乙醛脱氢酶2( ALDH2) 基因研究进展及其与饮酒行为的关系

:亚洲人群中普遍存在突变型的乙醛脱氢酶2 ( ALDH2 3 2) 。此酶突变后活性缺失,导致乙醛在肝脏内大量 累积使突变携带者在喝酒后会有脸红等不适反应,因此这可能影响他们的饮酒行为。由于ALDH2 3 2 等位基因 与饮酒行为相关,它也可能与酒精引起的肝脏损伤及某些癌症密切相关,而且,它在不同的亚洲人群中有不同的频 率分布。近年来对ALDH2 3 2 等位基因的序列结构、表达及其重要功能等有了更深入的了解,对ALDH2 的多态 性在研究方法、研究群体分布范围等都有很大进展。同时还讨论了不同地理分布、不同年龄结构、性别差异条件 下,中国人群中ALDH2 基因型频率与饮酒行为的关系。

β2受体遗传多态性与支气管哮喘患者肺功能关系研究

β_2肾上腺素受体（β_2AR）在哮喘患者中表现出遗传多态性。近年国外已对位点16及27进行了一些临床研究，但是所用基因分型方法不一，此外在中国人群这2个位点的多态性哮喘的关系至今仅有个别报道，我们采用所有样本测序方法，就其多态性与肺功能的关系进行初步探讨。

Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children

Background: Cyclooxygenase-2 (COX-2) plays essential roles in inflammation. Previous studies have suggested associations between prostaglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and prostaglandins production in asthma. Objective: We have invest

Association of pro staglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and Alzheimer's disease in Chinese

Cyclooxygenase-2 (COX-2, encoded by the gene prostaglandin-endoperoxide synthase 2, PTGS2) is a key enzyme in the conversion of arachidonic acid to prostaglandins. The prostaglandins produced by COX-2 are involved in inflammation and pain response in diff

Mitochondrial DNA Haplogroups M7b1 ' 2 and M8a Affect Clinical Expression of Leber Hereditary Optic Neuropathy in Chinese Families with the m.11778G -> A Mutation

Leber hereditary optic neuropathy (LHON) is the most extensively studied mitochondrial disease, with the majority of the cases being caused by one of three primary mitochondrial DNA (mtDNA) mutations. Incomplete disease penetrance and gender bias are two

5，6-二羟基-2-（4-羟苯基）-4-酮-4H-1-苯并吡喃基-7-羟基-β-D-葡萄糖醛酸在制药中的应用

本发明提供化合物5，6-二羟基-2-(4-羟苯基)-4-酮-4H-1-苯并吡喃基-7-羟基-β-D-葡萄糖醛酸在制备抗艾滋病药物中和在制备逆转录酶抑制剂药物中的应用。

2,4-二取代氨基-6-取代-[1,3,5]三嗪或1,3-嘧啶类化合物、其制备方法、药物组合物及用途

一种新型的2，4-二取代氨基-6-取代-[1，3，5]三嗪或1，3-嘧啶衍生物及其制备方法、药物组合物和其药理用途，其结构通式如式(I)所示，其中R1、R2、R3、R4、R5、R6、A、B、X、Y和Z的定义如说明书中所述。该类化合物与HIV-1整合酶具有很高结合活性，并且在底物竞争测试中能够有效的抑制整合酶对底物的结合。因此该类化合物是较强的HIV-1整合酶抑制剂，有望开发成为新的抗HIV病毒药物。

Trichosanthin suppresses the elevation of p38 MAPK, and Bcl-2 induced by HSV-1 infection in Vero cells

Trichosanthin (TCS) is a type I ribosome-inactivating protein (RIP) effective against HIV-1 and HSV-1 replication. The mechanism of its antiviral activity is not clear. Many believe that it is related to ribosome inactivation. Some RIPs and viral infectio

Synthesis and biological evaluation of N-acetyl-beta-aryl-1,2-didehydroethylamines as new HIV-1 RT inhibitors in vitro

A variety of N-acetyl-o-aryl-1,2-didehydroethylamines were synthesized by direct reduction-acetylation of beta-aryl-nitroolefins and assayed as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the first time. Compound 7a exhibited a TI v

4-Benzyl-5-ethyl-2-(2-furylcarbonylmethylsulfanyl) pyrimidin-6(1H)-one

The title compound, C19H18N2O3S, shows favourable activity against HIV-1. The phenyl ring is twisted with respect to the pyrimidine ring by 61.56 (9)degrees. Intermolecular N-H center dot center dot center dot O and C-H center dot center dot center dot O

Anti HIV-1 Agents 2. Discovery of Dibenzofurans as New HIV-1 Inhibitors In Vitro

Ten dibenzofurans were synthesized and evaluated as human immunodeficiency virus (HIV)-1 inhibitors in vitro for the first time. Among these compounds, compounds 1, 6, 7 and 8 demonstrated significant anti-HIV-1 activity. Especially compound 1 showed the

云南前突芽茧蜂与少毛蚜茧蜂2新种(膜翅目:蚜茧蜂科)

该文记述了云南蚜茧蜂科(Aphidiidae)2新种:昆明前突蚜茧蜂Lysaphidus kunmingensis sp. nov.和马龙少毛蚜茧蜂Pauesia malongensis sp. nov.