Biological variation of established and novel biomarkers for atherosclerosis: Results from a prospective, parallel-group cohort study.

BACKGROUND: Biomarkers are a promising tool for the management of patients with atherosclerosis, but their variation is largely unknown. We assessed within-subject and between-subject biological variation of biomarkers in peripheral artery disease (PAD) patients and healthy controls, and defined which biomarkers have a favorable variation profile for future studies. METHODS: Prospective, parallel-group cohort study, including 62 patients with stable PAD (79% men, 65±7years) and 18 healthy control subjects (44% men, 57±7years). Blood samples were taken at baseline, and after 3-, 6-, and 12-months. We calculated within-subject (CVI) and between-subject (CVG) coefficients of variation and intra-class correlation coefficient (ICC). RESULTS: Mean levels of D-dimer, hs-CRP, IL-6, IL-8, MMP-9, MMP-3, S100A8/A9, PAI-1, sICAM-1, and sP-selectin levels were higher in PAD patients than in healthy controls (P≤.05 for all). CVI and CVG of the different biomarkers varied considerably in both groups. An ICC≥0.5 (indicating moderate-to-good reliability) was found for hs-CRP, D-Dimer, E-selectin, IL-10, MCP-1, MMP-3, oxLDL, sICAM-1 and sP-selectin in both groups, for sVCAM in healthy controls and for MMP-9, PAI-1 and sCD40L in PAD patients. CONCLUSIONS: Single biomarker measurements are of limited utility due to large within-subject variation, both in PAD patients and healthy subjects. D-dimer, hs-CRP, MMP-9, MMP-3, PAI-1, sP-selectin and sICAM-1 are biomarkers with both higher mean levels in PAD patients and a favorable variation profile making them most suitable for future studies.

Combine to compete: improving fiscal forecast accuracy over time

Budget forecasts have become increasingly important as a tool of fiscal management to influence expectations of bond markets and the public at large. The inherent difficulty in projecting macroeconomic variables – together with political bias – thwart the accuracy of budget forecasts. We improve accuracy by combining the forecasts of both private and public agencies for Italy over the period 1993-2012. A weighted combined forecast of the deficit/ ratio is superior to any single forecast. Deficits are hard to predict due to shifting economic conditions and political events. We test and compare predictive accuracy over time and although a weighted combined forecast is robust to breaks, there is no significant improvement over a simple RW model.

Combine to compete: improving fiscal forecast accuracy over time

Budget forecasts have become increasingly important as a tool of fiscal management to influence expectations of bond markets and the public at large. The inherent difficulty in projecting macroeconomic variables – together with political bias – thwart the accuracy of budget forecasts. We improve accuracy by combining the forecasts of both private and public agencies for Italy over the period 1993-2012. A weighted combined forecast of the deficit/ ratio is superior to any single forecast. Deficits are hard to predict due to shifting economic conditions and political events. We test and compare predictive accuracy over time and although a weighted combined forecast is robust to breaks, there is no significant improvement over a simple RW model.

Intel·ligència competitiva en la gestió de recursos de talent (RRT)

Les organitzacions afronten una nova era industrial, la era de la Societat del Coneixement. Als recursos clàssics necessaris per mantenir-se competitiu en un mercat cada cop més exigent (RRHH, recursos naturals, recursos financers, etc.), s'hi ha afegit el recurs del coneixement, associat a les persones que tenen la capacitat d'aportar un elevat valor afegit a les organitzacions. Aquestes persones amb aptitud, actitud i sensibilitat per actuar amb intel·ligència són recursos de talent (RRT) i han de considerar-se un factor clau per qualsevol organització. L'estudi dut a terme sobre l'estat de l'art de la gestió de RRT evidencia la manca d'estratègies en aquest sentit. A més a més, s'han detectat alguns aspectes millorables en l'actual percepció entre informació-empresa. Per tots aquests motius, s'ha dut a terme una nova proposta per entendre la relació informacióempresa i s'ha desenvolupat un model de vigilància de RRT, que hauria de quedar integrat en l'estratègia de Gestió del Coneixement de qualsevol organització. L'estudi inclou també la presentació d'algunes eines de vigilància d'informació, fent incís en les eines de cerca d'informació a Internet, per la seva creixent rellevància. Aquesta nova situació industrial presentarà noves oportunitats de negoci relacionades amb la gestió de RRT, així com obrirà possiblement nous debats ètics sobre la conveniència o no, d'entendre les persones com a un recurs més per a les organitzacions.

A formação dos docentes de química: uma perspectiva multivariada aplicada à rede pública de ensino médio de Goiás

This paper presents a multivariate statistical analysis as a valuable tool for educational management applied to public high school chemistry teacher formation. From 2003 to 2007, a decrease of 10% in the number of public high schools was seen, as well as a reduction of 7% in the number of teachers. Contrarily, there was an increase in the number of university graduate teachers. Principal Component Analyses reveal that in 2003, most chemistry teachers were not university graduates. In 2007, eight Regional Offices of Education reported teachers holding academic degrees, qualifying them as chemistry teacher in the school system

YmpäristöjärjesteImän kehittäminen kouluissa

Ympäristöasioiden hallintajärjestelmät perustuvat kestävään kehitykseen. Peruslähtökohta ympäristöjärjestelmän käyttöönottoon on joko ideologiassa tai puhtaasti myynnin edistämisessä. Tässä diplomityössä lähestytään ympäristöjärjestelmää ensin yritysten näkökulmasta ja sen jälkeen koulujen ja oppilaitosten näkökulmista. Työn tavoitteina on vastata kysymykseen kuinka kehittää koulujen käyttämää Vihreä lippu ympäristöjärjestelmää entistä paremmaksi, sekä kuinka helpottaa Vihreä lippu ympäristöjärjestelmän käyttöönottoa kouluissa. Tämä tutkimus perustuu ympäristöministeriön rahoittamaan hankkeeseen "Kokemuksia Vihreä lippu ympäristöjärjestelmän käytöstä kouluissa". Hanke toteutettiin syksyn 2008 ja kevään 2009 aikana. Hankkeen tiedot kerättiin sekä kyselyiden että haastattelujen avulla. Tutkimus on luonteeltaan kvantitatiivinen, mutta siinä on myös kvalitatiivisen tutkimuksen elementtejä. Tutkimusmenetelmien yhdistäminen tässä tutkimuksessa lisää selvästi tutkimuksen validiutta. Tutkimuksen johtopaatokset näyttävät, että aivan "kivutta" ympäristöjärjestelmä ei synny kouluihin. Asiaa helpottaa suuresti, jos koulun johtoporras sitoutuu näyttävästi ympäristöjärjestelmään. Johdon sitoutuminen ympäristöjärjestelmään sitouttaa kaikki muut. Käyttöönottoa auttaa myös, jos ympäristöjärjestelmää käytetään johdon työkaluna. Lisaksi koulujen kannattaa olla avoimia kaikille sidosryhmille ja ottaa heitä reippaasti mukaan koulujen normaaliin arkeen. Myös koulujen ulkoinen ja sisäinen viestintä kannattaa ottaa suurennuslasin alle.

Enterprise architecture – the foundation for a strategy

This artcle describes work done with enterprise architecture of the National Digital Library. The National Digital Library is an initiative of the Finnish Ministry of Education and Culture. Its purpose is to promote the availability of the digital information resources of archives, libraries and museums, and to develope the long-term preservation of digital cultural heritage materials. Enterprise architectures are a tool for strategic management and planning. An enterprise architecture also functions as an aid at a more practical level. It shows, for example, what kind of changes and improvements may be made in one system without overlap or conflict with other systems.

Järjestelmätoimittajan suorituskyvyn mittaaminen johtamisen välineenä

Tutkimuksen tavoitteena on analysoida kokonaisratkaisuja tarjoavan järjestelmätoimittajan suorituskyvyn mittaamisen suunnittelua johdon päätöksenteon tukivälineeksi. Alitavoitteena oli suunnitella mittaristo case-yrityksen valitulle yksikölle sekä konsernitasolle. Tutkimuksen myötä havaittiin tarpeelliseksi tunnistaa järjestelmätoimittajan toimialatason vahvimmat ydinkyvykkyydet ja esittää ratkaisuja niiden mittaamiselle. Tutkimuksesta rajattiin mittariston hyödyntäminen yksilötason ohjauksessa. Tutkimusta lähestyttiin toiminta-analyyttisenä tapaustutkimuksena. Tutkimuksen yhteydessä määriteltiin järjestelmätoimittaja teollisen palveluliiketoiminnan toimijaksi, jonka mittaus painottuu asiakaslähtöisen toiminnan edistämiseen. Suurimmat haasteet muodostuivat aineettoman pääoman, pääosin uudistuvan ja uuden liiketoiminnan verkostojen mittaamisesta. Tutkimustuloksena voitiin havaita, että toimialatason keskeisimpiin ydinkyvykkyyksiin ja case-yrityksen linjaamiin menestystekijöihin pohjautunut tarkastelu onnistui tunnistamaan keskeisiä ongelmakohtia järjestelmätoimittajan mittariston suunnittelussa. Merkittävimmät toimenpidesuositukset ja laaditut mittariehdotukset painottavat asiakkaan prosessien tuntemista, oman osaamisen johtamista asiakkaan prosesseihin soveltuviksi, uusien innovaatioiden ja kyvykkyyksien luomista, erilaisten verkostojen tunnistamista ja kehittämistä, kyvykkyyksien johtamista ja tuotekeskeisen myynnin kehittämistä palvelukeskeiseen suuntaan. Tutkimus esittää näihin tuloksiin pohjautuvan mittariston ja prosessin aikana syntyneet mittariehdotukset.

Varallisuudenhoito indeksiosuusrahastoilla

Tämä Pro gradu–työ on käytännönläheinen sijoittajalähtöinen tutkimus varallisuudenhoidosta indeksiosuusrahastoilla. Tavoitteena on selvittää indeksiosuusrahastojen olemusta, niiden hyötyjä sekä mahdollisia haittapuolia. Toisena tavoitteena on rakentaa indeksiosuusrahastoista aikaisemman tutkimuksen pohjalta mallisalkku. Kolmantena tavoitteena on luoda Excelin portfolio-optimoinnilla salkku, jossa tutkitaan indeksiosuusrahastojen suoriutumista markkinoilla. Tämä optimointimetodi on rakennettu Mika Vaihekosken (2002) mukaan. Tutkimusmenetelmänä on empiirinen tutkimus. Tarkastelen aihetta pääosin liiketaloustieteellisestä näkökulmasta. Tutkimuksessa käytetään myös paljon rahoitusmarkkinalähtöistä näkökulmaa. Tutkimusaineisto koostuu kolmestakymmenestäneljästä Yhdysvaltain markkinoiden osake-, joukkovelkakirja- sekä raaka-aineindeksiosuusrahastosta. Aineisto on vuosilta 2006 – 2011 sisältäen 34x69 havaintoa. Portfolio-optimoinnissa käytetään neljää hyperbola-kerrointa. Empiiristen tutkimustulosten mukaan indeksiosuusrahastojen menneisyyden hyvät tuotot ennustaisivat hyvin tulevaisuuden hyviä tuottoja ainakin tämän tutkimuksen aikavälillä tammikuusta 2006 syyskuuhun 2011. Valinta-aikavälin 2006 – 2008 aineistosta muodostettu tangenttiportfolio menestyi suhteellisen hyvin hallussapitoaikavälillä 2009 – 2011. Tangenttiportfolio osoittautui ainakin tässä tutkielmassa käyttökelpoiseksi työkaluksi indeksiosuusrahastojen varallisuudenhallinnassa.

Reflexive model of research-based theatre – processing innovation at the crossroads of theatre, reflection and practice-based innovation activities

Contemporary organisations have to embrace the notion of doing ‘more with less’. This challenges knowledge production within companies and public organisations, forcing them to reorganise their structures and rethink what knowledge production actually means in the context of innovation and how knowledge is actually produced among various professional groups within the organisation in their everyday actions. Innovations are vital for organisational survival, and ‘ordinary’ employees and customers are central but too-often ignored producers of knowledge for contemporary organisations. Broader levels of participation and reflexive practices are needed. This dissertation discusses the missing links between innovation research conducted in the context of industrial management, arts, and culture; applied drama and theatre practices (specifically post-Boalian approaches); and learning – especially organising reflection – in organisational settings. This dissertation (1) explores and extends the role of research-based theatre to organising reflection and reflexive practices in the context of practice-based innovation, (2) develops a reflexive model of RBT for investigating and developing practice-based organisational process innovations in order to contribute to the development of a tool for innovation management and analysis, and (3) operationalises this model within private- and publicsector organisations. The proposed novel reflexive model of research-based theatre for investigating and developing practice-based organisational process innovations extends existing methods and offers a different way of organising reflection and reflexive practices in the context of general innovation management. The model was developed through five participatory action research processes conducted in four different organisations. The results provide learning steps – a reflection path – for understanding complex organisational life, people, and relations amid renewal and change actions. The proposed model provides a new approach to organising and cultivating reflexivity in practice-based innovation activities via research-based theatre. The results can be utilised as a guideline when processing practice-based innovation within private or public organisations. The model helps innovation managers to construct, together with their employees, temporary communities where they can learn together through reflecting on their own and each others’ experiences and to break down assumptions related to their own perspectives. The results include recommendations for practical development steps applicable in various organisations with regard to (i) application of research-based theatre and (ii) related general innovation management. The dissertation thus contributes to the development of novel learning approaches in knowledge production. Keywords: practice-based innovation, research-based theatre, learning, reflection, mode 2b knowledge production

Supplier Segmentation for Nordic Petrochemical Industry

Objective of this thesis was to map possibilities for systematic supplier management in field of chemical process industry. Through this study it was aimed to develop a tool for supplier management that could be integrated with operations in business unit. With developed tool suppliers should be able to be segmented based on their willingness and capability, and segmentation could be applied in purchasing decisions. In this thesis there was made a survey of methods that are recognized in literature to manage and allocate suppliers. This thesis recognizes segmentation as a method to group and select suppliers in procurement. Based on literature, a proposal for segmentation framework and evaluation criteria factors will be constituted. Based on theoretical proposal, in an expertise workshop a final segmentation framework was constituted, which covers segments with descriptions and evaluation part. Evaluation part includes an evaluation framework which helps to score suppliers with selected factors and leads to total grades in willingness and capability. These total grades will be the coordinates and they determine the segment where the supplier under evaluation belongs. In this thesis segments definitions, objectives, and road maps will be described.

Differential suppression of rice weeds by allelopathic plant aqueous extracts

Herbicidal potential of different plant aqueous extracts was evaluated against early seedling growth of rice weeds in pot studies. Plant aqueous extracts of sorghum (Sorghum bicolor), sunflower (Helianthus annuus), brassica (Brassica compestris), mulberry (Morris alba), eucalyptus (Eucalyptus camaldunensis), and winter cherry (Withania somnifera) at a spray volume of 18 L ha-1 each at the 2-4 leaf stage of rice weeds viz horse purslane (Trianthema portulacastrum) [broad-leaf], jungle rice (Echinochloa colona), and E. crus-galli (barnyard grass) [grasses] and purple nut sedge (Cyperus rotundus) and rice flat sedge (C. iria) [sedges]. The results showed significant interactive effects between plant aqueous extracts and the tested weed species for seedling growth attributes depicting that allelopathic inhibition was species-specific. Shoot and root length, lateral plant spread, biomass accumulation, and leaf chlorophyll contents in test species were all reduced by different extracts. The study suggested the suppressive potential of allelopathic plant aqueous extracts against rice weeds, and offered promise for their usefulness as a tool for weed management under field conditions.

FOOD PREFERENCE AND CONSUMPTION OF AQUATIC MACROPHYTES SUBMERGED BY SNAIL Pomacea canaliculata

ABSTRACTThe objective of this study was to evaluate the consumption potential, food preference and use of snail Pomacea canaliculata as a biocontrol agent of four submerged aquatic macrophytes (Ceratophyllumdemersum, Egeriadensa, Egerianajas and Hydrilla verticillata). Two experiments were performed. In the first experiment, the introduction of a snail took place and 10 grams of each macrophyte in plastic containers with 1 liter of water. The assessments of consumption by the snail were performed at each 48 hours, during 12 days. The second experiment was performed in 600 liters microcosms containing five snails in each experimental unit. Fifty grams of each macrophyte were offered the snails at the same time, adding the same amounts after seven, 14, 21 and 30 days. On both trials, the most consumed macrophyte by the P.canaliculata was H.verticillata (7.64 ± 1.0 g 48 h and 50 ± 0.18 g) respectively, significantly differing from the others. However, in the absence of H.verticilata, E.najas and E.densa were consumed. The preference of P.canaliculata for H.verticillata is very interesting, because this plant is exotic and problematic in Brazil, and the snail is one more tool for biological management of submerged aquatic macrophyte H.verticillata.

WHEAT HERBAGE AMENDMENTS ALTER EMERGENCE DYNAMICS, SEEDLING GROWTH OF LAMBSQUARTER AND SOIL PROPERTIES

ABSTRACT Crop allelopathy is a potential tool for weed management but allelopathic potential often varies among cultivars and developmental stages of crop. Bioassays were conducted to appraise the allelopathic potential of herbage (incorporated at 8 g kg-1 soil) of different hexaploid wheat (Triticum aestivum) cultivars (Millat-2011, AARI-2011, Lasani-2008 and Faisalabad-2008) collected at different crop growth stages [tillering (Z-30), anthesis (Z-60) and maturity (Z-90)] against lambsquarter (Chenopodium album). Mean emergence time taken by lambsquarter was prolonged over control by anthesis and maturity stage herbage of all wheat cultivars. Final emergence percentage was dropped by 3-17% in response to different growth stages of herbage collection. Maximum suppression in shoot (45 and 78%) and root (60 and 90%) length, and seedling dry biomass (65 and 96%) of lambsquarter over control was recorded under the amendment of anthesis and maturity stages herbage of wheat cultivars. Total chlorophyll contents declined in response to herbage collected at anthesis and maturity stage of all wheat cultivars over control. Phenolic contents on the other hand were increased. Activities of enzymatic antioxidants also varied among all wheat cultivars, and declined by the incorporation of tillering, anthesis and maturity stage herbage. Wheat herbage induced lipid peroxidation in lambsquarter seedling and higher malondialdehyde content (0.56 and 0.77 nmol g-1 FW) was observed by the incorporation of wheat cultivars herbage collected at anthesis and maturity stage, respectively. Anthesis and maturity stage herbage of wheat cultivars Millat-2011, AARI-2011 and Lasani-2008 was more phytotoxic than Faisalabad-2008. Moreover, tillering stage herbage of all wheat cultivars had less inhibitory potential against emergence, seedling growth and biochemical attributes of lambsquarter. Wheat herbage amendment increased the soil pH, phenolic, organic carbon and nitrogen contents as compared to control.

Allelopathic Influence of Residues from Sphagneticola trilobata on Weeds and Crops

The allelopathic effect studied in many cultures has currently generated great expectations that displayed a natural and environmentally friendly tool for weed management using bioherbicides. The objective of this work was to assess allelopathic influence of residues of S. trilobata on the germination and growth of weeds, as well as their relation with some crops and effects on soil properties. Results show that residues from S. trilobata have inhibited the germination of weeds (31.6 - 72%), increasingly with the applied dose. All residue doses of this specie have inhibited dicotyledonous germination, but only maximum concentration has affected monocotyledons. The residues did not affect onion germination, but stimulated it in radish and tomato, while the dose applied at 50% produced tomato stimulation and inhibition of cabbage. The effects of residues on hypocotyl growth in different crops showed changes in species response. For onion, the three doses had negative effects on the growth of hypocotyl, while tomato was stimulated. For radish, the growth was hindered by any dose applied, and were only different (50 and 100%) compared to control. For cabbage, only hypocotyl length was stimulated, when maximum dose (100%) was applied. For the radicle growth, in onion and radish no differences were found compared to control. While the tomato radicle growth was inhibited, in cabbage, all doses encouraged the elongation of the radicle. The dry mass of weed was affected by increased dose of residue (0.49 - 8.8 g m-2), however the soil microflora was stimulated, while the population of Azotobacter spp. was not affect. Some soil properties were affected, the level of organic material, Na+ and electrical conductivity were increased, while pH (H2O) decreased a bit, however it remained basic.