of Brazilian peanut cultivars in conservation tillage on sugarcane straw and pasture area.

Fields studies were conducted in 2004/2005 in order to evaluate the effects of tillage on nutrient content in aboveground biomass of two peanut cultivars, cultivated in rotation after mechanical harvested sugarcane and pastures. These trials were carried out in two types of soils; Oxisol and Ultisol, respectively in Ribeir?ao Preto and Mirassol, S?ao Paulo State, Brazil. The experimental design was split-plot with four replications. Tillage treatments (conventional, minimum and no-tillage) were main plots while sub-plots were peanut genotypes IAC-Tatu ST (Valencia market-type, erect growth habit, red seed coat, maturity range around 100 days after planting) and IAC-Caiap´o (Runner market-type, prostate growth habit, pink testa, maturity range more than 135 days). From 15 to 90 days after emergence, samples of leaves and stems were harvested, dried, weighted and ground to determine macro and micronutrient concentration. At 75 days after sowing, the cultivar IAC-Caiap´o showed higher contents of N, P, K, Cu, and Zn while IAC-Tatu presented higher concentrations of Ca, Mg, and S. Zn content was higher in conservation tillage than in conventional, mainly in Oxisoil for both of cultivars.

O papel da partilha de conhecimento na relação entre confiança e compromisso organizacional

Mestrado em Ciências Empresariais

Three essays on liquidity

Doutoramento em Gestão.

Avaliação da performance do árbitro de futebol 11 : estudo de caso

O aumento da carga física do jogo de futebol provocou uma maior exigência e desenvolvimento na condição física dos jogadores e por inerência, nos árbitros. Assim o presente estudo procurou identificar e desenvolver um teste para a avaliação dos árbitros de futebol. Foi realizada uma análise sistemática para identificação e descrição da produção científica na área da arbitragem no sentido de sustentar o argumento de insuficiência dos testes vigentes e propor o novo teste que denominámos ETSOR. Após esta, foi realizada uma aplicação piloto com recurso ao método de estudo de caso para testagem do ETSOR. Os resultados revelaram que existe uma dispersão nas formas e conteúdos abordados face à caracterização do árbitro de futebol de 11. A partir do método de meta-análise, é apresentada uma proposta de categorização dos conteúdos. Os resultados revelaram também que o teste FIFA não identifica as intensidades irregulares que decorrem das situações do jogo, nem representa a uma distribuição das intensidades dos esforços dos árbitros nas situações de jogo. O Teste ETSOR, como teste ecológico, capta em termos de densidade, de distribuição, de variação da potência e de resistência, os esforços dos árbitros nas situações de jogo, como testa a características das intensidades máximas da atividade do árbitro. Por último, os resultados reforçaram que este processo que se deve estender de forma periodizada ao longo de cada época tornando-se útil, na medida em que permite a otimização e monitorização da prestação do árbitro.