Caregivers of people with neurodegenerative diseases: profile and unmet needs from a population-based survey in South Australia.

INTRODUCTION: Neurodegenerative diseases (NDD) are characterized by progressive decline and loss of function, requiring considerable third-party care. NDD carers report low quality of life and high caregiver burden. Despite this, little information is available about the unmet needs of NDD caregivers. METHODS: Data from a cross-sectional, whole of population study conducted in South Australia were analyzed to determine the profile and unmet care needs of people who identify as having provided care for a person who died an expected death from NDDs including motor neurone disease and multiple sclerosis. Bivariate analyses using chi(2) were complemented with a regression analysis. RESULTS: Two hundred and thirty respondents had a person close to them die from an NDD in the 5 years before responding. NDD caregivers were more likely to have provided care for more than 2 years and were more able to move on after the death than caregivers of people with other disorders such as cancer. The NDD caregivers accessed palliative care services at the same rate as other caregivers at the end of life, however people with an NDD were almost twice as likely to die in the community (odds ratio [OR] 1.97; 95% confidence interval [CI] 1.30 to 3.01) controlling for relevant caregiver factors. NDD caregivers reported significantly more unmet needs in emotional, spiritual, and bereavement support. CONCLUSION: This study is the first step in better understanding across the whole population the consequences of an expected death from an NDD. Assessments need to occur while in the role of caregiver and in the subsequent bereavement phase.

Inflammation markers are associated with Cardiovascular diseases risk in adolescents The Young Hearts Project 2000

Purose: The traditional approach for identifying subjects at risk from cardiovascular diseases (CVD) is to determine the extent of clustering of biological risk factors adjusted for lifestyle. Recently, markers of endothelial dysfunction and low grade inflammation, including high sensitivity C-reactive protein (hsCRP), soluble intercellular adhesion molecules (sICAM), and soluble vascular adhesion molecules (sVCAM), have been included in the detection for high risk individuals. However, the relationship of these novel biomarkers with CVD risk in adolescents remains unclear. The purpose of this study, therefore, was to establish the association of hsCRP, sICAM, and sVCAM with CVD risk in an adolescent population.
Methods: Data from the Young Hearts 2000 cross-sectional cohort study, carried out in 1999-2001, were used. From a total of 2,017 male and female participants, 95 obese subjects were identified and matched according to age, sex, and cigarette smoking, with 95 overweight and 95 normal-weight adolescents. Clustered CVD risk was computed using a sum of Z-scores of biological risk factors. The relationship was described using multiple linear regression analyses.
Results: hsCRP, sICAM, and sVCAM showed significant associations with CVD risk. hsCRP and sICAM had a positive relation with CVD risk, whereas sVCAM showed an inverse relationship. In this study, lifestyle factors showed no relation with CVD risk.
Conclusion: The results fit the hypothesized role of low grade inflammation and endothelial dysfunction in CVD risk in asymptomatic adolescents. The inverse relationship of VCAM, however, is hard to explain and indicates the complex mechanisms underlying CVD. Further research is needed to draw firm conclusions on the biomarkers used.

Secondary prevention in the clinical management of patients with cardiovascular diseases. Core components, standards and outcome measures for referral and delivery.

Despite major improvements in diagnostics and interventional therapies, cardiovascular diseases remain a major health care and socio-economic burden both in western and developing countries, in which this burden is increasing in close correlation to economic growth. Health authorities and the general population have started to recognize that the fight against these diseases can only be won if their burden is faced by increasing our investment on interventions in lifestyle changes and prevention. There is an overwhelming evidence of the efficacy of secondary prevention initiatives including cardiac rehabilitation in terms of reduction in morbidity and mortality. However, secondary prevention is still too poorly implemented in clinical practice, often only on selected populations and over a limited period of time. The development of systematic and full comprehensive preventive programmes is warranted, integrated in the organization of national health systems. Furthermore, systematic monitoring of the process of delivery and outcomes is a necessity. Cardiology and secondary prevention, including cardiac rehabilitation, have evolved almost independently of each other and although each makes a unique contribution it is now time to join forces under the banner of preventive cardiology and create a comprehensive model that optimizes long term outcomes for patients and reduces the future burden on health care services. These are the aims that the Cardiac Rehabilitation Section of the European Association for Cardiovascular Prevention & Rehabilitation has foreseen to promote secondary preventive cardiology in clinical practice.

Reduced physical activity level and cardiorespiratory fitness in children with chronic diseases.

We aimed to compare physical activity level and cardiorespiratory fitness in children with different chronic diseases, such as type 1 diabetes mellitus (T1DM), obesity (OB) and juvenile idiopathic arthritis (JIA), with healthy controls (HC). We performed a cross-sectional study including 209 children: OB: n = 45, T1DM: n = 48, JIA: n = 31, and HC: n = 85. Physical activity level was assessed by accelerometer and cardiorespiratory fitness by a treadmill test. ANOVA, linear regressions and Pearson correlations were used. Children with chronic diseases had reduced total daily physical activity counts (T1DM 497 +/- 54 cpm, p = 0.003; JIA 518 +/- 28, p < 0.001, OB 590 +/- 25, p = 0.003) and cardiorespiratory fitness (JIA 39.3 +/- 1.7, p = 0.001, OB 41.7 +/- 1.2, p = 0.020) compared to HC (668 +/- 35 cpm; 45.3 +/- 0.9 ml kg(-1) min(-1), respectively). Only 60.4% of HC, 51.6% of OB, 38.1% of JIA and 38.5% of T1DM children met the recommended daily 60 min of moderate-to-vigorous physical activity. Low cardiorespiratory fitness was associated with female gender and low daily PA. Children with chronic diseases had reduced physical activity and cardiorespiratory fitness. As the benefits of PA on health have been well demonstrated during growth, it should be encouraged in those children to prevent a reduction of cardiorespiratory fitness and the development of comorbidities.

Acid-Base, Surface electron donating and catalytic properties of binary oxides of Zr with rare earth elements

Department of Applied Chemistry, Cochin University of Science and Technology

Teaching maths to pupils with different learning styles.

Recurso donde se analizan las diferentes formas en que se pueden enseñar las matemáticas a alumnos con distintos estilos de aprendizaje y cómo identificarlos. Ofrece de un modo práctico los posibles modos de comprender algunos de los conceptos necesarios para los exámenes de GCSE: el concepto de número, los modelos para la multiplicación y la división, el valor ordinal y decimales, fracciones, relación, proporción, porcentajes, el álgebra, forma, espacio, las medidas, los ángulos, círculos y manejo de datos. Incluye: ideas para utilizar en clase; propuestas para enseñar conceptos básicos de una manera visual; consejos prácticos y orientaciones; recursos fotocopiables.

100 ideas for supporting pupils with ADHD.

Guía que proporciona a los que trabajan con niños con trastorno por déficit de atención con hiperactividad (TDAH), cien ideas prácticas para apoyar y desarrollar su aprendizaje. Están organizadas en trece secciones que incluyen información a los padres, medicamentos, TDAH y el aula. Cubren toda la edad escolar con ideas para desarrollar estrategias efectivas que ayuden al niño en sus habilidades individuales, como la escritura, la comprensión, el procesamiento de tareas, con el fin de alentar el desarrollo de sus habilidades sociales y autoestima.

100 ideas for supporting pupils with social, emotional and behavioural difficulties.

Guía que proporciona a los que trabajan con niños con dificultades sociales, emocionales y de conducta cien ideas prácticas de cómo apoyar y desarrollar su aprendizaje. Las ideas están organizadas en quince secciones que incluyen información que va, entre otras, desde la creación de un entorno de aprendizaje, el apoyo al alumno, el desarrollo de técnicas de gestión eficaz del aula, o cómo hacer frente a los comportamientos profundamente difíciles.

100 ideas for supporting pupils with dyspraxia and DCD.

Guía que proporciona ideas y sugerencias para apoyar a los que trabajan con niños y jóvenes con trastornos de coordinación del desarrollo (TCD) y dispraxia. Sin embargo, muchas de las ideas son útiles para todos los niños de la clase, con y sin dificultades de coordinación motriz. La guía está estructurada en secciones relativas a educación preescolar, primaria y secundaria. Todas las actividades son seguras para usar con todos los niños en el entorno escolar.

100 ideas for supporting pupils with dyslexia.

Esta guía proporciona a los que trabajan con niños disléxicos cien ideas sobre cómo apoyar su desarrollo de aprendizaje. Incluye listas que van desde la identificación de las necesidades de cada alumno a sus estilos de aprendizaje para el desarrollo en lectura, escritura, habilidades numéricas y de comunicación.

Language for learning : a practical guide for supporting pupils with language and communication difficulties across the curriculum.

Este manual proporciona una guía a los profesionales y profesores que apoyan a los alumnos con dificultades en el habla, el lenguaje y/o comunicación en las etapas clave 1 y 2 en los centros ordinarios. Su objetivo es apoyar la práctica inclusiva, ayudar a los lectores a: identificar dificultades en el habla y el lenguaje; planificar un currículo diferenciado; facilitar el desarrollo de habilidades a través de experiencias significativas de aprendizaje; capacitar a los alumnos para acceder al plan de estudios. Se completa con recursos fotocopiables, actividades y pegatinas. También es útil para profesores especialistas, logopedas y psicopedagogos.

Intervention in reading processes in pupils with Specific Language Impairment (SLI)

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