La historia de la ciencia en los libros de texto : la(s) hip??tesis de Avogadro

Resumen tomado de la revista

Propuesta curricular de hip??tesis de progresi??n para conceptos estructurantes de ecolog??a

Resumen en ingl??s

El papel de la pr??ctica en el desarrollo de la competencia motriz infantil : la hip??tesis de la variabilidad

Se aplica la hip??tesis de la variabilidad al practicar en el aprendizaje motor infantil de la teor??a del esquema de R. Achmidt. Se estructura en tres partes. En la primera se revisan los diferentes modelos explicativos del desrrollo motor. En la segunda se analiza la Teor??a del esquema de Richard Schmidt y su hip??tesis de variabilidad al practicar. En la tercera se presentan diferentes estudios experimentales a partir de los supuestos evaluados en las otras dos partes. Se analizan diferentes aspectos de la variabilidad al practicar (parametros variados, tipo de organizaci??n). Se estudia el papel de las estrategias instructivas aunadas a la pr??ctica variable aleatoria. Investigaci??n cuantitativa y cualitativa. Los resultados apoyan la hip??tesis de Schmidt y destacan la importancia de la organizaci??n de la pr??tica variable en la infancia. Se sugieren propuestas de actuaci??n para el futuro.

Aplicaci??n del m??todo Bootstrap al contraste de hip??tesis en la investigaci??n educativa

Resumen del autor. Resumen en castellano e ingl??s. Este art??culo se incluye en el monogr??fico 'Educaci??n social'

Una hip??tesis sobre las Novelas Ejemplares

An??lisis de la afinidad y concordancia entre las Novelas Ejemplares con las obras esc??nicas de Cervantes. Se baraja la posibilidad de que las Novelas Ejemplares sean antiguas comedias de Cervantes, que m??s tarde ??ste refundi?? en prosa para adaptarlas al gusto de la ??poca.

Contraste de la hip??tesis de se??alizaci??n : una panor??mica

Resumen basado en el de la publicaci??n. Notas a pie de p??gina

Hip Hop Lab : educación a través del arte y la cultura urbanos.

Resumen basado en el de la publicación. - El articulo forma parte de una sección de la revista dedicada a creatividad y educación

Hip hop en el aula

Bibliograf??a al final del art??culo

El giro pedag??gico en la investigaci??n sobre la transferencia interling????stica : repasando las hip??tesis de interdependencia y del umbral ling????stico

Resumen basado en el de la publicaci??n

El cambio que rima. Creando espacios alternativos de contestación cultural desde el hip hop. Estudio del caso de raperos de El Alto y La Paz

A través de este trabajo se pretende comprender cómo se construye un espacio de contestación cultural y político desde una expresión artística como rap, que para aquellos que son sus seguidores, es parte de la “cultura Hip Hop”. Para cumplir este objetivo, el presente estudio desarrolla en el primer capítulo una recapitulación metodológica del camino trazado, es decir la explicación de las técnicas, herramientas y enfoques desde los que se trataron el tema, y por qué éstas se eligieron. En el segundo capítulo se da una breve reseña sobre el movimiento de rap a nivel mundial y nacional para luego concretar el desarrollo del movimiento en La Paz y El Alto. Finalmente, el tercer capítulo pretende mostrar el camino que une a los raperos con el público. Este es el eje del último capítulo, pues a través del presente documento, se plantea la relación entre músicos, activistas o artistas, con un público determinado. Esta tesis es una forma de entender cómo jóvenes de distinta procedencia y visiones sobre la vida, actúan en su sociedad y hablan de su realidad creando espacios de contestación que interpelan y responden a hechos concretos que afectan su cotidianeidad.

Proteomic analysis of resting and thrombin-stimulated platelets reveals the translocation and functional relevance of HIP-55 in platelets

The platelet surface is a dynamic interface that changes rapidly in response to stimuli to coordinate the formation of thrombi at sites of vascular injury. Tight control is essential as loss of organisation may result in the inappropriate formation of thrombi (thrombosis) or excessive bleeding. In this paper we describe the comparative analysis of resting and thrombin-stimulated platelet membrane proteomes and associated proteins to identify proteins important to platelet function. Surface proteins were labelled using a biotin tag and isolated by NeurtrAvidin affinity chromatography. Liquid phase IEF and SDS-PAGE were used to separate proteins, and bands of increased intensity in the stimulated platelet fractions were digested and identified by FT-ICR mass spectrometry. Novel proteins were identified along with proteins known to be translocated to the platelet surface. Furthermore, many platelet proteins revealed changes in location associated with function, including G6B and Hip-55. HIP-55 is an SH3-binding protein important in T-cell receptor signalling. Further analysis of HIP-55 revealed that this adaptor protein becomes increasingly associated with both Syk and integrin beta 3 upon platelet activation. Analysis of HIP-55 deficient platelets revealed reduced fibrinogen binding upon thrombin stimulation, suggesting HIP-55 to be an important regulator of platelet function.

Lack of association between lipaemia and central adiposity in subjects with an atherogenic lipoprotein phenotype (ALP)

OBJECTIVE: To investigate the associations between indices of adiposity and cardiovascular risk factors in individuals with an atherogenic lipoprotein phenotype (ALP). SUBJECTS: Fifty-five men, aged 34-69 y, body mass index (BMI) 22-35 kg/m2, with an ALP lipid profile (triglycerides (TG) 1.5-4.0 mmol/l, HDL<1.1 mmol/l; %LDL-3>40% total LDL). DESIGN: Each participant provided a fasting blood sample and underwent an 8 h postprandial assessment and had anthropometric measurements taken. OUTCOME MEASURES: BMI, waist circumference (W), waist-to-hip ratio (W/H), sum of skinfolds (SSK), fasting and postprandial concentrations of glucose, insulin and plasma lipids, post-heparin lipase activity, and apoE genotype. RESULTS: The expected positive associations between BMI, W and SSK and fasting and postprandial insulin were observed (r=0.42-0.65). Little association between glucose responses and any measures of adiposity was evident. Unexpectedly, there were no positive associations between measures of central adiposity (W and W/H) and fasting and postprandial TG responses, with a trend towards negative associations in this study group (TG AUC vs W, r=-0.23, P=0.097; TG IAUC vs W/H, r=-0.26, P=0.068). Subgroup analysis indicated that lack of a positive association between central adiposity and postprandial TG values was more evident in those with one E4 allele (r=-0.42, P=0.077) relative to non-E4 carriers (r=-0.16, P=0.430). The expected positive associations between insulin and TG responses were not observed (r=-0.03 to -0.36). CONCLUSION: In this ALP group the expected positive association between TG responses and a centralized distribution of body fat was not observed, particularly in individuals with an apoE4 genotype. Our findings are not in line with the view that there is a clear causal relationship between insulin resistance and the lipid abnormalities associated with ALP.

Nutritional status and clinical outcome in elderly female surgical orthopaedic patients

The possible relationship between nutritional status and clinical outcome following orthopaedic hip surgery was investigated. The nutritional status of 60 elderly female patients admitted for elective total hip replacement (THR) and emergency fractured neck of femur surgery (FNF) was measured over time. Specific measures of clinical outcome, including well-being and functional status, were monitored during hospital stay and at 4, 8 and 26 weeks following discharge. Patients were allocated to a high nutritional risk group where any three of the following were less than the 5th percentile value: serum albumin, haemoglobin, triceps skinfold thickness, mid-upper arm muscle circumference and body weight. Using this definition, malnutrition was present in 4% of THR patients and 41% of FNF patients. It was found that the high risk patients had significantly longer convalescence periods, (median stay27.5 days compared with 0 days, P < 0.0009), and a greater proportion were dependent upon walking frames at 6 months (46% compared with 11%, P < 0.01). Fifty percent of the high risk patients had been living independently prior to admission, in contrast only 29% had returned to their homes at 6 months after discharge. The results indicate an apparent link between clinical outcome and nutritional status based upon the allocation procedure employed, which has the potential for ensuring cost-effective nutritional intervention.