Total eclipse of the heart: the AM CVn Gaia14aae/ASSASN-14cn

We report the discovery and characterization of a deeply eclipsing AM CVn-system, Gaia14aae (=ASSASN-14cn). Gaia14aae was identified independently by the All-Sky Automated Survey for Supernovae (ASAS-SN; Shappee et al.) and by the Gaia Science Alerts project, during two separate outbursts. A third outburst is seen in archival Pan-STARRS-1 (PS1; Schlafly et al.; Tonry et al.; Magnier et al.) and ASAS-SN data. Spectroscopy reveals a hot, hydrogen-deficient spectrum with clear double-peaked emission lines, consistent with an accreting double-degenerate classification. We use follow-up photometry to constrain the orbital parameters of the system. We find an orbital period of 49.71 min, which places Gaia14aae at the long period extremum of the outbursting AM CVn period distribution. Gaia14aae is dominated by the light from its accreting white dwarf (WD). Assuming an orbital inclination of 90° for the binary system, the contact phases of the WD lead to lower limits of 0.78 and 0.015 M⊙ on the masses of the accretor and donor, respectively, and a lower limit on the mass ratio of 0.019. Gaia14aae is only the third eclipsing AM CVn star known, and the first in which the WD is totally eclipsed. Using a helium WD model, we estimate the accretor's effective temperature to be 12 900 ± 200 K. The three outburst events occurred within four months of each other, while no other outburst activity is seen in the previous 8 yr of Catalina Real-time Transient Survey (CRTS; Drake et al.), Pan-STARRS-1 and ASAS-SN data. This suggests that these events might be rebrightenings of the first outburst rather than individual events.

Hydrogel-forming microneedle arrays made from light-responsive materials for on-demand transdermal drug delivery

We describe, for the first time, stimuli-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically-relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micromolding. The obtained MN arrays showed good mechanical properties. The system was loaded with up to 5% (w/w) ibuprofen included in a light-responsive 3,5-dimethoxybenzoin conjugate. Raman spectroscopy confirmed the presence of the conjugate inside the polymeric MN matrix. In vitro, this system was able to deliver up to three doses of 50 mg of ibuprofen upon application of an optical trigger over a prolonged period of time (up to 160 hours). This makes the system appealing as a controlled release device for prolonged periods of time. We believe that this technology has potential for use in ?on-demand? delivery of a wide range of drugs in a variety of applications relevant to enhanced patient care.

Abdominal Aortic Aneurysm Genetic Associations: Mostly False? A Systematic Review and Meta-analysis

OBJECTIVE/BACKGROUND: Many associations between abdominal aortic aneurysm (AAA) and genetic polymorphisms have been reported. It is unclear which are genuine and which may be caused by type 1 errors, biases, and flexible study design. The objectives of the study were to identify associations supported by current evidence and to investigate the effect of study design on reporting associations.

METHODS: Data sources were MEDLINE, Embase, and Web of Science. Reports were dual-reviewed for relevance and inclusion against predefined criteria (studies of genetic polymorphisms and AAA risk). Study characteristics and data were extracted using an agreed tool and reports assessed for quality. Heterogeneity was assessed using I(2) and fixed- and random-effects meta-analyses were conducted for variants that were reported at least twice, if any had reported an association. Strength of evidence was assessed using a standard guideline.

RESULTS: Searches identified 467 unique articles, of which 97 were included. Of 97 studies, 63 reported at least one association. Of 92 studies that conducted multiple tests, only 27% corrected their analyses. In total, 263 genes were investigated, and associations were reported in polymorphisms in 87 genes. Associations in CDKN2BAS, SORT1, LRP1, IL6R, MMP3, AGTR1, ACE, and APOA1 were supported by meta-analyses.

CONCLUSION: Uncorrected multiple testing and flexible study design (particularly testing many inheritance models and subgroups, and failure to check for Hardy-Weinberg equilibrium) contributed to apparently false associations being reported. Heterogeneity, possibly due to the case mix, geographical, temporal, and environmental variation between different studies, was evident. Polymorphisms in nine genes had strong or moderate support on the basis of the literature at this time. Suggestions are made for improving AAA genetics study design and conduct.

Existence results for elliptic equations with singular terms

Esta dissertação estuda em detalhe três problemas elípticos: (I) uma classe de equações que envolve o operador Laplaciano, um termo singular e nãolinearidade com o exponente crítico de Sobolev, (II) uma classe de equações com singularidade dupla, o expoente crítico de Hardy-Sobolev e um termo côncavo e (III) uma classe de equações em forma divergente, que envolve um termo singular, um operador do tipo Leray-Lions, e uma função definida nos espaços de Lorentz. As não-linearidades consideradas nos problemas (I) e (II), apresentam dificuldades adicionais, tais como uma singularidade forte no ponto zero (de modo que um "blow-up" pode ocorrer) e a falta de compacidade, devido à presença do exponente crítico de Sobolev (problema (I)) e Hardy-Sobolev (problema (II)). Pela singularidade existente no problema (III), a definição padrão de solução fraca pode não fazer sentido, por isso, é introduzida uma noção especial de solução fraca em subconjuntos abertos do domínio. Métodos variacionais e técnicas da Teoria de Pontos Críticos são usados para provar a existência de soluções nos dois primeiros problemas. No problema (I), são usadas uma combinação adequada de técnicas de Nehari, o princípio variacional de Ekeland, métodos de minimax, um argumento de translação e estimativas integrais do nível de energia. Neste caso, demonstramos a existência de (pelo menos) quatro soluções não triviais onde pelo menos uma delas muda de sinal. No problema (II), usando o método de concentração de compacidade e o teorema de passagem de montanha, demostramos a existência de pelo menos duas soluções positivas e pelo menos um par de soluções com mudança de sinal. A abordagem do problema (III) combina um resultado de surjectividade para operadores monótonos, coercivos e radialmente contínuos com propriedades especiais do operador de tipo Leray- Lions. Demonstramos assim a existência de pelo menos, uma solução no espaço de Lorentz e obtemos uma estimativa para esta solução.

Estudo da variabilidade genética de marcadores moleculares ligados ao gene da MGP e sua aplicação para paternidades em Sparus aurata

Dissertação de Mestrado, Biologia Marinha, Especialização em Biotecnologia Marinha, Faculdade de Ciências do Mar e do Ambiente, Universidade do Algarve, 2008

Genetic characterization of the South Portugal population with GlobalFilerTM Express kit - internal validation and forensic applications

Tese de mestrado. Biologia (Biologia Humana e Ambiente). Universidade de Lisboa, Faculdade de Ciências, 2014

Enhancing Student Learning Experiences in Sport Psychology Modules Using Practical Activities

The University of Worcester states in its most recent strategic plan (2013 – 2018) a set of enduring values that guide and direct the activities of the institution. The first listed, and perhaps the most important value is the striving to be “an outstanding university at which to be a student”. This is further supplemented by values such as “to inspire our students to reach their full potential through excellent, innovative teaching, scholarship and research” (University of Worcester 2013: p.4). One of the many ways in which the institution strives to provide this outstanding educational experience is through regular engagement, both formal and informal, with students at a number of points in each semester. Regular experiences of collating formal and informal feedback has led to the identification of a common theme amongst Higher National Diploma (HND) students in the Institute of Sport and Exercise Sciences (ISES), where they consistently request ‘more practicals’. The ISES modules however are designed to incorporate a high degree of interaction, practical activities and tasks. This is especially important for those studying at HND level as research suggests differences in learning preferences exist when compared to undergraduate students, the former preferring a more tactile style of learning (Peters et al. 2008). Using an introductory Sport Psychology HND module as an example, practical activities and tasks are fully embedded in the taught sessions to enable contextual links to be made between the learning outcomes and their subsequent use. Examples of these include: a. interviewing athletes to produce a performance profile (Butler & Hardy 1992); b. completing psychometric instruments such as the Competitive State Anxiety Inventory-2 (CSAI-2) to measure competitive anxiety in sport (Martens et al. 1990) and demonstrate data collection and construct measurement; c. performing relaxation interventions on the students to demonstrate how specific techniques (in this instance, decreasing somatic anxiety) might work in practice; d. demonstrating how observational learning facilitates skill acquisition by creating experimental conditions that the students participate in, in teaching a new skill. Nevertheless owing to the students' previously stated on-going requests for more practical activities, it became evident that assumptions about what students consider an effective means of experiential or active learning in the context of sport-related disciplines of study needed to be investigated. This is where the opportunity to undertake an action research project arose, this being a practical method commonly employed in pedagogical enquiry to aid reflection on teaching and assessment practice for the purposes of working towards continuous improvement.

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.

Blood pressure loci identified with a gene-centric array.

Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies have identified 47 distinct genetic variants robustly associated with BP, but collectively these explain only a few percent of the heritability for BP phenotypes. To find additional BP loci, we used a bespoke gene-centric array to genotype an independent discovery sample of 25,118 individuals that combined hypertensive case-control and general population samples. We followed up four SNPs associated with BP at our p < 8.56 × 10(-7) study-specific significance threshold and six suggestively associated SNPs in a further 59,349 individuals. We identified and replicated a SNP at LSP1/TNNT3, a SNP at MTHFR-NPPB independent (r(2) = 0.33) of previous reports, and replicated SNPs at AGT and ATP2B1 reported previously. An analysis of combined discovery and follow-up data identified SNPs significantly associated with BP at p < 8.56 × 10(-7) at four further loci (NPR3, HFE, NOS3, and SOX6). The high number of discoveries made with modest genotyping effort can be attributed to using a large-scale yet targeted genotyping array and to the development of a weighting scheme that maximized power when meta-analyzing results from samples ascertained with extreme phenotypes, in combination with results from nonascertained or population samples. Chromatin immunoprecipitation and transcript expression data highlight potential gene regulatory mechanisms at the MTHFR and NOS3 loci. These results provide candidates for further study to help dissect mechanisms affecting BP and highlight the utility of studying SNPs and samples that are independent of those studied previously even when the sample size is smaller than that in previous studies.

No association between ApoE polymorphism and febrile seizures.

Seizures associated with fever are a common pediatric problem, affecting about 2-7 % of children between 3 months and 5 years of age. Differentiation of febrile seizures from acute symptomatic seizures secondary to central nervous system infections or seizures associated with fever in children with epilepsy is essential to provide appropriate treatment and follow-up care. Here, we tested the hypothesis that children who exhibit simple febrile seizures during early childhood, but do not develop epileptic seizures later in life, might preferentially carry the ApoE2 allele of the gene coding for the apolipoprotein E. We did not find any differences in the distribution of ApoE alleles or genotypes between individuals who exhibited simple febrile seizures (n = 93) and age-matched, typically developing subjects (n = 80). We found that the observed allele and genotype frequencies did not deviate from Hardy-Weinberg equilibrium, which suggests that the frequencies of ApoE alleles and genotypes are stable in the Swiss population from which our samples were derived. Across both groups of subjects (n = 173), we found an ApoE2 allele frequency of 0.064, an ApoE3 frequency of 0.829 and an ApoE4 frequency of 0.107. Our findings are consistent with previous reports of the distribution of ApoE polymorphism for European subjects free of any neurological disorders, and show that the different alleles of the gene coding for the apolipoprotein E are not associated with the occurrence of simple febrile seizures.

Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants.

One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age-standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are affecting the number of adults with diabetes. We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence-defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs-in 200 countries and territories in 21 regions, by sex and from 1980 to 2014. We also calculated the posterior probability of meeting the global diabetes target if post-2000 trends continue. We used data from 751 studies including 4,372,000 adults from 146 of the 200 countries we make estimates for. Global age-standardised diabetes prevalence increased from 4.3% (95% credible interval 2.4-7.0) in 1980 to 9.0% (7.2-11.1) in 2014 in men, and from 5.0% (2.9-7.9) to 7.9% (6.4-9.7) in women. The number of adults with diabetes in the world increased from 108 million in 1980 to 422 million in 2014 (28.5% due to the rise in prevalence, 39.7% due to population growth and ageing, and 31.8% due to interaction of these two factors). Age-standardised adult diabetes prevalence in 2014 was lowest in northwestern Europe, and highest in Polynesia and Micronesia, at nearly 25%, followed by Melanesia and the Middle East and north Africa. Between 1980 and 2014 there was little change in age-standardised diabetes prevalence in adult women in continental western Europe, although crude prevalence rose because of ageing of the population. By contrast, age-standardised adult prevalence rose by 15 percentage points in men and women in Polynesia and Micronesia. In 2014, American Samoa had the highest national prevalence of diabetes (>30% in both sexes), with age-standardised adult prevalence also higher than 25% in some other islands in Polynesia and Micronesia. If post-2000 trends continue, the probability of meeting the global target of halting the rise in the prevalence of diabetes by 2025 at the 2010 level worldwide is lower than 1% for men and is 1% for women. Only nine countries for men and 29 countries for women, mostly in western Europe, have a 50% or higher probability of meeting the global target. Since 1980, age-standardised diabetes prevalence in adults has increased, or at best remained unchanged, in every country. Together with population growth and ageing, this rise has led to a near quadrupling of the number of adults with diabetes worldwide. The burden of diabetes, both in terms of prevalence and number of adults affected, has increased faster in low-income and middle-income countries than in high-income countries. Wellcome Trust.

Registre de la sénéchaussée de Carcassonne, contenant principalement des lettres de saint Louis et de Philippe le Hardi.

Entré à la Bibliothèque du roi en 1732 parmi les mss. de Jean-Baptiste Colbert; cf. Delisle, Cab. des mss., I, 439-547; Omont, Concordances des mss. latins, 48-77; — n° 5 du "Catalogue des mss. envoyez par M. Boudon & portez dans la bibliotheque de Monseigneur le 10. decembre 1680... Registre de st Louis & de Philippe le Hardy"; cf. latin 9364, f. 53-54; Delisle, Cab. des mss, I, 473

De vitio proprietatis religiosorum.

F. 1-8 De vitio proprietatis religiosorum. « Jhesus, Maria, Franciscus. Sequitur... vicio proprietatis religiosorum » (titre effacé, lisible en partie à la lumière ultra-violette). « Manifestum videtur esse quod persone religiose viri et femine ordinem approbatum professe pro proprietatis vicio alligate nullo modo possint salvari... — ... nec continue. Vide Johannem Andree in regulam Non est obligatorium in novella super librum sextum et sic est finis ». F. 9-279 [BARTHOLOMAEUS DE RINONICO PISANUS] Liber de conformitatibus. « Incipit liber de conformitatibus beati Francisci quamvis plurimum breviatus tres partiales libros complectens... » (éd. dans Analecta franciscana sive chronica, IV-V, Quaracchi, 1906-1912). L. I, Conformitatum I-XII secundae partes : « Prima conformitas. Franciscus declaratur, expositio sequitur. Declarata prima parte primi fructus conformitatis que fuit de Christo (que [sic] ego pro nunc scribere non intendo sed solum que spectant ad beatum Franciscum etc.) manifestat nunc consequenter secundam partem ipsius enodare... — ... lucem Christum perveniamus. Amen. Sic ergo prelibatis apparet declarata secunda pars istius 12mi [sic] conformitatis videlicet Franciscus reserator... tam in isto duodecimo quam in precedentibus et subsequentibus conformitatibus sit laus Deo. Amen » (éd. cit., IV, 33-60, 69-82, 95-100, 108-113, 116-124, 138-149, 156-164, 175-364, 369-457, 464-485, 493-564, 580-632) (9-177v) ; — L. II, Conformitates I-XII, incomplet : « Incipit secundus liber et sequitur secunda pars prime conformitatis secundi libri videlicet Franciscus divulgatur. Expositio. Magister summus et verax... — ... patet ad fratres » (177v-224v), avec variantes et lacunes : Conformitas I, pars 2, incomplète de la fin par lacune matérielle (ibid., V, 10-13) (177v-178v) ; II et III, manquent par lacune matérielle ; IV, pars 2 (ibid., 100-123) (179-189) ; pars 1, fragm. (ibid., 97-100) (189-190v) ; V, texte abrégé (ibid., 123-144) (190v-199v) ; VI, pars 2, texte abrégé (ibid., 159-182) (199v-206) ; VII, pars 2, texte abrégé (ibid., 189-198) (206-208v) ; VIII, pars 2, texte abrégé (ibid., 208-211) (208v-209v) ; IX, texte abrégé (ibid., 211-226) (209v-213) ; X, pars 2 (ibid., 232-233) (213-214) ; XI, texte abrégé (ibid., 233-259) (214-224) ; XII, pars 2, texte abrégé (ibid., 275-277) (224-224v) ; — L. III, Conformitates I-IX, incomplet de la fin : « Incipit liber tercius de conformitate vite beati Francisci ad vitam Jhesu Christi. Fructus primus et conformitas et 2us in ordine Jhesus cum suis comedens, Franciscus emulatur. Expositio prime partis... Virtus illa et sapientia divina qua omnia a Deo fiunt... — ... ad orandum. Lc. XI in quo fuit captus... » (ibid., 333-459) (225-279). Ce texte a été aussi publié sous le nom de BARTHOLOMAEUS ALBISIUS PISANUS ; cf. Sbaralea, Supplementum, I, 114-117. Au contreplat supérieur, cote : « 87 » de l'inventaire après décès de Claude Hardy ; cf. ms. Latin 9363, f. 139. Acheté par Baluze pour la bibliothèque de Colbert ; cf. ibid., f. 145v et add. du ms. Latin 3114A.

Chronique de Normandie, jusqu'en 1217.

Contient : « Cy ensuivent les croniques de Normandie. Pour ce que ceulx de bonne voulenté qui tendent venir à honneur selon Dieu par vaillance et par hardement... » ; « ... cel an s'esmeurent les Chrestiens de toutes terres de Chrestienté à eulx croisier pour aler en Jherusalem conquerre [la Sainte Terre] »

Recueil de copies de pièces.

Contient : 1 « Processus summarius, cum arresto deffuncti domini ducis Alenconii. Anno 1458 ». En latin ; 2 « La Proposition des ambassadeurs de Philippes, duc de Bourgongne, pour monsieur d'Alençon, devant le roy » ; 3 « La Responce du roy [CHARLES VII] aux ambassadeurs de monsieur de Bourgongne, rendue par monseigneur de Constances, le quatorziesme septembre 1458, au chasteau de Vendosme » ; 4 « L'Arrest donné contre monsieur d'Allençon par l'advis du roy et de tous les princes, pairs et seigneurs de son conseil. assistans à ce jugement » ; 5 « Lettre de [FRANÇOIS, duc D']ANJOU, au Sr de Villeroy, secretaire d'Estat. 1579 » ; 6 Lettre de FRANÇOIS, duc D'ANJOU, à Henri III ; 7 « Lettre de [LOUIS DE BOURBON, duc] DE MONTPENSIER », au roi Henri III. « De Rennes, le douziesme jour de mars 1578 » ; 8 « Harangue prononcée à Londres, au conseil privé d'Angleterre, par messire BARNABE BRISSON, president au parlement de Paris, le neufviesme jour d'avril 1581 », sur le fait du mariage de la reine E???lizabeth d'Angleterre avec François, duc d'Anjou ; 9 « Articles de mariage d'entre la roine d'Angleterre et [François], duc d'Anjou » ; 10 « Advertissement sur la reception et publication du concille de Trente, par monseigneur DESPESSES, advocat du roy, 1583 » ; 11 « Littera missa ad [Sixtum Quintum pontificem] et data in collegio Sorbonae, anno 1590, die 29 aprilis ». En latin ; 12 « Arrest du conseil privé du roy du vingt quatriesme jour de septembre mil cinq cens soixante et trois, touchant le biffement de certain arrest du parlement de Paris » ; 13 « Extraict des registres de parlement, touchant le duc de Lorraine, demandeur en grace, l'an 1597 » ; 14 « Arrest contre ceux d'Orleans, aux premiers troubles. 1562 » ; 15 « Arrest de la cour de parlement contre Poltrot. 1562 » ; 16 « Arrest de la cour de parlement contre l'admiral, autre que celuy de l'an 1572, et plusieurs autres. 1562 » ; 17 « Arrest de la cour de parlement contre Robert de La Haye, Anthoine Fumée, Nicolle Compaing et autres, aux premiers troubles, 1562 » ; 18 « Autre Arrest de ladicte cour contre Geoffroy Vallée. 1574 » ; 19 « Arrest de la cour de parlement contre Nicollas Salcede, escuier, sieur d'Auvilliers en Normandie. 1582 » ; 20 « Arrest de ladicte cour de parlement contre deux sorciers de Berry. 1583 » ; 21 « Arrest de ladicte cour contre Anthoine Oudouart, dit le capitaine Michery. 1584 » ; 22 « Arrest de la cour de parlement contre Pierre Desquests, escuier, Sr de Belleville. 1584 » ; 23 « Autre Arrest de ladite cour contre un nommé Rangue Miraille, Italien, nigromant. 1587 » ; 24 « Arrest à l'encontre de Joseph Chasteau, dit Pierre Gillot, serviteur des Bianques. 1586 » ; 25 « Arrest des Bianques. 1586 » ; 26 « Arrest de la cour de parlement » contre « Me Nicolas Dadou, sodomite... 1586 » ; 27 « Arrest du prevost HARDY contre Marie Le Maire, meurtriere de la dame de L'Orme, pres St Gervais, sa maistresse. 1587 » ; 28 « Arrest de la cour de parlement contre Jehanne Jacquemain », accusée de « blasphemes... contre l'honneur du saint sacrement et de l'Eglise.... 1586 » ; 29 « Arrest de la cour de parlement contre Radegonde et Claude Foucault, heretiques. 1588 » ; 30 « Arrest de ladicte cour de parlement contre Pierre Guitet, trinitaire et anabaptiste. 1588 » ; 31 « Arrest donné en la chambre des monnoyes contre un faux monnoyeur condamné à estre bouilly. 1587 » ; 32 « Arrest notable, par lequel de vingt et deux editz que le roy avoit envoyez à la cour pour les publier, elle en a rebutté vingtz pour les causes y declarées. 1578 » ; 33 « Arrest prononcé le [29] juillet 1535 sur lettres patentes contre les accusez d'erreurs heretiques et sectes nouvelles, avec le plaidoyé de Me JACQUES CAPPEL, advocat du roy » ; 34 « Fait qualiffié pour un couppe bourse condamné à estre pendu. 1549 » ; 35 « Priere qui se faisoit tous les jours en la chambre de monsieur le prince » de Condé « par Me THEODORE DE BELZE, lorsque ledict prince tenoit la ville de Paris assiegée et qu'il estoit malade, en decembre 1562 » ; 36 « Priere des medecins de mons. le prince » de Condé « malade, qu'ilz faisoient en sa chambre avant que l'approcher » ; 37 « Lettre de monseigneur VIRET à madame la princesse de Condé, malade. 1564 » ; 38 « Arrest contre les Tarquetz et autres. 1554 » ; 39 « Arrest de la cour de parlement contre François Le Breton. 1586 » ; 40 « Arrest de la cour de parlement contre Jehan d'Alençon. Du [18] juillet 1474 » ; 41 « Arrest de la cour de parlement contre le connestable de Saint Paul. 1475 » ; 42 « Arrest de la cour de parlement contre messire Philippes de Commines. 1488 » ; 43 « Arrest de la cour de parlement contre Me Claude de Chauvreux, conseiller en ladicte cour, accusé de fausseté. 1496 » ; 44 « Arrest donné contre messire Jacques de Beaulne, general des finances. 1527 » ; 45 « Arrest de la cour de parlement, donné contre un escollier qui se faisoit appeller le cappitaine des Bouttefeux. 1557 » ; 46 « Arrest de declaration d'innocence de monsieur le prince de Condé. 1567 » ; 47 « Doleance que a faicte messire GILLES BOURDIN, procureur general du roy, sur la cruauté commise en la personne de Me Baptiste Sapin, en son vivant conseiller du roy en sa cour de parlement, le XII novembre 1562 » ; 48 « Arrest du parlement de Bordeaux contre le cardinal de Sourdis. Du [30] decembre 1606 » ; 49 « Dicton prononcé à la condemnation du comte Sebastiano de Montecucul[l]o, empoisonneur de feu monsieur le dauphin de France. 1536 » ; 50 « Arrest de la cour de parlement, donné contre le chancellier Poyet. 1545 » ; 51 « Coppie de la sentence prononcée contre Jacques Spifame, evesque de Nevers, à Geneve, et executé audit lieu, le 25 mars 1566 » ; 52 « Extrait d'un arrest de la cour de parlement de Paris, donné en l'année 1568 contre les regens et docteurs qui se trouverroient estre de la religion nouvelle. 1568 » ; 53 « Extraict des choses notables contenues en un registre de la cour de parlement, jugées et arrestées, depuis le mardy IXe aoust 1401 jusques au [21] decembre 1431 » ; 54 « Extraits de la chronique que l'on appelle scandaleuse » ; 55 « Extrait de la chronique de Saint Denis » ; 56 « Quelques Dattes d'années pour memoires » ; 57 « Les Ages des enfans du roy Henry second et de Catherine de Medicis, sa femme » ; 58 « Abjuration de Me Claude d'Espence, faite publiquement par luy dans l'eglise Saint Mederic, à Paris, le dimanche [22] juillet 1543 » ; 59 « Discours des raisons et persuasions de la paix. 1568 » ; 60 « Dialogue de Mercure et Proserpine, à l'imitation de ceux de Lucian, publié l'an 1591 » ; 61 « Lettre du roy HENRY [III] au comte de Montbeliart, peu apres sa blessure. 1589 » ; 62 « Discours de la mort et derniers propos du feu roy [Henri] troisiesme, en l'année 1589 » ; 63 « Coppie de la declaration envoyée à monseigneur le premier president de Harlay pour jurer et signer la Ligue » ; 64 « Response dudit sieur premier president au Sr de Brannivelli, qui luy avoit apporté ou envoyé la dite declaration » ; 65 « Extraict des registres du conseil general de l'union des catholiques ». 31 août 1589 ; 66 « Advis sur la bulle du pape Sixte [Quint], touchant la fulmination du roy de Navarre et du prince de Condé... 1585 » ; 67 « Discours sur la preseance debatue entre les roys d'Espagne et de France, faict par messire AUGUSTIN CRAVALLER, à Rome. 1586 » ; 68 « Response à ce que les François alleguent au contraire de ce que cy dessus a esté desduit » ; 69 « La derniere Demande des princes de la Ligue au roy. 1585 » ; 70 « Lettre de monseigneur le duc DE MAYENNE au roy. 1587 » ; 71 « Autre Lettre du duc DE MAYENNE au roy, pour excuse du rapt de la fille de La Vaugion, enlevée par luy, au retour de son voyage de Guyenne » ; 72 « Advis au roy de Navarre, sur l'estat de ce temps. [10] febvrier 1587 » ; 73 « Lettre de monseigneur DE LA GUESLE, procureur general, à monsieur de La Guesle, president, son pere, escrite de Paris à Chartres, le [25] juin 1587 » ; 74 « Testament de la roine mere CATHERINE DE MEDICIS. 1589 » ; 75 « Lettre du roy DE NAVARRE aux Suisses. 1585 » ; 76 « Discours de monseigneur TH. SIBILET, advocat en parlement, sur les affaires de l'année 1589 » ; 77 « Lettre escritte en Angleterre par un François, huguenot, à un autre François, huguenot, sur la conspiration faicte contre la roine [Élisabeth]. 1586 » ; 78 Mémoire sur « le combat des sieurs de Jarnac et de La Chastigneraye. 1547 » ; 79 « Coppie de la lettre escritte à monseigneur d'Espernon par monseigneur DE BELLIEVRE, en l'année 1595 » ; 80 « Lettre escritte de Lion par un serviteur du roy à un sien amy à Tours, du [11] febvrier 1594, contenant au vray ce qui s'est passé en la reduction de la ville en l'obeissance de Sa Majesté, les 7, 8 et 9 jour de febvrier 1594 » ; 81 « Extraict des principaux chefs d'accusation qui ont faict soulever le peuple de Lion contre le duc de Nemours et causé son emprisonnement » ; 82 « Discours envoyé de Brignolles, en Provence, sur un estrange accident advenu au mesme temps à monseigneur d'Espernon, et comme il en a esté garanty miraculeusement. 1595 »