Leonie Herwartz-Emden / Verena Schurt / Wiebke Waburg (Hrsg.): Mädchen in der Schule, Empirische Studien zu Heterogenität in monoedukativen und koedukativen Kontexten. Opladen: Barbara Budrich 2010 [Rezension]

Rezension von: Leonie Herwartz-Emden / Verena Schurt / Wiebke Waburg (Hrsg.): Mädchen in der Schule, Empirische Studien zu Heterogenität in monoedukativen und koedukativen Kontexten, Opladen: Barbara Budrich 2010 (289 S.; ISBN 978-3-8664-9139-7)

Silke Trumpa: Elternperspektiven – Rekonstruktionen an einer Freien Schule, Studien zur Bildungsgangforschung, Band 31, Opladen & Farmington Hills, MI: Barbara Budrich 2010 [Rezension]

Rezension von: Silke Trumpa: Elternperspektiven – Rekonstruktionen an einer Freien Schule, Studien zur Bildungsgangforschung, Band 31, Opladen & Farmington Hills, MI: Barbara Budrich 2010 (276 S.; ISBN 978-3-86649-346-9)

Daniela Böhringer / Ute Karl / Hermann Müller / Wolfgang Schröer / Stephan Wolff: Den Fall bearbeitbar halten, Gespräche in Jobcentern mit jungen Menschen. Opladen & Farmington Hills: Verlag Barbara Budrich 2012 [Rezension]

Rezension von: Daniela Böhringer / Ute Karl / Hermann Müller / Wolfgang Schröer / Stephan Wolff: Den Fall bearbeitbar halten, Gespräche in Jobcentern mit jungen Menschen, Opladen & Farmington Hills: Verlag Barbara Budrich 2012 (265 S.; ISBN 978-3-86649-451-0)

Miriam Hellrung: Lehrerhandeln im individualisierten Unterricht, Entwicklungsaufgaben und ihre Bewältigung. Opladen / Farmington Hills: Verlag Barbara Budrich 2010 [Rezension]

Rezension von: Miriam Hellrung: Lehrerhandeln im individualisierten Unterricht, Entwicklungsaufgaben und ihre Bewältigung, Opladen / Farmington Hills: Verlag Barbara Budrich 2010 (276 S.; ISBN 978-3-86649-338-4)

Gerald Blaschke (Hrsg.): Schule schnuppern. Eine videobasierte Studie zum Übergang in die Grundschule. Opladen, Berlin & Toronto: Verlag Barbara Budrich 2012 (196 S.) [Rezension]

Rezension von: Gerald Blaschke (Hrsg.): Schule schnuppern. Eine videobasierte Studie zum Übergang in die Grundschule. Opladen, Berlin & Toronto: Verlag Barbara Budrich 2012 (196 S.; ISBN 978-3-86649-497-8)

Fritz Bohnsack: Wie Schüler die Schule erleben. Zur Bedeutung der Anerkennung, der Bestätigung und der Akzeptanz von Schwäche. Opladen, Berlin, Toronto: Verlag Barbara Budrich 2013 (285 S.) [Rezension]

Rezension von: Fritz Bohnsack: Wie Schüler die Schule erleben. Zur Bedeutung der Anerkennung, der Bestätigung und der Akzeptanz von Schwäche. Opladen, Berlin, Toronto: Verlag Barbara Budrich 2013 (285 S.; ISBN 978-3-8474-0049-3)

Georg Breidenstein: Zeugnisnotenbesprechung. Zur Analyse der Praxis schulischer Leistungsbewertung. Opladen / Berlin / Toronto: Barbara Budrich 2012 (101 S.) [Rezension]

Rezension von: Georg Breidenstein: Zeugnisnotenbesprechung. Zur Analyse der Praxis schulischer Leistungsbewertung. Opladen / Berlin / Toronto: Barbara Budrich 2012 (101 S.; ISBN 978-3-86649-466-4)

Elke Kleinau / Barbara Rendtorff (Hrsg.): Differenz, Diversität und Heterogenität in erziehungswissenschaftlichen Diskursen. Schriftenreihe der Sektion Frauen- und Geschlechterforschung in der Deutschen Gesellschaft für Erziehungswissenschaft(DGfE), Band 3, Opladen u.a.: Barbara Budrich Verlag 2013 (156 S.) [Rezension]

Rezension von: Elke Kleinau / Barbara Rendtorff (Hrsg.): Differenz, Diversität und Heterogenität in erziehungswissenschaftlichen Diskursen. Schriftenreihe der Sektion Frauen- und Geschlechterforschung in der Deutschen Gesellschaft für Erziehungswissenschaft(DGfE), Band 3, Opladen u.a.: Barbara Budrich Verlag 2013 (156 S.; ISBN 978-3-8474-0073-8)

Acute Exercise Decreases Trb3 Protein Levels In The Hypothalamus Of Obese Rats.

To evaluate the effects of acute exercise on the TRB3 protein levels and interaction between TRB3/Akt proteins in the hypothalamus of obese rats. In addition, we evaluated the relationship between TRB3 and endoplasmic reticulum stress (ER stress) and verified whether an acute exercise session is able to influence these processes. In the first part of the study, the rats were divided into three groups: control (lean) - fed with a standard rodent chow, DIO - fed with a high fat diet and DIO submitted to a swimming acute exercise protocol (DIO-EXE). In the second part of the study, we used other three groups: control (lean) receiving an intracerebroventricular (i.c.v.) infusion of vehicle, lean receiving an i.c.v. infusion of thapsigargin, and lean receiving an i.c.v infusion of thapsigargin and performing an acute exercise session. Four hours after the exercise session, the food intake was measured and the hypothalamus was dissected and separated for subsequent protein analysis by immunoblotting and Real Time PCR. The acute exercise session reduced the TRB3 protein levels, disrupted the interaction between TRB3/Akt proteins, increased the phosphorylation of Foxo1 and restored the anorexigenic effects of insulin in the hypothalamus of DIO rats. Interestingly, the suppressive effects of acute exercise on TRB3 protein levels may be related, at least in part, to the decrease of ER stress (evaluated though pancreatic ER kinase phosphorylation - pPERK and C/EBP homologous protein - CHOP protein levels) in the hypothalamus. In conclusion, the reduction of hypothalamic TRB3 protein levels mediated by exercise may be associated with the reduction of ER stress. These data provided a new mechanism by which an acute exercise session improves insulin sensitivity in hypothalamus and restores food intake control in obesity.

Cumulative doses of radioiodine in the treatment of differentiated thyroid carcinoma: knowing when to stop

OBJECTIVE: Evaluate the efficacy of cumulative doses (CDs) of 131I-iodide therapy (RIT) in differentiated thyroid cancer (DTC). SUBJECTS AND METHODS: The probability of progressive disease according to CDs was evaluated in patients < 45 years old and > 45 years old and correlated to tumor-node-metastasis (TNM), thyroglobulin values, histological types and variants, age, and zduration of the disease. RESULTS: At the end of a follow-up period of 69 ± 56 months, 85 out of 150 DTC patients submitted to fixed doses RIT had no evidence of disease, 47 had stable disease and 18 had progressive disease. Higher CDs were used in the more aggressive variants (p < 0.0001), higher TNM stages (p < 0.0001), and follicular carcinomas (p = 0.0034). Probability of disease progression was higher with CDs > 600 mCi in patients > 45 years old and with CDs > 800 mCi in patients < 45 years. CONCLUSION: Although some patients may still respond to high CDs, the impact of further RIT should be carefully evaluated and other treatment strategies may be warranted.

Metabólitos séricos da vitamina D não se correlacionam com pressão arterial em adolescentes

OBJETIVO: O objetivo deste estudo foi avaliar a associação entre o estado nutricional da vitamina D, a adiposidade e a pressão arterial (PA) em adolescentes. MÉTODOS: Foi realizada avaliação antropométrica, da composição corporal, da ingestão alimentar, de medidas bioquímicas e aferição da PA de 205 adolescentes, com média de idade de 18,2 anos. RESULTADOS: Destes, 12,19% apresentaram PA elevada. O nível sérico médio da 25OHD foi 29,2(0,8) ng/mL, e 62% dos adolescentes apresentaram insuficiência de vitamina D. Não foi encontrada correlação significativa entre a PAS e a PAD com a 25OHD e a 1,25(OH)2D. Houve correlação negativa entre a PAD com os níveis séricos de adiponectina, e tanto a PAS quanto a PAD apresentaram correlação positiva com a circunferência da cintura em ambos os sexos. CONCLUSÃO: Não houve relação entre os níveis séricos de vitamina D e a PA. Porém, a gordura visceral apresenta risco potencial para elevação da PA em adolescentes.

Folato, B6 e B12 na adolescência: níveis séricos, prevalência de inadequação de ingestão e alimentos contribuintes

OBJETIVO: Investigar os níveis séricos e a prevalência de inadequação da ingestão dietética de folato e das vitaminas B6 e B12, identificando os alimentos contribuintes para a ingestão desses nutrientes. MÉTODOS: Estudo observacional, transversal, em adolescentes de 16 a 19 anos, de ambos os sexos, conduzido em Indaiatuba (SP). Coletou-se o registro alimentar de 3 dias não consecutivos. A dieta habitual foi estimada pela remoção da variabilidade intrapessoal, e a prevalência de inadequação da ingestão, pelo método da estimated average requirement como ponto de corte. As análises bioquímicas de folato, B6 e B12 foram conduzidas de acordo com os métodos aceitos na literatura. RESULTADOS: O estudo foi conduzido com 99 adolescentes, a maioria do sexo feminino (58,6%), com média de idade de 17,6 (desvio padrão, DP 0,9) anos. As médias da concentração sérica de folato, B6 e B12 foram de 9,2 (DP 3,4) ng/mL, 18,7 (DP 5,1) nmol/L e 397,5 (DP 188,4) pg/mL, respectivamente; e a prevalência de inadequação da ingestão das vitaminas foi de 15,2, 10,2 e < 1%, respectivamente. Os alimentos que mais contribuíram para a ingestão dos nutrientes foram, para folato: pão francês, macarrão e feijões; para B6: arroz branco, carne de frango e carne bovina; e para B12: carne bovina magra, leite integral e carne bovina gorda. CONCLUSÕES: As prevalências de inadequação de folato, B6 e B12 mostraram-se baixas, possivelmente em decorrência da melhoria do acesso e da disponibilidade de alimentos, fontes dietéticas das vitaminas. Os feijões, presentes na dieta tradicional brasileira, ainda estão entre os principais alimentos que contribuíram para a ingestão de folato, mesmo após a fortificação mandatória com ácido fólico no Brasil.

The Relationship between Population Structure and Aluminum Tolerance in Cultivated Sorghum

Background: Acid soils comprise up to 50% of the world's arable lands and in these areas aluminum (Al) toxicity impairs root growth, strongly limiting crop yield. Food security is thereby compromised in many developing countries located in tropical and subtropical regions worldwide. In sorghum, SbMATE, an Al-activated citrate transporter, underlies the Alt(SB) locus on chromosome 3 and confers Al tolerance via Al-activated root citrate release. Methodology: Population structure was studied in 254 sorghum accessions representative of the diversity present in cultivated sorghums. Al tolerance was assessed as the degree of root growth inhibition in nutrient solution containing Al. A genetic analysis based on markers flanking Alt(SB) and SbMATE expression was undertaken to assess a possible role for Alt(SB) in Al tolerant accessions. In addition, the mode of gene action was estimated concerning the Al tolerance trait. Comparisons between models that include population structure were applied to assess the importance of each subpopulation to Al tolerance. Conclusion/Significance: Six subpopulations were revealed featuring specific racial and geographic origins. Al tolerance was found to be rather rare and present primarily in guinea and to lesser extent in caudatum subpopulations. Alt(SB) was found to play a role in Al tolerance in most of the Al tolerant accessions. A striking variation was observed in the mode of gene action for the Al tolerance trait, which ranged from almost complete recessivity to near complete dominance, with a higher frequency of partially recessive sources of Al tolerance. A possible interpretation of our results concerning the origin and evolution of Al tolerance in cultivated sorghum is discussed. This study demonstrates the importance of deeply exploring the crop diversity reservoir both for a comprehensive view of the dynamics underlying the distribution and function of Al tolerance genes and to design efficient molecular breeding strategies aimed at enhancing Al tolerance.

A Novel Organotellurium Compound (RT-01) as a New Antileishmanial Agent

Leishmaniasis is a neglected disease and endemic in developing countries. A lack of adequate and definitive chemotherapeutic agents to fight against this infection has led to the investigation of numerous compounds. The aim of this study was to investigate the effect of RT-01, an organotellurane compound presenting biological activities, in 2 experimental systems against Leishmania amazonensis. The in vitro system consisted of promastigotes and amastigotes forms of the parasite, and the in vivo system consisted of L. amazonensis infected BALB/c mice, an extremely susceptible mouse strain. The compound proved to be toxic against promastigotes and amastigotes. The study also showed that treatment with RT-01 produces an effect similar to that treatment with the reference antimonial drug, Glucantime, in L. amazonensis infected mice. The best results were obtained following RT-01 intralesional administration (720 mu g/kg/day); mice showed significant delay in the development of cutaneous lesions and decreased numbers of parasites obtained from the lesions. Significant differences in tissue pathology consisted mainly of no expressive accumulation of inflammatory cells and well-preserved structures in the skin tissue of RT-01-treated mice compared with expressive infiltration of infected cells replacing the skin tissue in lesions of untreated mice. These findings highlight the fact that the apparent potency of organotellurane compounds, together with their relatively simple structure, may represent a new avenue for the development of novel drugs to combat parasitic diseases.