“ Da Moda ao Resíduo e do Resíduo à Moda”: um contributo sustentável no uso da pele residual na Indústria do calçado

Dissertação de mestrado em Design e Marketing

IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis of infected macrophages

The fate of infected macrophages is a critical aspect of immunity to mycobacteria. By depriving the pathogen of its intracellular niche, apoptotic death of the infected macrophage has been shown to be an important mechanism to control bacterial growth. Here, we show that IL-17 inhibits apoptosis of Mycobacterium bovis BCG- or Mycobacterium tuberculosis-infected macrophages thus hampering their ability to control bacterial growth. Mechanistically, we show that IL-17 inhibits p53, and impacts on the intrinsic apoptotic pathway, by increasing the Bcl2 and decreasing Bax expression, decreasing cytochrome c release from the mitochondria, and inhibiting caspase-3 activation. The same effect of IL-17 was observed in infected macrophages upon blockade of p53 nuclear translocation. These results reveal a previously unappreciated role for the IL-17/p53 axis in the regulation of mycobacteria-induced apoptosis and can have important implications in a broad spectrum of diseases where apoptosis of the infected cell is an important host defense mechanism.

Implementação de um sistema de gestão e monitorização de embalagens retornáveis em ambiente industrial

Dissertação de mestrado em Engenharia de Sistemas

Processamento e caracterização mecânica e metalográfica de compósitos adiamantados à base de cobre-níquel obtidos por hot pressing

Dissertação de mestrado em Engenharia de Materiais

Estudo da logística do armazenamento e distribuição interna de consumíveis clínicos de uma unidade hospitalar

Dissertação de mestrado em Engenharia Industrial

Estudo exploratório sobre as concepções e estratégias de intervenção de professores em face do bullying escolar

Este estudo qualitativo objetivou identificar o conhecimento de professores do 6º ano do ensino fundamental sobre o bullying e as intervenções por eles desenvol- vidas. Participaram dez professores, e os dados foram coletados por meio de questio- nários estruturados. As análises seguiram os pressupostos da análise de conteúdo, em sua modalidade temática. Verificou-se, nos resultados, uma compreensão insuficiente dos professores que incidia na capacidade de identificação e na maneira como intervi- nham nos episódios de bullying entre os alunos. Depreende-se que o bullying constitui um aspecto importante a ser trabalhado com os professores, considerando a proximi- dade com a questão e o papel essencial que podem assumir no seu enfrentamento.

Jogos sérios para reabilitação cognitiva

Dissertação de mestrado integrado em Engenharia e Gestão de Sistemas de Informação

A protecção constitucional da família por via dos impostos: um estudo comparado entre o ordenamento jurídico Angolano e o ordenamento jurídico Português

Dissertação de mestrado em Direito Tributário e Fiscal

School health promotion and teacher professional identity

PURPOSE – Health and education are inextricably linked. Health promotion sits somewhat uncomfortably within schools, often remaining a marginal aspect of teachers’ work. The purpose of this paper is to examine the compatibility of an HP-initiative with teacher professional identity. DESIGN/METHODOLOGY/APPROACH – A qualitative research design was adopted consisting of semi-structured interviews. In total, 49 teachers in two school districts in the Auvergne region in central France were interviewed in depth post having completed three years’ involvement in a health promoting schools initiative called “Learning to Live Better Together” (“Apprendre a Mieux Vivre Ensemble”). FINDINGS – Teachers in the study had a broad conceptualisation of their role in health promotion. In keeping with international trends, there was more success at classroom than at whole school level. While generally teachers can be reluctant to engage with health promotion, the teachers in this study identified having little difficulty in understanding their professional identity as health promoters and identified strong compatibility with the HP-initiative. PRACTICAL IMPLICATIONS – Teachers generally viewed professional development in health promotion in a positive light when its underlying values were commensurate with their own and when the context was seen as compatible with the school mission. The promotion of health in schools needs to be sensitive to professional identity and be tailored specifically to blend more successfully with current teacher identity and practice. ORIGINALITY/VALUE – The promotion of health in schools needs to be sensitive to professional identity and be tailored specifically to blend more successfully with current teacher identity and practice.

Influence of casting condition on the anisotropy of the fracture properties of Steel Fibre Reinforced Self-Compacting Concrete (SFRSCC)

Identification of the tensile constitutive behaviour of Fibre Reinforced Concrete (FRC) represents an important aspect of the design of structural elements using this material. Although an important step has been made with the introduction of guidance for the design with regular FRC in the recently published fib Model Code 2010, a better understanding of the behaviour of this material is still necessary, mainly for that with self-compacting properties. This work presents an experimental investigation employing Steel Fibre Self-Compacting Concrete (SFRSCC) to cast thin structural elements. A new test method is proposed for assessing the post-cracking behaviour and the results obtained with the proposed test method are compared with the ones resulted from the standard three-point bending tests (3PBT). Specimens extracted from a sandwich panel consisting of SFRSCC layers are also tested. The mechanical properties of SFRSCC are correlated to the fibre distribution by analysing the results obtained with the different tests. Finally, the stress-crack width constitutive law proposed by the fib Model Code 2010 is analysed in light of the experimental results.

Relatório de atividade profissional

Dissertação de mestrado em Ciências – Formação Contínua de Professores (área de especialização em Biologia e Geologia)

Modelação de processos de negócio: análise comparativa de linguagens

Dissertação de mestrado integrado em Engenharia e Gestão de Sistemas de Informação

Desenvolvimento de um mecanismo automatizado de limpeza de uma grelha de uma barragem mini-hídrica

Dissertação de mestrado integrado em Engenharia Mecânica

Design of mechatronic system for handling bedridden people

Dissertação de mestrado em Engenharia Mecatrónica

Formação e avaliação de desempenho: contributos para o desenvolvimento profissional

Tese de Doutoramento em Ciências da Educação (Especialidade em Desenvolvimento Curricular)