Características biológicas de los principales recursos pelágicos marinos peruanos en la primavera 2001

Se observó la distribución, estructura por tamaños, estado reproductivo y niveles de biomasa de los principales recursos pelágicos

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension.

Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%-2% of the population variation in BP and hypertension. This suggests the existence of more undiscovered common variants. We conducted a genome-wide association study in 1,621 hypertensive cases and 1,699 controls and follow-up validation analyses in 19,845 cases and 16,541 controls using an extreme case-control design. We identified a locus on chromosome 16 in the 5' region of Uromodulin (UMOD; rs13333226, combined P value of 3.6×10(-11)). The minor G allele is associated with a lower risk of hypertension (OR [95%CI]: 0.87 [0.84-0.91]), reduced urinary uromodulin excretion, better renal function; and each copy of the G allele is associated with a 7.7% reduction in risk of CVD events after adjusting for age, sex, BMI, and smoking status (H.R. = 0.923, 95% CI 0.860-0.991; p = 0.027). In a subset of 13,446 individuals with estimated glomerular filtration rate (eGFR) measurements, we show that rs13333226 is independently associated with hypertension (unadjusted for eGFR: 0.89 [0.83-0.96], p = 0.004; after eGFR adjustment: 0.89 [0.83-0.96], p = 0.003). In clinical functional studies, we also consistently show the minor G allele is associated with lower urinary uromodulin excretion. The exclusive expression of uromodulin in the thick portion of the ascending limb of Henle suggests a putative role of this variant in hypertension through an effect on sodium homeostasis. The newly discovered UMOD locus for hypertension has the potential to give new insights into the role of uromodulin in BP regulation and to identify novel drugable targets for reducing cardiovascular risk.

Strategic Enterprise Architecture Management - Challenges, Best Practices, and Future Developments

The discipline of Enterprise Architecture Management (EAM) deals with the alignment of business and information systems architectures. While EAM has long been regarded as a discipline for IT managers this book takes a different stance: It explains how top executives can use EAM for leveraging their strategic planning and controlling processes and how EAM can contribute to sustainable competitive advantage. Based on the analysis of best practices from eight leading European companies from various industries the book presents crucial elements of successful EAM. It outlines what executives need to do in terms of governance, processes, methodologies and culture in order to bring their management to the next level. Beyond this, the book points how EAM might develop in the next decade allowing today's managers to prepare for the future of architecture management.

La deconstrucción del héroe en la “nueva novela de guerra” europea

En este estudio abordaremos fundamentalmente el análisis de tres obras de literatura de guerra quecreemos representativas del género en un momento, tras la I Guerra Mundial, en que éste toma unaposición de apología del movimiento antibelicista. El fuego (diario de una escuadra) (1916) deHenri Barbusse, Sin novedad en el frente (1929) de Erich Maria Remarque e Imán (1930) de RamónJ. Sender dan una visión detallada de un fenómeno, la guerra, que causa un punto de inflexión en eldiscurso literario tradicional. Por ende, este estudio, podría decirse, trata sobre la literatura de guerray su apología del antibelicismo, aunque sería quedarse algo corto. Este pequeño tratado intentaráexplicar cómo la literatura, a lo largo de la historia, construye el tropo del héroe que acabaconvirtiéndose en una especie de figura moral de la sociedad occidental y cómo él mismo esfagocitado, devorado o deconstruido por la propia literatura y ética humana.

Impacto do algodoeiro Bt na dinâmica populacional do pulgão-do-algodoeiro em casa de vegetação

O objetivo deste trabalho foi desenvolver um protocolo experimental para avaliar o impacto do algodoeiro Bt na bionomia e na escolha de plantas para colonização pelo pulgão-do-algodoeiro (Aphis gossypii). A bionomia do pulgão foi avaliada em casa de vegetação com insetos criados em gaiolas individuais com plantas de algodão Bt, da variedade DP 404 BG (Bollgard), ou sua isolinha não transformada DP 4049. Gaiolas contendo vasos com plantas de algodoeiro Bt e não-Bt foram usadas como arena de escolha, para a avaliação de preferência de adultos alados. O período pré-reprodutivo e reprodutivo, a longevidade, a curva de sobrevivência, a produção de prole total e diária por fêmea e a curva acumulada de produção de prole da população não apresentaram diferenças significativas. Não foi observada diferença na escolha de plantas para colonização por indivíduos alados, o que indica taxas equivalentes de colonização nas populações iniciais. O algodoeiro Bt não afeta a dinâmica populacional de A. gossypii e não aumenta seu potencial de risco como praga.

Body mass index and risk of head and neck cancer in a pooled analysis of case-control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium.

BACKGROUND: Head and neck cancer (HNC) risk is elevated among lean people and reduced among overweight or obese people in some studies; however, it is unknown whether these associations differ for certain subgroups or are influenced by residual confounding from the effects of alcohol and tobacco use or by other sources of biases. METHODS: We pooled data from 17 case-control studies including 12 716 cases and the 17 438 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for associations between body mass index (BMI) at different ages and HNC risk, adjusted for age, sex, centre, race, education, tobacco smoking and alcohol consumption. RESULTS: Adjusted ORs (95% CIs) were elevated for people with BMI at reference (date of diagnosis for cases and date of selection for controls) 25.0-30.0 kg/m(2) (0.52, 0.44-0.60) and BMI >/=30 kg/m(2) (0.43, 0.33-0.57), compared with BMI >18.5-25.0 kg/m(2). These associations did not differ by age, sex, tumour site or control source. Although the increased risk among people with BMI 25 kg/m(2) was present only in smokers and drinkers. CONCLUSIONS: In our large pooled analysis, leanness was associated with increased HNC risk regardless of smoking and drinking status, although reverse causality cannot be excluded. The reduced risk among overweight or obese people may indicate body size is a modifier of the risk associated with smoking and drinking. Further clarification may be provided by analyses of prospective cohort and mechanistic studies.

IAC-R-järjestelmän käyttöönotto

Tämä työ tehtiin Bosch Rexroth Oy:n Vantaan yksikölle. Työssä selvitettiin servo-järjestelmien historiaa ja kehitystä sekä nykyaikaisen servojärjestelmän käyttöönottoa kenttäväylän avulla. Työssä tutustuttiin IAC-R servosolenoidiventtiiliin, joka on tarkoitettu eritoten sahateollisuuden käyttöön. Työn tarkoituksena oli tuottaa lyhyt helppolukuinen manuaali IAC-R-järjestelmän käyttöönotosta Bosch Rexroth Oy:n ja heidän asiakkaiden käyttöön. Manuaalin avulla tulisi lähes kenen tahansa teknisesti riittävän pätevän henkilön pystyä ottamaan IAC-R-järjestelmä käyttöön, parametrisoida ja virittää järjestelmä. Työ aloitettiin tutustumalla IAC-R-järjestelmään, sen komponentteihin ja käyttöoppaaseen, Profibus DP-kenttäväylään ja WinHPT-ohjelmaan jolla järjestelmän parametrisointi on tarkoitettu suoritettavan. Työn alkupuolella järjestelmää parametrisointia koestettiin minimikokoonpanossa ilman hydrauliikkaa. Järjestelmää voidaan koestaa jopa kotioloissa. Loppupuolella järjestelmä liitettiin hydrauliikkasylinteriin jolla suoritettiin varsinainen koestus. Työn tuloksena todettiin että nykyaikaisen digitaalisen servojärjestelmän käyttöönotto on tehty erittäin helpoksi erilaisten ohjelmien avulla. IAC-R- järjestelmän parametrisointi ohjelma WinHPT todettiin erittäin helpoksi käyttää, ja käyttäjän ei tarvitse tietää varsinaisesta väyläliikenteestä ja sen toiminnasta mitään. Säätötekniikkaan ei tässä työssä varsinaisesti kiinnitetty huomiota, mutta jos käyttäjä hallitsee säätötekniikan perusteet, on järjestelmän säätäminen erittäin helppoa.

Statskunskap och politik

Samlingen med signum HB VIc1 finns vid huvudbiblioteket och innehåller litteratur om statskunskap och politik till och med år 1999. Liknande litteratur finns i anslutning till ämnet Statskunskap. Litteratur om statskunskap och politik har ingått i bokdonationer såväl från hemlandet som från Sverige. Några donatorer av speciellt stora samlingar statsvetenskaplig litteratur kan nämnas, J.V. Brummer, J.A. Nordman, Rafael Erich, Ernst Estlander, Erik Ehrström och Tor von Wright. Politisk litteratur har donerats av Edvard Öhrnberg, Märta Björkenheim, Rafael Erich, Ernst Estlander, Hjalmar Crohn, Erik Ehrström, Carl von Bonsdorff, Jon Hartman, Allan Wallenius, Nils Källström och Hjalmar J. Procopé. Friexemplar som erhållits från och med år 1919 samt inköp har kompletterat samlingen. Litteraturen i samlingen söks med sökfunktionen Signum och söktermen HB VIc1. Litteratur tryckt före 1980 söks manuellt i den systematiska kortkatalogen. Retroaktiv inmatning i databasen Alma gör att litteratur tryckt mellan 1830 och 1979 med tiden blir sökbar i Alma. Från och med år 2000 ingår litteratur om statskunskap och politik i en numerus currens-samling.

Cânfora: um bom modelo para ilustrar técnicas de RMN

The use of Nuclear Magnetic Resonance spectroscopy to establish the three-dimensional structures of molecules is an important component of modern Chemistry courses. The combination of techniques that can be used for this purpose is conveniently illustrated by their application to the camphor molecule. This paper presents applications of several techniques used in NMR spectral interpretation in an increasing order of complexity. The result of individual experiments is illustrated in order to familiarize the user with the way connectivity through bonds and through space is established from 1D/2D-NMR spectra and molecular stereochemistry is determined from different NMR experiments.