48 resultados para Inherent chirality


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Stress/strain sensors constitute a class of devices with a global ever-growing market thanks to their use in many fields of modern life. They are typically constituted by thin metal foils deposited on flexible supports. However, the low inherent resistivity and limited flexibility of their constituents make them inadequate for several applications, such as measuring large movements in robotic systems and biological tissues. As an alternative to the traditional compounds, in the present work we will show the advantages to employ a smart material, polyaniline (PANI), prepared by an innovative environmentally friendly route, for force/strain sensor applications wherein simple processing, environmental friendliness and sensitivity are particularly required.

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Tese de Doutoramento em Ciências Jurídicas (área de especialização em Ciências Jurídicas Públicas).

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Tese de Doutoramento em Estudos da Criança (área de especialização em Literatura para a Infância).

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Tese de Doutoramento em Arquitectura / Cultura Arquitectónica.

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Dissertação de mestrado em Direito dos Contratos e da Empresa

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Dissertação de mestrado em Engenharia e Gestão da Qualidade

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Dissertação de mestrado integrado em Engenharia e Gestão Industrial

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Dissertação de mestrado em Engenharia Industrial

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Dissertação de mestrado integrado em Engenharia Mecânica

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Dissertação de mestrado integrado em Engenharia de Materiais

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Urothelial bladder carcinoma (UBC) is an intricate malignancy with a variable natural history and clinical behavior. Despite developments in diagnosis/prognosis refinement and treatment modalities, the recurrence rate is high, and progression from non-muscle to muscle invasive UBC commonly leads to metastasis. Moreover, patients with muscle-invasive or extra-vesical disease often fail the standard chemotherapy treatment, and overall survival rates are poor. Thus, UBC remains a challenge in the oncology field, representing an ideal candidate for research on biomarkers that could identify patients at increased risk of recurrence, progression, and chemo-refractoriness. However, progress toward personalized medicine has been hampered by the unique genetic complexity of UBC. Recent genome-wide expression and sequencing studies have brought new insights into its molecular features, pathogenesis and clinical diversity, revealing a landscape where classical pathology is intersected by the novel and heterogeneous molecular groups. Hence, it seems plausible to postulate that only an integrated signature of prognostic/predictive biomarkers inherent in different cancer hallmarks will reach clinical validation. In this review, we have summarized ours and others' research into novel putative biomarkers of progression and chemoresistance that encompass several hallmarks of cancer: tumor neovascularization, invasion and metastasis, and energy metabolism reprogramming of the tumor microenvironment.

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Dissertação de mestrado integrado em Engenharia Eletrónica Industrial e de Computadores

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Tese de Doutoramento em Ciências da Educação (Especialidade em Literacias e Ensino do Português)

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Programa Doutoral em Engenharia Eletrónica e de Computadores

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Dissertação de mestrado integrado em Engenharia Civil