Usage of substances and their dosage regimes in pharmacological animal models of schizophrenia

Background: Contrary to what is generally thought schizophrenia is a very common mental health issue. For this, several animal models are used to assess the illness in order to develop a definitive. The most widely spread paradigm is the use of pharmacological models. Aim: The aim of this review is to display which are the most used insults for the assessment of social behaviour related negative symptoms in animal models as well as to ascertain which is the most adequate regime. Design: Literature review. Methods: PubMed database was used for this article by the search of the indexed “schizophrenia”, “animal models”, “social behaviour” and “negative symptoms” descriptors. With the exception of a single article due to it value this review is based on articles from 10 years onwards. Besides, only clinical trials and reviews written in English or Spanish and that had laboratory rodents as target population were accepted. Results: The studies assessed agree that pharmacological models (specially those regarding the NMDA receptor antagonists) are a valuable means for the experimental investigation of negative symptoms in schizophrenia with the necessity to emphasise that only some negative symptoms (anhedonia and social interaction, mainly) can be experimentally assessed. Conclusions: There is not enough evidence regarding the fours aspects of this review. PCP, Ketamine or MK-801 in sub-acute dosage regimes are currently the most indicated insults to mimic schizophrenic symptoms in rodents, although further research in needed, albeit other substances are valuable as well. (In English language exclusively)

As razões do direito: um estudo da razão pública a partir do modelo liberal-igualitário de John Rawls

Em 1993, John Rawls, notável filósofo e professor da distinta Harvard University, publicou seu Political Liberalism, um livro em que pela primeira vez sintetiza sistematicamente o conceito de razão pública, uma ideia chave de sua teoria da justiça como equidade (justice as fairness). Segundo Rawls, a razão pública consiste fundamentalmente no modo e conteúdo adequados ao debate e à fundamentação de escolhas essenciais de justiça no espaço público de uma democracia constitucional. Nesse sentido, Rawls advoga que o único meio razoável de justificação da coerção estatal reside no reconhecimento e/ou obtenção de consensos (overlapping consensus) em relação às escolhas essenciais de uma sociedade democrática, o que só é possível se atores públicos e privados se despojarem de suas respectivas doutrinas filosóficas ou morais abrangentes ao debater e decidir tais questões essenciais de justiça. A presente dissertação tem por objetivo analisar a proposta de razão pública de Rawls, dentro do contexto de sua teoria da justiça como equidade, propondo-se a verificar se o pensamento rawlsiano procede no contexto jurídico-filosófico da pós-modernidade e se a sua teoria pode ser concretamente aplicada aos ordenamentos jurídicos contemporâneos, em especial no que tange ao conteúdo e pleno exercício da liberdade religiosa pelos cidadãos de um estado constitucional democrático.

Las competencias docentes del profesor de la Facultad de Filosofía de la Universidad Central del Ecuador y su incidencia en la calidad educativa

515 p.

Structural Synthesis of 3-DoF Spatial Fully Parallel Manipulators

In this paper, the architectures of three degrees of freedom (3-DoF) spatial, fully parallel manipulators (PMs), whose limbs are structurally identical, are obtained systematically. To do this, the methodology followed makes use of the concepts of the displacement group theory of rigid body motion. This theory works with so-called 'motion generators'. That is, every limb is a kinematic chain that produces a certain type of displacement in the mobile platform or end-effector. The laws of group algebra will determine the actual motion pattern of the end-effector. The structural synthesis is a combinatorial process of different kinematic chains' topologies employed in order to get all of the 3-DoF motion pattern possibilities in the end-effector of the fully parallel manipulator.

Certificación energética de la vivienda de Txomin Jauregui y proyecto de posibles mejoras.

[ES]Este trabajo tiene como objetivo principal la consecución de la calificación energética de la vivienda de Txomin Jauregui, y por consiguiente el estudio de las posibles mejoras que puedan llevarse a cabo en ella. Se trabajará con el programa informático CE3X y mediante un simple proceso se obtendrá el certificado. Una vez obtenida la calificación, se trabajará en las mejoras que puedan aplicarse para beneficio del propietario del inmueble. En este informe se recoge todo el proceso a seguir para obtener el certificado, las mejoras a aplicar y el nuevo certificado que se obtendrá tras la implantación de las mejoras. En los anexos se recoge información complementaria que facilitará la comprensión del proceso al lector de este documento.

Certificación energética y proyecto de posibles mejoras de la vivienda carretera Basurto-Castrejana 23 2ºB.

[ES]Se realizará la certificación energética de la vivienda sita en Ctra. Basurto-Castrejana 23 2ºB, mediante la herramienta CE3x, facilitada por el Gobierno de España. Se proyectarán, además, mejoras técnicas a implementar en el edificio para elevar su calificación energética, las cuales se analizarán tanto técnica como económicamente, eligiendo finalmente la solución óptima.

Insights into mechanism kinematics for protein motion simulation

Background: The high demanding computational requirements necessary to carry out protein motion simulations make it difficult to obtain information related to protein motion. On the one hand, molecular dynamics simulation requires huge computational resources to achieve satisfactory motion simulations. On the other hand, less accurate procedures such as interpolation methods, do not generate realistic morphs from the kinematic point of view. Analyzing a protein's movement is very similar to serial robots; thus, it is possible to treat the protein chain as a serial mechanism composed of rotational degrees of freedom. Recently, based on this hypothesis, new methodologies have arisen, based on mechanism and robot kinematics, to simulate protein motion. Probabilistic roadmap method, which discretizes the protein configurational space against a scoring function, or the kinetostatic compliance method that minimizes the torques that appear in bonds, aim to simulate protein motion with a reduced computational cost. Results: In this paper a new viewpoint for protein motion simulation, based on mechanism kinematics is presented. The paper describes a set of methodologies, combining different techniques such as structure normalization normalization processes, simulation algorithms and secondary structure detection procedures. The combination of all these procedures allows to obtain kinematic morphs of proteins achieving a very good computational cost-error rate, while maintaining the biological meaning of the obtained structures and the kinematic viability of the obtained motion. Conclusions: The procedure presented in this paper, implements different modules to perform the simulation of the conformational change suffered by a protein when exerting its function. The combination of a main simulation procedure assisted by a secondary structure process, and a side chain orientation strategy, allows to obtain a fast and reliable simulations of protein motion.

La desinstitucionalización escolar en la modernidad tardía. La escuela de los desheredados.

414 p.: graf.

Estudio de caso de Organización de Empresas: IBERDROLA y su Programa SAVIA

Fenómenos como la globalización y la tecnología traen consigo cambios que están alterando las reglas del juego en el mundo empresarial. La protagonista del panorama actual es la innovación y para trabajar en ello las claves del éxito son la motivación, el trabajo en equipo y un rol directivo que evolucione hacia el papel de Líder-Coach-Facilitador, afirmando la importancia de los factores organizacionales. Bajo estas premisas, a lo largo del documento se analizan las áreas organizativas de trabajo en equipo, de comunicación, de liderazgo y de motivación, reflejadas en una empresa referente como es IBERDROLA, que profundiza y recopila los aspectos mencionados en su modelo de competencias al que denomina Programa SAVIA. A partir de ahí y siguiendo el camino de la mejora continua, se plantearán unas propuestas personales.

CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels

Inhibition of the mitochondrial Na+/Ca2+ exchanger (NCLX) by CGP37157 is protective in models of neuronal injury that involve disruption of intracellular Ca2+ homeostasis. However, the Ca2+ signaling pathways and stores underlying neuroprotection by that inhibitor are not well defined. In the present study, we analyzed how intracellular Ca2+ levels are modulated by CGP37157 (10 mu M) during NMDA insults in primary cultures of rat cortical neurons. We initially assessed the presence of NCLX in mitochondria of cultured neurons by immunolabeling, and subsequently, we analyzed the effects of CGP37157 on neuronal Ca2+ homeostasis using cameleon-based mitochondrial Ca2+ and cytosolic Ca2+ ([Ca2+](i)) live imaging. We observed that NCLX-driven mitochondrial Ca2+ exchange occurs in cortical neurons under basal conditions as CGP37157 induced a decrease in [Ca-2](i) concomitant with a Ca2+ accumulation inside the mitochondria. In turn, CGP37157 also inhibited mitochondrial Ca2+ efflux after the stimulation of acetylcholine receptors. In contrast, CGP37157 strongly prevented depolarization-induced [Ca2+](i) increase by blocking voltage-gated Ca2+ channels (VGCCs), whereas it did not induce depletion of ER Ca2+ stores. Moreover, mitochondrial Ca2+ overload was reduced as a consequence of diminished Ca2+ entry through VGCCs. The decrease in cytosolic and mitochondrial Ca2+ overload by CGP37157 resulted in a reduction of excitotoxic mitochondrial damage, characterized here by a reduction in mitochondrial membrane depolarization, oxidative stress and calpain activation. In summary, our results provide evidence that during excitotoxicity CGP37157 modulates cytosolic and mitochondrial Ca2+ dynamics that leads to attenuation of NMDA-induced mitochondrial dysfunction and neuronal cell death by blocking VGCCs.

Suelos de habitación - suelos de corrales: los casos de Atxoste y Los Husos

[ES] La secuencia estratigráfica de un yacimiento arqueológico responde a dos variables relacionables, aportaciones naturales y actividades antrópicas: la conjunción de analíticas propias de la arqueología y la geología permite descifrar los caracteres de dicha sedimentación y reconocer su origen. Se han aplicado exámenes sedimentológicos y químicos a los yacimientos de Atxoste y Los Husos: por sus tipologías son representativos de la dinámica cultural habida a lo largo del Holoceno y sirven en la comprensión de la formación de yacimientos arqueológicos. Ligeros elementos constructivos y la distribución de los items arqueológicos han permitido, además, delomitar una cabaña adosada al abrigo en Atxoste y los cierres de un corral en el covacho de Los Husos.

Ignacio Barandiarán Maestu: una experiencia didáctica e investigadora de la prehistoria

Texto sometido a juicio de J. Fernández Eraso, M. García Díez, L. Zapata, A. Arrizabalaga, A. Tarriño y M. Aguirre, quienes han aportado ideas y correcciones de diversa índole (Grupo de Investigación Consolidado y de Alto Rendimiento: 9/UPV00155.130-14570/2002).

La circulación de materias primas líticas en la transición Mesolítico / Neolítico antiguo en el País Vasco. Los abrigos de Mendandia, Kanpanoste y Aizpea

Homenaje a Ignacio Barandiarán Maestu / coord. por Javier Fernández Eraso, Juan Santos Yanguas

Las ocupaciones rupestres en el fin de la Antigüedad. Los materiales cerámicos de Los Husos (Laguardia, Alava)

Homenaje a Ignacio Barandiarán Maestu / coord. por Javier Fernández Eraso, Juan Santos Yanguas.