RARβ gene methylation is a candidate for primary glioblastoma treatment planning.

Background: We screened RARβ methylation in primary glioblastoma multiforme (GBM) and the results were evaluated based on the clinical data and treatment type. Objective: The objective of this study was to find new areas for the usage of MS-HRM applications in the determination of methylation levels in primary GBM samples and it shows the association of RARβ methylation with the clinical outcome. Methods: In our study, tumor samples were collected during surgical resection by the Department of Neurosurgery. The clinical and radiologic data was carefully reviewed, compared, and evaluated with the histological results. The methylation status of RARβ was determined by using MS-HRM. Results: RARβ gene methylation was detected in 24 out of 40 cases (60%), with different quantitative methylation levels. The mean survival time was 19 months form ethylated cases and 15 months for the non-methylated cases. The survival time of the patients who received treatment was 25 months and the survival time of the patients who received radiotherapy alone or where no treatment protocol applied was 15-20 months. Therefore, a significant difference in survival rates has been observed (P<0.05). This study indicates a potential prognostic value for GBM treatment planning. Conclusion: Our study is the first study to investigate RARβ methylation in primary GBMs. We conclude that the RARβ gene could be a new prognostic and predictive candidate marker to designate the treatment protocol for primary GBMs. Keywords:

Recursos humanos e gestão da qualidade: "estudos de caso" em instituições particulares de solidariedade social no Concelho de Estremoz

Neste trabalho discute-se a relevância da performance nas Instituições de Solidariedade Social, com especial incidência a Gestão de Recursos Humanos, e a implementação da Gestão da Qualidade Total, na medida que se multiplicam as exigências em torno da eficiência, quantidade e qualidade dos serviços, e uma maior flexibilidade para assegurar a competitividade a nível nacional. A Gestão Estratégica de Recursos Humanos é a resposta possível e sustentada, de colocar os colaboradores no centro das Instituições, apelando à autonomia, criatividade, talento, estímulos, aspirações individuais e cooperativas, e considerar que são os colaboradores que fazem o sucesso das Instituições. Com este trabalho pretende-se chamar a atenção para a importância da GRH dentro das Instituições de Solidariedade Social, fazendo um diagnóstico da laboração na área de recursos humanos e propondo um plano de intervenção/reorganização destes mesmos serviços. Este trabalho de Dissertação segue a metodologia de três estudos de caso cuja recolha de dados foi realizada, tendo por base diversas fontes: análise documental, observação direta, questionário. Verificamos que as Instituições, objetos de estudo revelam poucos conhecimentos a nível da gestão de recursos humanos, e no que concerne à gestão da qualidade, duas das intuições não tem qualquer conhecimento, apenas a Cerciestemoz trabalha em prol da qualidade uma vez que é, uma Instituição já com vários certificados de qualidade. Face ao estudo empírico realizado constatamos que existe alguma dificuldade em prevalecer a gestão de recursos humanos e a gestão da qualidade, porque terão que estar inseridas as políticas de Gestão Recursos Humanos para que os colaboradores se sintam mais motivados e responsáveis pelas funções que desempenham, o que não é visível neste momento; ABSTRACT: This research discusses the relevance of performance in social solidarity institutions, with a focus on Human Resource Management, and the implementation of Total Quality Management, to the extent that multiply the requirements around efficiency, quantity and quality of services and greater flexibility to ensure competitiveness at national level. The Strategic Human Resource Management is possible and sustained response, placing employees at the center of the institutions, calling for autonomy, creativity, talent, stimuli, individual aspirations and cooperative skills, and consider that it is the employees that make the success of the institutions. This work is intended to draw attention to the importance of HRM in the institutions of social solidarity, making a diagnosis of laboring in the area of human resources and proposing an action plan / reorganization of these same services. This Master's work follows the methodology of three case studies in which data collection was carried out, based on several sources: document analysis, direct observation, questionnaire. We found that the institutions, objects of study reveal little knowledge in the management of human resources, and with regard to quality management, two of intuitions do not have any knowledge, only Cerciestemoz works for the quality since it is a institution already with several quality certificates. Given the empirical study found that there is some difficulty prevail human resource management and quality management, they will have to be inserted the policies of Human Resources Management for employees and feel more motivated and responsible for the functions they perform, the which is not visible at this time.

Human resource management reform in the Indonesian civil service : towards strategic fit?

Studies of strategic HRM have dominated HRM research over the last three decades. Focusing on the HRM-organisation performance relationship, researchers take various themes and perspectives in their approach to strategic HRM. Among these themes, two contrasting approaches of strategic HRM continue to flourish: first, the best practice approach suggests that certain HRM practices will have the same effect irrespective of context and, second, the best fit approach suggests that the choice of HRM practices should be designed in accordance with an organisations’ specific context. While there is little consensus on what constitutes strategic HRM, the most common feature agreed in this field is the notion of the strategic integration; aligning HRM practices with organisations’ overall strategic objectives (vertical fit) and with each other (horizontal fit). Utilising the best fit approach as its theoretical framework, this study examines how vertical and horizontal fit is practised in the Indonesian civil service and what factors likely influence the prevalence of vertical and horizontal fit in the Indonesian civil service context. This study is significant for two important reasons. Firstly, the literature suggests that there are limited studies examining the best fit concept in the civil sector despite its implementation in the private sector positively contributing to organisational performance improvement. Secondly, the study provides enlightenment on how the best fit approach could contribute to performance improvement in the Indonesian civil service. This is in line with the fact that negative images of the Indonesian civil service are continuously highlighted although various HRM reform initiatives have been put in place. To achieve the objectives of the study, the qualitative case study approach accompanied by semi-structured interviews was employed involving 53 senior officials and one focus group discussion from eight Indonesian government agencies, consisting of three central agencies mandated to manage human resources, the National Bureaucratic Reform Team and four line agencies from both central and local governments. Thematic analysis was employed for data analyses and NVIVO software was used to manage the data. The study suggests three main findings. First, various HRM initiatives in relation to the HRM reform have been introduced in the Indonesian civil service differentiating them from the old HRM practices. However, the findings indicate that some HRM policies are still contradicting and hinder vertical and horizontal fit. Second, despite the contradictory policies, vertical and horizontal fit can be seen in the line agencies which have been acknowledged as ‘reformed agencies’. This demonstrates that the line agencies play an important role in aligning HRM practices with the line agencies’ goals and objectives and with one another although they are bounded by HRM policies that are unlikely to support the vertical and horizontal fit concept. Third, factors influencing the prevalence of vertical and horizontal fit include knowledge of contemporary HRM in both central agencies and line agencies, commitment from the line agencies’ leaders, devolvement of HRM to the line agencies and the socio-political and economic environments of the Indonesian civil service. The findings of the study raise policy, practical and theoretical implications. In terms of policy implications, the study highlights the importance of fit in HRM policies to support the achievement of the line agencies’ goals. Therefore, when formulating an HRM policy, the central agencies need to ensure that the HRM policy is linked to line agencies’ goals and to other HRM policies. This is to ensure synchronisation among the policies and thus maximising the achievement of the line agencies’ goals. From the practical perspectives, the study highlights important points which can be learned by the central agencies in carrying out their strategic role with regard to the formulation of HRM policies; by the line agencies in maximising the contribution of HRM to the achievement of the goals and objectives of the agencies through the implementation of the best fit concept, and by the leaders of the agencies in providing continuous support to each of the involved parties in the line agencies and involving the HRM department in all agency’s strategic decision-making. In relation to the theoretical implication, it is clear that the best fit approach is not thoroughly applied due to factors discussed previously. However, this does not mean that the best fit concept cannot be implemented. As argued by McCourt & Ramgutty-Wong (2003), instead of adopting the whole concept of best fit, a modulated approach reflecting the best fit concept, such as selecting individual HRM practices and experimenting with devolution, is possible for civil service organisations which still embrace centralised HRM systems. As demonstrated in the findings, some of the line agencies being studied seem to be ready to adopt the best fit approach given that they have knowledge of the best fit concept, strong support from the top leader, less political intervention and less corruption, collusion, and nepotism practices in their HRM practices.

A gestão de recursos humanos na InnoWave Technologies

Mestrado em Gestão de Recursos Humanos

Recrutamento e selecção na Tap Portugal

Mestrado em Gestão de Recursos Humanos

Conhecer, compreender e explorar a consultoria de recursos humanos : O caso da SDO

Mestrado em Gestão de Recursos Humanos

The role of participative leadership and trust-based mechanisms in eliciting intern performance: evidence from China.

In this article, we investigate the relationship between participative leadership and job performance within the internship setting. Based on two-waves of survey data obtained from 309 intern-supervisor dyads, we find that participative leadership has a positive relationship with job performance, and that affective trust mediates that relationship. We also find that although cognitive trust is not significantly related to intern job performance, it mediates the relationship between participative leadership and affective trust. Our findings contradict those of previous research which question the effectiveness of participative leadership in short-term employment situations such as internships. They also highlight the importance of designing internships to be reflective of typical performance situations, characterized by participative leadership practices, rather than more directive leadership practices.

An application of an extended effort-reward imbalance model to police absenteeism behaviour

Purpose – Frequent absences from work can be highly disruptive, whilst also potentially indicating problematic working conditions that can lead to increased withdrawal behaviour. The purpose of this paper is to test the predictive capability of an expanded effort-reward imbalance model on employee absenteeism within the context of policing.

Design/methodology/approach – Three separate reward systems are identified by the effort-reward imbalance model. In this study, the authors assessed these individual components for their contribution to officer withdrawal behaviour in the form of absenteeism frequency. Data were gathered from a sample of operational officers (n=553) within a large Australian police agency.

Findings – Findings indicate that there was a strong influence of social rewards such as social support and recognition in the workplace on officer absenteeism rates. Low workload was associated with a higher frequency of absenteeism suggesting a potential underloading effect. There were a number of significant interactions providing support for the effort-reward imbalance mechanism and the separation of the reward construct. Security rewards were particularly influential and significantly moderated the relationship between effort and absenteeism.

Research limitations/implications – Differential effects of occupational rewards were identified in the study, indicating that there are significant opportunities for expansion of the effort-reward imbalance model along with opportunities for HRM practitioners in terms of employee recognition and remuneration programmes. This research was focused on a specific sample of operational officers, therefore should be expanded to include multiple occupational groups.

Originality/value – This paper considers and expanded model of worker strain and contributes a longitudinal assessment of the association between perceived effort and reward systems and worker absenteeism.

Why resilience managers aren’t resilient, and what human resource management can do about it

Prior resilience research typically focuses on either the individual or the organisational level of analysis, emphasises resilience in relation to day-to-day stressors rather than extreme events and is empirically under-developed. In response, our study inductively theorises about the relationships between individual and organisational resilience, drawing upon a large-scale study of resilience work in UK and French organisations. Our first-hand accounts of resilience work reveal the micro-processes involved in producing resilient organisations, and highlight the challenges experienced in doing resilience work in large organisations. We show that these micro-processes have significant implications for resilience at both individual and organisational levels, and draw implications for how HRM interventions can help to promote individual, and thus organisational, resilience.

Rapid identification and differentiation of Mycobacterium avium subspecies paratuberculosis types by use of real-time PCR and high-resolution melt analysis of the MAP1506 locus

High-resolution melt (HRM) analysis can identify sequence polymorphisms by comparing the melting curves of amplicons generated by real-time PCR amplification. We describe the application of this technique to identify Mycobacterium avium subspecies paratuberculosis types I, II, and III. The HRM approach was based on type-specific nucleotide sequences in MAP1506, a member of the PPE (proline-proline-glutamic acid) gene family.

El capital intelectual y su relación con la innovación en la universidad CES

En la sociedad actual del conocimiento las universidades tienen la responsabilidad de generar conocimiento e innovaciones para ofrecer soluciones a problemas de comunidades de interés. Para lograrlo las universidades deben enfocarse en su activo más importante, su capital intelectual. Hasta ahora las investigaciones relacionadas con el capital intelectual y la innovación en las universidades, son limitadas a pesar de ser un elemento estratégico para la dirección de estas organizaciones, ya que estos aspectos le representan valor en el tiempo, por tanto esta investigación busca establecer cuál es la relación que existe entre el capital intelectual y la innovación en la Universidad CES. El objetivo de esta investigación era identificar el grado de relación entre capital intelectual e innovación en la Universidad CES. La metodología del estudio, es un estudio cuantitativo, de tipo descriptivo explicativo, con un diseño transversal, que permitió establecer el efecto del capital intelectual sobre la innovación de la Universidad CES. La población del fueron los directivos, líderes de los grupos de investigación y los coordinadores de investigación de la Universidad CES. Según los resultados obtenidos, este estudio determinó que el capital intelectual no tiene una relación estadísticamente significativa con la innovación personal de la Universidad CES y se determinó también que las tres dimensiones del capital intelectual tienen una relación estadísticamente significativa con los resultados de la innovación en la Universidad CES. El principal aporte de este estudio fue ofrecer evidencias sobre el capital intelectual como una de las principales fuentes de innovación para la Universidad.

Modelo de competencias en TIC para el personal de una organización del sector eléctrico

La presente investigación pretendió incorporar el uso intensivo de TIC en los procedimientos establecidos y necesarios en los procesos de generación, distribución y control de la energía, lo que se expresa en un manual para el sistema de gestión humana de la organización analizada. La investigación partió de un levantamiento de un estado del arte, continuó con la realización de un análisis de actitudes y aptitudes de los colaboradores, basado en propuestas teóricas y mejores prácticas existentes del medio, y, por último, concluyó con un manual de gestión humana en el que se indican las competencias en los diferentes perfiles de la organización para el uso de TIC y su aplicación, con el propósito de alinearse con las perspectivas y objetivos de la organización analizada al tener como base la perdurabilidad y la competitividad de la misma.

O compromisso organizacional como o grande desafio da gestão estratégica de recursos humanos : O caso dos projectos de outsourcing da IBM Portugal

Num contexto empresarial globalizado, a gestão de recursos humanos assume importância crescente. A valorização do capital humano e a preocupação com o compromisso e produtividade das pessoas revelam-se imperativos para a gestão de recursos humanos na contemporaneidade. As políticas e práticas de recursos humanos revelam-se a forma mais eficaz de comprometer as pessoas e, consequentemente, melhorar a performance organizacional. Este trabalho final de mestrado resultou de um estágio realizado num agrupamento complementar de empresa da IBM. Além das actividades desenvolvidas em contexto organizacional, efectuou-se urna descrição de todo o processo de gestão de recursos humanos e analisou-se a relação entre as políticas e práticas de recursos humanos e o compromisso organizacional, nas suas diferentes dimensões. Os resultados deste diagnóstico revelam que os colaboradores apresentam índices elevados de compromisso organizacional para com o ACE. Este compromisso materializa-se no alinhamento dos objectivos de negócio com os objectivos dos colaboradores. A principal causa destes índices elevados de compromisso são as políticas e práticas de recursos humanos. ABSTRACT: ln a globalized business environment, HRM assumes increasing importance. The human capital and concern for the commitment and productivity of people tum out to be imperative for the contemporary human resource management. Policies and practices of human resources prove to be the most effective way to engage people and thus improve organizational performance. This scientific work resulted from one stage held in a complementary group of the IBM Company. Besides the activities in organizations, took place a description of the whole process of resource management and examined the relationship of policies and practices in human resources with organizational commitment, in its various levels. The results of this diagnosis show that employees have high levels of organizational commitment towards the ACE. This commitment is materialized in the alignment of business goals with employee objectives. The main cause of these high levels of commitment are the policies and practices of human resources.