Quistos aracnoideus : quais as indicações cirúrgicas?

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014

Terapêutica da amigdalite aguda em idade pediátrica : estudo transversal sobre antibioterapia nos cuidados de saúde primários e urgência hospitalar em 2012

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014

Angioedema hereditário : um caso de angioedema recorrente

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014

Quando a oftalmologia diagnostica uma patologia sistémica : a propósito de um caso clínico

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2014

Efavirenz versus Nevirapina : comparação da efectividade e do perfil de segurança, a longo prazo, no tratamento da infecção por vírus da imunodeficiência humana tipo 1

Tese de mestrado, Doenças Infecciosas Emergentes, Universidade de Lisboa, Faculdade de Medicina, 2016

A retrospective survey of cancer in relation to occupation /

"Contract no. HSM 99-73-5."

Computer-based patient monitoring systems /

Prepared under contract no. HSM 110-70-406.

Smoking and health bulletin.

Vols. for issued as DHEW publication no. (HSM) ; as DHEW publication no. (CDC)

Guidelines for evaluation of continuing education programs in mental health /

Reprinted 1975

Occupational exposure to nitric acid.

Issued March 1976.

Feasibility study covering nationwide occupational safety and health manpower survey /

"Contract No. HSM 99-73-88."

Mortality experience of the AFL-CIO United Brotherhood of Carpenters and Joiners of America, 1969-1970 /

Photocopy. Springfield, Va. : National Technical Information Service, U.S. Dept. of Commerce.

Acute conditions, incidence and associated disability, United States.

Vols. for 1957/59 issued as U.S. National Health Survey. Health statistics, ser. B. Public Health Service publication ; 1961/62 as Vital and health statistics ; as U.S. Dept. of Health Education and Welfare. DHEW publication no. (HSM); as U.S. Dept. of health, Education, and Welfare. DHEW publication no. (HRA); as U.S. Dept. of Health, Education, and Welfare. DHEW publication no. (PHS)

The Toxic substances list.

Vols. for issued as United States. Dept. of Health Education and Welfare. DHEW publication no. (HSM); issued as United States Dept. of Health Education and Welfare. HEW publication no. (NIOSH).

Excipient characterization and particle engineering to develop directly compressed orally disintegrating tablets

ODTs have emerged as a novel oral dosage form with a potential to deliver a wide range of drug candidates to paediatric and geriatric patients. Compression of excipients offers a costeffective and translatable methodology for the manufacture of ODTs. Though, technical challenges prevail such as difficulty to achieve suitable tablet mechanical strength while ensuring rapid disintegration in the mouth, poor compressibility of preferred ODT diluent Dmannitol, and limited use for modified drug-release. The work investigates excipients’ functionality in ODTs and proposes new methodologies for enhancing material characteristics via process and particle engineering. It also aims to expand ODT applications for modified drug-release. Preformulation and formulation studies employed a plethora of techniques/tests including AFM, SEM, DSC, XRD, TGA, HSM, FTIR, hardness, disintegration time, friability, stress/strain and Heckel analysis. Tableting of D-mannitol and cellulosic excipients utilised various compression forces, material concentrations and grades. Engineered D-mannitol particles were made by spray drying mannitol with pore former NH4HCO3. Coated microparticles of model API omeprazole were prepared using water-based film forming polymers. The results of nanoscopic investigations elucidated the compression profiles of ODT excipients. Strong densification of MCC (Py is 625 MPa) occurs due to conglomeration of physicomechanical factors whereas D-mannitol fragments under pressure leading to poor compacts. Addition of cellulosic excipients (L-HPC and HPMC) and granular mannitol to powder mannitol was required to mechanically strengthen the dosage form (hardness >60 N, friability <1%) and to maintain rapid disintegration (<30 sec). Similarly, functionality was integrated into D-mannitol by fabrication of porous, yet, resilient particles which resulted in upto 150% increase in the hardness of compacts. The formulated particles provided resistance to fracture under pressure due to inherent elasticity while promoted tablet disintegration (50-77% reduction in disintegration time) due to porous nature. Additionally, coated microparticles provided an ODT-appropriate modified-release coating strategy by preventing drug (omeprazole) release.