Characteristics of a large population of patients with refractory epilepsy attending tertiary referral centers in Italy


Autoria(s): ALEXANDRE JR., Veriano; CAPOVILLA, Giuseppe; FATTORE, Cinzia; FRANCO, Valentina; GAMBARDELLA, Antonio; GUERRINI, Renzo; BRIOLA, Francesca La; LADOGANA, Marianna; ROSATI, Eleonora; SPECCHIO, Luigi Maria; STRIANO, Salvatore; PERUCCA, Emilio; SOPHIE Study Grp
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2010

Resumo

P>The characteristics of 1,124 consecutive adults and children with refractory epilepsy attending 11 tertiary referral centers in Italy were investigated at enrollment into a prospective observational study. Among 933 adults (age 16-86 years), the most common syndromes were symptomatic (43.7%) and cryptogenic (39.0%) focal epilepsies, followed by idiopathic (8.1%) and cryptogenic/symptomatic generalized (6.2%) epilepsies. The most common syndrome among 191 children was symptomatic focal epilepsy (35.1%), followed by cryptogenic focal (18.8%), cryptogenic/symptomatic generalized (18.3%), undetermined whether focal or generalized (16.8%), and idiopathic generalized (7.3%). Primarily and secondarily generalized tonic-clonic seizures were reported in 27.8% of adults and 16.8% of children. The most commonly reported etiologies were mesial temporal sclerosis (8.0%) and disorders of cortical development (6.2%) in adults, and disorders of cortical development (14.7%) and nonprogressive encephalopathies (6.8%) in children. More than three-fourths of subjects in both age groups were on antiepileptic drug (AED) polytherapy.

Italian Medicines Agency

CAPES Foundation, Brazil

[FARM52K2WM]

Identificador

EPILEPSIA, v.51, n.5, p.921-925, 2010

0013-9580

http://producao.usp.br/handle/BDPI/24849

10.1111/j.1528-1167.2009.02512.x

http://dx.doi.org/10.1111/j.1528-1167.2009.02512.x

Idioma(s)

eng

Publicador

WILEY-BLACKWELL PUBLISHING, INC

Relação

Epilepsia

Direitos

restrictedAccess

Copyright WILEY-BLACKWELL PUBLISHING, INC

Palavras-Chave #Epilepsy #Drug resistance #Clinical features #Epidemiology #Clinical Neurology
Tipo

article

original article

publishedVersion