Mitochondrial DNA Haplogroups M7b1 ' 2 and M8a Affect Clinical Expression of Leber Hereditary Optic Neuropathy in Chinese Families with the m.11778G -> A Mutation

Leber hereditary optic neuropathy (LHON) is the most extensively studied mitochondrial disease, with the majority of the cases being caused by one of three primary mitochondrial DNA (mtDNA) mutations. Incomplete disease penetrance and gender bias are two

The authors thank the patients for donating DNA samples, Jin-Xin Zhang (The Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-Sen University) for statistical assistance, and the reviewers for critical comments on the earl