969 resultados para Juan Manuel de Prada


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[EN]In the newEuropean higher education space, Universities in Europe are exhorted to cultivate and develop multilingualism. The European Commission’s 2004–2006 action plan for promoting language learning and diversity speaks of the need to build an environment which is favourable to languages. Yet reality indicates that it is English which reigns supreme and has become the main foreign language used as means of instruction at European universities. Internationalisation has played a key role in this process, becoming one of the main drivers of the linguistic hegemony exerted by English. In this paper we examine the opinions of teaching staff involved in English-medium instruction, from pedagogical ecologyof-language and personal viewpoints. Data were gathered using group discussion. The study was conducted at a multilingual Spanish university where majority (Spanish), minority (Basque) and foreign (English) languages coexist, resulting in some unavoidable linguistic strains. The implications for English-medium instruction are discussed at the end of this paper.

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Proiektu pilotu honekin medikuntzarako tresna lagungarri bat sortu da Jaiotzetiko Sortzen Diren Errore Metabolikoak (JASODEM) diagnostikatzeko. Horretarako, Gurutzeta Ospitaleko Metabolismo Laborategiko adituarekin eta UPV/EHUko Informatika Fakultateko ERABAKI taldearen arteko elkar-lana funtsezkoa izan da. Amaierako produktua Web zerbitzari batean egongo da exekutagarri. Web aplikazioaren bitartez, medikuak gaixo ezberdinei diagnostikoak egiteko aukera izango du. Horretarako aski da Praktika Klinikorako Gidaren exekuzio bat abiaraztea eta bertan pazienteari inguruan eskatzen diren datuak sartzea. Exekuzio prozesuan zehar badago sistematik irten eta ondoren lanarekin berriz jarraitzea, modu honetan froga klinikoak beharren arabera egiten direlarik, diagnostiko prozesuko kostua murriztuz. Bestalde, Praktika Klinikorako Gidan agertzen diren kontzeptuen inguruko informazioa jasotzeko funtzionalitatea eskaintzen zaio erabiltzaileari. Proiektua garatzeko aukeratu den metodologiaren jarraipen zehatza egitea eta kalitatezko dokumentazioa sortzea ezinbestekoa da. Proiektu honen garapenerako, Rational Unified Process (RUP) metodologia eta honi euskarria ematen dioten tresneria erabili da. Proiektuaren analisirako eta Jakintza Ingeniaritzarako CommonKADS metodologia erabili da.

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Evaluación de BPMS aplicado a la gestión de ensayos clínicos.Creación de un prototipo a partir de un estudio clínico real.

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Juan Manuel Abascal Palazón, Antonio Caballos Rufino, Santiago Castellanos Garcia y Juan Santos Yanguas (eds.)

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En este trabajo se identifican los compuestos característicos de la atmósfera de Bilbao, se presentan las concentraciones obtenidas experimentalmente y en función a estas y los gradientes observados se identifican posibles focos de emisión.

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Dirigido por JON BARREDO en colaboración de MAITE INSAUSTI. Diseño gráfico y tratamiento de la imágen HAYDÉ NEGRO .-- 54 p.

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El oxígeno es el elemento más abundante en la corteza terrestre, constituye el 46.5% del peso total y el 94.07% de su volumen 1 . A su vez el 21% del volumen total de la atmósfera está compuesto por oxígeno 2 ( siendo así el segundo elemento más abundante). Por lo tanto, es obvia la influencia que tiene en la Química Inorgánica esta mayoritaria presencia de oxígeno, que se manifiesta tanto en disoluciones como en estado sólido. Al estudiar la influencia que ejerce el oxígeno en el estado sólido, lo común es encontrarse con lo s óxidos metálicos. Sin embargo, no es tan fácil encontrarse con oxoaniones (dejando a un lado por supuesto la notable excepción que tienen los silicatos). De hecho, polioxoaniones con tres o más átomos de oxígeno se encuentran solamente en dos regiones de la tabla periódica ( Figura 1 ) . Sin embargo, los átomos de vanadio, molibdeno y wolframio (denominados átomos adenda ) tienen la capacidad de formar clústeres metal - oxígeno siempre y cuando estos metales de transición se encuentren en su estado de oxidació n más alto (vanadio (V), molibdeno (VI) y wolframio (VI). Tal es la importancia que tiene este tipo de compuestos en la química y en el uso que se les puede dar (principalmente en actividades catalíticas), que la Química de los Polioxomentalatos constituye una de las líneas de investigación que más está creciendo en las últimas décadas

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El objetivo principal de este trabajo fin de grado es resaltar las novedades que ha incorporado el Reglamento 1215/2012 en el objetivo de un avance en la consecución de un verdadero espacio judicial europeo con el objeto de potenciar la libre circulación de las resoluciones judiciales en materia civil y mercantil en el ámbito de la Unión Europea. Los dos grandes objetivos de la reforma, la eliminación del exequátur y la extensión de las reglas unificadas de competencia con el propósito de suprimir la remisión a las reglas nacionales cuando el demandado no está domiciliado en un estado miembro, son objeto de estudio y crítica en este trabajo.

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El objetivo del Trabajo de Fin de Grado ha sido combinar tres bloques de análisis: el derecho normativo interno español en materia de derecho internacional privado, el derecho comparado en el marco de la Unión Europea y el derecho europeo (los reglamentos en vigor) y los dos proyectos de reglamento en esta materia actualmente en tramitación. Mediante el trabajo se persigue demostrar la necesidad y oportunidad de que el derecho europeo, sin armonizar sustantivamente las regulaciones de cada estado miembro, utilice las técnicas del derecho internacional para seleccionar el Tribunal competente, designar la ley aplicable reconocimiento y ejecución de decisiones judiciales en materia del derecho de familia internacional y centrándonos en el sector de régimen económico matrimonial en defecto de pacto.

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Síntesis, caracterización química y estudio estructural de un complejo metalorgánico soportado sobre un polioxovanadato.

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Background Ubiquitination is known to regulate physiological neuronal functions as well as to be involved in a number of neuronal diseases. Several ubiquitin proteomic approaches have been developed during the last decade but, as they have been mostly applied to non-neuronal cell culture, very little is yet known about neuronal ubiquitination pathways in vivo. Methodology/Principal Findings Using an in vivo biotinylation strategy we have isolated and identified the ubiquitinated proteome in neurons both for the developing embryonic brain and for the adult eye of Drosophila melanogaster. Bioinformatic comparison of both datasets indicates a significant difference on the ubiquitin substrates, which logically correlates with the processes that are most active at each of the developmental stages. Detection within the isolated material of two ubiquitin E3 ligases, Parkin and Ube3a, indicates their ubiquitinating activity on the studied tissues. Further identification of the proteins that do accumulate upon interference with the proteasomal degradative pathway provides an indication of the proteins that are targeted for clearance in neurons. Last, we report the proof-of-principle validation of two lysine residues required for nSyb ubiquitination. Conclusions/Significance These data cast light on the differential and common ubiquitination pathways between the embryonic and adult neurons, and hence will contribute to the understanding of the mechanisms by which neuronal function is regulated. The in vivo biotinylation methodology described here complements other approaches for ubiquitome study and offers unique advantages, and is poised to provide further insight into disease mechanisms related to the ubiquitin proteasome system.

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Hallux valgus (HV) is a highly-prevalent forefoot deformity associated with progressive subluxation and osteoarthritis of the first metatarsophalangeal joint; it is believed to be associated with depression. The aim of the present study was to determine the association of patients with varying degrees of HV involvement to depression using the Beck Depression Inventory (BDI). The sample consisted of 102 participants (mean age: 45.1±1.6), who attended an outpatient centre where self-report data were recorded. The degree of HV deformity was determined in both feet, and the scores on the BDI were compared. A total of 38.24% of the sample had depression, with an average BDI score of 10.55±12.36 points. There was a statistically-significant association between the degree and presence of HV in both feet (P=0.0001). People with a greater degree of HV deformity in any foot also have a significant increase in depression based on BDI scores, regardless of sex.

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Objectives. This paper explores the use of regression models for estimating health status of schizophrenic patients, from a Bayesian perspective. Our aims are: 1- To obtain a set of values of health states of the EQ-5D based on self-assessed health from a sample of schizophrenic patients. 2- To analyse the differences in the health status and in patients’ perceptions of their health status between four mental-health districts in Spain. Methods. We develop two linear models with dummy variables. The first model seeks to obtain an index of the health status of the patients using a VAS as a dependent variable and the different dimensions of EQ-5D as regressors. The second model allows to analyse the differences between the self-assessed health status in the different geographic areas and also the differences between the patients’ self-assessed health states, irrespective of their actual health state, in the different geographic areas. The analysis is done using Bayesian approach with Gibbs sampling (computer program WinBUGS 1.4). Data concerning self-assessed EQ-5D with VAS from four geographic areas of schizophrenic patients were obtained for the purposes of this analysis. Results. We obtained the health status index for this sample and analysed the differences for this index between the four geographic areas. Our study reveals variables that explain the differences in patients’ health status and differences in their health states assessment. We consider four possible scenarios.

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Income inequality undermines societies: The more inequality, the more health problems, social tensions, and the lower social mobility, trust, life expectancy. Given people's tendency to legitimate existing social arrangements, the stereotype content model (SCM) argues that ambivalence-perceiving many groups as either warm or competent, but not both-may help maintain socio-economic disparities. The association between stereotype ambivalence and income inequality in 37 cross-national samples from Europe, the Americas, Oceania, Asia, and Africa investigates how groups' overall warmth-competence, status-competence, and competition-warmth correlations vary across societies, and whether these variations associate with income inequality (Gini index). More unequal societies report more ambivalent stereotypes, whereas more equal ones dislike competitive groups and do not necessarily respect them as competent. Unequal societies may need ambivalence for system stability: Income inequality compensates groups with partially positive social images. © 2012 The British Psychological Society.