President William Howard Taft and First Lady Nellie Taft at South Bass Island

This picture shows President William Howard Taft and First Lady Helen Herron Taft readying to lay the cornerstone of Perry's Victory and International Peace Memorial on South Bass Island in August 1912. The monument was built between 1912 and 1915 to commemorate Commodore Oliver Hazard Perry's victory on Lake Erie over the British fleet in September 1813. It also represented the lasting peace between the U.S., Canada, and England.

Conception, synthèse et activité anticancéreuse d’analogues basés sur la molécule FTY720 (Gilenya)

FTY720 (aussi connu sous le nom de Fingolimod ou Gilenya) agit sur les récepteurs sphingosine-1-phosphate (S1P) et induit la suppression du système immunitaire (immunosuppression). Cette molécule est reconnue pour avoir une activité contre plusieurs cellules cancéreuses. Cette activité est indépendante de l’action sur les récepteurs S1P et on attribue plutôt la mort (apoptose) des cellules cancéreuse à la capacité que possède la molécule à réduire le transport des nutriments dans la cellule. Toutefois, malgré ses nombreux avantages, FTY720 ne peut pas être utilisé afin de traiter des humains puisque l’activation secondaire des récepteurs S1P1 et S1P3 mènent à une diminution du rythme cardiaque (bradycardie) chez les patients. Notre groupe s’est donc concentré sur la synthèse d’analogues qui potentiellement n’activeraient pas le récepteur S1P tout en gardant une activité biologique contre plusieurs cellules cancéreuses. Malgré le fait que nos analogues agissent également sur la diminution du transport des nutriments dans les cellules, nous ne connaissons pas le mécanisme d’action par lequel ceux-ci agissent. Au passage, le projet de recherche ci-présenté nous aura par ailleurs permis de développer une grande variété de sondes photo-actives dans l’espoir d’isoler une ou plusieurs protéines qui seraient impliquées dans le mécanisme d’action.

Intraspecific individual variation of temperature tolerance associated with oxygen demand in the European sea bass (Dicentrarchus labrax)

The European sea bass (Dicentrarchus labrax) is an economically important fish native to the Mediterranean and Northern Atlantic. Its complex life cycle involves many migrations through temperature gradients that affect the energetic demands of swimming. Previous studies have shown large intraspecific variation in swimming performance and temperature tolerance, which could include deleterious and advantageous traits under the evolutionary pressure of climate change. However, little is known of the underlying determinants of this individual variation. We investigated individual variation in temperature tolerance in 30 sea bass by exposing them to a warm temperature challenge test. The eight most temperature-tolerant and eight most temperature-sensitive fish were then studied further to determine maximal swimming speed (U-CAT), aerobic scope and post-exercise oxygen consumption. Finally, ventricular contractility in each group was determined using isometric muscle preparations. The temperature-tolerant fish showed lower resting oxygen consumption rates, possessed larger hearts and initially recovered from exhaustive exercise faster than the temperature-sensitive fish. Thus, whole-animal temperature tolerance was associated with important performance traits. However, the temperature-tolerant fish also demonstrated poorer maximal swimming capacity (i.e. lower UCAT) than their temperature-sensitive counterparts, which may indicate a trade-off between temperature tolerance and swimming performance. Interestingly, the larger relative ventricular mass of the temperature-tolerant fish did not equate to greater ventricular contractility, suggesting that larger stroke volumes, rather than greater contractile strength, may be associated with thermal tolerance in this species.

What can exploratory modelling tell us about the ecobiology of European sea bass ( Dicentrarchus labrax ): a comprehensive overview

European sea bass, Dicentrarchus labrax, is a highly valuable species in Europe, both for aquaculture in the Mediterranean Sea and for commercial and recreational fisheries in the North East Atlantic Ocean. Subjected to increasing fishing pressure, the wild population has recently experienced significant recruitment fluctuation as well as a northward extension of its distribution area in the North Sea. While the nature of the ecological and/or physiological processes involved remains unresolved, ontogenetic habitat shifts and adult site fidelity could increase the species’ vulnerability to climate change and overfishing. As managers look for expert information to propose management scenarios leading to sustainable exploitation, exploratory modelling appears to be a cost-efficient approach to enhance the understanding of recruitment dynamics and the spatio-temporal scales over which fish populations function. A conceptual modelling framework and its specific data requirements are discussed to tackle some sound ecological questions regarding this species. We consequently provide an updated review of current knowledge on bass population structure, biology and ecology. This paper will hence be particularly valuable to develop spatially-explicit models of European sea bass dynamics under environmental and anthropogenic forcing. Knowledge gaps requiring further research efforts are also reported.

Pilot scale production of sea bass (Dicentrarchus labrax) fry

Determination of rearing data enabled production of sea bass fry for three years in Station DEVA-SUD, CNEXO, France. The larval breeding process is described. The food consists of the ROlÎfer Brachionus plicatilis, then nauplii and 1 mm long metanauplii of the Brachiopod Artemia salina. Weaning on dry pellets oceurs when larvae are 35 days old when an optimum temperature curve is respected. Production of season 1977-78 was 380 000 two month old weaned fry.

Larval rearing of sea bass (Dicentrarchus labrax (L.) with a high survival

An experiment of larval rearing of sea bass is described. Larval density ranged from 50/l at the beginning of the experiment, to 1,4 fingerling/l after 3 months. Fingerlings were fed at that time with a pelletized artificial diet. Average weight was 0,8 g. Survival from the newly hatched larvae was 38%.

Double bass and electric bass: the case study of John Patitucci

The electric bass and double bass are two different instruments sharing a common function: they link harmony with rhythm, especially when talking about jazz music. The capacity of a bassist to fully support an ensemble is something that can be achieved individually playing electric or double bass. However there are some bassists who, despite of the technical differences between these two instruments, choose to play both. Some of these performers are true masters using and switching electric and double bass according to the different musical settings. It is possible to define similarities and differences between the electric and double bass, but is it viable to use similar approaches too? In order to investigate this field, I focus my research on one exemplar player who combines all the qualities needed to both play electric than double bass: John Patitucci, an inspiration for bassists of all generations and a musician who synthesizes all the fundamental characteristics of an ideal bass player. This dissertation is inspired by Patitucci’s example and by the urge to fill a gap in the specialized literature concerning the history and application of different left and right hand techniques on the electric and double bass. The main purpose of this study is to create the backbone of a bass program for teaching both instruments using John Patitucci as example. His technical approach on both instruments and his soloing vocabulary are points of departure of this dissertation. I begin my study with the historical origins of Patitucci’s techniques ending with the development of exercises created in order to teach his techniques and vocabulary to those who aspire to play electric and double bass; RESUMO: Baixo elétrico e contrabaixo, dois instrumentos distintos que partilham uma função comum: a possibilidade de produzir um conjunto de notas capazes de interligar uma grelha harmonia a uma base rítmica, criando uma coesão estética e musical, sobretudo na música jazz. A capacidade de um baixista de conseguir alcançar de forma eficiente esta ligação como sólido suporte para um “ensemble” musical está na base de uma sua eventual afirmação profissional. Há músicos que apesar das diferencias técnicas entre estes dois instrumentos, decidiram tocar ambos; alguns deles conseguiram destacarse, usando e trocando o baixo elétrico e o contrabaixo para servir melhor diferentes situações musicais. O contrabaixo e baixo elétrico têm características em comum mas ao mesmo tempo diferem por apresentar algumas diferenças técnica substanciais; será por isso possível abordar, explorar e aprender ambos utilizando uma mesma base metodológica? Com o intuito de explorar esta possibilidade direcionei a minha pesquisa para o estudo de um músico que no curso da sua longa carreira consegui grande destaque em quanto baixista elétrico e contrabaixista. John Patitucci é a síntese desta tipologia de músico, sendo uma fonte de inspiração para baixistas de todas as gerações. Esta dissertação é inspirada no seu exemplo e no desejo de colmatar o vazio presente na literatura musical comum aos dois instrumentos sobre a história e aplicação das técnicas da mão esquerda e direita. O foco principal é a criação de uma base sólida para o futuro desenvolvimento de um programa de ensino comum para o baixo eléctrico e o contrabaixo, utilizando o vocabulário técnico e improvisativo de Patitucci como ponto de partida. A dissertação aborda as origens históricas das técnicas utilizadas por Patitucci desenvolvendo, numa fase sucessiva, exercícios criados com a função de ensinar as suas técnicas aos que desejarem aprofundar a prática do baixo elétrico e do contrabaixo.

Les enjeux juridiques concernant les nouveaux modèles d’affaires basés sur la commercialisation des données

Cet essai est présenté en tant que mémoire de maîtrise dans le cadre du programme de droit des technologies de l’information. Ce mémoire traite de différents modèles d’affaires qui ont pour caractéristique commune de commercialiser les données dans le contexte des technologies de l’information. Les pratiques commerciales observées sont peu connues et l’un des objectifs est d’informer le lecteur quant au fonctionnement de ces pratiques. Dans le but de bien situer les enjeux, cet essai discutera d’abord des concepts théoriques de vie privée et de protection des renseignements personnels. Une fois ce survol tracé, les pratiques de « data brokerage », de « cloud computing » et des solutions « analytics » seront décortiquées. Au cours de cette description, les enjeux juridiques soulevés par chaque aspect de la pratique en question seront étudiés. Enfin, le dernier chapitre de cet essai sera réservé à deux enjeux, soit le rôle du consentement et la sécurité des données, qui ne relèvent pas d’une pratique commerciale spécifique, mais qui sont avant tout des conséquences directes de l’évolution des technologies de l’information.

Les enjeux juridiques concernant les nouveaux modèles d’affaires basés sur la commercialisation des données

Cet essai est présenté en tant que mémoire de maîtrise dans le cadre du programme de droit des technologies de l’information. Ce mémoire traite de différents modèles d’affaires qui ont pour caractéristique commune de commercialiser les données dans le contexte des technologies de l’information. Les pratiques commerciales observées sont peu connues et l’un des objectifs est d’informer le lecteur quant au fonctionnement de ces pratiques. Dans le but de bien situer les enjeux, cet essai discutera d’abord des concepts théoriques de vie privée et de protection des renseignements personnels. Une fois ce survol tracé, les pratiques de « data brokerage », de « cloud computing » et des solutions « analytics » seront décortiquées. Au cours de cette description, les enjeux juridiques soulevés par chaque aspect de la pratique en question seront étudiés. Enfin, le dernier chapitre de cet essai sera réservé à deux enjeux, soit le rôle du consentement et la sécurité des données, qui ne relèvent pas d’une pratique commerciale spécifique, mais qui sont avant tout des conséquences directes de l’évolution des technologies de l’information.

Ted Botsford double bass with Marissa Winship and Megan McElroy, piano November 13, 2016

Concert Program