Cartulaire de l'abbaye de Bourbourg (dioc. de Thérouanne).

Acquis le 21 avril 1800 par envoi du préfet du Nord; cf. Delisle, Cab. des mss., II, 32

« Mémoires du droit particulier du Roy sur les villes et chastellenies de Dunquerque, Bourbourg et Gravelines », sur la « dignité du chastelain de Lille en Flandre, et les droits qui appartiennent au Roy en ceste qualité », comprenant une « généalogie des seigneurs possesseurs de ces villes et chastelains jusques à présent, avec le mémoire des terres alliénées aux Pays-Bas de l'ancien domaine de Navarre », par Georges GALLAND.

En 22 chapitres. — Aux feuillets 5-6, carte gravée : « Flandriae pars occidentalis... ; Amstelodami, sumptibus Henrici Hondii. » — Aux feuillets 46-47, autre carte gravée : « Flandria gallica, continens castellanias Insulensem, Duacensem, Orchianensem, civitatem dominiumque Tornacense... ; Amstelodami, Joannes Janssonius. » — Les feuillets 7-9, 59, 60, et les notes marginales sont de la main de Georges Galland. Table des chapitres en tête du volume.

Nouveau manuel complet du brasseur ou L'art de faire toutes sortes de bières : contenant les procédés de cet art tels qu'ils sont usités en Angleterre, en Allemagne et en France... /

Mode of access: Internet.

Quantum theory of the far-off-resonance continuous-wave Raman laser: Heisenberg-Langevin approach

We present the quantum theory of the far-off-resonance continuous-wave Raman laser using the Heisenberg-Langevin approach. We show that the simplified quantum Langevin equations for this system are mathematically identical to those of the nondegenerate optical parametric oscillator in the time domain with the following associations: pump pump, Stokes signal, and Raman coherence idler. We derive analytical results for both the steady-state behavior and the time-dependent noise spectra, using standard linearization procedures. In the semiclassical limit, these results match with previous purely semiclassical treatments, which yield excellent agreement with experimental observations. The analytical time-dependent results predict perfect photon statistics conversion from the pump to the Stokes and nonclassical behavior under certain operational conditions.

Frequent MAGE mutations in human melanoma.

Abstract: Background: Cancer/testis (CT) genes are expressed only in the germ line and certain tumors and are most frequently located on the X-chromosome (the CT-X genes). Amongst the best studied CT-X genes are those encoding several MAGE protein families. The function of MAGE proteins is not well understood, but several have been shown to potentially influence the tumorigenic phenotype. Methodology/Principal Findings: We undertook a mutational analysis of coding regions of four CT-X MAGE genes, MAGEA1, MAGEA4, MAGEC1, MAGEC2 and the ubiquitously expressed MAGEE1 in human melanoma samples. We first examined cell lines established from tumors and matching blood samples from 27 melanoma patients. We found that melanoma cell lines from 37% of patients contained at least one mutated MAGE gene. The frequency of mutations in the coding regions of individual MAGE genes varied from 3.7% for MAGEA1 and MAGEA4 to 14.8% for MAGEC2. We also examined 111 fresh melanoma samples collected from 86 patients. In this case, samples from 32% of the patients exhibited mutations in one or more MAGE genes with the frequency of mutations in individual MAGE genes ranging from 6% in MAGEA1 to 16% in MAGEC1. Significance: These results demonstrate for the first time that the MAGE gene family is frequently mutated in melanoma.

Human babesiosis in Europe

Human babesiosis in Europe came to medical attention in 1957 and until now 19 cases have been reported, most of them due to Babesia divergens. The onset of the disease is characterized by hemoglobinuria, high fever and renal failure ensue rapidly. The patients were generally asplenic and resident in a rural area. Intraerythrocytic pleomorphic parasites (1-3 µm) observed in stained thin blood smears are essential for Genus diagnosis. Parasitemia varyed from 5 to 80% of red blood cells. Massive blood exchange transfusion (2-3 blood volumes) followed by intravenous clindamycine (3-4 times daily) and oral quinine (600 mg base, 3 times daily) were successfully used in the treatment of three recent cases. Splenectomised individuals should be aware for prevention.