The Elevated Interferon Gamma Production is an Important Immunological Marker in HAM/TSP Pathogenesis


Autoria(s): MONTANHEIRO, P. A.; OLIVEIRA, A. C. Penalva de; SMID, J.; FUKUMORI, L. M. I.; OLAH, I.; DUARTE, A. J. da S.; CASSEB, J.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

19/10/2012

19/10/2012

2009

Resumo

Human T-lymphotropic virus type 1 (HTLV-1) is the agent of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), which may Occur in > 5% of patients during their lifetime. HTLV-1-infection causes disturbances in the immune system, and the viral load may also play an important role in the pathogenesis of HAM/TSP. Some cytokines are involved in the pathogenesis of this disorder. We have determined IL-2, IL-4, IL-10, IL-12 p70, IFN-gamma and TNF-alpha production among HTLV-1-infected subjects from our HTLV-out Clinic in Institute of Infectious `Emilio Ribas` in Sao Paulo city, Brazil. PBMC obtained from healthy controls (n = 32), asymptomatic HTLV-1 carriers (n = 68) and HAM/TSP patients (n = 44) were grown in the absence and in the presence of phytohaemagglutinin (PHA), and the supernatants` fluids were measured for cytokines production. IL-2 levels were increased in the a-symptomatic HTLV-1 carriers, and IFN-gamma was increased in both groups of patients (asymptomatic HTLV-1 carriers and more significantly among HAM/TSP patients). IL-4, IL-10, TNF-alpha and IL-12 p70 levels were not significantly increased on both groups of patients, as compared with controls. The major finding Of this Study is that IFN-gamma was an important cytokine for the HAM/TSP pathogenesis. Therefore, immune modulation of IFN-gamma may be critical to treat of HAM/TSP patients.

FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil)[03/00841-3]

FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil)[03/08901-5]

FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil)[04/00329-3]

Identificador

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, v.70, n.4, p.403-407, 2009

0300-9475

http://producao.usp.br/handle/BDPI/23211

10.1111/j.1365-3083.2009.02291.x

http://dx.doi.org/10.1111/j.1365-3083.2009.02291.x

Idioma(s)

eng

Publicador

WILEY-BLACKWELL PUBLISHING, INC

Relação

Scandinavian Journal of Immunology

Direitos

restrictedAccess

Copyright WILEY-BLACKWELL PUBLISHING, INC

Palavras-Chave #VIRUS TYPE-I #CD8(+) T-CELLS #HTLV-I #SPASTIC PARAPARESIS #NEUROLOGIC DISEASE #ANTIBODIES #INFECTION #LOAD #Immunology
Tipo

article

original article

publishedVersion