The poetical works of Robert Southey : complete in one volume.

Mode of access: Internet.

The experienced English housekeeper : for the use and ease of ladies, housekeepers, cooks, &c., written purely from practice : dedicated to the Hon. Lady Elizabeth Warburton, whom the author lately served as housekeeper : consisting of several hundred original receipts, most of which never appeared in print /

Includes recipes for wine, mead, and other liquors; illustrations of kitchen stoves using coal; illustrations of layout of dishes for multi-course meal. Sample recipes: To bake herrings, To make cream pancakes, To make a blanc-mange of isinglass, To make cowslip wine.

Poems /

Bound in blue paper over boards ; printed paper label on cover; cream paper shelfback; stamped in gold on spine.

Token of regard presented to the pupils of the Elm-Wood School, /

"Errata": leaf at end.

Evaluation of mammary-gland development in Holstein and Jersey calves as a measure of potential producing capacity /

Cover title.

The simple life,

Translation of La vie simple.

Qānūnchah fī al-ṭibb, [880, i.e. 1475 or 1476].

Fine copy of al-Jaghmīnī's (d.1344) Qānūnchah, a compendium on medicine and an extract from Ibn Sīnā’s Qānūn. Brockelmann treats this author as distinct from an astronomer of the same name who died in 1221.

Dairy products /

Latest issue consulted: Apr. 3, 1997.

Mother West Wind "how" stories,

Series list on p. [ii].

The mammary gland.

Includes bibliographies.

I'industria tartarica; materie prime derivanti dal vino.

Mode of access: Internet.

Milking machines and mastitis.

Mode of access: Internet.

La ruta de Judith /

Mode of access: Internet.

Antitumor activity of 3-ingenyl angelate: Plasma membrane and mitochondrial disruption and necrotic cell death

Options for skin cancer treatment currently include surgery, radiotherapy, topical chemotherapy, cryosurgery, curettage, and electrodes-sication. Although effective, surgery is costly and unsuitable for certain patients. Radiotherapy can leave a poor cosmetic effect, and current chemotherapy is limited by low cure rates and extended treatment schedules. Here, we describe the preclinical activity of a novel topical chemotherapeutic agent for the treatment of skin cancer, 3-ingenyl angelate (PEP005), a hydrophobic diterpene ester isolated from the plant Euphorbia peplus. Three daily topical applications of 42 nmol (18 mug) of PEP005 cured a series of s.c. mouse tumors (B16 melanoma, LK2 UV-induced squamous cell carcinoma, and Lewis lung carcinoma; it = >14 tumors/group) and human tumors (DO4 melanoma, HeLa cervical carcinoma, and PC3 and DU145 prostate carcinoma; it = >4 tumors/group) previously established (5-10 mm(3)) on C57BL/6 or Fox1(nu) mice. The treatment produced a mild, short-term erythema and eschar formation but, ultimately, resulted in excellent skin cosmesis. The LD90 for PEP005 for a panel of tumor cell lines was 180-220 muM. Electron microscopy showed that treatment with PEP005 both ill vitro (230 tot) and ill vivo (42 nmol) rapidly caused swelling of mitochondria and cell death by primary necrosis. Cr-51 release, uptake of propidium iodide, and staining with the mitochondria dye JC1, revealed that PEP005 (230 muM) treatment of tumor cells ill vitro resulted in a rapid plasma membrane perturbation and loss of mitochondrial membrane potential. PEP005 thus emerges as a new topical anti-skin cancer agent that has a novel mode of action involving plasma membrane and mitochondrial disruption and primary necrosis, ultimately resulting in an excellent cosmetic outcome.

Factors affecting the formation of a skin reservoir for topically applied solutes

The reservoir function of the skin is an important determinant of the duration of action of a topical solute. The reservoir can exist in the stratum corneum, in the viable avascular tissue (viable epidermis and supracapillary dermis) and in the dermis. A steroid reservoir in the stratum corneum has been demonstrated by the reactivation of a vasoconstrictor effect by occlusion or application of a placebo cream to the skin some time after the original topical application of steroid. Other solutes have also been reported to show a reservoir effect in the skin after topical application. A simple compartmental model is used to understand why reactivation of vasoconstriction some time after a topical steroid application shows dependency on time, topical solute concentration and the product used to cause reactivation. The model is also used to show which solutes are likely to show a reservoir effect and could be potentially affected by desquamation, especially when the turnover of the skin is abnormally rapid. A similar form of the model can be used to understand the promotion of reservoir function in the viable tissue and in the dermis in terms of effective removal by blood perfusing the tissues. Copyright (C) 2004 S. Karger AG, Basel.