864 resultados para Drug Related Problems
Resumo:
Global warming mitigation has recently become a priority worldwide. A large body of literature dealing with energy related problems has focused on reducing greenhouse gases emissions at an engineering scale. In contrast, the minimization of climate change at a wider macroeconomic level has so far received much less attention. We investigate here the issue of how to mitigate global warming by performing changes in an economy. To this end, we make use of a systematic tool that combines three methods: linear programming, environmentally extended input output models, and life cycle assessment principles. The problem of identifying key economic sectors that contribute significantly to global warming is posed in mathematical terms as a bi criteria linear program that seeks to optimize simultaneously the total economic output and the total life cycle CO2 emissions. We have applied this approach to the European Union economy, finding that significant reductions in global warming potential can be attained by regulating specific economic sectors. Our tool is intended to aid policymakers in the design of more effective public policies for achieving the environmental and economic targets sought.
Resumo:
Tämän diplomityön päätavoite on selvittää keinoja Woikoski Oy:n jakelulogistiikan kustannustehokkuuden kehittämiseksi. Päätavoite voidaan jakaa osatavoitteisiin, joita ovat varastonohjauksen kehittäminen ja jakelun kuljetustoimintojen tehostaminen. Varastoinnin nykytilaa arvioitiin ABC-analyysin avulla. Saatujen tulosten pohjalta määritettiin luokkakohtaiset varastonohjaussäännöt ja kiertonopeustavoitteet, jotka yhdessä muodostavat yritykselle varastopolitiikan. Havaitut ongelmat kulminoituivat jatkuvan varastoseurannan puuttumiseen, suuriin varastotasoihin sekä kysynnänhallinnan puutteisiin. Toimenpidesuosituksina yrityksen tulee investoida tehokkaaseen varastonhallintajärjestelmään sekä aloittaa systemaattinen kysynnän ennustaminen. Kuljetuksiin liittyviksi toimenpiteiksi ehdotetaan runko- ja jakelukuljetusten reittien sekä jakelualueiden optimointia ja tuloksena saadun jakelumallin käyttöönottoa. Nykyistä jakelurahtien hinnoittelua suositellaan tarkennettavaksi siten, että jakelukustannuksia ja toimitusmääriä eritellään nykyistä tarkemmin ja asiakkaille kohdistetaan rahtikustannuksia todenmukaisin perustein. Lisäksi logistiikkatoimintaa tulee yhtenäistää eri toimipaikkojen kesken ja toimintojen mittaamista on tehostettava organisaatiossa.
Resumo:
The ventral striatum / nucleus accumbens has been implicated in the craving for drugs and alcohol which is a major reason for relapse of addicted people. Craving might be induced by drug-related cues. This suggests that disruption of craving-related neural activity in the nucleus accumbens may significantly reduce craving in alcohol-dependent patients. Here we report on preliminary clinical and neurophysiological evidence in three male patients who were treated with high frequency deep brain stimulation of the nucleus accumbens bilaterally. All three had been alcohol dependent for many years, unable to abstain from drinking, and had experienced repeated relapses prior to the stimulation. After the operation, craving was greatly reduced and all three patients were able to abstain from drinking for extended periods of time. Immediately after the operation but prior to connection of the stimulation electrodes to the stimulator, local field potentials were obtained from the externalized cables in two patients while they performed cognitive tasks addressing action monitoring and incentive salience of drug related cues. LFPs in the action monitoring task provided further evidence for a role of the nucleus accumbens in goal-directed behaviors. Importantly, alcohol related cue stimuli in the incentive salience task modulated LFPs even though these cues were presented outside of the attentional focus. This implies that cue-related craving involves the nucleus accumbens and is highly automatic.
Resumo:
RFID-teknologian käyttöönotto on vakaassa kasvussa ja kiinnostus tekniikan soveltami-seen on erityisesti yksilöseurannan alueella. Diplomityössä on tutkittu RFID -teknologian mahdollisuuksia puolustusvoimien normaaliolojen kriittisen yksilöseurattavan materiaalin hallintaan. Case-joukko-osastona tutkimuksessa on toiminut Karjalan Prikaati. Tutkimus-aihetta on tarkasteltu prosessiajattelun näkökulmasta, mutta myös tiedon keräämistä on käsitelty. RFID-pohjainen tieto eroaa perinteisellä tavalla kerätystä tiedosta. RFID-teknologian hyödyntäminen tarjoaa kuitenkin entistä monipuolisemman ja virheettö-mämmän tiedon keräämisen reaaliajassa, joten se tukee hyvin prosessimaista toimintaa. Tutkimuksen painopisteenä on ollut logistiikan resurssien käytön tehostaminen RFID-teknologiaan tukeutuvan prosessimaisen toiminnan kautta. Tehokas prosessimainen toi-minta soveltuu hyvin sotilasorganisaatioihin. Prosessien määrittely ja kuvaaminen autta-vat tunnistamaan niissä ilmeneviä ongelmia ja samalla kuvaamaan mahdollisten muutos-ten vaikutukset prosesseihin sekä organisaatioihin. Perusteet prosessien uudelleen suun-nittelulle lähtevät prosessimaisen toiminnan tunnistamisesta ja kuvaamisesta. Case-joukko-osaston nykytilan kartoituksessa havaittiin, että joukko-osastotasolta on tähän asti puuttunut kokonaisvaltainen prosessimainen toimintatapa. Nykytila-analyysin pohjalta tutkimustyössä rakennettiin yksilöseurattavan materiaalin käsittelyä kuvaava toimintaprosessi, joka muodostui kuudesta eri osaprosessista. Tutki-mustyölle valitun painopisteen mukaisesti osaprosesseista viisi liittyi logistiikkaan ja kun-nossapitoon yksi. Tämän jälkeen keskityttiin tutkiman RFID-tekniikan avulla saavutetta-via keskeisiä hyötyjä. RFID-teknologian ja prosessimaisen toiminnan avulla joukko-osastotasolla on saavutettavissa useita hyötyjä verrattuna nykytilan toimintaan. Uudessa toimintatavassa keskeisiä tunnistettuja hyötyjä ovat toiminnan automatisoituminen, teho-kas tiedonkeruu, toiminnan hyvä laatu ja tehokkuus. Toiminnan tehokkuutta organisaati-on logistisissa toiminnoissa on siis mahdollista kasvattaa ja samalla lisätä näkyvyyttä toimitusketjun sisälle ja sen eri vaiheisiin. Lisäksi RFID-teknologian käyttöönotolla pys-tytään tukemaan hyvin puolustusvoimien kunnossapidon strategista kumppanuutta.
Resumo:
The aim of the thesis is to design a suitable thermal model that can be used as a tool for constructing the TEFC squirrel cage induction machine in addition to the electromagnetic model. A lumped-parameter thermal model is developed. The related problems and aspects of implementation are discussed in details. Losses are calculated analytically and the loss values are used in the thermal model. The sensitivity analysis is introduced to determine the most critical parameters of the model.
Resumo:
With the occurrence of fossil fuels such as oil, gas and coal we found new sources of energy that have played a critical role in the progress of our modern society. Coal is very ample compared to the other two fossil fuels. Global coal reserves at the end of 2005 were estimated at 847,5 billion tones. Along with the major energy sources, coal is the most fast growing fuel on a global basis, it provides 26% of primary energy needs and remains essential to the economies of many developed and developing countries. Coal-fired power generation accounts for 41% of the world‘s total electricity production and in some countries, such as South Africa, Poland, China, Australia, Kazakhstan and India is on very high level. Still, coal utilization represents challenges related to high emissions of air pollutants such as sulphur and nitrogen dioxides, particulate matter, mercury and carbon dioxide. In relation to these a number of technologies have been developed and are in marketable use, with further potential developments towards ―Near Zero Emission‖ coal plants. In present work, coals mined in Russia and countries of Former Soviet Union were reviewed. Distribution of coal reserves on the territory of Russia and the potential for power generation from coal-fired plants across Russia was shown. Physical and chemical properties of coals produced were listed and examined, as main factor influencing on design of the combustion facility and incineration process performance. The ash-related problems in coal-fired boilers were described. The analysis of coal ash of Russia and countries of Former Soviet Union were prepared. Feasible combustion technologies also were reviewed.
Resumo:
The number of autonomous wireless sensor and control nodes has been increasing rapidly during the last decade. Until recently, these wireless nodes have been powered with batteries, which have lead to a short life cycle and high maintenance need. Due to these battery-related problems, new energy sources have been studied to power wireless nodes. One solution is energy harvesting, i.e. extracting energy from the ambient environment. Energy harvesting can provide a long-lasting power source for sensor nodes, with no need for maintenance. In this thesis, various energy harvesting technologies are studied whilst focusing on the theory of each technology and the state-of-the-art solutions of published studies and commercial solutions. In addition to energy harvesting, energy storage and energy management solutions are also studied as a subsystem of a whole energy source solution. Wireless nodes are also used in heavy-duty vehicles. Therefore a reliable, long-lasting and maintenance-free power source is also needed in this kind of environment. A forestry harvester has been used as a case study to study the feasibility of energy harvesting in a forestry harvester’s sliding boom. The energy harvester should be able to produce few milliwatts to power the target system, an independent limit switch.
Resumo:
Tämä diplomityö on osa Lappeenrannan teknillisen yliopiston ja Visedo Oy:n yhteistyöprojektia. Työssä selvitetään pyörivien sähkökoneiden kotelointeja koskevia standardeja ja niiden vaikutukset koneiden suunnittelulle ja valmistukselle. Lisäksi työssä käsitellään aksiaalivuokoneen jäähdytykseen liittyviä ongelmia, kehitetään koneen nykyisiä jäähdytysratkaisuja ja ideoidaan käytettävissä olevia uusia jäähdytysmenetelmiä. Kehitysideoiden rajoitteena toimii koneelta vaadittu kotelointiluokka IP 64 – IP 68 sekä koneelle määritetty kestomagnetoitu aksiaalivuorakenne. Sähkökoneiden kotelointeja koskevien standardien asettamien vaatimusten määrittäminen tapahtui suurilta osin kirjallisuusselvityksenä. Standardien vaikutukset koneiden suunnittelulle ja valmistettavuudelle on selvitetty standardien kotelointien rakenteelle asettamien vaatimusten perusteella. Aksiaalivuokoneen jäähdytysongelmien selvittäminen, käytössä olevien jääh-dytysratkaisujen kehittäminen ja uusien menetelmien ideointi suoritettiin projektiluontoisesti yhdessä eri alojen asiantuntijoista koostuvan jäähdytystyöryhmän kanssa. Työn tuloksena laadittiin Visedo Oy:lle standardikäsikirja, jonka avulla Visedon sähkökoneiden tuoteperheeseen kuuluvien koneiden suunnitteluvaiheessa voidaan varmistaa koneiden standardienmukaisuus. Käsikirjassa on myös esitetty huomioita eri kotelointiluokkien asettamista vaatimuksista koneiden valmistukselle. Aksiaalivuokoneiden jäähdytykseen liittyen tavoitteena oli ratkaista aksiaalivuokoneisiin liittyviä jäähdytysongelmia. Työn tuloksena saa-tiin selville aksiaalivuokoneissa jäähdytyksen kehittämistä vaativat kohteet, laadittiin nykyisten jäähdytysratkaisujen parannusehdotuksia ja kehitettiin täysin uusia jäähdytysmenetelmiä.
Resumo:
The objective of this paper is to contribute to the literature concerning absorptive capacity by revealing the factors affecting the absorptive capacity of MNC parent company toward subsidiary and most particularly the effects of intra-organizational antecedents. The theoretical framework is build around previous findings on knowledge sharing and absorptive capacity. The empirical part of the study is a qualitative research which includes in-depth interviews and analysis of secondary data based on a single case company. The results showed that organizational structure, internal communication, informal networks, formal networks, internationalization, human resources management, shared language, meetings, trust, participation in decision-making, level of awareness, IT system, level of adaptation to market specifications and job rotation influence parent company’s absorptive capacity. Moreover, related problems to these antecedents have been identified. Additionally, recommendations to solve these problems are formulated. In the end, directions for future research on this topic are given.
Resumo:
Investigation of high pressure pretreatment process for gold leaching is the objective of the present master's thesis. The gold ores and concentrates which cannot be easily treated by leaching process are called "refractory". These types of ores or concentrates often have high content of sulfur and arsenic that renders the precious metal inaccessible to the leaching agents. Since the refractory ores in gold manufacturing industry take a considerable share, the pressure oxidation method (autoclave method) is considered as one of the possible ways to overcome the related problems. Mathematical modeling is the main approach in this thesis which was used for investigation of high pressure oxidation process. For this task, available information from literature concerning this phenomenon, including chemistry, mass transfer and kinetics, reaction conditions, applied apparatus and application, was collected and studied. The modeling part includes investigation of pyrite oxidation kinetics in order to create a descriptive mathematical model. The following major steps are completed: creation of process model by using the available knowledge; estimation of unknown parameters and determination of goodness of the fit; study of the reliability of the model and its parameters.
Resumo:
Rahanpesu on rikollisesta toiminnasta hankitun varallisuuden siirtoa lailliseen talousjärjestelmään. Rahanpesu on liitännäinen teko ja se edellyttää aina esirikosta. Esirikos voi olla mikä tahansa rikos, josta varallisuutta hankitaan - huumausainerikos tai talousrikos. Tutkielmassa on selvitetty lainopillista menetelmää käyttäen Suomen rahanpesulain ja ilmoitusmenettelyn tavoitteita ja sisältöä, sekä kansainvälisen rahanpesusäännöstön vaikutuksia Suomen säännöstöön. Empiiristä aineistoa kerättiin teemahaastattelujen avulla ja sen avulla selvitettiin, miten Suomen ilmoitusvelvolliset noudattavat laissa ja ilmoitusmenettelyssä asetettuja velvollisuuksia käytännössä. Tutkimustulosten mukaan, ilmoitusvelvollisiin kohdistetaan suora normatiivinen ohjaus. Ilmoitusvelvolliset noudattavat, hyväksyvät sääntelyn ja uskovat siihen. Tämä auttaa Suomen viranomaisia rahanpesutorjuntatyössä. Suomen rahanpesusäännöstöä on kehitetty vuosien aikana vastamaan kansainvälisiä vaatimuksia. Sääntelyssä on vielä puutteita. On olemassa myös muita ulkopuolisia tekijöitä, jotka hankaloittavat rahanpesun tehokasta torjuntaa.
Resumo:
This study examines the practice of supply chain management problems and the perceived demand information distortion’s (the bullwhip effect) reduction with the interfirm information system, which is delivered as a cloud service to a company operating in the telecommunications industry. The purpose is to shed light in practice that do the interfirm information system have impact on the performance of the supply chain and in particularly the reduction of bullwhip effect. In addition, a holistic case study of the global telecommunications company's supply chain is presented and also the challenges it’s facing, and this study also proposes some measures to improve the situation. The theoretical part consists of the supply chain and its management, as well as increasing the efficiency and introducing the theories and related previous research. In addition, study presents performance metrics for the bullwhip effect detection and tracking. The theoretical part ends in presenting cloud -based business intelligence theoretical framework used in the background of this study. The research strategy is a qualitative case study, supported by quantitative data, which is collected from a telecommunication sector company's databases. Qualitative data were gathered mainly with two open interviews and the e-mail exchange during the development project. In addition, other materials from the company were collected during the project and the company's web site information was also used as the source. The data was collected to a specific case study database in order to increase reliability. The results show that the bullwhip effect can be reduced with the interfirm information system and with the use of CPFR and S&OP models and in particularly combining them to an integrated business planning. According to this study the interfirm information system does not, however, solve all of the supply chain and their effectiveness -related problems, because also the company’s processes and human activities have a major impact.
Resumo:
Voimansiirtolinjojen ristikkopylväiden rakentamisessa on tyypillisesti käytetty osittaiskierteisiä ruuveja, mutta työmaatyöskentelyä helpottaisi siirtyminen täyskierteisten ruuvien käyttöön. Tämä mm. vähentäisi käytettävien ruuvinimikkeiden määrää. Tämän diplomityön tarkoituksena on selvittää laskemalla ja Ftower -laskentaohjelmaa käyttämällä, onko siirtyminen täyskierteisten ruuvien käyttöön mahdollista. Tarkastelua suoritetaan lisäksi myös FEM -analyysilla. Lisäksi tarkastellaan myös muita voimansiirtolinjojen ruuviliitoksiin liittyviä ongelmia, ja pyritään löytämään näihin ratkaisuehdotuksia.
Resumo:
While red-green-blue (RGB) image of retina has quite limited information, retinal multispectral images provide both spatial and spectral information which could enhance the capability of exploring the eye-related problems in their early stages. In this thesis, two learning-based algorithms for reconstructing of spectral retinal images from the RGB images are developed by a two-step manner. First, related previous techniques are reviewed and studied. Then, the most suitable methods are enhanced and combined to have new algorithms for the reconstruction of spectral retinal images. The proposed approaches are based on radial basis function network to learn a mapping from tristimulus colour space to multi-spectral space. The resemblance level of reproduced spectral images and original images is estimated using spectral distance metrics spectral angle mapper, spectral correlation mapper, and spectral information divergence, which show a promising result from the suggested algorithms.
Resumo:
Autism is a developmental disorder that is characterized by abnonnal social interactions and communications as well as repetitive and restricted activities and interests. There is evidence of a genetic component, as 5% of younger siblings are diagnosed if their older sibling has been diagnosed. Autism is generally not diagnosed until age 3 at the earliest, yet it has been shown that early intervention for children with autism can greatly increase their functioning. Because of this, it is important that symptoms of autism are identified as early as possible so that diagnosis can occur as soon as possible to allow these children the earliest intervention. This thesis was divided into two parts. The first looked at the psychometrics of two proposed measures, the Parent Observation Checklist (POC), administered monthly, and the Infant Behavior Summary Evaluation (mSE), administered bimonthly, to see if they can be used with the infant population to identify autistic symptoms in infants who are at high risk for autism or related problems because they have an older sibling with autism. Study 1 reported acceptable psychometric properties of both the POC and IBSE in terms of test-retest reliability, internal consistency, construct validity and predictive validity. These results provide preliminary evidence that parent report measures can help to detect early symptoms of ASD in infants. The POC was shown to differentiate infants who were diagnosed from a matched group that was not diagnosed by 3 years of age. The second part of this thesis involved a telephone interview of parents who reported developmental and/or behavior problems in their high-risk infants that may be early signs of Autism Spectrum Disorder (ASD). During the interview, a service questionnaire was administered to see what interventions (including strategies recommended by the researchers) their at risk infants and affected older siblings were receiving, how satisfied the parents were with them and how effective they felt the interventions were. 3 Study 2 also yielded promising results. Parents utilized a variety of services for at risk infants and children with ASD. The interventions included empirically validated early intervention (e.g., ABA) to non-empirically validated treatments (e.g., diet therapy). The large number of nonempirically validated treatments parents used was surprising, yet parents reported being involved and satisfied, and thought that the services were effective. Parents' perceptions of their stress levels went down slightly and feelings of competence rose when they accessed services for their infants. Overall, the results of this thesis provide new evidence that parent-report methods hold promise as early detection instruments for ASD in at-risk infants. More research is needed to further validate these instruments as well as to understand the variables related to the parents' choice of early intervention for their at risk and affected children.