Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
19/10/2012
19/10/2012
2011
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| Resumo |
To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000 mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance (p = 0.01) and a shorter half-life (p = 0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients. (C) 2011 Elsevier B.V. All rights reserved. CNPq (Brazil) Italian Ministry of Health |
| Identificador |
EPILEPSY RESEARCH, v.94, n.1/Fev, p.117-120, 2011 0920-1211 http://producao.usp.br/handle/BDPI/25051 10.1016/j.eplepsyres.2011.01.007 |
| Idioma(s) |
eng |
| Publicador |
ELSEVIER SCIENCE BV |
| Relação |
Epilepsy Research |
| Direitos |
restrictedAccess Copyright ELSEVIER SCIENCE BV |
| Palavras-Chave | #Levetiracetam #Pharmacokinetics #Drug interaction #Enzyme induction #Epilepsy #RAT-LIVER #METABOLISM #COMEDICATION #SERUM #AGE #Clinical Neurology |
| Tipo |
article original article publishedVersion |
