Knowledge translation in men’s health research: development and delivery of content for use online

Background: Men can be hard to reach with face-to-face health-related information, while increasingly, research shows that they are seeking health information from online sources. Recognizing this trend, there is merit in developing innovative online knowledge translation (KT) strategies capable of translating research on men’s health into engaging health promotion materials. While the concept of KT has become a new mantra for researchers wishing to bridge the gap between research evidence and improved health outcomes, little is written about the process, necessary skills, and best practices by which researchers can develop online knowledge translation.
Objective: Our aim was to illustrate some of the processes and challenges involved in, and potential value of, developing research knowledge online to promote men’s health.

Methods: We present experiences of KT across two case studies of men’s health. First, we describe a study that uses interactive Web apps to translate knowledge relating to Canadian men’s depression. Through a range of mechanisms, study findings were repackaged with the explicit aim of raising awareness and reducing the stigma associated with men’s depression and/or help-seeking. Second, we describe an educational resource for teenage men about unintended pregnancy, developed for delivery in the formal Relationship and Sexuality Education school curricula of Ireland, Northern Ireland (United Kingdom), and South Australia. The intervention is based around a Web-based interactive film drama entitled “If I Were Jack”.

Results: For each case study, we describe the KT process and strategies that aided development of credible and well-received online content focused on men’s health promotion. In both case studies, the original research generated the inspiration for the interactive online content and the core development strategy was working with a multidisciplinary team to develop this material through arts-based approaches. In both cases also, there is an acknowledgment of the need for gender and culturally sensitive information. Both aimed to engage men by disrupting stereotypes about men, while simultaneously addressing men through authentic voices and faces. Finally, in both case studies we draw attention to the need to think beyond placement of content online to delivery to target audiences from the outset.

Conclusions: The case studies highlight some of the new skills required by academics in the emerging paradigm of translational research and contribute to the nascent literature on KT. Our approach to online KT was to go beyond dissemination and diffusion to actively repackage research knowledge through arts-based approaches (videos and film scripts) as health promotion tools, with optimal appeal, to target male audiences. Our findings highlight the importance of developing a multidisciplinary team to inform the design of content, the importance of adaptation to context, both in terms of the national implementation context and consideration of gender-specific needs, and an integrated implementation and evaluation framework in all KT work.

Molecular markers for predicting recurrence, progression and outcomes of bladder cancer (do the poster boys need new posters

Purpose of review
Molecular markers for bladder cancer recurrence and
progression continue to drive many research programmes.
Translating the laboratory findings into the clinical environment
where these markers are used in clinical decision making has
proved problematic. In the clinical arena, stage and grade are
still the main focus for decisions about patient management.
There is however an evolution in bladder cancer research from
single-marker/single-pathway research to a more global
assessment of the tumour cell with DNA microarrays and
proteomics.
Recent findings
In the last year, DNA microarray assessment has revealed
several interesting molecular markers such as p33ING1 and
DEK. Parallel ‘conventional’ single-pathway research has
focused on new novel markers such as HER2/neu, survivin and
matrix metalloproteinase 2 (MMP-2). Molecular markers that
have a long-standing association with bladder cancer
progression such as p53, E-cadherin and Ki-67 have been
reviewed by both single-marker studies and by microarray
studies and their status remains important.
Summary
It is an exciting time in the molecular biology research of bladder
cancer as the focus changes to assess the global genetic and
protein expression within tumour cells. From such a wealth of
information it is likely that molecular markers will make the
translation from benchside to bedside.

Translation as an Evaluative Concept

Testing the hypothesis that the concept of translation is evaluative rather than merely descriptive, Blumczyński analyses its increasingly popular use in three areas: political discourse, life writing and biomedical publications. He argues that translation as an evaluative concept is concerned with profound rather than superficial issues: to translate something is to assert its significance and value. At the same time, translation brings to the surface real and authentic things, producing its therapeutic value: it makes us more visible to ourselves, exposes pretences and thus brings relief. Finally, translation delivers on its own ethical imperative by breaking the spell of proverbial good intentions and bringing things to completion.

Novel opportunities for thymidylate metabolism as a therapeutic target

For over 40 years, the fluoropyrimidine 5-fluorouracil (5-FU) has remained the central agent in therapeutic regimens employed in the treatment of colorectal cancer and is frequently combined with the DNA-damaging agents oxaliplatin and irinotecan, increasing response rates and improving overall survival. However, many patients will derive little or no benefit from treatment, highlighting the need to identify novel therapeutic targets to improve the efficacy of current 5-FU-based chemotherapeutic strategies. dUTP nucleotidohydrolase (dUTPase) catalyzes the hydrolysis of dUTP to dUMP and PPi, providing substrate for thymidylate synthase (TS) and DNA synthesis and repair. Although dUTP is a normal intermediate in DNA synthesis, its accumulation and misincorporation into DNA as uracil is lethal. Importantly, uracil misincorporation represents an important mechanism of cytotoxicity induced by the TS-targeted class of chemotherapeutic agents including 5-FU. A growing body of evidence suggests that dUTPase is an important mediator of response to TS-targeted agents. In this article, we present further evidence showing that elevated expression of dUTPase can protect breast cancer cells from the expansion of the intracellular uracil pool, translating to reduced growth inhibition following treatment with 5-FU. We therefore report the implementation of in silico drug development techniques to identify and develop small-molecule inhibitors of dUTPase. As 5-FU and the oral 5-FU prodrug capecitabine remain central agents in the treatment of a variety of malignancies, the clinical utility of a small-molecule inhibitor to dUTPase represents a viable strategy to improve the clinical efficacy of these mainstay chemotherapeutic agents.

Traduzir Macau: a auto-referência como estratégia criativa

Traduzir Macau é uma proposta de trabalho que tem por base o auto-referencial como exercício de produção e de auto-reflexão. É um projeto que tem como estratégia o uso do relacionamento do processo criativo com a vivência, nomeadamente as expectativas e consequências da passagem pelo território de Macau a pretexto de uma exposição na Livraria Portuguesa. Ao investigar na arte o padrão auto-referencial, pretendeuse abrir uma perspectiva crítica e sensível de observação e análise da arte contemporânea.

Perception-based painterly rendering: funcionality and interface design

Painterly rendering (non-photorealistic rendering or NPR) aims at translating photographs into paintings with discrete brush strokes, simulating certain techniques (im- or expressionism) and media (oil or watercolour). Recently, our research into visual perception and models of processes in the visual cortex resulted in a new rendering scheme, in which detected lines and edges at different scales are translated into brush strokes of different sizes. In order to prepare a version which is suitable for many users, including children, the design of the interface in terms of window and menu system is very important. Discussions with artists and non-artists led to three design criteria: (1) the interface must reflect the procedures and possibilities that real painters follow and use, (2) it must be based on only one window, and (3) the menu system must be very simple, avoiding a jungle of menus and sub-menus. This paper explains the interface that has been developed.

French-greek machine translation of imperative sentences: issues in aspect and mood from a controlled language perspective

The present dissertation examines how grammatical aspect and mood are handled by machine translation (MT) systems within the scope of imperative sentences (orders, recommendations) when dealing with the language pair French-Greek (unidirectional, towards Greek). As the grammatical category of aspect is not expressed in the same way in both languages, choosing the correct aspect value when translating a verb from French to Greek can pose problems. We are interested in describing the types of errors that occur and their frequency in a corpus taken from texts pertaining to the security domain and from technical manuals, where imperative sentences are very common. In order to further delimit our research, our sample consists of sentences that comply with the general principles of simplicity and readability provided by several controlled language guidelines and aimed at higher translatability when having MT in mind. In a second phase, this study aims at discovering how modifying some of the control rules would help (or not) the MT systems better decide upon the translation of aspect and mood.

Estratégias e dificuldades dos alunos na tradução de problemas que envolvem equações : um estudo com alunos do 7.º ano de escolaridade

Relatório da prática de ensino supervisionada, Mestrado em Ensino da Matemática, Universidade de Lisboa, 2011

Motivos de beleza e amor no cancioneiro popular português e sérvio

Tese de doutoramento, Linguística (Linguística Aplicada), Universidade de Lisboa, Faculdade de Letras, 2014

O repertório cerâmico da sala nº 1(Vidigueira), na sequência Neolítico final e Calcolítico do Alentejo Médio

O trabalho aqui proposto tem como objectivo central, a realização de análises ao conjunto dos recipientes cerâmicos pertencentes ao povoado da Sala nº1. Repertório esse, que se baseou no acervo retirado do sítio arqueológico Sala nº1, intervencionado pelo Professor Victor S. Gonçalves (1988, 1989 e 1995). As análises e descrições efectuadas foram sempre norteadas para a tentativa de estabelecer uma sequência de formas que se pudesse verificar quanto à sua normalização e frequência nos contextos presentes ao povoado da Sala nº1. Traduzindo nessa realidade, a diacronia transversal entre os estratos arqueológicos pertencentes ao Neolítico final e os estratos pertencentes ao Calcolítico. Tendo sempre como parâmetros de análise, as metodologias e critérios descritivos dos recipientes cerâmicos, presentes nos trabalhos publicados sobre as realidades cronológicas semelhantes no Sul de Portugal. O próprio conjunto de recipientes cerâmicos aqui analisado foi submetido a essas metodologias, com fim de obter primordialmente as formas e as tipologias a que pertencem. Nesse sentido procurei criar um quadro de referência local e regional, e posteriormente coloca-lo num enquadramento geral do Neolítico final e início do Calcolítico do Alentejo Médio, tentando verificar as similitudes nos quadros tipológicos existentes, como os estabelecidos por Carlos Tavares da Silva e Joaquina Soares. Sendo este um estudo que abrange um tempo cronológico de praticamente 1500 anos, premiei através da amplitude dos contornos que moldaram esta análise, algumas perspectivas possíveis. Quer ao nível das tipologias, quer ao nível das estratégias de ocupação do território, aplicáveis para o espaço e o tempo em análise. Verificando a realidade escassa nos contextos alentejanos (publicados), em que a cultura material se integra numa estratigrafia e cronologias com uma diacronia semelhante à do povoado da Sala nº1. Tentei integrar este povoado num estudo que não sendo comparativo, tivesse essa componente em relação às tipologias e formas cerâmicas identificadas. Procurou-se dar enfase à realidade artefactual das taças carenadas, e à sua possível evolução para formas mais adaptáveis ao uso e consumo quotidiano das comunidades contemporâneas das fases Calcolíticas do povoado.

Why are we Waiting? Research, Policy and Practice in Recruiting and Supporting Same Gender Couples in Child Adoption

The adoption process is renowned for its difficulties, however gay and lesbian couples face unique, additional challenges when choosing parenthood through adoption. The Adoption and Children’s Act (2002), Equality Act (2006) and the Sexual Orientation Regulations act (2007) are some of the recent policy changes aimed at ‘smoothing out’ the adoption process for same-gender couples (Cosis-Brown & Kershaw, 2008). Resultantly, there appear to be more cases of gay adoption than ever before (Equality Britain, 2005), however, anecdotal evidence suggests that across the UK the practice of recruiting and supporting gay and lesbian adopters is inconsistent. Whilst some local authorities encourage and emphasise the importance of stability and high quality care for vulnerable looked after children regardless of parental sexuality (Mallon, 2007); yet case studies of gay and lesbian couples seeking adoption demonstrate the unique challenges they encounter in the adoption process because of religious views (Hicks, 2005) or the attitudes towards same gender parenting of adoption panels and social workers within an unspoken hierarchy (Ahmed, 2008; Dennis, 2006). Government’s drive towards adoption (Unwin and Misca, 2013) of children in care as a favoured alternative should lead to recognition of same-gender couples as an under-utilised resource of potential adopters to be used in the best interest of the children who are looked after. The poster will present the results of research undertaken by the authors during 2012-13 highlighting how research on same-gender parenthood over the past decades has influenced the recent developments in the adoption policy and practice in the UK and worldwide. The poster will identify areas of potential barriers encountered in translating these policy changes in the current practice of adoption with a particular focus on professionals’ attitudes towards same-gender couples as potential adopters.

A aprendizagem da função afim no 8º ano : uma proposta apoiada nas tecnologias e na educação financeira

Trabalho de projeto de mestrado, Educação (Área de especialidade em Didática da Matemática), Universidade de Lisboa, Instituto de Educação, 2015

A programação linear no 11º ano : estratégias e dificuldades na resolução de problemas

Relatório da Prática de Ensino Supervisionada, Mestrado em Ensino da Matemática, Universidade de Lisboa, 2015