The Elevated Interferon Gamma Production is an Important Immunological Marker in HAM/TSP Pathogenesis
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2009
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Resumo |
Human T-lymphotropic virus type 1 (HTLV-1) is the agent of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), which may Occur in > 5% of patients during their lifetime. HTLV-1-infection causes disturbances in the immune system, and the viral load may also play an important role in the pathogenesis of HAM/TSP. Some cytokines are involved in the pathogenesis of this disorder. We have determined IL-2, IL-4, IL-10, IL-12 p70, IFN-gamma and TNF-alpha production among HTLV-1-infected subjects from our HTLV-out Clinic in Institute of Infectious `Emilio Ribas` in Sao Paulo city, Brazil. PBMC obtained from healthy controls (n = 32), asymptomatic HTLV-1 carriers (n = 68) and HAM/TSP patients (n = 44) were grown in the absence and in the presence of phytohaemagglutinin (PHA), and the supernatants` fluids were measured for cytokines production. IL-2 levels were increased in the a-symptomatic HTLV-1 carriers, and IFN-gamma was increased in both groups of patients (asymptomatic HTLV-1 carriers and more significantly among HAM/TSP patients). IL-4, IL-10, TNF-alpha and IL-12 p70 levels were not significantly increased on both groups of patients, as compared with controls. The major finding Of this Study is that IFN-gamma was an important cytokine for the HAM/TSP pathogenesis. Therefore, immune modulation of IFN-gamma may be critical to treat of HAM/TSP patients. FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil)[03/00841-3] FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil)[03/08901-5] FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil)[04/00329-3] |
Identificador |
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, v.70, n.4, p.403-407, 2009 0300-9475 http://producao.usp.br/handle/BDPI/23211 10.1111/j.1365-3083.2009.02291.x |
Idioma(s) |
eng |
Publicador |
WILEY-BLACKWELL PUBLISHING, INC |
Relação |
Scandinavian Journal of Immunology |
Direitos |
restrictedAccess Copyright WILEY-BLACKWELL PUBLISHING, INC |
Palavras-Chave | #VIRUS TYPE-I #CD8(+) T-CELLS #HTLV-I #SPASTIC PARAPARESIS #NEUROLOGIC DISEASE #ANTIBODIES #INFECTION #LOAD #Immunology |
Tipo |
article original article publishedVersion |