983 resultados para Emilio Navea


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This paper draws together contributions to a scientific table discussion on obesity at the European Science Open Forum 2008 which took place in Barcelona, Spain. Socioeconomic dimensions of global obesity, including those factors promoting it, those surrounding the social perceptions of obesity and those related to integral public health solutions, are discussed. It argues that although scientific accounts of obesity point to large-scale changes in dietary and physical environments, media representations of obesity, which context public policy, pre-eminently follow individualistic models of explanation. While the debate at the forum brought together a diversity of views, all the contributors agreed that this was a global issue requiring an equally global response. Furthermore, an integrated ecological model of obesity proposes that to be effective, policy will need to address not only human health but also planetary health, and that therefore, public health and environmental policies coincide.

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Background: Budesonide has a long history as intranasal drug, with many marketed products. Efforts should be made to demonstrate the therapeutic equivalence and safety comparability between them. Given that systemic availability significantly varies from formulations, the clinical comparability of diverse products comes to be of clinical interest and a regulatory requirement. The aim of the present study was to compare the systemic availability, pharmacodynamic effect, and safety of two intranasal budesonide formulations for the treatment of rhinitis. Methods: Eighteen healthy volunteers participated in this randomised, controlled, crossover, clinical trial. On two separated days, subjects received a single dose of 512 mu g budesonide (4 puffs per nostril) from each of the assayed devices (Budesonida nasal 64 (R), Aldo-Union, Spain and Rhinocort 64 (R), AstraZeneca, Spain). Budesonide availability was determined by the measurement of budesonide plasma concentration. The pharmacodynamic effect on the hypothalamic-adrenal axis was evaluated as both plasma and urine cortisol levels. Adverse events were tabulated and described. Budesonide availability between formulations was compared by the calculation of 90% CI intervals of the ratios of the main pharmacokinetic parameters describing budesonide bioavailability. Plasma cortisol concentration-time curves were compared by means of a GLM for Repeated Measures. Urine cortisol excretion between formulations was compared through the Wilcoxon's test. Results: All the enroled volunteers successfully completed the study. Pharmacokinetic parameters were comparable in terms of AUC(t) (2.6 +/- 1.5 vs 2.2 +/- 0.7), AUCi (2.9 +/- 1.5 vs 2.4 +/- 0.7), t(max) (0.4 +/- 0.1 vs 0.4 +/- 0.2), C(max)/AUC(i) (0.3 +/- 0.1 vs 0.3 +/- 0.0), and MRT (5.0 +/- 1.4 vs 4.5 +/- 0.6), but not in the case of C(max) (0.9 +/- 0.3 vs 0.7 +/- 0.2) and t(1/2) (3.7 +/- 1.8 vs 2.9 +/- 0.4). The pharmacodynamic effects, measured as the effect over plasma and urine cortisol, were also comparables between both formulations. No severe adverse events were reported and tolerance was comparable between formulations. Conclusion: The systemic availability of intranasal budesonide was comparable for both formulations in terms of most pharmacokinetic parameters. The pharmacodynamic effect on hypothalamic-pituitary-adrenal axis was also similar. Side effects were scarce and equivalent between the two products. This methodology to compare different budesonide-containing devices is reliable and easy to perform, and should be recommended for similar products intented to be marketed or already on the market.

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XI, 529 p.

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El presente estudio es una investigación llevada a cabo con chicos y chicas de entre 12 y 13 años sobre los hábitos deportivos y el sedentarismo. El estudio se ha llevado a cabo en 3 centros escolares vizcaínos diferentes: Lauro Ikastola (Loiu), Txorierri ikastetxea (Derio) y Colegio Miribilla (Bilbao) con el fin de abarcar y analizar una mayor heterogeneidad de alumnos. Hoy en día el sedentarismo infantil es un factor de ri esgo muy importante entre los más jóvenes y por ello es de vital importancia trabajar y proponer una serie de acciones y estrategias para incentivar a los adolescentes a llevar una vida activa y saludable.

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Aprovechando la problemática surgida en Alava respecto a las prestaciones de los monitores deportivos en Deporte Escolar, el presente trabajo se centra en estudiar si existe o no relación laboral en la figura del monitor deportivo en Deporte Escolar. Partiendo de la complejidad que plantea este ámbito, los objetivos concretos son, por un lado, clarificar las diferentes relaciones que se presentan en la prestación personal de los monitores de deporte escolar y, por otro lado, exponer diversas opciones de las que AMPAs y clubes deportivos disponen a fin adecuar su realidad jurídica a la normativa.

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En la sociedad actual, el ejercicio físico se considera un factor determinante para la consecución de una vida saludable. Gracias a los avances tecnológicos y la constante evolución del conocimiento de la actividad física y sus beneficios, la sociedad, en general, goza de numerosas facilidades a la hora de poder realizar cualquier actividad física que genere una mejoría para uno mismo. Pero, a pesar de ello, hay rincones de la sociedad a los que los beneficios del ejercicio no han llegado aún . En el siguiente proyecto estudiaré, por una parte, e lrégimen de aislamiento de los centros penitenciarios; a su vez, profundizaré en los perjuicios que puedan sufrir los internos en este régimen, y en los beneficios que pueda tener el ejercicio físico en los reclusos que sufren el aislamiento. Por último, propondré un programa de ejercicio, que a su vez pueda compenetrarse con el reglamento penitenciario, buscando los beneficios del ejercicio para las personas que se encuentren en esta situación.

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Juan F. Alcina, Emilio Blanco, Pedro M. Cátedra, Javier Cercas, José María Micó, Rafael Ramos e Íñigo Ruiz Arzálluz con textos de Eugenio Asensio, Juan Benet, Fernando Lázaro Carreter y José-Carlos Mainer

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La existencia de un acelerado envejecimiento de la poblaci??n a nivel mundial ha hecho que la sanidad se plantee buscar alternativas con el fin de atajar y solucionar este tipo de problemas. En el presente trabajo se intenta ver todo lo que rodea a las ca??das y como prevenirlas aportando una base te??rica para entender mejor lo que este problema conlleva. En la parte emp??rica del trabajo, mediante la actividad f??sica adaptada y la realizaci??n del test de Tinetti se pretende observar como dicha actividad f??sica, en el colectivo de la tercera edad, puede mejorar el estado f??sico reduciendo dichas ca??das. Los resultados obtenidos del estudio aluden a la actividad f??sica adaptada como una estrategia no farmacol??gica muy v??lida para la mejora de la salud y prevenci??n de ca??das.

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A lo largo de este trabajo responder?? a la pregunta en la que me cuestiono si una persona sedentaria puede ser una persona sana ??nicamente mediante la alimentaci??n. Para ello hablar?? del sedentarismo, qu?? es lo que consideramos persona sana y algunas de las razones por las que una persona llega a ser sedentaria y no realiza actividad f??sica. A su vez, veremos en qu?? consiste una correcta alimentaci??n, los errores nutricionales m??s comunes, y a su vez investigaremos la alimentaci??n en personas sedentarias.

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Part A

A problem restricting the development of the CuCl laser has been the decrease in output power with increases of tube temperature above 400°C. At that temperature the CuCl vapor pressure is about .1 torr. This is a small fraction of the buffer gas pressure (He at 10 torr).

The aim of the project was to measure the peak radiation temperature (assumed related to the mean energy of electrons) in the laser discharge as a function of the tube temperature. A 24 gHz gated microwave radiometer was used.

It was found that at the tube temperatures at which the output power began to deteriorate, the electron radiation temperature showed a sharp increase (compared with radiation temperature in pure buffer).

Using the above result, we have postulated that this sudden increase is a result of Penning ionization of the Cu atoms. As a consequence of this process the number of Cu atoms available for lasing decrease.

PART B

The aim of the project was to study the dissociation of CO2 in the glow discharge of flowing CO2 lasers.

A TM011 microwave (3 gHz) cavity was used to measure the radially averaged electron density ne and the electron-neutral collision frequency in the laser discharge. An estimate of the electric field is made from these two measurements. A gas chromatograph was used to measure the chemical composition of the gases after going through the discharge. This instrument was checked against a mass spectrometer for accuracy and sensitivity.

Several typical laser mixtures were .used: CO2-N2-He (1,3,16), (1,3,0), (1,0,16), (1,2,10), (1,2,0), (1,0,10), (2,3,15), (2,3,0), (2,0,15), (1,3,16)+ H2O and pure CO2. Results show that for the conditions studied the dissociation as a function of the electron density is uniquely determined by the STP partial flow rate of CO2, regardless of the amount of N2 and/or He present. The presence of water vapor in the discharge decreased the degree of dissociation.

A simple theoretical model was developed using thermodynamic equilibrium. The electrons were replaced in the calculations by a distributed heat source.

The results are analyzed with a simple kinetic model.

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[es]En este Trabajo Fin de Grado se ha determinado la estructura de un anestésico, fluoroxeno,utilizando espectroscopia de rotación.