System-wide approaches to uncover Th2 cell lineage commitment

T helper (Th) cells are vital regulators of the adaptive immune system. When activated by presentation of cognate antigen, Th cells demonstrate capacity to differentiate into functionally distinct effector cell subsets. The Th2 subset is required for protection against extracellular parasites, such as helminths, but is also closely linked to pathogenesis of asthma and allergies. The intracellular molecular signal transduction pathways regulating T helper cell subset differentiation are still incompletely known. Moreover, great majority of studies regarding Th2 differentiation have been conducted with mice models, while studies with human cells have been fewer in comparison. The goal of this thesis was to characterize molecular mechanisms promoting the development of Th2 phenotype, focusing specifically on human umbilical cord blood T cells as an experimental model. These primary cells, activated and differentiated to Th2 cells in vitro, were investigated by complementary system-wide approaches, targeting levels of mRNA, proteins, and lipid molecules. Specifically, the results indicated IL4-regulated recruitment of nuclear protein, and described novel components of the Th2-promoting STAT6 enhanceosome complex. Furthermore, the development of the activated effector cell phenotype was found to correlate with remodeling of the cellular lipidome. These findings will hopefully advance the understanding of human Th2 cell lineage commitment and development of Th2-associated disease states.

De-escalation of commitment management strategy in IT project management methodology: case of ERP implementation project by IT consulting company

According to several surveys and observations, the percentage of successfully conducted IT projects without over-budgeting and delays in time schedule are extremely low. Many projects also are evaluated as failures in terms of delivered functionality. Nuldén (1996) compares IT projects with bad movies; after watching for 2 hours, one still tries to finish it even though one understands that it is a complete waste of time. The argument for that is 'I've already invested too much time to terminate it now'. The same happens with IT projects: sometimes the company continues wasting money on these projects for a long time, even though there are no expected benefits from these projects. Eventually these projects are terminated anyway, but until this moment, the company spends a lot. The situation described above is a consequence of “escalation of commitment” - project continuation even after a manager receives negative feedback of the project’s success probability. According to Keil and Mähring (2010), even though escalation can occur in any type of project, it is more common among complex technological projects, such as IT projects. Escalation of commitment very often results in runaway projects. In order to avoid it, managers use de-escalation strategies, which allow the resources to be used in more effective. These strategies lead to project termination or turning around, which stops the flow of wasted investments. Numbers of researches explore escalation of commitment phenomena based on experiments and business cases. Moreover, during the last decade several frameworks were proposed for de-escalation strategy. However, there is no evidence of successful implementation of the de-escalation of commitment strategy in the literature. In addition, despite that fact that IT project management methodologies are widely used in the companies, none of them cover the topic of escalation of commitment risks. At the same time, there are no researches proposing the way to implement de-escalation of commitment strategy into the existing project management methodology The research is focused on a single case of large ERP implementation project by the consulting company. Hence, the main deliverables of the study include suggestions of improvement in de-escalation methods and techniques in the project and in the company. Moreover, the way to implement these methods into existing project management methodology and into the company general policies is found.

Palkan ulkopuoliset palkitsemiskeinot ja niiden vaikutus henkilöstön sitoutumiseen ja motivaatioon

This paper examines the rewarding models (excluding salary) used by Finnish companies, and their affect on the personnel's motivation and commitment. Both intrinsic and extrinsic motivation are examined. Both employers and employees have been interviewed. The results show that by using intangible rewarding methods, the employers can affect the employees' intrinsic motivation, and the employees find this kind of rewarding preferable.

Henkilöstön sitoutuminen muutoksessa - Case: Etelä-Karjalan sosiaali- ja terveyspiiri

Tutkimuksen tarkoituksena oli selvittää, mitkä tekijät vaikuttavat henkilöstön sitoutumiseen muutoksessa. Tutkimuksen teoriaosiossa käsitellään ensiksi muutossitoutumista vahvistavia ja siinä huomioitavia tekijöitä muutosprosessissa onnistuneen muutosjohtamisen kautta, jonka jälkeen syvennytään niihin tekijöihin jotka erityisesti vaikuttavat henkilöstön muutossitoutumiseen. Tutkimuksen empiirisen aineiston muodostivat Etelä-Karjalan sosiaali- ja terveyspiirin ikäihmisten palveluiden kolmentoista henkilön haastattelut. Henkilöistä kymmenen toimi työntekijätehtävissä, kaksi lähiesimiestehtävissä sekä yksi johtoryhmässä. Haastatteluaineisto kerättiin sekä analysoitiin laadullisella tutkimusmenetelmällä. Tutkimustulokset osoittavat, että henkilöstön muutossitoutumiseen vaikuttivat eniten viestintä sekä sen ilmeneminen case-organisaation muutosprosessissa. Kaikki puutteet ja onnistuneisuudet muutosjohtamisessa kiteytyivät viestintään; henkilöstön muutossitoutumisen kannalta erityisesti esimiehen hallitsemaan viestintään ja muutosjohtajuuteen. Muutosviestinnän ollessa onnistunutta se vahvisti selkeästi henkilöstön luottamusta muutosprosessin vaiheissa ja näin lisäsi muutokseen sitoutumista.

Supplier codes of conduct: Acting responsibly in global supply chains

Nowadays the Western companies are considered responsible for the social and environmental issues in their whole supply chains. To influence the practices of their suppliers the Western companies have created suppliers codes of conduct (SCCs) which express their requirements. Suppliers’ compliance with the SCCs is checked through audits. The purpose of this thesis is to analyze SCCs as a means for Western companies to ensure socially and environmentally responsible actions in their global supply chains, and the sub-objectives are to find out 1) how well do the SCCs and their auditing work at suppliers’ production sites and 2) how can possible problems related to SCCs and their auditing be solved. This is a qualitative research carried out in the form of a case study with two case companies. In this study both primary and secondary data is used. The primary data is collected in the form of interviews of the case company representatives and three external experts. Based on a theoretical framework of previous research in the fields of corporate social responsibility and supply chain management, a model with eleven factors, which influence the success of SCC implementation and the auditing of SCC –implementation, is drafted. Also several different best-practices to help to solve and avoid possible problems related to SCC -implementation and auditing have been identified from previous research. Based on the findings of this study the theoretical model has been updated adding two new influential factors. It seems that how well the SCC and its auditing work at suppliers’ production sites depends on the joint effect of thirteen influential factors: buyer’s purchasing policy, supplier’s motivation, buyer’s commitment, the solving of agency problems, the contents of the SCC, supplier’s role and the buyer-supplier –relationship, complexity of supply chain, the limitations of the smaller buyers, cooperation through a business association or multi-stakeholder system, the role of supplier’s employees, SCC –related communication and supplier’s understanding, cheating in audits and the auditors. The possible problems related to SCCs and their auditing can be solved by adopting best-practices. Nine of the theoretical best-practices stand out from the findings of this study: 1) two-way communication and collecting feedback from suppliers, 2) the philosophy of continuous improvement, 3) long-term business relationships with the supplier, 4) informing the supplier about the advantages of SCC –compliance, 5) rewarding code-compliant suppliers, 6) building collaborative, good buyer-supplier relationships, 7) supporting and advising the supplier, 8) joining a business association or multi-stakeholder system and 9) interviewing supplier’s employees as a part of the audits.

Ei-henkilöityvän organisatorisen luottamuksen merkitys YT-neuvotteluja läpikäyvän kuntaomisteisen ICT-palveluyhtiön toiminnassa

Tutkimuksessa tarkasteltiin mikä on ei-henkilöityvän organisatorisen luottamuksen merkitys yrityksen toiminnassa ja voidaanko ei-henkilöityvää organisatorista luottamusta jälleenrakentaa ja kehittää yrityksessä, joka parhaillaan käy YT-neuvotteluita. Tutkimusongelmaa lähestyttiin ei-henkilöityvän organisatorisen luottamuksen viitekehyksen kautta. Tutkimus toteutettiin kvalitatiivisena tapaustutkimuksena kuntaomisteisessa ICT-palveluyhtiössä. Kvalitatiivinen tutkimusaineisto kerättiin puolistrukturoidulla teemahaastattelukyselylomakkeella ja vastaukset analysoitiin sisällönanalyysimenetelmällä. Tutkimuksessa saatujen tulosten perusteella yrityksen henkilöstön kokemalla ei-henkilöityvällä organisatorisella luottamuksella yritystä kohtaan on yhteys työntekijöiden työmotivaation, työtehokkuuteen ja sitoutumiseen ja vaikutus yrityksen toimintaan. Luottamuksen jälleenrakentaminen ja kehittäminen organisaatiossa edellyttävät toimenpiteitä yrityksen johdolta.

The advantages and disadvantages of logistics centralization and decentralization from employee’s perspective

Tämän tutkimuksen tarkoituksena on havainnoida keskittämisen ja hajauttamisen hyötyjä ja haittoja logistiikassa, ja selventää mitä tekijöidä tulee huomioida näiden kahden rakenteen väliltä valitessa. Tutkimus kokoaa molempien rakenteiden hyödyt ja haitat hyödyntämällä sekä haastateltujen työntekijöiden osaamista ja mielipiteitä että aiheeseen liittyvää kirjallisuutta. Päätavoitteena on lisätä ymmärrystä siitä, miten organisaatiorakenne vaikuttaa logistiseen toimintaan.

Commitment in Finnish–Japanese strategic alliances

Finnish companies have usually formed a strategic alliance as entry mode when entering the Japanese market. However, these strategic alliances have not been studied in a general level and it remains unknown, what kind cooperation the Finnish companies are operating with their Japanese partners. Especially Finnish companies that aims to penetrate the Japanese market are eager to know more about this. The recent studies on topic have focused on a single industry or company and that is why more general level study was needed. The purpose of this study is to analyze types of Finnish–Japanese strategic alliances from the Finnish point of view. The analysis is conducted by answering the questions what strategic alliance types appear in the strategic alliances between Japanese and Finnish companies, and how commitment affects strategic alliance type. This study also examines how committed Finnish–Japanese strategic alliances are. In this study multiple case study was selected as research method. The data is collected by interviewing six representative of Finnish companies in Japan individually. Multiple case study was chosen for this study, because this study is interested in the topic in general level and this research method is suitable for this kind of research. From the interviews common attributes were pointed out and from them the big picture of the topic was created. Types of strategic alliances were determined by using previous literature on that topic. Two different types of strategic alliance were discovered: supplier alliance which is the most common one and learning alliance. The commitment of strategic alliance was measured visually by utilizing a figure that was modified for this study.The figure is originally based on earlier studies on strategic alliance types and their connection to ownership and commitment. By utilizing the figure it was noticed that commitment affects strategic alliance types: the more there is commitment involved, the more there is cooperation. Finnish–Japanese strategic alliances are not very committed despite they have existed for a long time. However, there is potential to be more committed. That is why Finnish companies should increase the commitment and attract the partners to develop the strategic alliances, because it would possible increase competitive advantage. This would be beneficial to all members within the strategic alliance.

Myymälähenkilöstön sitoutuminen ja motivaatio kohdeorganisaatiossa

Tutkielman tavoitteena oli selvittää myymälähenkilöstön sitoutumiseen ja motivointiin vaikuttavia tekijöitä. Tarkoituksena oli löytää keinoja, joilla organisaatio voisi motivoida työntekijöitä parempaan suoriutumiseen ja joilla vahvistaa henkilöstön sitoutumista organisaatioon. Empiirinen tutkimus toteutettiin kvalitatiivisella tapaustutkimusmenetelmällä ja tukitusmetodina käytettiin teemahaastattelua. Haastateltava otosryhmä koostui kohdeorganisaation myymälähenkilöstön työtekijöistä. Tutkimuksessa saatiin selville, että työntekijöiden sitoutumisen tasoon selkeimmin vaikuttavat tekijät ovat kannustava työilmapiiri, luottamusta rakentava viestintä ja työntekijän kuunteleminen esimiestyössä. Motivaation osalta tärkeimmiksi vaikuttajiksi tutkimuksessa nousi positiivinen ilmapiiri ja oikeudenmukainen palkitseminen.

CSR and CSR communication’s effect on prospective employees

The aim of this Master’s Thesis was to examine whether corporate social responsibility and CSR communication has effect on company’s image in the eyes of 18-25 year olds young job seekers and thus study young adults perceptions on these issues. By utilizing previous academic literature a through picture of the main topics was built and by conducting quantitative research, research’s aim was sought to answer. The framework defines the link between research’s main concepts corporate image, CSR and CSR communication and how this can lead to attracting prospective employees. A quantitative research method was applied and an online survey was sent to people whom had applied for L&T by June during the year 2015. Out of these people, those who were aged 18-15 and had vocational education were qualified to answer the survey. The data was analyzed by utilizing statistical analysis and causal relationships were found though which the explanation of perceptions and impacts was possible. The results showed that young adults are influenced by CSR and CSR communication and thus these factors have an impact on prospective employees.

Suorituskyvyn johtaminen metalliteollisuuden yrityksessä

Tutkimuksen tavoitteena on selvittää, mitkä tekijät ovat tärkeimpiä yrityksen suorituskyvyn johtamisessa metalliteollisuusyrityksessä. Tavoitteena on myös löytää tekijät, joilla henkilökunta saadaan motivoitua ja sitoutettua yrityksen toimintaan. Lisäksi tavoitteena on saada selvitettyä kohdeyrityksen suorituskyvyn johtamisen nykytila. Tutkimus on empiirinen tutkimus, jossa käytetään kvantitatiivista eli määrällistä analyysia. Tutkimuksen teoreettisessa osuudessa tarkastellaan tutkimuksen aihetta perehtymällä aikaisempiin tutkimuksiin ja kirjallisuuteen. Kohdeyrityksen nykytilan kartoituksessa käytettiin valmista SUMO-kartoitusta, joka mittaa työmotivaation ja toiminnan tehostumisen taustalla vaikuttavia tekijöitä. Suorituskyvyn menestyksellinen johtaminen metalliteollisuusyrityksessä vaatii toimivaa suorituskyvyn mittaamisjärjestelmää, jota analysoimalla pystytään tekemään päätöksiä tulevaisuuden toimenpiteistä. Suorituskyvyn mittaaminen pitäisi lisäksi kytkeä palkitsemiseen. Työntekijöiden työmotivaatioon ja sitoutumiseen voidaan vaikuttaa monella tapaa. Työmotivaatioon ja sitoutumiseen vaikuttavat työntekijöiden vaikutus- ja koulutusmahdollisuudet sekä palkitseminen, viestintä ja tavoitteet. Näiden tekijöiden luomisessa johtaminen on avainasemassa.

Commitment in Finnish–Japanese strategic alliances

Finnish companies have usually formed a strategic alliance as entry mode when entering the Japanese market. However, these strategic alliances have not been studied in a general level and it remains unknown, what kind cooperation the Finnish companies are operating with their Japanese partners. Especially Finnish companies that aims to penetrate the Japanese market are eager to know more about this. The recent studies on topic have focused on a single industry or company and that is why more general level study was needed. The purpose of this study is to analyze types of Finnish–Japanese strategic alliances from the Finnish point of view. The analysis is conducted by answering the questions what strategic alliance types appear in the strategic alliances between Japanese and Finnish companies, and how commitment affects strategic alliance type. This study also examines how committed Finnish–Japanese strategic alliances are. In this study multiple case study was selected as research method. The data is collected by interviewing six representative of Finnish companies in Japan individually. Multiple case study was chosen for this study, because this study is interested in the topic in general level and this research method is suitable for this kind of research. From the interviews common attributes were pointed out and from them the big picture of the topic was created. Types of strategic alliances were determined by using previous literature on that topic. Two different types of strategic alliance were discovered: supplier alliance which is the most common one and learning alliance. The commitment of strategic alliance was measured visually by utilizing a figure that was modified for this study. The figure is originally based on earlier studies on strategic alliance types and their connection to ownership and commitment. By utilizing the figure it was noticed that commitment affects strategic alliance types: the more there is commitment involved, the more there is cooperation. Finnish–Japanese strategic alliances are not very committed despite they have existed for a long time. However, there is potential to be more committed. That is why Finnish companies should increase the commitment and attract the partners to develop the strategic alliances, because it would possible increase competitive advantage. This would be beneficial to all members within the strategic alliance.